The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The developmental origins of chronic adult disease
Abstract
Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin-dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. Coronary heart disease and the disorders related to it arise through a series of interactions between environmental influences and the pathways of development that preceded them. These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574
Fetal origins of coronary heart disease
Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570
Self-citationFetal and infant growth and impaired glucose tolerance at age 64
Hales, C. N., Barker, D. J., Clark, P. M., Cox, L. J., Fall, C., Osmond, C., & Winter, P. D. (1991) · BMJ · doi:10.1136/bmj.303.6809.1019 · Cited by 2,708
Phenotypic Plasticity and the Origins of Diversity
West-Eberhard, M. J. (1989) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.20.110189.001341 · Cited by 2,110
Fetal origins of adult disease: strength of effects and biological basis
Barker, D., Eriksson, J., Forsén, T., & Osmond, C. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.6.1235 · Cited by 2,024
Compensation for a bad start: grow now, pay later?
Metcalfe, N. B., & Monaghan, P. (2001) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(01)02124-3 · Cited by 1,948
Health consequences of obesity
Reilly, J. J. (2003) · Archives of Disease in Childhood · doi:10.1136/adc.88.9.748 · Cited by 1,652
Calvert, H., Horwich, A., Newlands, E. S., Beǵent, R. H. J., Rustin, G. J. S., Kaye, S. B., Harris, A. L., Williams, C. J., & Slevin, M. L. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92709-2 · Cited by 1,183
Nephron Number in Patients with Primary Hypertension
Keller, G., Zimmer, G., Mall, G., Ritz, E., & Amann, K. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020549 · Cited by 1,102
The role of size at birth and postnatal catch-up growth in determining systolic blood pressure
Huxley, R., Shiell, A. W., & Law, C. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018070-00002 · Cited by 1,046
Research works printed but not linked: 1
- Bateson P, 1999, Design for a life: how behaviour develops
Cited by
Sorted by citations
Items 101–200 of 790
Glyphosate Herbicide: Reproductive Outcomes and Multigenerational Effects
Milesi, M. M., Lorenz, V., Durando, M., Rossetti, M. F., & Varayoud, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.672532 · Cited by 83
Association Between Birth in a High Stroke Mortality State, Race, and Risk of Dementia
Gilsanz, P., Mayeda, E. R., Glymour, M. M., Quesenberry, C. P., & Whitmer, R. A. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.1553 · Cited by 84
Vrijkotte, T. G. M., Hrudey, J., & Twickler, M. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3452 · Cited by 82
Early postnatal nutrition and programming of the preterm neonate
Wiedmeier, J. E., Joss‐Moore, L. A., Lane, R. H., & Neu, J. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00370.x · Cited by 84
Iglesias‐Platas, I., Martín-Trujillo, Á., Petazzi, P., Guillaumet-Adkins, A., Esteller, M., & Monk, D. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu347 · Cited by 80
Meas, T., Deghmoun, S., Alberti, C., Carreira, E., Armoogum, P., Chevenne, D., & Lévy‐Marchal, C. (2010) · Diabetologia · doi:10.1007/s00125-009-1650-y · Cited by 79
“Being born small for gestational age (SGA) has been associated with an increased risk of insulin resistance (IR) and metabolic syndrome (MS) [1, 2].”
BackgroundHoang, V. M., Byass, P., Dao, L. H., Nguyen, T. K. C., & Wall, S. (2007) · PubMed Central · Cited by 79
Dixon, L., Sparks, N. H. C., & Rutherford, K. (2016) · Poultry Science · doi:10.3382/ps/pev343 · Cited by 80
“Similarly the human fetal environment has been shown to have lasting effects on offspring phenotype with correlations being found between low birth weight and later ill health (Barker, 2004).”
BackgroundDeterminants of Early Life Leptin Levels and Later Life Degenerative Outcomes
Alexe, D. M., Syridou, G., & Petridou, E. T. (2006) · Clinical Medicine & Research · doi:10.3121/cmr.4.4.326 · Cited by 77
Determinant of Low Birth Weight Infants: A Matched Case Control Study
Sutan, R., Mohtar, M., Mahat, A. N., & Tamil, A. M. (2014) · Open Journal of Preventive Medicine · doi:10.4236/ojpm.2014.43013 · Cited by 77
“Open Journal of Preventive Medicine, 4, 91-99. http://dx.doi.org/10.4236/ojpm.2014.43013 Keywords Low Birth Weight; Maternal Factors; Matched Case Control *Corresponding author.”
