Cited by 790Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

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The developmental origins of chronic adult disease

Barker, DJP·2004·Acta Paediatrica

DOI 10.1111/j.1651-2227.2004.tb00236.x

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Abstract

Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin-dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. Coronary heart disease and the disorders related to it arise through a series of interactions between environmental influences and the pathways of development that preceded them. These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth.

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Background
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“FIGURE 9 | Long Evans (LE) strain recapitulates the Sprague Dawley (S) genotype in the Dio3 exon and its promoter. Standard sequencing traces of four novel polymorphisms within the Dio3 promoter region and their location relative to the Dio3 start site are shown. (A) G/A at −360 bp upstream of Dio3; (B) A/T at −335 bp…”
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“These findings suggest the role of maternal infections in the fetal programming of cardiovascular and diabetes risk factors emphasized by Barker (Barker 2004; Barker and Osmond 1986; Hales and Barker 2001).”
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“Background The influence of prenatal factors in the development of conditions such as heart disease, diabetes, and obesity is well reported, with maternal health and the prenatal environment known to influence development throughout the life-course [1].”
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Stumped by the Hump: The Curious Rise and Fall of Norwegian Birthweights, 1991–2007
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Identification of Latent Risk Clinical Attributes for Children Born Under IUGR Condition Using Machine Learning Techniques
Van, S. N., Marques, J. A. L., Biala, T., & Li, Y. (2020) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2020.105842 · Cited by 11
Energy‐ and protein‐enriched formula improves weight gain in infants with malnutrition due to cardiac and noncardiac etiologies
Goday, P. S., Lewis, J. D., Sang, C. J., George, D. E., McGoogan, K. E., Safta, A. M., Seth, A. K., & Krekel, C. (2021) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2308 · Cited by 11
The value of predicting restriction of fetal growth and compromise of its wellbeing: Systematic quantitative overviews (meta-analysis) of test accuracy literature
Morris, R. K., Khan, K. S., Coomarasamy, A., Robson, S. C., & Kleijnen, J. (2007) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-7-3 · Cited by 11
Size at Birth and Motor Activity During Stress in Children Aged 7 to 9 Years
Schlotz, W., Jones, A., Phillips, N. M. M., Godfrey, K. M., & Phillips, D. I. W. (2007) · PEDIATRICS · doi:10.1542/peds.2006-3277 · Cited by 11
Normative data for triceps and subscapular skinfold thicknesses of Chinese infants
Fok, T., Hon, K. E., Ng, P.-C., WONG, M. E., So, H., LAU, T. J., Chow, C., Lee, W., & The Hong Kong Neonatal Measurements Working Group (2006) · Acta Paediatrica · doi:10.1080/08035250600714318 · Cited by 11
“Intrauterine growth restriction might also be associated with increased risk of adult chronic diseases [22,23].”
Background
Risk stratification model to detect early pulmonary disease in infants with cystic fibrosis diagnosed by newborn screening
Britton, L. J., Oates, G. R., Oster, R. A., Self, S. T., Troxler, R. B., Hoover, W., Gutierrez, H. H., & Harris, W. T. (2016) · Pediatric Pulmonology · doi:10.1002/ppul.23536 · Cited by 11
“Attempts to interrupt socioeconomic mechanisms affecting CF lung health need to be applied in very early infancy, before disease trajectory is established.(44) Our findings augment the literature concerning the role of social and physical environment for CF lung health, and emphasize the need to add paternal education…”
Background
Birth weight is not causally associated with adult asthma: results from instrumental variable analyses
Zeng, P., Yu, X., & Zhou, X. (2019) · Scientific Reports · doi:10.1038/s41598-019-44114-5 · Cited by 11
Metabolic implications of GH treatment in small for gestational age
Delemarre, E. M., Rotteveel, J., & de Waal, H. A. D. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0163 · Cited by 11
Biospecimens in the HEALthy Brain and Child Development (HBCD) Study: Rationale and protocol
Sullivan, E. L., Bogdan, R., Bakhireva, L. N., Levitt, P. R., Jones, J., Sheldon, M., Croff, J. M., Thomason, M. E., Lo, J. O.-T., MacIntyre, L., et al. (2024) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2024.101451 · Cited by 10
“…(e.g., deprivation, enrichment) and exposures (e.g. substances (i.e. opioids, tobacco, marijuana and alcohol), toxicants, and nutrients)) during these sensitive periods may affect developmental trajectories (e.g., psychopathology, physical health, cognition) across the lifespan (Barker, 2004).”
Background
Mapping outdoor habitat and abnormally small newborns to develop an ambient health hazard index
Nielsen, C. C., Amrhein, C., & Osornio-Vargas, Á. R. (2017) · International Journal of Health Geographics · doi:10.1186/s12942-017-0117-5 · Cited by 13
The effect of low birth weight as an intrauterine exposure on the early onset of sarcopenia through possible molecular pathways
Celik, D., Campisi, M., Cannella, L., & Pavanello, S. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13455 · Cited by 10
“55 A strong association between TNF α and insulin resistance further underlines the complex relationship.”
Background
Hyperglycemia and lower diet quality in pregnant overweight women and increased infant size at birth and at 13months of age — STEPS study
Mäkelä, J., Lagström, H., Kaljonen, A., Simell, O., & Niinikoski, H. (2013) · Early Human Development · doi:10.1016/j.earlhumdev.2013.01.007 · Cited by 10
“The phenomenon called fetal programming or ‘small-baby syndrome’ as a consequence of maternal starvation has been widely acknowledged and known to contribute to higher risk of chronic diseases later in life [2–5] but effects of excessive maternal nutrition have been more poorly characterized.”
Background
Preserving Cardiovascular Health in Young Children: Beginning Healthier by Starting Earlier
Horn, L. V., Vincent, E., & Perak, A. M. (2018) · Current Atherosclerosis Reports · doi:10.1007/s11883-018-0729-7 · Cited by 10
Kidney impairment in fetal growth restriction: three‐dimensional evaluation of volume and vascularization
Senra, J. C., Yoshizaki, C. T., Doro, G. F., Ruano, R., Gibelli, M. A. B. C., Rodrigues, A. S., Koch, V. H. K., Krebs, V. L. J., Zugaib, M., Francisco, R. P. V., et al. (2020) · Prenatal Diagnosis · doi:10.1002/pd.5778 · Cited by 10
Prenatal environment impacts telomere length in newborn dairy heifers
