Cited by 790Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

The developmental origins of chronic adult disease

Barker, DJP·2004·Acta Paediatrica

DOI 10.1111/j.1651-2227.2004.tb00236.x

Open this paper in CoChat — free account

Abstract

Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin-dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. Coronary heart disease and the disorders related to it arise through a series of interactions between environmental influences and the pathways of development that preceded them. These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth.

Integrity signals

Registry

Crossref · 10.1111/j.1651-2227.2004.tb00236.x

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574
Fetal origins of coronary heart disease
Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570
Self-citation
Fetal and infant growth and impaired glucose tolerance at age 64
Hales, C. N., Barker, D. J., Clark, P. M., Cox, L. J., Fall, C., Osmond, C., & Winter, P. D. (1991) · BMJ · doi:10.1136/bmj.303.6809.1019 · Cited by 2,708
Phenotypic Plasticity and the Origins of Diversity
West-Eberhard, M. J. (1989) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.20.110189.001341 · Cited by 2,110
Fetal origins of adult disease: strength of effects and biological basis
Barker, D., Eriksson, J., Forsén, T., & Osmond, C. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.6.1235 · Cited by 2,024
Compensation for a bad start: grow now, pay later?
Metcalfe, N. B., & Monaghan, P. (2001) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(01)02124-3 · Cited by 1,948
Health consequences of obesity
Reilly, J. J. (2003) · Archives of Disease in Childhood · doi:10.1136/adc.88.9.748 · Cited by 1,652
CARBOPLATIN OR CISPLATIN?
Calvert, H., Horwich, A., Newlands, E. S., Beǵent, R. H. J., Rustin, G. J. S., Kaye, S. B., Harris, A. L., Williams, C. J., & Slevin, M. L. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92709-2 · Cited by 1,183
Nephron Number in Patients with Primary Hypertension
Keller, G., Zimmer, G., Mall, G., Ritz, E., & Amann, K. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020549 · Cited by 1,102
The role of size at birth and postnatal catch-up growth in determining systolic blood pressure
Huxley, R., Shiell, A. W., & Law, C. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018070-00002 · Cited by 1,046