BackgroundInfluentialFetal programming of atherosclerosis: Possible role of the mitochondria
Leduc, L., Levy, E. H., Bouity-Voubou, M., & DELVIN, E. E. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2009.12.005 · Cited by 76
Birth size, early life weight gain, and mid-childhood cardiometabolic health
Perng, W., Hajj, H., Belfort, M., Rifas-Shiman, S., Kramer, M., Gillman, M., & Oken, E. (2016) · Jornal de Pediatria · doi:10.1016/j.jpeds.2016.02.053 · Cited by 69
Maternal Psychological Resilience During Pregnancy and Newborn Telomere Length: A Prospective Study
Verner, G., Epel, E. S., Lahti‐Pulkkinen, M., Kajantie, E., Buß, C., Lin, J., Blackburn, E. H., Räikkönen, K., Wadhwa, P. D., & Entringer, S. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19101003 · Cited by 76
“We and others have reported that this initial setting of the system exhibits developmental plasticity, and that the effects of suboptimal developmental conditions appear to be mediated, in part, by the programming actions of maternal-placentalfetal biological processes (4-6).”
BackgroundAssociation Between Maternal Thyroid Hormones and Birth Weight at Early and Late Pregnancy
Zhang, C., Yang, X., Zhang, Y., Guo, F., Yang, S., Peeters, R. P., Korevaar, T. I. M., Fan, J., & Huang, H. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00390 · Cited by 74
McPherson, N. O., Bakos, H. W., Owens, J. A., Setchell, B. P., & Lane, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071459 · Cited by 76
“Fetal development and size are not only determinants of a healthy pregnancy but can also pre determine the likelihood of developing adult chronic disease [48,49].”
BackgroundUtero-placental Doppler ultrasound for improving pregnancy outcome
Stampalija, T., Gyte, G. M., & Alfirević, Ž. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008363.pub2 · Cited by 73
Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly
Arosio, B., D’Addario, C., Gussago, C., Casati, M., Tedone, E., Ferri, E., Nicolini, P., Rossi, P. D., Maccarrone, M., & Mari, D. (2014) · BioMed Research International · doi:10.1155/2014/169203 · Cited by 73
“Furthermore, epigenetic mechanisms may play an important role in the developmental origins of adult health and disease by providing a mechanism underlying the latent effects of adverse fetal, infant, and childhood environments on late-life chronic disease [91–93].”
BackgroundOkada, T., Takahashi, S., Nagano, N., Yoshikawa, K., Usukura, Y., & Hosono, S. (2014) · Pediatric Research · doi:10.1038/pr.2014.164 · Cited by 73
“Their subsequent studies demonstrated that infants with low birth weight (LBW) or born small for gestational age (SGA) are associated with increased rates of type 2 diabetes, hypertension, and coronary heart disease in adulthood (3,4).”
BackgroundWhen two obese parents are worse than one! Impacts on embryo and fetal development
McPherson, N. O., Bell, V. G., Zander‐Fox, D., Fullston, T., Wu, L., Robker, R. L., & Lane, M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00230.2015 · Cited by 78
“Being small for gestational age is associated with increased risk of noncommunicable diseases in offspring (4, 34), with combined paternal and maternal obesity previously shown to amplify metabolic syndrome and liver damage in a rodent model (67).”
BackgroundEpigenetics and the developmental origins of lung disease
Joss‐Moore, L. A., Albertine, K. H., & Lane, R. H. (2011) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2011.07.018 · Cited by 72
“The developmental origins of disease hypothesis describes the origins of adult disease in terms of perinatal “plasticity” in the face of sub-optimal environmental conditions [1].”
BackgroundSaif, Z., Hodyl, N. A., Stark, M. J., Fuller, P. J., Cole, T. J., Lu, N. Z., & Clifton, V. L. (2015) · Placenta · doi:10.1016/j.placenta.2015.05.001 · Cited by 71
“This, in turn, may contribute to an increased risk of cardio-respiratory, metabolic disorders and allergy in later life [7].”