Meesters, M., Eetvelde, M. V., Martens, D. S., Nawrot, T. S., Dewulf, M., Govaere, J., & OPSOMER, G. (2023) · Scientific Reports · doi:10.1038/s41598-023-31943-8 · Cited by 10
Gender‐specific differences in birthweight and the odds of puberty: NHANES III, 1988–94
Olivo‐Marston, S., Graubard, B. I., Visvanathan, K., & Forman, M. R. (2010) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2010.01097.x · Cited by 10
DUALIDAD DE MALNUTRICIÓN EN EL HOGAR ANTIOQUEÑO (COLOMBIA): BAJO PESO EN LOS MENORES DE 19 AÑOS Y EXCESO DE PESO EN LOS ADULTOS
María Victoria Benjumea, R., Estrada, A., & Martha Cecilia Álvarez, U. (2006) · Revista chilena de nutrición · doi:10.4067/s0717-75182006000100004 · Cited by 10
Trombofilia hereditaria y pérdidas de embarazo. Estudio de una cohorte de Argentina
Wingeyer, S. D. P., Aranda, F. M., Udry, S., Latino, J. O., & Larrañaga, G. F. D. (2018) · Medicina Clínica · doi:10.1016/j.medcli.2017.12.019 · Cited by 9
Genome-wide epigenetic signatures of childhood adversity in early life: Opportunities and challenges
Sasaki, A., & Matthews, S. G. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000843 · Cited by 10
Maternal prenatal psychological distress and motor/cognitive development in two-year-old offspring: The Japan Environment and Children’s Study
Mori, M., Nishigori, T., Ogata, Y., Suzuki, T., Satô, A., Murata, T., Kyozuka, H., Yamaguchi, A., Metoki, H., Shinohara, Y., et al. (2023) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174422000691 · Cited by 9
1. Neurobehavioral Medicine and Stress-Related Disorders
Hellhammer, D. H., & Hellhammer, J. (2008) · KARGER eBooks · doi:10.1159/000118798 · Cited by 9
Epigenetics of Reproduction
McCarthy, M. M., & Rissman, E. F. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00052-1 · Cited by 9
Impact of economic crises on offspring health and the developmental origins of health and disease concept
Sdona, E., Briana, D. D., & Malamitsi‐Puchner, A. (2019) · Acta Paediatrica · doi:10.1111/apa.15040 · Cited by 10
Expression level of long noncoding RNA H19 of normotensive placentas in late pregnancy relates to the fetal growth restriction
Tsunoda, Y., Kudo, M., Wada, R., Ishino, K., Kure, S., Sakatani, T., Takeshita, T., & Naito, Z. (2020) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14260 · Cited by 9
“adulthood.(6,7) Although there are many possible causes of FGR, including fetal, maternal and placental factors,(8,9) the etiology of most cases is not fully known.”
Background
Hepatic lipid metabolism in adult rats using early weaning models: sex-related differences
Bertasso, I. M., Pietrobon, C. B., da Silva, B. S., Miranda, R. A., Bonfleur, M. L., Balbo, S. L., Manhães, A. C., OLIVEIRA, E. B. D., de Moura, E. G., & Lisboa, P. C. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420000495 · Cited by 9
Alterations to Placental Glucocorticoid Receptor Expression with Alcohol Consumption
Young, S. L., Saif, Z., Meakin, A. S., McMaster, E. S., Hayes, N., Gallo, L. A., Reid, N., Moritz, K. M., & Clifton, V. L. (2021) · Reproductive Sciences · doi:10.1007/s43032-020-00413-1 · Cited by 9
“linked to chronic disease in later life [11, 12].”
Background
Reproductive Characteristics and Pregnancy Outcomes in Hidden Celiac Disease Autoimmunity
Celdir, M. G., Choung, R. S., Rostamkolaei, S. K., Jansson‐Knodell, C. L., King, K. S., Larson, J. J., Absah, I., & Murray, J. A. (2021) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001148 · Cited by 9
Grain consumption before and during pregnancy and birth weight in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Yonezawa, Y., Obara, T., Yamashita, T., Ishikuro, M., Murakami, K., Ueno, F., Noda, A., Onuma, T., Sugawara, J., Suzuki, S., et al. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00939-w · Cited by 9
Birth Weight and Adult Obesity Index in Relation to the Risk of Hypertension: A Prospective Cohort Study in the UK Biobank
Zhang, Y., Liang, J., Liu, Q., Fan, X., Xu, C. Y., Gu, A., Zhao, W., & Hang, D. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.637437 · Cited by 9
“Epidemiological evidence has shown an association between low birth weight and obesity in adulthood (27).”
Background
Programmed frozen embryo transfer cycles are associated with a higher risk of abnormal placental development: a retrospective cohort study of singleton live births
Wang, F., Wang, Q., Song, Y. K., Ding, J., Li, H., & Meng, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1202044 · Cited by 9
“Frontiers in Endocrinology 09 hypothesis, placental dysplasia leads to poor perinatal outcomes as well as long-term health risks later in life (25, 26).”
Background
Perinatal and early life factors associated with symptoms of depression in Brazilian children
Pereira, T. S., da Sílva, A. A. M., Alves, M. T. S. S. D. B. E., Simões, V. M. F., Batista, R. F. L., Rodriguez, J. D. M., de Figueiredo, F. P., Filho, F. L., Barbieri, M. A., & Bettiol, H. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-605 · Cited by 9
“Some studies have investigated the association between low birth weight/preterm birth and health problems in later life [13].”
Background
Association between maternal food group intake and birth size
Loy, S. L., Mohamad, M., & Jan, J. M. H. (2013) · Cited by 9
Placental abruption in parents who were born small: registry‐based cohort study
Rasmussen, S., Ebbing, C., Linde, L. E., & Baghestan, E. (2017) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14837 · Cited by 9
Tyrosine phosphorylation of Kv1.5 is upregulated in intrauterine growth retardation rats with exaggerated pulmonary hypertension
Fu, L., Lv, Y., Zhong, Y., He, Q., Liu, X., & Du, L. (2017) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20176237 · Cited by 9
“IUGR is defined as having a birth weight below the 10th percentile of the corresponding gestational age (3).”
Background
Obesity, metabolic syndrome, and disorders of energy balance
Weiss, R., & Lustig, R. H. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4858-7.00031-7 · Cited by 9
Proteomic analysis of fetal programming‐related obesity markers
Lee, J.-H., Yoo, J. Y., You, Y., Kwon, W., Lee, S. M., Pang, M., & Kim, Y. J. (2015) · PROTEOMICS · doi:10.1002/pmic.201400359 · Cited by 9
“The FR condition is accepted as a true model of fetal programming that results in low birth weight, which predisposes individuals to developing obesity, type II diabetes, and metabolic syndrome [7, 17].”
Background
Puberty as a DOHaD programming window: high-fat diet induces long-term hepatic dysfunction in male rats
dos Santos, B. G., Miranda, R. A., Saavedra, L. P. J., Francisco, F. A., Ribeiro, M. V. G., Ferreira, A. R. O., Ferreira-Junior, M. D., Cavalcante, K. V. N., Xavier, C. H., de Moura, E. G., et al. (2023) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174423000272 · Cited by 8
Nanotechnological Approaches For the Treatment of Placental Dysfunction: Recent Trends and Future Perspectives
Zhao, J., Zhang, J., Xu, Y., Dong, J., Dong, Q., Zhao, G., & Shi, Y. (2023) · Nanomedicine · doi:10.2217/nnm-2023-0194 · Cited by 8