Show all 53 references

Research works printed but not linked: 1

Bateson P, 1999, Design for a life: how behaviour develops

Sorted by citations

Items 701–790 of 790

Association between Maternal Food Group Intake and Birth Size (Perkaitan antara Pemakanan Ibu Semasa Mengandung dengan Saiz Kelahiran Bayi)
Mohamad, M., & Jan, J. M. H. (2013)
The Merging of Mental and Physical Health Mechanisms
Lawrence, D. A. (2015)
The influence of maternal mental health, attachment and hormonal factors on a mother’s attachment to her fetus during pregnancy
Hart, K. (2015)
Educational Institutions in Delaware, Maryland, New Jersey, Pennsylvania, Virginia, and West Virginia, the USDA, and the Maryland Feed Industry Council are collaborators in the planning and funding of The Mid-Atlantic Nutrition Conference.
Bequette, B. W., Adams, M., Patterson, P. H., Scaletti, R., Timmons, J. R., Miller, T., Harter-Dennis, J. M., Shore, E., Mitchell, R., Farms, P., et al. (2009)
Diabetes Illness Narratives among Mexican Immigrants in the U.S.-Mexico Border Region
Bedwell, R. M. (2017) · UA Campus Repository (The University of Arizona)
Autophagy and Fetal Programming
Maloyan, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805253-2.00019-5
Evaluating a Lifestyle Intervention During Pregnancy Aimed at Reducing Child Obesity Risk
Dingwall‐Harvey, A. L. J. (2019) · uO Research (University of Ottawa) · doi:10.20381/ruor-22995
Understanding the effects of maternal undernutrition in early gestation on placental development in late gestation
Case, G. A. M. V. G. (2018) · doi:10.32469/10355/67713
Avaliação do volume e da vascularização renais ao ultrassom tridimensional em fetos com restrição de crescimento intrauterino
Senra, J. C. (2019) · doi:10.11606/t.5.2019.tde-13022019-153144
The association between birthweight and grandparental type 2 diabetes and cardiovascular disease in a multiethnic population
Kjøllesdal, M. K. R., Jenum, A. K., Næss, Ø., & Sletner, L. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000758
“13 Eligible women (1) lived in the study districts, (2) planned to give birth in one of the study hospitals, (3) were <20 weeks pregnant, (4) could communicate in Norwegian or any of the eight study languages (Arabic, English, Sorani, Somali, Tamil, Turkish, Urdu, and Vietnamese), and (5) were able to give an informed…”
Background
Influência da ausência da melatonina maternal durante a gestação e lactação sobre a neurogênese e sobre o desenvolvimento somático e sensório-motor da prole.
Teixeira, L. C. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2019.tde-25092019-123349
In utero undernourishment during WWII: Effects on height and weight of young adult women
Czapla, Z., Liczbińska, G., Piontek, J., & Malina, R. M. (2020) · Anthropological Review · doi:10.2478/anre-2020-0004 · Cited by 1
Effects of Psychological Stress during Pregnancy on FE3 in Maternal Serum
Wang, Q., Ma, H., Zhang, R., Zhai, F., Li, X., Hou, J., & Yang, L. (2020) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/440/5/052087
Mechanistic exploration of Cangfu Daotan Decoction for patients with polycystic ovary syndrome by transcriptome sequencingPreprint
Chen, C.-Y., Jiang, X., Wang, C., & Ding, C. (2020) · doi:10.21203/rs.3.rs-19780/v1
Impacto de un impuesto a las bebidas azucaradas sobre las finanzas del sistema de salud en Colombia
Ruiz, R., & Duván, A. (2020)
Caloric restriction and the developing brain
Matté, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817986-4.00050-x
Pharmacotherapy of Sleep Disorders During Pregnancy and Nursing
Mikoteit, T., & Hatzinger, M. (2021) · Springer eBooks · doi:10.1007/978-3-319-56015-1_458-1
Estrogens and female developing brain: two sides of the coin
Резніков, А. Г. (2021) · Reproductive Endocrinology · doi:10.18370/2309-4117.2021.59.8-12
Mortalidad neonatal en el marco de los Objetivos de Desarrollo del Milenio y nuevos objetivos post-2015
(2018) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2018.238
Effects of Diet on the Microbiome and Serum Metabolome of South Asian Infants at 1 YearPreprint
Bruce, C. Y., Shanmuganathan, M., Azab, S. M., Britz‐McKibbin, P., Anand, S. S., de Souza, R. J., & Stearns, J. C. (2021) · medRxiv · doi:10.1101/2021.09.28.21264268
“For example, rapid weight 38 gain during early life increases risk of adult cardiovascular disease [3,4].”
Background
Predictors of Nutritional Status and Academic Performance of Under-Five Early Childhood Development Children in Zimbabwe
Ndava, M., Musemwa, L., Ndhleve, S., & Zhou, L. (2021) · Journal of International Cooperation and Development · doi:10.36941/jicd-2021-0010