BackgroundSystematic review and meta-analysis of middle cerebral artery Doppler to predict perinatal wellbeing
Morris, R. K., Say, R., Robson, S. C., Kleijnen, J., & Khan, K. S. (2012) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2012.07.027 · Cited by 70
Anthropometric Characterization of Impaired Fetal Growth
Victora, C. G., Villar, J., Barros, F. C., Ismail, L. C., Chumlea, C., Papageorghiou, A. T., Bertino, E., Ohuma, E. O., Lambert, A. W., Carvalho, M., et al. (2015) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2015.1431 · Cited by 69
Lukaszewski, M., Mayeur, S., Fajardy, I., Delahaye, F., Dutriez-Casteloot, I., Montel, V., Dickès-Coopman, A., Laborie, C., Lésage, J., Vieau, D., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00011.2011 · Cited by 69
“This led to the concept of developmental origin of health and diseases (DOHaD), also called “fetal programming” (2, 54).”
BackgroundPreeclampsia and Cardiovascular Risk for Offspring
Wojczakowski, W., Kimber-Trojnar, Ż., Dziwisz, F., Słodzińska, M., Słodziński, H., & Leszczyńska‐Gorzelak, B. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143154 · Cited by 68
“The hypotheses of both Barker and the Developmental Origins of Health and Disease are based on the concept that exposure to negative conditions during fetal life at a critical time of organ development may increase risk of disease in later life [20,111,112].”
BackgroundWhat Are Imprinted Genes Doing in the Brain?
Davies, W., Isles, A. R., Humby, T., & Wilkinson, L. S. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77576-0_5 · Cited by 68
Socioeconomic status and health outcomes: cystic fibrosis as a model
Oates, G. R., & Schechter, M. S. (2016) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2016.1196140 · Cited by 69
“The concept of early-life programming [49], for example, stipulates that exposures and experiences during early life”
BackgroundEpigenetics: linking social and environmental exposures to preterm birth
Burris, H. H., Baccarelli, A., Wright, R. O., & Wright, R. J. (2015) · Pediatric Research · doi:10.1038/pr.2015.191 · Cited by 69
“While the developmental origins of health and disease hypothesis has been well established for cardiovascular and metabolic health (41), this study supports continued investigation into fetal origins of pregnancy outcomes in subsequent generations.”
Buttery, S. C., Zysman, M., Vikjord, S. A. A., Hopkinson, N. S., Jenkins, C. R., & Vanfleteren, L. E. G. W. (2021) · Respirology · doi:10.1111/resp.14032 · Cited by 71
Occurrence of Ochratoxin A and Aflatoxin M1 in human breast milk in Sari, Iran
Afshar, P., Shokrzadeh, M., Kalhori, S., Babaee, Z., & Saravi, S. S. S. (2012) · Food Control · doi:10.1016/j.foodcont.2012.12.009 · Cited by 66
Early postnatal growth failure in preterm infants is not inevitable
Andrews, E. T., Ashton, J. J., Pearson, F., Beattie, R. M., & Johnson, M. J. (2018) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2018-315082 · Cited by 66
Early-life programming of adipose tissue
Moreno‐Méndez, E., Quintero-Fabián, S., Fernández‐Mejía, C., & Lazo-de-la-Vega-Monroy, M.-L. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422420000037 · Cited by 72
“weight after birth, particularly in the face of high energy intake, resulting in adult obesity and metabolic diseases(12,14).”
BackgroundManna, C., Lacconi, V., Rizzo, G., LORENZO, A. D., & Massimiani, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020659 · Cited by 69
Ferreira, J. C., Choufani, S., Grafodatskaya, D., Butcher, D. T., Zhao, C., Chitayat, D. A., Shuman, C. T., Kingdom, J. C., Keating, S., & Weksberg, R. (2011) · Epigenetics · doi:10.4161/epi.6.4.14554 · Cited by 66
“Low birthweight percentile also has a long-term impact on adult health.(7-16) Notably, such individuals have an increased risk of coronary artery disease,(17) osteoporosis and osteoarthritis,(18) hypertension, type 2 diabetes and obesity.”