Authors: Barker, D.
Affiliations: Southampton General Hospital (GB)
Corresponding author: Barker, DJP
Venue: Acta Paediatrica
Publisher: Wiley
Published: 2004-11
Volume: 93
Issue: s446
Pages: 26-33
ISSN: 0365-1436 (ISSN-L)
0803-5253
1651-2227
DOI: 10.1111/j.1651-2227.2004.tb00236.x
OpenAlex: W2143230895
Cited by: 790
References: 53
Citations by year: 2026: 19 · 2025: 38 · 2024: 49 · 2023: 42 · 2022: 36 · 2021: 63 · 2020: 55 · 2019: 42 · 2018: 39 · 2017: 37 · 2016: 33 · 2015: 40 · 2014: 37 · 2013: 40 · 2012: 45
FWCI: 17.36
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 792 d)
Locations: Acta Paediatrica (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: developmental origins of health and disease, low birth weight, coronary artery disease, stroke, hypertension, type 2 diabetes, developmental plasticity, fetal growth restriction, gestational age, child weight gain, environmental influences on development
MeSH terms: Adult, Birth Weight, Cardiovascular Diseases, Child, Child Development, Child, Preschool, Chronic Disease, Diabetes Mellitus, Type 2, Female, Humans, Infant, Infant, Newborn, Male

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