“In addition, many children who experience undernutrition will be at increased risk of developing chronic diseases (Barker, 2004) as well as later physical and work incapacitation (Grantham-McGregor et al., 2005; Kabubo-Mariara et al., 2006; Gaskin et al., 2014).”
Background
Clinical Use of 3D Sonography
Kurjak, A., & Barišić, L. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-83434-0_13
Cystic Fibrosis
Oates, G. R., & Schechter, M. S. (2016) · Respiratory medicine · doi:10.1007/978-3-319-43447-6_9
Individual and Environmental Factors Contributing to and/or Associated with Childhood Obesity
Goran, M. I. (2016) · CRC Press eBooks · doi:10.1201/9781315370958-13
Chronic Diseases
Lenz, G. (2008) · Springer eBooks · doi:10.1007/978-1-4020-5614-7_393
Decreased Term and Postterm Birthweight in the United States
(2011) · Survey of Anesthesiology · doi:10.1097/01.sa.0000398709.15292.48
Prenatal environment and developmental trajectories: the intrauterine growth restriction
Lovato, I., Simonelli, A., Visentin, S., Priante, E., Baraldi, E., & Sacchi, C. (2022) · Minerva Pediatrics · doi:10.23736/s2724-5276.22.06949-x
Early nutrition: Effects on infants’ growth and body composition
Giannì, M. L., Morniroli, D., Vizzari, G., & Mosca, F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824389-3.00019-2
Fetal growth retardation as a complication of post-COVID endotheliitis: causes, consequences, ways of prevention
Жабченко, И. А., & Lishchenko, I. S. (2022) · Reproductive Endocrinology · doi:10.18370/2309-4117.2022.65.44-52
Pharmacotherapy of Sleep Disorders During Pregnancy and Nursing
Mikoteit, T., & Hatzinger, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_458
Anthropometric measurements from 6 to 12 months of age in Khartoum State, Sudan 2020
Abbas, M. N., Ali, I., Abdalla, M. S., & Musa, O. A. A. (2022) · Sudanese Journal of Paediatrics · doi:10.24911/sjp.106-1599924097
Sex-specific associations between birthweight and objectively measured energy intake in adulthoodPreprint
Guerithault, N., Stinson, E. J., de Baca, T. C., Looker, H. C., Votruba, S. B., Piaggi, P., Gluck, M. E., Krakoff, J. A., & Chang, D. C. (2023) · Research Square · doi:10.21203/rs.3.rs-2518158/v1
Early-life nutrition and obesity risk
Kouwenhoven, S. M. P. (2023) · doi:10.5463/thesis.108
A Life Course Approach to Women’s Reproductive Health
Magnus, M. C., & Fraser, A. (2023) · doi:10.1093/oso/9780192864642.003.0002
Einführung in biologische und psychobiologische Aspekte des PCOS
Barry, J. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-24461-2_1
Prenatal stress increases corticosterone levels in offspring by impairing placental glucocorticoid barrier functionPreprint
Liu, H., Wang, R., Zhu, J., Li, Y., Li, J., Yao, G. X., Ma, S., & Guan, S. (2023) · Research Square · doi:10.21203/rs.3.rs-3303973/v1
On obesogenic diet exposure of parents and sex-specific programming of overweight in mouse offspringPreprint
Czechowski, P., Hoffmann, A., Dommel, S., Blüher, M., & Klöting, N. (2023) · Research Square · doi:10.21203/rs.3.rs-3491044/v1
Childhood growth of singletons conceived following assisted reproductive technology - does gonadotropin stimulation matter?Preprint
Minger, M., Sommer, G., Mitter, V. R., Purtschert, L. A., von Wolff, M., & Schwartz, A. K. (2023) · Research Square · doi:10.21203/rs.3.rs-3473942/v1
Endocrine-Disrupting Chemicals (EDCs) and Reproductive Outcomes
D’Angelo, A., & Pier, G. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-36494-5_8
Identifying changes to placental gene expression in pregnancies with a small for gestational age infant
O’Callaghan, J. L. (2023) · Queensland University of Technology · doi:10.5204/thesis.eprints.244719
Better Teeth, Better Health? The Relationship Between Enamel Hypoplasia and Osteological Stress Markers in Eba Population of Northern Serbia
Gavrilović, M. K. (2023) · Arheologija i prirodne nauke · doi:10.18485/arhe_apn.2023.19.2
Sex-specific associations between birthweight and objectively measured energy intake in healthy indigenous American adults
Guerithault, N., Stinson, E. J., de Baca, T. C., Looker, H. C., Votruba, S. B., Piaggi, P., Gluck, M. E., Krakoff, J. A., & Chang, D. C. (2024) · Appetite · doi:10.1016/j.appet.2024.107334
When Germ Theory Didn’t Matter
Barrett, R., Zuckerman, M. K., Dudgeon, M. R., & Armelagos, G. J. (2024) · doi:10.1093/oso/9780192843135.003.0004
Agriculture and the First Emerging Infections
Barrett, R., Zuckerman, M. K., Dudgeon, M. R., & Armelagos, G. J. (2024) · doi:10.1093/oso/9780192843135.003.0003
Proportion and risk factors of low birth weight among neonates delivered at Omdurman Maternity Hospital, Sudan
Mahmoud, A. A. A., Shaaban, K. M. A., Noureddin, A. A., Mohamed, S. O. O., Abdalhameed, M. A. M. A., Elzubeir, K. B. K., Mohammednoor, M., & Mirghani, E. M. A. (2024) · Sudanese Journal of Paediatrics · doi:10.24911/sjp.106-1693680388
