Unveiling the gut microbiota composition and functionality associated with constipation through metagenomic analyses
Open accessAbstract
Functional constipation (FC) is a gastrointestinal disorder with a high prevalence among the general population. The precise causes of FC are still unknown and are most likely multifactorial. Growing evidence indicates that alterations of gut microbiota composition contribute to constipation symptoms. Nevertheless, many discrepancies exist in literature and no clear link between FC and gut microbiota composition has as yet been identified. In this study, we performed 16 S rRNA-based microbial profiling analysis of 147 stool samples from 68 FC individuals and compared their microbial profiles with those of 79 healthy subjects (HS). Notably, the gut microbiota of FC individuals was shown to be depleted of members belonging to Bacteroides, Roseburia and Coprococcus 3 . Furthermore, the metabolic capabilities of the gut microbiomes of five FC and five HS individuals were evaluated through shotgun metagenomics using a MiSeq platform, indicating that HS are enriched in pathways involved in carbohydrate, fatty acid and lipid metabolism as compared to FC. In contrast, the microbiomes corresponding to FC were shown to exhibit high abundance of genes involved in hydrogen production, methanogenesis and glycerol degradation. The identified differences in bacterial composition and metabolic capabilities may play an important role in development of FC symptoms.
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Healthy volunteers' microbiomes were richer in genes for carbohydrate, fatty acid, and lipid metabolism, while functional constipation patients had more genes tied to methanogenesis, hydrogen production, and glycerol.
“Furthermore, healthy volunteers were found to have a gut microbiome enriched in genes involved in carbohydrate, fatty acid, and lipid metabolism while FC patients harbored a high abundance of genes involved in methanogenic pathways, hydrogen production, and glycerol162.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [162]
Fecal microbiome analysis found less Bacteroides, Roseburia, and Coprococcus in functional constipation patients than in healthy volunteers.
“Taxonomic profiling of the fecal microbiome from patients with functional constipation (FC) and healthy volunteers has shown decreased abundance of Bacteroides, Roseburia, and Coprococcus in FC patients.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [162]
Shotgun metagenomic sequencing by Mancabelli et al. does not support altered short-chain fatty acid production in functional constipation, which may be explained by very small sample size.
“Shotgun metagenomic sequencing by Mancabelli et al . [ 32 ] does not support altered SCFA production in FC, which may be explained by very small sample size.”
From Role of gut microbiota in functional constipation (2021) · cites this paper as [32]
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Acupuncture influences multiple diseases by regulating gut microbiota
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Roles of Chinese Medicine and Gut Microbiota in Chronic Constipation
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Total Transit Time and Probiotic Persistence in Healthy Adults: A Pilot Study
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Altered Gut Microbic Flora and Haemorrhoids: Could They Have a Possible Relationship?
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The Latest Data Concerning the Etiology and Pathogenesis of Irritable Bowel Syndrome
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Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome
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- Authors
- Mancabelli, L., Milani, C., Lugli, G. A., Turroni, F., Mangifesta, M., Viappiani, A., Ticinesi, A., Nouvenne, A., Meschi, T., van Sinderen, D., & Ventura, M.
- Affiliations
- University of Parma (IT)
- Corresponding author
- Ventura, Marco
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-08-29
- Volume
- 7
- Issue
- 1
- Pages
- 9879-9879
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5575163
- OpenAlex
- W2748998801
- Cited by
- 182
- References
- 48
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 28 · 2023: 23 · 2022: 29 · 2021: 21 · 2020: 18 · 2019: 16 · 2018: 5 · 2017: 1
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by)
- HAL (submittedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- Fondazione Cariparma
- Joint Programming Initiative A healthy diet for a healthy life
- Science Foundation Ireland (SFI/12/RC/, 12/RC/2273, 12/RC/, SFI/12/RC/2273.)
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università degli Studi di Parma
- APC Microbiome Institute (SFI/12/RC/2273)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- functional constipation, gut microbiota, microbial community composition, microbial metabolic pathways, Bacteroides, Roseburia, carbohydrate metabolism, fatty acid metabolism, lipid metabolism, hydrogen production, methanogenesis, glycerol degradation, 16S rRNA gene profiling, shotgun metagenomics
- MeSH terms
- Gastrointestinal Microbiome, Constipation, Gene Amplification, Humans, RNA, Ribosomal, 16S, Case-Control Studies, Metagenome, Metagenomics
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