Cited by 790Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

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The developmental origins of chronic adult disease

Barker, DJP·2004·Acta Paediatrica

DOI 10.1111/j.1651-2227.2004.tb00236.x

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Abstract

Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin-dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. Coronary heart disease and the disorders related to it arise through a series of interactions between environmental influences and the pathways of development that preceded them. These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth.

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“, glomerular hypertrophy of the irradiated PND3 kidneys may reflect hyperfiltration as a compensation for low numbers of nephrons.(23) In the superficial cortex, morphologically small incomplete glomeruli with insufficient capillaries were observed in irradiated PND3 kidneys, but not in the juxtamedullary cortex.”
Background
In Vivo Administration of Phosphatidic Acid, a Direct Alcohol Target Rescues Fetal Growth Restriction and Maternal Uterine Artery Dysfunction in Rat FASD Model
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“A variety of data indicate that nutritional problems of the fetus, such as low birth weight, can have long-term effects on the onset of diabetes or cardiovascular disease ( 21 , 22).”
Background
Effectiveness of PMT Supplement Biscuit to Hemoglobin Content of Pregnant Woman in Pare Pare City
Sampeangin, H., Thaha, R., Hadju, V., Siraddjudin, S., & Mallongi, A. (2017) · International Journal of Sciences: Basic and Applied Research · Cited by 1
Neurodevelopmental and Behavioral Effects of Variations in Omega-3 Polyunsaturated Fatty Acids Levels in Vulnerable Populations
Rodrigues, D. M., Manfro, G. G., & Silveira, P. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815238-6.00019-5 · Cited by 1
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“vascular diseases, systolic blood pressure) (Barker 2004; Poulter et al. 1999).”
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History of nutritional education and childhood obesity during the age of increasing scale of the problem
Woźniak, D., & Drzymała-Czyż, S. (2021) · Medycyna Ogólna i Nauki o Zdrowiu · doi:10.26444/monz/143352 · Cited by 1
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Raza, R. (2021) · doi:10.37962/ibras/2021/146-148 · Cited by 1
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The Role of Genomic Imprints in Placental Biology
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The role of Toll-like receptors in the development of immunological tolerance in neonates
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Preventing Vitamin B12 deficiency in South Asian women of childbearing age - the VitB12 study
Mearns, G. J. (2012) · Tuwhera (Auckland University of Technology)
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“Via linkage with national mortality records, and subsequently clinical examination of surviving study members, birth weight was shown to be related to a range of adult cardiovascular outcomes: coronary heart disease, stroke and their risk factors, such as hypertension and type 2 diabetes.(5) While this body of work wa…”
Background
MATERNAL OBESITY ,M ETABOLISM, AND PREGNANCY OUTCOMES
King, J. C. (2006)
TheMotherortheFetus?11-HydroxysteroidDehydrogenase Type2NullMiceProvideEvidenceforDirectFetal ProgrammingofBehaviorbyEndogenousGlucocorticoids
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Polychlorinated biphenyls, dichlorodiphenyldichloroethylene, and infant development and growth: an analysis of the PIN Babies Study
Pan, I. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/eazz-e742
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Coall, D. A., Callan, A. C., Dickins, T. E., & Chisholm, J. S. (2015) · Australasian Journal of Paramedicine
Incidence of Pleurisy in Diabetics and Hypertension Patients
Oh, H. R., Kim, M. J., You, H. S., Kim, I. S., Shin, S. H., Lee, E. J., Kang, S. S., & Hyun, S. H. (2016) · Korean Journal of Clinical Laboratory Science · doi:10.15324/kjcls.2016.48.1.30
“뿐만 아니라 성인병의 새로운 요인이 현재에도 발견 되고 있으며, 성인병 질환이 나타나는 연령도 점점 낮아지는 추세 이다[2].”
The Health Status and Lifestyle Behaviours of UniversityStudents in Nigeria by Sex and Ethnicity
Agwu, M. E. (2014) · Research Repository (University of Gloucestershire)

Authors: Barker, D.
Affiliations: Southampton General Hospital (GB)
Corresponding author: Barker, DJP
Venue: Acta Paediatrica
Publisher: Wiley
Published: 2004-11
Volume: 93
Issue: s446
Pages: 26-33
ISSN: 0365-1436 (ISSN-L)
0803-5253
1651-2227
DOI: 10.1111/j.1651-2227.2004.tb00236.x
OpenAlex: W2143230895
Cited by: 790
References: 53
Citations by year: 2026: 19 · 2025: 38 · 2024: 49 · 2023: 42 · 2022: 36 · 2021: 63 · 2020: 55 · 2019: 42 · 2018: 39 · 2017: 37 · 2016: 33 · 2015: 40 · 2014: 37 · 2013: 40 · 2012: 45
FWCI: 17.36
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 792 d)
Locations: Acta Paediatrica (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: developmental origins of health and disease, low birth weight, coronary artery disease, stroke, hypertension, type 2 diabetes, developmental plasticity, fetal growth restriction, gestational age, child weight gain, environmental influences on development
MeSH terms: Adult, Birth Weight, Cardiovascular Diseases, Child, Child Development, Child, Preschool, Chronic Disease, Diabetes Mellitus, Type 2, Female, Humans, Infant, Infant, Newborn, Male

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