Application of DOHaD hypothesis to the Effect of Stress Levels in Pregnant Women on the Fetus and Baby’s Mental Health: A Literature Review
Sugsihita, K. (2024) · Gynecology & Reproductive Health · doi:10.33425/2639-9342.1242
The Intrauterine Environment and Early Infancy
Fan, W., Zlatnik, M. G., Charlesworth, A., & Woodruff, T. J. (2024) · doi:10.1093/oso/9780197662526.003.0014
Claudicação em vacas prenhes - influências no desenvolvimento neonatal e na morfometria cerebral de bezerros após o nascimento
Reis, G. A. (2024) · doi:10.11606/t.10.2024.tde-13052024-161327
Gene expression in normal-weight mice offspring from parents on Western Diets suggests altered risk for obesity and metabolic diseasePreprint
Czechowski, P., Hoffmann, A., Dommel, S., Jaïs, A., Blüher, M., & Klöting, N. (2024) · Research Square · doi:10.21203/rs.3.rs-3491044/v2
Infections néonatales précoces
Guen, C. G., Launay, E., & Zayat, N. (2024) · Réanimation et Soins Intensifs en Néonatologie · doi:10.1016/b978-2-294-77019-7.00116-4
Hypertension induced by peri-pubertal protein restriction depends on renin-angiotensin system dysfunction in adult male rats
Ferreira, A. R. O., Ribeiro, M. V. G., Peres, M. N. C., Lopes, G. K. G., Saavedra, L. P. J., Piovan, S., Barbosa, L. F., Raposo, S. R., Almeida, D. L., Malta, A., et al. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.09.003
Childhood growth of singletons conceived following intracytoplasmic sperm injection – irrelevance of gonadotropin stimulation
Minger, M., Sommer, G., Mitter, V. R., Purtschert, L. A., von Wolff, M., & Schwartz, A. K. (2024) · Frontiers in Reproductive Health · doi:10.3389/frph.2024.1453697
Ablation of the evolutionarily acquired functions of the Atp1b4 gene in mice protects against obesity and increases metabolic capacityPreprint
Modyanov, N. N., Russo, L., Ghosh, S. L., Castañeda, T. R., Marathe, H. G., Bourey, R. E., Najjar, S. M., & de la Serna, I. L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.26.640446
Consumption of low-protein or high-fat diets during peripubertal age alter spermatozoa, testis and epididymis of pubertal rats
Bomfim, L. P., Silva, M. S. D. S., da Costa, I. R., Luiz, K. G., Quadreli, D. H., Bispo, M. B., Mathias, P. C. D. F., & Fernandes, G. S. A. (2025) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s204017442500008x
Desenvolvimento de crianças nascidas durante a epidemia do vírus Zika no Brasil: uma geração em risco?
de Britto, J. A. A., Lopes, M. D. C. B., Guida, L. D. C., de Freitas, M. R. B., Barros, L. B. D. P., Gomes, S. C., & Moreira, M. E. L. (2025) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232025304.15022023
Quantifying prenatal and postnatal mortality in extreme early onset fetal growth restriction: A systematic review and incidence analysis
Qaderi, S., Bonanni, G., Parsaei, M., Rojhani, E., Chauhan, S. D., Krispin, E., Fauza, D. O., David, A. L., Aagaard, K. M., & Shamshirsaz, A. A. (2025) · Pregnancy · doi:10.1002/pmf2.70034
“…extreme preterm birth (PTB) impose a broad spectrum of adverse pregnancy outcomes, including fetal and neonatal death [5, 6], necrotizing enterocolitis [5], respiratory complications, neurodevelopmental disorders [7–10], and lifelong health risks such as obesity and hypertensive diseases [11–13].”
Administração intraperitoneal de metformina a filhotes durante a lactação altera parâmetros biométricos em ratos adultos aos 180 dias
Rodrigues, W. N. D. S., Martins, M. V., & Mathias, P. C. D. F. (2025) · Arquivos do Mudi · doi:10.4025/arqmudi.v29i3.76690
Bridging gaps in risk factor control and adherence to recommended lifestyle among Non-Elderly hypertensive patients
Zhang, H., Zhang, Z., Zhu, J., Du, C., Jin, H., Zhang, W., Liu, X., & Zeng, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-15136-z
Smaller birth size may be associated with lower physical activity in adult women
Słojewska, K., Galbarczyk, A., Klimek, M., Mijas, M. E., Tubek-Krokosz, A., Miłkowska, K., Ścibor, M., & Grazyna Jasienska, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-14620-w
Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study
Zhang, Y., Lin, Z., He, X., Lu, J., Tan, P., Huang, Q., & Zhang, K. (2025) · American Journal of Hypertension · doi:10.1093/ajh/hpaf154
Kupffer cells are regulators of intergenerational signalling in MASLD
Ramachandran, P. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.08.027
Short- and Long-Term Effects of Undernutrition During Adolescence on Oxidative Status and Glucose Homeostasis in Male and Female Rats
Paul, J. S., Ribeiro, A. J. R., Kipper, A. C. S., Souza, M. D. O., dos Santos, T. C., da Silva, K. P., Rodrigues, A. M. D., Antunes, M. F., Fabiane, I. Z., Braga, A. J. L., et al. (2025) · Biology · doi:10.3390/biology14101352