BackgroundPrenatal maternal psychopathology and stress and offspring HPA axis function at 6 years
Molenaar, N. M., Tiemeier, H. W., van Rossum, E. F. C., Hillegers, M. H. J., Bockting, C., Hoogendijk, W. J. G., van den Akker, E. L., den Berg, M. P. L., & Marroun, H. E. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.003 · Cited by 68
“This has led scientists to propose models adapted to the ‘developmental programming hypothesis’ (Barker, 1998, 1999, 2004).”
InfluentialMaternal nutritional manipulations program adipose tissue dysfunction in offspring
Lecoutre, S., & Breton, C. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00158 · Cited by 70
“Based on the concept of Developmental Origin of Health andDisease (Barker, 2004), it has been hypothesized that maternal nutritional manipulations during the perinatal period may program the development and cause dysfunction in offspring’s adipose tissue later in life.”
BackgroundDecreased term and postterm birthweight in the United States: impact of labor induction
Zhang, X., Joseph, K. S., & Kramer, M. S. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.03.044 · Cited by 64
“been associated with common chronic diseases in adulthood.(7)”
BackgroundKing, S. E., McBirney, M., Beck, D., Sadler‐Riggleman, I., Nilsson, E. E., & Skinner, M. K. (2019) · Current Zoology · doi:10.1093/eep/dvz008 · Cited by 62
Heart rate variability analysis of normal and growth restricted children
Aziz, W., Schlindwein, F. S., Wailoo, M. P., Biala, T., & Rocha, F. C. (2011) · Clinical Autonomic Research · doi:10.1007/s10286-011-0149-z · Cited by 63
“association of low birth weight and cardiovascular disease has been described [4].”
BackgroundInfluentialDevelopment of insulin resistance and its relation to diet in the obese child
Cañete, R., Gil‐Campos, M., Aguilera, C. M., & Gil, Á. (2007) · European Journal of Nutrition · doi:10.1007/s00394-007-0648-9 · Cited by 63
“birth weight and children born premature or small for gestational age with a rapid postnatal weight gain have been related to risk factors for the development of IR, type 2 diabetes mellitus and cardiovascular disease in childhood [ 4 ].”
BackgroundManaging the Prenatal Environment to Enhance Livestock Productivity
Greenwood, P. L., Bell, A. W., Vercoe, P. E., & Viljoen, G. J. (2009) · Springer eBooks · doi:10.1007/978-90-481-3135-8 · Cited by 66
“Proliferation of progenitor cells and differentiation of cells into specific tissues occur in early gestation, and differences in these processes may have effects on later development [5, 63].”
BackgroundInfluentialGene-nutrient interactions during fetal development
Maloney, C., & Rees, W. D. (2005) · Reproduction · doi:10.1530/rep.1.00523 · Cited by 65
“However, if this ‘programming’ of metabolism during embryonic and fetal development is inappropriate for the long term nutritional environment it may lead to adverse long term sequelae for the offspring (Sayer et al. 2004, Yajnik 2004, Barker 2004).”
BackgroundChurch, M. W., Jen, K. ‐. C., Anumba, J. I., Jackson, D. A., Adams, B. R., & Hotra, J. W. (2009) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.09.006 · Cited by 61
“This is known as the Barker or “Fetal Programming” Hypothesis [10].”
BackgroundJia, Y., Li, R., Cong, R., Yang, X., Sun, Q., Parvizi, N., & Zhao, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063855 · Cited by 61
“Growing evidence demonstrates that low birth weight due to maternal malnutrition is associated with an increased risk of metabolic syndrome in adult offspring [8,9].”
