Cited by 790Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

The developmental origins of chronic adult disease

Barker, DJP·2004·Acta Paediatrica

DOI 10.1111/j.1651-2227.2004.tb00236.x

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Abstract

Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin-dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. Coronary heart disease and the disorders related to it arise through a series of interactions between environmental influences and the pathways of development that preceded them. These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth.

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Influential
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BackgroundInfluential
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Background
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Background
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“These observations have participated in establishing the Developmental Origin of Health and Disease (DOHaD) hypothesis.(2) This concept states that an adverse environment in utero or during infancy, including dysnutrition, can program or imprint the development of several tissues, including the adipose tissue.”
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The appearance of discretionary income: Influence on the prevalence of under- and over-nutrition
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Perinatal Nutrition Programs the Hypothalamic Melanocortin System in Offspring
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“In the DOHaD literature, growth in weight, length/height, and body mass index (BMI) have often been studied at birth and during infancy and childhood for their associations with adiposity, obesity, blood pressure, and other cardiometabolic outcomes later in life.(6, 12-16) One of the”
Background
Aberrant NMDA-dependent LTD after perinatal ethanol exposure in young adult rat hippocampus
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Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment
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“It is clear that early life events impact organ development and function deleteriously, and thus programme infants for increased vulnerability to developing adulthood disease [28,29].”
Background
Epigenetic control of cardiovascular health by nutritional polyphenols involves multiple chromatin-modifying writer-reader-eraser proteins
Declerck, K., Szic, K. S. V., Palagani, A., Heyninck, K., Haegeman, G., Morand, C., Milenković, D., & Berghe, W. V. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150825141720 · Cited by 29
Feto-placental vascular dysfunction as a prenatal determinant of adult cardiovascular disease
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“have a disproportionately high fat mass in relation to lean body mass, which will lead to insulin resistance [7].”
Background
Increased Expression of MicroRNA‐206 Inhibits Potassium Voltage‐Gated Channel Subfamily A Member 5 in Pulmonary Arterial Smooth Muscle Cells and Is Related to Exaggerated Pulmonary Artery Hypertension Following Intrauterine Growth Retardation in Rats
Lv, Y., Fu, L., Zhang, Z., Gu, W., Luo, X., Zhong, Y., Xu, S., Wang, Y., Yan, L., Li, M., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010456 · Cited by 28
“5 on PASMCs in IUGR rats after 2 weeks of hypoxia, causing exaggerated PAH in adults as previously suggested.1 The progression and outcome of PAs underlie PAH following IUGR.”
BackgroundInfluential
Diet and the developing immune system
Langley‐Evans, S. C., & Carrington, L. J. (2006) · Lupus · doi:10.1177/0961203306070001 · Cited by 29
Controversies in the management of hyperglycemia in the ELBW infant.
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Predictors of growth velocity in early infancy in a resource-poor setting
Olusanya, B. O., & Renner, J. K. (2011) · Early Human Development · doi:10.1016/j.earlhumdev.2011.05.002 · Cited by 28
Oxidative injury of the pulmonary circulation in the perinatal period: Short‐ and long‐term consequences for the human cardiopulmonary system
de Wijs-Meijler, D. P. M., Duncker, D. J., Tibboel, D., SCHERMULY, R. T., Weißmann, N., Merkus, D., & Reiss, I. K. M. (2016) · Pulmonary Circulation · doi:10.1086/689748 · Cited by 28
Placental Elasticity and Histopathological Findings in Normal and Intra-Uterine Growth Restriction Pregnancies Assessed with Strain Elastography in Ex Vivo Placenta
Durhan, G., Unverdi, H. G., Deveci, C. D., BÜYÜKŞİRECİ, M., Karakaya, J., Değirmenci, T., Bayrak, A., Koşar, P. N., Hücümenoğlu, S., & Ergün, Y. (2016) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2016.08.037 · Cited by 28
Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels
Gagné‐Ouellet, V., Breton, É., Thibeault, K., Fortin, C., Cárdenas, A., Guérin, R., Perron, P., Hivert, M., & Bouchard, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010329 · Cited by 30
Metabolic Impact of Growth Hormone Treatment in Short Children Born Small for Gestational Age
Lebl, J., Lebenthal, Y., Koloušková, S., Steensberg, A., Jøns, K., Kappelgaard, A., Ibáñez, L., & Phillip, M. (2011) · Hormone Research in Paediatrics · doi:10.1159/000329729 · Cited by 27
“Although the main aim of GH treatment in short SGA children is to increase height, additional metabolic effects derived from this therapy may modify food intake, appetite and body composition, and potentially result in favourable long-term metabolic benefits. SGA children with spontaneous catch-up growth appear to be…”
Background
Body Mass Index and Height From Infancy to Adulthood and Carotid Intima-Media Thickness at 60 to 64 Years in the 1946 British Birth Cohort Study
Johnson, W., Kuh, D. J., Tikhonoff, V., Charakida, M., Woodside, J., Whincup, P. H., Hughes, A. D., Deanfield, J. E., & Hardy, R. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302572 · Cited by 27
Obesity, Metabolic Syndrome and Disorders of Energy Balance
Han, J. C., & Weiss, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00024-5 · Cited by 27
Nutritional genomics: a practical approach by early life conditioning with dietary phosphorus
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“However, if this ‘programming’ of metabolism during embryonic and fetal development is inappropriate for the long-term nutritional environment it may lead to adverse long term consequences for the offspring (Sayer et al., 2004; Yajnik, 2004; Barker, 2004).”
Background
Low-Protein Diet-Induced Fetal Growth Restriction Leads to Exaggerated Proliferative Response to Vascular Injury in Postnatal Life
Chisaka, T., Mogi, M., Nakaoka, H., Kan‐no, H., Tsukuda, K., Wang, X., Bai, H., Shan, B., Kukida, M., Iwanami, J., et al. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv072 · Cited by 26
From Birth to “Immunohealth,” Allergies and Enterocolitis
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Fetal developmental programing: insights from human studies and experimental models
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“[9] proposed that the primary programing influence experienced by the human fetus is maternal nutrition.”
Background
Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression
O’Neill, K. M., Irwin, R. E., Mackin, S.-J., Thursby, S.-J., Thakur, A., Bertens, C., Masala, L., Loughery, J., McArt, D. G., & Walsh, C. P. (2018) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0182-4 · Cited by 25
Racial differences of early vascular aging in children and adolescents
Kruger, R., Gafane-Matemane, L. F., & Kagura, J. (2020) · Pediatric Nephrology · doi:10.1007/s00467-020-04593-5 · Cited by 26
Reduction of Mitochondrial Function by FCCP During Mouse Cleavage Stage Embryo Culture Reduces Birth Weight and Impairs the Metabolic Health of Offspring1
Zander‐Fox, D., Fullston, T., McPherson, N. O., Sandeman, L., Kang, W. X., Good, S. B., Spillane, M., & Lane, M. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.114.123489 · Cited by 27
“In these studies, offspring also displayed changes to glucose homeostasis, insulin resistance, and lipid metabolism; however, whether this resulted from increased adiposity accumulation with age, or vice versa, remains to be elucidated [58–63].”
Background