“In terms of the developmental origins of health and disease (DOHaD) paradigm, different cardiometabolic impairments, such as obesity, hypertension and type 2 diabetes mellitus (T2DM), have been associated with protein and/or calorie-energy malnutrition during critical stages of development [2–4].”
Infant buccal telomere length: associations with maternal distress in pregnancy and offspring temperament
Soerensen, A. E., den Bergh, B. R. H. V., Braeken, M. A. K. A., van den Heuvel, M. I., Martens, D. S., Vos, S., & Nawrot, T. S. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1657714
Obesity/Perinatal Origins of Obesity
Kwok, T. C., Ojha, S., & Symonds, M. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-443-23940-3.00041-7
Melatonin enhances vitrified mouse blastocyst development by mitigating oxidative stress and preserving mitochondrial function
Zhou, D., Chen, Q., Bai, Y., Ye, M., Jia, Y., Chen, X., Bükülmez, O., Li, M., Yeung, W. S. B., Norman, R. J., et al. (2025) · Molecular Human Reproduction · doi:10.1093/molehr/gaaf054
The Role of Mitochondria in the Metabolic Syndrome and Insulin Resistance
Marı́n-Garcı́a, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4599-9_21
Origen neonatal de la síndrome metabòlica en l'adult
Pentinat, T. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Additional file 1 of Risk of low birthweight associated with the timing and frequency of antenatal care visits in Lao PDR: a retrospective cohort study
Nagatani, S., Horiuchi, S., Takahashi, K., Matsuura, M., Ounchit, K., & Yamaoka, K. (2024) · Figshare · doi:10.6084/m9.figshare.26569336
Additional file 1 of Food habits in pregnancy and its association with gestational diabetes mellitus: results from a prospective cohort study in public hospitals of urban India
Deepa, R., Lewis, M. G., van Schayck, O. C. P., & Babu, G. R. (2020) · Figshare · doi:10.6084/m9.figshare.13257594
Additional file 2 of Risk of low birthweight associated with the timing and frequency of antenatal care visits in Lao PDR: a retrospective cohort study
Nagatani, S., Horiuchi, S., Takahashi, K., Matsuura, M., Ounchit, K., & Yamaoka, K. (2024) · Figshare · doi:10.6084/m9.figshare.26569339
Additional file 1 of Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies
Rahimlou, M., Mousavi, M. A., Chiti, H., Peyda, M., & Mousavi, S. N. (2024) · Figshare · doi:10.6084/m9.figshare.25546954
INFLUENCE OF PRE-START DIETS WITH LIMITED MINERAL CONTENT ON METABOLISM IN CHICKENS
TSINOVІY, O., HURENKO, D., Ishchenko, Y., Baydevlatova, O., & OLKHOVSKA, T. (2025) · The Scientific and Technical Bulletin of the Institute of Animal Science NAAS of Ukraine · doi:10.32900/2312-8402-2025-135-171-184
Maternal internalizing symptoms as a mechanism linking pre- and postnatal COVID-19 pandemic exposure with preschool-aged children’s neurodevelopment
Finegold, K. E., Knight, J. A., Hung, R. J., Dennis, C., Shah, P. S., Wong, J., Bertoni, K., Levitan, R. D., Jenkins, J. M., Matthews, S. G., et al. (2026) · Archives of Women s Mental Health · doi:10.1007/s00737-026-01686-2
“…by developmental theories such as the Developmental Origins of Health and Disease (DOHaD) framework and the prenatal programming hypothesis (Barker 2004), which together posit that the prenatal brain, which undergoes rapid growth and is highly malleable, is especially vulnerable to…”
Developmental stress and the urban-rural health spectrum in medieval Denmark
Kelmelis, S., & DeWitte, S. N. (2026) · International Journal of Paleopathology · doi:10.1016/j.ijpp.2026.03.002
Implication des mécanismes épigénétiques dans la programmation de l'adiposité chez la descendance de mères obèses
Lecoutre, S. (2017) · theses.fr (ABES) · doi:10.70675/65a35937ze6d1z436ezb142z7812e3f38007
Adult cardiovascular dysfunction induced by peri-pubertal high-fat diet exposure is mediated by the renin-angiotensin axis in male rats
Ribeiro, M. V. G., Ferreira, A. R. O., Barbosa, L. F., Lopes, G. K. G., Piovan, S., Saavedra, L. P. J., Raposo, S. R., Gomes, R. M., Malta, A., Almeida, D. L., et al. (2026) · Nutrition Research · doi:10.1016/j.nutres.2026.03.013
Gestational Hypertension as a Mediator of Prenatal Ozone Exposure and Term Low Birth Weight: Birth Cohort Study
Zhang, Y., Liu, Q., Song, M., Huang, Q., Zhao, Q., Tao, Q., Zhang, C., Li, Q., & Wang, Q. (2026) · JMIR Public Health and Surveillance · doi:10.2196/81412
Autocuidado y entrenamiento interválico de alta intensidad: promotores de salud cardiovascular en escolares
Oyarzún, M. L., Ávila-Pizarro, Y., Obando-Calderón, N. I., Paredes-Arévalo, L., & Lugo-Armenta, J. G. (2025) · Hacia la Promoción de la Salud · doi:10.17151/hpsal.2025.30.3.7
Food insecurity in a cohort of Jamaican women in the preconception and prenatal periodPreprint