BackgroundChurch, M. W., Jen, K. ‐. C., Dowhan, L., Adams, B. R., & Hotra, J. W. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.12.008 · Cited by 65
Standards of Practice for Culturally Competent Nursing Care: A Request for Comments
Douglas, M. K., Pierce, J. U., Rosenkoetter, M. M., Callister, L. C., Hattar‐Pollara, M., Lauderdale, J. L., Miller, J. E., Milstead, J. A., Nardi, D. A., & Pacquiao, D. F. (2009) · Journal of Transcultural Nursing · doi:10.1177/1043659609334678 · Cited by 61
Retinal vascular imaging in early life: insights into processes and risk of cardiovascular disease
Li, L., Ikram, M. K., & Wong, T. Y. (2015) · The Journal of Physiology · doi:10.1113/jp270947 · Cited by 61
“Early life CVD risk factors might exert their influence through a series of complicated mechanisms, including adverse in utero programming (Barker, 2004a, 2005), IUGR (Barker, 2004a, 2005), lack of physical activity (Malina, 1996), unbalanced nutrition (Barclay et al. 2008), childhood hypertension…”
BackgroundInfluentialOutcome‐based comparison of SMFM and ISUOG definitions of fetal growth restriction
Roeckner, J. T., Pressman, K., Odibo, L., Duncan, J. R., & Odibo, A. O. (2021) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.23638 · Cited by 60
Parental characteristics as predictors of birthweight
Xue, F., Willett, W. C., ROSNER, B. A., Forman, M. R., & Michels, K. B. (2007) · Human Reproduction · doi:10.1093/humrep/dem316 · Cited by 59
“…has been related to several chronic diseases, including breast cancer (Michels and Xue, 2006), cardiovascular diseases (Rich-Edwards et al., 1997; Barker, 2004), diabetes (Rich-Edwards et al., 1999) and hypertension (Curhan et al., 1996), although the pathology underlying this relation is…”
Campisano, S., la Colla, A. B., Echarte, S. M., & Chisari, A. N. (2019) · Nutrition Research Reviews · doi:10.1017/s0954422418000239 · Cited by 59
“Food intake absence and excess are the two main types of energy malnutrition that predispose to the appearance of diseases in adulthood, according to the hypothesis of ‘developmental origins of health and disease’((1)).”
BackgroundCaparrós-González, R. A., de la Torre‐Luque, A., Romero‐Gonzalez, B., Quesada-Soto, J. M., Alderdice, F. A., & Peralta‐Ramírez, M. I. (2021) · Midwifery · doi:10.1016/j.midw.2021.102939 · Cited by 69
Dong, S., Zhang, K., Guo, Y., Ding, J., Feng, J.-C., Yao, S., Yao, S., Rong, Y., Jiang, F., Chen, J., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00865-3 · Cited by 58
“05/15)) with 4 plausible confounders selected based on previously published studies: birth weight [19, 30, 31], years of educational attainment and age completed full time education [32–34], and maternal smoking around birth [35–38].”
Amino Acids and the Early Mammalian Embryo: Origin, Fate, Function and Life-Long Legacy
Leese, H. J., McKeegan, P. J., & Sturmey, R. G. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18189874 · Cited by 60
“In fulfilling this ‘gatekeeper’ role [7], female reproductive tract fluids have a key role in the ‘Developmental Origins of Health and Disease’ (DOHaD) concept [8] alongside the nature of the diet and its impact, for example, on body mass index, which in turn, can influence early embryo metabolism.”
BackgroundCalvert, L., Green, M. P., Iuliis, G. N. D., Dun, M. D., Turner, B. D., Clarke, B. O., Eamens, A. L., Roman, S. D., & Nixon, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.799043 · Cited by 62
Diet, sensitive periods in flavour learning, and growth
Trabulsi, J., & Mennella, J. A. (2012) · International Review of Psychiatry · doi:10.3109/09540261.2012.675573 · Cited by 58
“Diet composition and subsequent growth during infancy affect later-life health outcome (Barker, 2004; Lucas, 1998, 2005b).”
