Cited by 566T-cell and B-cell ImmunologyImmune cells in cancerCancer, Hypoxia, and Metabolism

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Metabolic switching and fuel choice during T‐cell differentiation and memory development

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van der Windt, Gerritje J. W., Pearce, Erika L.·2012·Immunological Reviews

DOI 10.1111/j.1600-065x.2012.01150.xPMC PMC3645891

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Abstract

Summary: Clearance or control of pathogens or tumors usually requires T‐cell‐mediated immunity. As such, understanding the mechanisms that govern the function, maintenance, and persistence of T cells will likely lead to new treatments for controlling disease. During an immune response, T‐cell development is marked by striking changes in metabolism. There is a growing appreciation that these metabolic changes underlie the capacity of T cells to perform particular functions, and this has led to a recent focus on the idea that the manipulation of cellular metabolism can be used to shape adaptive immune responses. Although interest in this area has grown in the last few years, a full understanding of the metabolic control of T‐cell functions, particularly during an immune response in vivo , is still lacking. In this review, we first provide a basic overview of metabolism in T cells, and then we focus on recent studies providing new or updated insights into the regulation of metabolic pathways and how they underpin T‐cell differentiation and memory T‐cell development.

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Authors: van der Windt, G. J. W., & Pearce, E. L.
Affiliations: Department of Pathology & Immunology Washington University School of Medicine St. Louis MO USA
Washington University in St. Louis (US)
Corresponding author: Pearce, Erika L.
ORCID: Pearce, Erika L.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2012-08-14
Volume: 249
Issue: 1
Pages: 27-42
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.1600-065x.2012.01150.x
PMC: PMC3645891
OpenAlex: W1999195849
Cited by: 563
References: 157
Citations by year: 2026: 38 · 2025: 52 · 2024: 44 · 2023: 55 · 2022: 58 · 2021: 53 · 2020: 54 · 2019: 44 · 2018: 41 · 2017: 35 · 2016: 22 · 2015: 26 · 2014: 23 · 2013: 14 · 2012: 3
FWCI: 1.95
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Emerald Foundation
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
National Institutes of Health
National Cancer Institute (R21CA158823)
National Institute of Allergy and Infectious Diseases (R01AI091965)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: T cell metabolism, metabolic switch, fuel selection, T cell differentiation, memory T cells, metabolic reprogramming, adaptive immune response, T cell immunity
MeSH terms: Animals, Cell Differentiation, Energy Metabolism, Humans, Immunity, Cellular, Immunologic Memory, Lymphocyte Activation, Mitochondria, T-Lymphocytes, Cell Proliferation

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Metabolic switching and fuel choice during T‐cell differentiation and memory development

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