Taylor‐Bryan, C., Badaloo, A. V., Younger-Coleman, N. O., Brown, O., Frater-Williams, J. K., Baker, T. M., Thomas, D. J., & Gordon-Strachan, G. M. (2026) · Research Square · doi:10.21203/rs.3.rs-9117914/v1
Early-life factors associated with developmental trajectories of internalizing and externalizing symptoms from early childhood through adolescence: Rhea mother—child cohort in Crete, Greece
Koutra, K., Mouatsou, C., Margetaki, K., Roumeliotaki, T., Psoma, S., Kampouri, M., & Chatzi, L. (2026) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-026-03103-6
“…significant impact on development, with evidence suggesting that antenatal and early-life adversities, including sociodemographic challenges such as low socioeconomic status and parental educational level, can influence the developing organism and increase the risk of diseases later in life [ 31].”
Impacts of ambient temperature on pregnant women's cardiovascular function and variations related to fetal sex
Masdoumier, C., DeStaffan, B., Adélaïde, L., Barbalat, G., Delorme, P., Génard-Walton, M., Guilbert, A., Hough, I., Kloog, I., Launay, L., et al. (2026) · Environmental Research · doi:10.1016/j.envres.2026.124742
Features of Alteration in MAPK Pathway Activity in the Postnatal Brain of a Rat Model of Sporadic Alzheimer’s Disease
Muraleva, N. A., Stefanova, N. A., & Kolosova, N. G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125430
“These early alterations do not cause an immediate pathology but, consistently with the Developmental Origins of Health and Disease concept [1,3–5], establish a phenotype of heightened vulnerability.”
Cardiovascular health among young adults: Do childhood neighborhoods matter?
Goldman, N., Pratt, B., Sohn, H., Enkel, S. L., Allen, N. B., Ning, H., Lloyd‐Jones, D. M., & Notterman, D. A. (2026) · SSM - Population Health · doi:10.1016/j.ssmph.2026.101941
“…suboptimal CVH, it may primarily be the result of neighborhood influences close to the time of birth – i.e., many scholars have shown that exposures during the fetal period and infancy have significant effects on cardiovascular health among adults (Barker, 2004; Barker et al., 1989; Gillman, 2010).”
Heatwaves and neonatal outcomes beyond preterm birth and low birth weight: A scoping review
Bhatt, A. H., Nimbalkar, S. M., Nimbalkar, A. A., & Bharti, L. K. (2026) · Journal of Neonatal-Perinatal Medicine · doi:10.1177/19345798261450476
Linking maternal childhood maltreatment to health-related and psychosocial risk factors during pregnancy: intergenerational implications for early child development
Reyentanz, E., Gerlach, J., Eichler, A., Vasileva, M., & Golub, Y. (2026) · European Journal of Psychotraumatology · doi:10.1080/20008066.2026.2709188
“Research grounded in the developmental origins of health and disease (DOHaD) hypothesis (Barker, 2004) has identified a variety of health-related and psychosocial risk factors that can be involved to explain the intergenerational transmission of mental health problems from mother to child (Hartman…”
Insulin receptor substrate 2 regulates placental syncytiotrophoblast differentiation at the maternal-fetal interface
Grinat, J., Moya-Navamuel, M., Blanco-Cueto, P., Alemán-Juanes, C., Hernandez-Diaz, N., Mellado-López, M., Galán, A., Noon, L. A., Burks, D. J., Clercq, K. D., et al. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.103061
“…fails to meet fetal metabolic demands and is associated with an increased risk of cardiovascular and metabolic disease later (legend continued on next page) in life, including heart disease, hypertension, type 2 diabetes, and stroke (Barker, 2004; Brosens et al., 2011; Militello et al., 2009).”
Development and Computational Validation of Neonatal Acute Kidney Injury Risk Model (PC-NAKI) using synthetic data: Hybrid Innovation and Clinical FramingPreprint
Nada, A., Ahmed, Y., Khadro, N., Diab, N., Mazo, A., Martorell-Bendezu, L., Kraus, N., Ngo, L., Adie, M., Baig, S., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10733049/v1
Overcrowding, Climate and Pandemics in Late Anthropocene
Sharov, K., Захарова, Л. А., & Sharova, N. P. (2026) · Springer eBooks · doi:10.1007/978-981-95-9585-3_1
Maternal obesity accelerates cardiomyocyte maturation and programs adult heart dysfunction in offspringPreprint
Farhi, D., Gilles, D., Donnarumma, E., Pataluch, N., Louis, M., Blandin, C., Mougenot, N., Wai, T., Galès, C., & Balse, E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.07.757474
Perfil de expressão dos mIRNAS da família mIR-200 e mIR-192 no rim total e glomérulos isolados de ratos submetidos à restrição protéica in útero
Sene, L. D. B. (2012) · Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences

Authors: Barker, D.
Affiliations: Southampton General Hospital (GB)
Corresponding author: Barker, DJP
Venue: Acta Paediatrica
Publisher: Wiley
Published: 2004-11
Volume: 93
Issue: s446
Pages: 26-33
ISSN: 0365-1436 (ISSN-L)
0803-5253
1651-2227
DOI: 10.1111/j.1651-2227.2004.tb00236.x
OpenAlex: W2143230895
Cited by: 790
References: 53
Citations by year: 2026: 19 · 2025: 38 · 2024: 49 · 2023: 42 · 2022: 36 · 2021: 63 · 2020: 55 · 2019: 42 · 2018: 39 · 2017: 37 · 2016: 33 · 2015: 40 · 2014: 37 · 2013: 40 · 2012: 45
FWCI: 17.36
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 792 d)
Locations: Acta Paediatrica (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: developmental origins of health and disease, low birth weight, coronary artery disease, stroke, hypertension, type 2 diabetes, developmental plasticity, fetal growth restriction, gestational age, child weight gain, environmental influences on development
MeSH terms: Adult, Birth Weight, Cardiovascular Diseases, Child, Child Development, Child, Preschool, Chronic Disease, Diabetes Mellitus, Type 2, Female, Humans, Infant, Infant, Newborn, Male

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The developmental origins of chronic adult disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Citations

Cites

Cited by

Related

Metadata

Record

About these checks