BackgroundPregnancy Complications and the Risk of Metabolic Syndrome for the Offspring
Ryckman, K. K., Borowski, K. S., Parikh, N. I., & Saftlas, A. F. (2013) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-013-0308-y · Cited by 62
The Role of LIN28-let-7-ARID3B Pathway in Placental Development
Ali, A., Bouma, G. J., Anthony, R. V., & Winger, Q. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103637 · Cited by 57
Molle, R. D., Laureano, D. P., Alves, M. B., Reis, T. M., Desai, M., Ross, M. G., & Silveira, P. P. (2015) · Brain Research · doi:10.1016/j.brainres.2015.05.019 · Cited by 60
Gheissari, R., Liao, J., Garcia, E., Pavlovic, N., Gilliland, F. D., Xiang, A. H., & Chen, Z. (2022) · Toxics · doi:10.3390/toxics10080458 · Cited by 58
The Epidemiology of Low Birthweight
Kramer, M. S. (2013) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000348382 · Cited by 56
Nomura, Y., John, R. M., Janssen, A. B., Davey, C., Finik, J. M., Buthmann, J. L., Glover, V. A. S., & Lambertini, L. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4347-3 · Cited by 58
Zeng, P., & Zhou, X. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00618 · Cited by 57
Association of birth weight with asthma‐related outcomes at age 2 years
Taveras, E. M., Camargo, C. A., Rifas‐Shiman, S. L., Oken, E., Gold, D. R., Weiss, S. T., & Gillman, M. W. (2006) · Pediatric Pulmonology · doi:10.1002/ppul.20427 · Cited by 55
Intrauterine Growth Retardation - A Review Article
Murki, S. (2014) · Journal of Neonatal Biology · doi:10.4172/2167-0897.1000135 · Cited by 56
“from the mother and adapts to this inadequate nutrient supply in a number of ways [94-99]:”
BackgroundMorris, R. K., Selman, T. J., Verma, M., Robson, S. C., Kleijnen, J., & Khan, K. S. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.04.017 · Cited by 55
Ruffaner‐Hanson, C. D., Noor, S., Sun, M. S., Solomon, E. R., Marquez, L. E., Rodriguez, D. E., Allan, A. M., Caldwell, K. K., Bakhireva, L. N., & Milligan, E. D. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114121 · Cited by 56
“Barker's hypothesis on Developmental Origins of Health and Disease (DOHaD) postulates that susceptibility to chronic diseases is, at least in part, determined by physiologic changes in response to an altered prenatal environment (Barker, 2004; Lange et al., 2013; Popova et al., 2016).”
BackgroundSzeto, I. M. Y., Das, P., Aziz, A. A., & Anderson, G. H. (2009) · International Journal of Obesity · doi:10.1038/ijo.2008.281 · Cited by 54
Kramer, M. S., Martin, R. M., Bogdanovich, N., Вильчук, К. У., Dahhou, M., & Oken, E. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.079590 · Cited by 54
Aspirin Prophylaxis During Pregnancy: A Systematic Review and Meta-Analysis
Choi, Y. J., & Shin, S. (2021) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2021.01.032 · Cited by 58
Genetic Analyses in Small-for-Gestational-Age Newborns
Stalman, S. E., Solanky, N., Ishida, M., Alemán-Charlet, C., Abu-Amero, S. N., Alders, M. M., Alvizi, L., Baird, W., Demetriou, C., Henneman, P., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01843 · Cited by 54
“FGR is associated with significant perinatal morbidity and mortality (3) and babies with FGR can be predisposed to metabolic diseases later in life (4).”
BackgroundArnott, G., Roberts, D. J., Rooke, J. A., Turner, S. P., Lawrence, A. B., & Rutherford, K. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5463 · Cited by 52
Maturana, C. J., Aguirre, A., & Sáez, J. C. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22409 · Cited by 51
Irwin, R. E., Thursby, S.-J., Ondičová, M., Pentieva, K. D., McNulty, H., Richmond, R. C., Caffrey, A., Lees‐Murdock, D. J., McLaughlin, M., Cassidy, T., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0618-0 · Cited by 53
“it can also affect phenotype and predisposition to childhood and adulthood disease [41].”
BackgroundLaitinen, K., Hoppu, U., Hämäläinen, M., Linderborg, K. M., Moilanen, E., & Isolauri, E. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000203158.31452.9e · Cited by 52
“The accumulating data point to the early fetal period and infancy as the critical phase (1).”
