Cited by 790Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

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The developmental origins of chronic adult disease

Barker, DJP·2004·Acta Paediatrica

DOI 10.1111/j.1651-2227.2004.tb00236.x

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Abstract

Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin-dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. Coronary heart disease and the disorders related to it arise through a series of interactions between environmental influences and the pathways of development that preceded them. These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth.

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Background
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Background
Effects of prenatal exposure to the 1983–1985 Ethiopian great famine on the metabolic syndrome in adults: a historical cohort study
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“Moreover, additional researches are needed to examine the association between famine exposure in the postnatal life and adult NCD.”
Influential
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“While the mechanisms responsible for the long-term effects are not clearly understood, these have been suggested to involve genomic, epigenetic, and environmental factors (Barker, 2004; Weaver et al., 2004; Jirtle and Skinner, 2007).”
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Effect of Birth Weight and Early Pregnancy BMI on Risk for Pregnancy Complications
Andraweera, P. H., Dekker, G., Leemaqz, S., McCowan, L. M. E., Myers, J., Kenny, L. C., Walker, J. J., Poston, L., & Roberts, C. T. (2018) · Obesity · doi:10.1002/oby.22375 · Cited by 17
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Consequences of nutrition during gestation, and the challenge to better understand and enhance livestock productivity and efficiency in pastoral ecosystems
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“This has arisen primarily out of epidemiological studies on humans and experiments on animals (mostly rodents) that demonstrate adverse consequences for adult health and well being due to stressors imposed during fetal life, resulting in the ‘Fetal Origins’ (Barker 2004) and ‘Thrifty Phenotype’ (Hales and Barker 2001)…”
Fetal Origins of Malarial Disease: Cord Blood Cytokines as Risk Markers for Pediatric Severe Malarial Anemia
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Early-life Pb exposure as a potential risk factor for Alzheimer’s disease: are there hazards for the Mexican population?
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“It is correlated with chronic diseases in adulthood, including hypertension, coronary heart disease, obesity, and diabetes (Jornayvaz et al. 2016; Barker 2004).”

Authors: Barker, D.
Affiliations: Southampton General Hospital (GB)
Corresponding author: Barker, DJP
Venue: Acta Paediatrica
Publisher: Wiley
Published: 2004-11
Volume: 93
Issue: s446
Pages: 26-33
ISSN: 0365-1436 (ISSN-L)
0803-5253
1651-2227
DOI: 10.1111/j.1651-2227.2004.tb00236.x
OpenAlex: W2143230895
Cited by: 790
References: 53
Citations by year: 2026: 19 · 2025: 38 · 2024: 49 · 2023: 42 · 2022: 36 · 2021: 63 · 2020: 55 · 2019: 42 · 2018: 39 · 2017: 37 · 2016: 33 · 2015: 40 · 2014: 37 · 2013: 40 · 2012: 45
FWCI: 17.36
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 792 d)
Locations: Acta Paediatrica (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: developmental origins of health and disease, low birth weight, coronary artery disease, stroke, hypertension, type 2 diabetes, developmental plasticity, fetal growth restriction, gestational age, child weight gain, environmental influences on development
MeSH terms: Adult, Birth Weight, Cardiovascular Diseases, Child, Child Development, Child, Preschool, Chronic Disease, Diabetes Mellitus, Type 2, Female, Humans, Infant, Infant, Newborn, Male

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The developmental origins of chronic adult disease

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