Authors: Barker, D.
Affiliations: Southampton General Hospital (GB)
Corresponding author: Barker, DJP
Venue: Acta Paediatrica
Publisher: Wiley
Published: 2004-11
Volume: 93
Issue: s446
Pages: 26-33
ISSN: 0365-1436 (ISSN-L)
0803-5253
1651-2227
DOI: 10.1111/j.1651-2227.2004.tb00236.x
OpenAlex: W2143230895
Cited by: 790
References: 53
Citations by year: 2026: 19 · 2025: 38 · 2024: 49 · 2023: 42 · 2022: 36 · 2021: 63 · 2020: 55 · 2019: 42 · 2018: 39 · 2017: 37 · 2016: 33 · 2015: 40 · 2014: 37 · 2013: 40 · 2012: 45
FWCI: 17.36
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 792 d)
Locations: Acta Paediatrica (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: developmental origins of health and disease, low birth weight, coronary artery disease, stroke, hypertension, type 2 diabetes, developmental plasticity, fetal growth restriction, gestational age, child weight gain, environmental influences on development
MeSH terms: Adult, Birth Weight, Cardiovascular Diseases, Child, Child Development, Child, Preschool, Chronic Disease, Diabetes Mellitus, Type 2, Female, Humans, Infant, Infant, Newborn, Male

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The developmental origins of chronic adult disease

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