BackgroundVargas-Martínez, F., Uvnäs-Moberg, K., Petersson, M., Olausson, H. A., & Jiménez-Estrada, I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.001 · Cited by 51
Bluett‐Duncan, M., Kishore, M. T., Patil, D. M., Satyanarayana, V. A., & Sharp, H. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253790 · Cited by 54
Maternal asthma and microRNA regulation of soluble HLA-G in the airway
Nicodemus‐Johnson, J., Laxman, B., Stern, R. K., Sudi, J., Tierney, C. N., Norwick, L. M., Hogarth, D. K., McConville, J. F., Naureckas, E. T., Sperling, A. I., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.037 · Cited by 50
Gallagher, D., Rosenn, B., Toro‐Ramos, T., Paley, C., Gidwani, S., Horowitz, M., Crane, J., Lin, S. X., Thornton, J. C., & Pi-Sunyer, X. (2018) · Obesity · doi:10.1002/oby.22079 · Cited by 56
“of developing obesity and related cardiometabolic diseases (1,2).”
Utero-placental Doppler ultrasound for improving pregnancy outcome
Stampalija, T., Alfirević, Ž., & Gyte, G. M. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008363 · Cited by 50
Kupffer cell programming by maternal obesity triggers fatty liver disease
Huang, H., Balzer, N. R., Seep, L., Šplíchalová, I., Blank-Stein, N., Viola, M. F., Taveras, E. F., Acil, K., Fink, D., Petrovic, F., et al. (2025) · Nature · doi:10.1038/s41586-025-09190-w · Cited by 52
Fetal-Derived Immune Cells at the Roots of Lifelong Pathophysiology
Mass, E., & Gentek, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.648313 · Cited by 47
“Developmental Programming of EMP-Derived Cells by Adverse Early Life Environments It is now firmly established that the likelihood of developing a non-communicable disease in adulthood is strongly influenced by environmental factors in early life, including the fetal period (Barker, 2004).”
BackgroundPrenatal Exposure to Nonpersistent Chemical Mixtures and Fetal Growth: A Population-Based Study
van den Dries, M. A., Keil, A. P., Tiemeier, H. W., Pronk, A., Spaan, S., Santos, S., Asimakopoulos, A. G., Kannan, K., Gaillard, R., Guxens, M., et al. (2021) · Environmental Health Perspectives · doi:10.1289/ehp9178 · Cited by 49
Effect of maternal food restriction on fetal rat lung lipid differentiation program
Karadag, A., Sakurai, R., Wang, Y., Guo, P., Desai, M., Ross, M. G., Torday, J. S., & Rehan, V. K. (2009) · Pediatric Pulmonology · doi:10.1002/ppul.21030 · Cited by 49
Neuropharmacology of drugs and alcohol in mother and fetus
Pollard, I. (2007) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2006.12.001 · Cited by 49
“Much has been learned since David Barker and colleagues first proposed that suboptimal intrauterine growth might alter fetal development in ways that predispose the offspring to a range of diseases in adulthood.(19) As nutrition directly or indirectly influences epigenetic processes that fine-tune DNA function, the nu…”
InfluentialThe influence of industry-related air pollution on birth outcomes in an industrialized area
Bergstra, A. D., Brunekreef, B., & Burdorf, A. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115741 · Cited by 48
“In addition, effects of LBW on coronary heart disease and the related disorders stroke, hypertension and non-insulin-dependent diabetes during later-life have been observed (Barker, 2004).”
BackgroundRazak, N. A., Shariff, Z. M., Taib, M. N. M., Gan, W. Y., & Tan, K. (2016) · BMC Pediatrics · doi:10.1186/s12887-016-0700-0 · Cited by 47
“For example, an undernourished mother during pregnancy will send a signal to her fetus that the environment outside might be harsh and the fetus will respond to this signal by reducing body size and altering metabolism for survival after birth [3].”
BackgroundEnvironmental lead exposure, maternal thyroid function, and childhood growth
Lamb, M. R., Janevic, T. M., Liu, X., Cooper, T. B., Kline, J. K., & Factor-Litvak, P. R. (2007) · Environmental Research · doi:10.1016/j.envres.2007.09.012 · Cited by 46
Andersen, H. R., Wohlfahrt‐Veje, C., Dalgård, C., Christiansen, L., Main, K. M., Nellemann, C., Murata, K., Jensen, T. K., Skakkebæk, N. E., & Grandjean, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036830 · Cited by 46
“There is increasing evidence that prenatal and early postnatal environmental factors might influence the risk [49,50].”
Oyston, C., Stanley, J. L., Oliver, M. H., Bloomfield, F. H., & Baker, P. N. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07662 · Cited by 46
“These fetuses have an increased risk of significant perinatal morbidity and mortality,(1,2) neurodevelopmental impairment in childhood,(3) and an increased risk of adult onset chronic diseases.(4) Currently, there are no clinically available treatments that can improve fetal growth.”
BackgroundKramer, M. S., Zhang, X., Dahhou, M., Yang, S., Martin, R. M., Oken, E., & Platt, R. W. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kww109 · Cited by 50
Cope, H. A., Blake, B. E., Love, C. A., McCord, J. P., Elmore, S. A., Harvey, J. B., Chappell, V. A., & Fenton, S. E. (2021) · Emerging contaminants · doi:10.1016/j.emcon.2021.10.004 · Cited by 47
“Low weight at birth and in early life has been associated with the development of metabolic syndrome later in life in humans and mouse models [5,58,59].”
BackgroundPan, I., Daniels, J. L., Herring, A. H., Rogan, W. J., Siega‐Riz, A. M., Goldman, B. D., & Sjödin, A. (2010) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2010.01114.x · Cited by 45
Lim, A. L., Ng, S., Leow, S. C. P., Choo, R. W. M., Ito, M., Chan, Y. H., Goh, S. K., Tng, E., Kwek, K. Y. C., Chong, Y. S., et al. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-100858 · Cited by 45
Prenatal origins of postnatal variation in growth, development and productivity of ruminants
Bell, A. W., & Greenwood, P. L. (2016) · Animal Production Science · doi:10.1071/an15408 · Cited by 45
Higher concentrations of branched-chain amino acids in breast milk of obese mothers
Luca, A. D., Hankard, R., Alexandre-Gouabau, M. C., Ferchaud‐Roucher, V., Darmaun, D., & Boquien, C. (2016) · Nutrition · doi:10.1016/j.nut.2016.05.013 · Cited by 45
Abrous, D. N., Koehl, M., & Lemoine, M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01172-4 · Cited by 51
Prenatal programming of postnatal productivity and health of livestock: a brief review
Bell, A. W. (2006) · Australian Journal of Experimental Agriculture · doi:10.1071/ea06006 · Cited by 45
“During the late 1980s and early 1990s, Barker and colleagues published a series of papers, briefly reviewed by Barker (2004), suggesting inverse relations between birth weight and the incidence or risk of death from several common matureonset diseases, including cardiovascular disease, stroke, impaired glucose toleran…”
BackgroundRole of nutrients in the development of neonatal immune response
Cunningham–Rundles, S., Lin, H., Lin, D. H., Dnistrian, A. M., Cassileth, B. R., & Perlman, J. M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00236.x · Cited by 45
Óvilo, C., Gonzalez‐Bulnes, A., Benítez, R., Ayuso, M., Barbero-Fernández, A., Pérez-Solana, M. L., Barragán, C., Astiz, S., Fernández, A., & López-Bote, C. J. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002948 · Cited by 45
Balaguer, N., Moreno, I., Herrero, M., Gonzáléz-Monfort, M., Vilella, F., & Simón, C. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.02.047 · Cited by 45
Metadata
- Authors
- Barker, D.
- Affiliations
- Southampton General Hospital (GB)
- Corresponding author
- Barker, DJP
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2004-11
- Volume
- 93
- Issue
- s446
- Pages
- 26-33
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2143230895
- Cited by
- 790
- References
- 53
- Citations by year
- 2026: 19 · 2025: 38 · 2024: 49 · 2023: 42 · 2022: 36 · 2021: 63 · 2020: 55 · 2019: 42 · 2018: 39 · 2017: 37 · 2016: 33 · 2015: 40 · 2014: 37 · 2013: 40 · 2012: 45
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- developmental origins of health and disease, low birth weight, coronary artery disease, stroke, hypertension, type 2 diabetes, developmental plasticity, fetal growth restriction, gestational age, child weight gain, environmental influences on development
- MeSH terms
- Adult, Birth Weight, Cardiovascular Diseases, Child, Child Development, Child, Preschool, Chronic Disease, Diabetes Mellitus, Type 2, Female, Humans, Infant, Infant, Newborn, Male
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
