The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The developmental origins of chronic adult disease
Abstract
Low birthweight is now known to be associated with increased rates of coronary heart disease and the related disorders stroke, hypertension and non-insulin-dependent diabetes. These associations have been extensively replicated in studies in different countries and are not the result of confounding variables. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. Coronary heart disease and the disorders related to it arise through a series of interactions between environmental influences and the pathways of development that preceded them. These diseases are the product of branching pathways of development in which the branchings are triggered by the environment before and after birth.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574
Fetal origins of coronary heart disease
Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570
Self-citationFetal and infant growth and impaired glucose tolerance at age 64
Hales, C. N., Barker, D. J., Clark, P. M., Cox, L. J., Fall, C., Osmond, C., & Winter, P. D. (1991) · BMJ · doi:10.1136/bmj.303.6809.1019 · Cited by 2,708
Phenotypic Plasticity and the Origins of Diversity
West-Eberhard, M. J. (1989) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.20.110189.001341 · Cited by 2,110
Fetal origins of adult disease: strength of effects and biological basis
Barker, D., Eriksson, J., Forsén, T., & Osmond, C. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.6.1235 · Cited by 2,024
Compensation for a bad start: grow now, pay later?
Metcalfe, N. B., & Monaghan, P. (2001) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(01)02124-3 · Cited by 1,948
Health consequences of obesity
Reilly, J. J. (2003) · Archives of Disease in Childhood · doi:10.1136/adc.88.9.748 · Cited by 1,652
Calvert, H., Horwich, A., Newlands, E. S., Beǵent, R. H. J., Rustin, G. J. S., Kaye, S. B., Harris, A. L., Williams, C. J., & Slevin, M. L. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92709-2 · Cited by 1,183
Nephron Number in Patients with Primary Hypertension
Keller, G., Zimmer, G., Mall, G., Ritz, E., & Amann, K. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020549 · Cited by 1,102
The role of size at birth and postnatal catch-up growth in determining systolic blood pressure
Huxley, R., Shiell, A. W., & Law, C. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018070-00002 · Cited by 1,046
Research works printed but not linked: 1
- Bateson P, 1999, Design for a life: how behaviour develops
Cited by
Sorted by citations
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087
Every Newborn: progress, priorities, and potential beyond survival
Lawn, J. E., Blencowe, H., Oza, S., You, D., Lee, A. C., Waiswa, P., Lalli, M., Bhutta, Z., Barros, A. J., Christian, P., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60496-7 · Cited by 1,929
Van den Bergh, B. R. H., van den Heuvel, M. I., Lahti, M., Braeken, M., de Rooij, S. R., Entringer, S., Hoyer, D., Roseboom, T., Räikkönen, K., King, S., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.003 · Cited by 1,181
“The ‘fetal programming hypothesis’ (Seckl and Holmes, 2007), the ‘developmental programming hypothesis’ (Barker, 2004; Langley-Evans, 2006; Langley-Evans, 2015), and the ‘Developmental Origins of Health and Disease (DOHaD) hypothesis’ (Barker, 2004; Barker,”
BackgroundMore than a feeling: A unified view of stress measurement for population science
Epel, E. S., Crosswell, A. D., Mayer, S. E., Prather, A. A., Slavich, G. M., Puterman, E., & Mendes, W. B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.001 · Cited by 1,077
Bujold, E., Roberge, S., Lacasse, Y., Bureau, M., Audibert, F., Marcoux, S., Forest, J., & Giguère, Y. (2010) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181e9322a · Cited by 1,112
“80 mg or less daily (4) 81 mg or more daily (6)”
BackgroundHuman placenta and trophoblast development: key molecular mechanisms and model systems
Knöfler, M., Haider, S., Saleh, L., Pollheimer, J., Gamage, T. K. J. B., & James, J. L. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03104-6 · Cited by 818
Cnossen, J. S., Morris, R. K., ter Riet, G., Mol, B. W. J., van der Post, J. A. M., Coomarasamy, A., Zwinderman, A. H., Robson, S. C., Bindels, P. J. E., Kleijnen, J., et al. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.070430 · Cited by 719
“Adults who were affected by intrauterine growth restriction in utero are at increased risk for cardiovascular disease, hypertension and type 2 diabetes.(4,5) Pre-eclampsia and intrauterine growth restriction are characterized by abnormal placenta formation,(6) which results in inadequate uteroplacental blood flow.”
BackgroundGenome-wide associations for birth weight and correlations with adult disease
Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J. J., Feenstra, B., van Zuydam, N. R., Gaulton, K. J., Grarup, N., et al. (2016) · Nature · doi:10.1038/nature19806 · Cited by 508
Blake, B. E., & Fenton, S. E. (2020) · Toxicology · doi:10.1016/j.tox.2020.152565 · Cited by 499
“Third, it is possible that PFAS-related adverse health outcomes observed in adulthood are latent manifestations of perturbations during sensitive periods of development (Barker 2004).”
BackgroundImpact of obesity on male fertility, sperm function and molecular composition
Palmer, N. O., Bakos, H. W., Fullston, T., & Lane, M. (2012) · Spermatogenesis · doi:10.4161/spmg.21362 · Cited by 403
Effect of in vitro culture of human embryos on birthweight of newborns
Dumoulin, J. C. M., Land, J. A., van Montfoort, A. P. A., Nelissen, E. C. M., Coonen, E., Derhaag, J. G., Schreurs, I. E. L., Dunselman, G. A. J., Kester, A. D. M., Geraedts, J. P. M., et al. (2010) · Human Reproduction · doi:10.1093/humrep/dep456 · Cited by 359
Maternal Obesity, Metabolism, and Pregnancy Outcomes
King, J. C. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132249 · Cited by 341
Developmental programming of health and disease
Langley‐Evans, S. C. (2006) · Proceedings of The Nutrition Society · doi:10.1079/pns2005478 · Cited by 338
“The environment encountered during fetal life and infancy appears to be strongly related to risk of non-communicable diseases in adult life (Barker, 2004).”
BackgroundPreterm Birth and Body Composition at Term Equivalent Age: A Systematic Review and Meta-analysis
Johnson, M. J., Wootton, S. A., Leaf, A., & Jackson, A. A. (2012) · PEDIATRICS · doi:10.1542/peds.2011-3379 · Cited by 317
Landrigan, P. J., & Goldman, L. R. (2011) · Health Affairs · doi:10.1377/hlthaff.2011.0151 · Cited by 320
Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the CoLaus study
Jornayvaz, F. R., Vollenweider, P., Bochud, M., Mooser, V., Waeber, G., & Marques-Vidal, P. M. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0389-2 · Cited by 298
“Background Low birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes [1], which are components of the metabolic syndrome [2].”
BackgroundResultDelahaye, F., Breton, C., Risold, P., Enache, M., Dutriez-Casteloot, I., Laborie, C., Lésage, J., & Vieau, D. (2007) · Endocrinology · doi:10.1210/en.2007-1263 · Cited by 266
The role of nutrition on epigenetic modifications and their implications on health
Jiménez-Chillarón, J. C., Díaz, R., Martínez, D., Pentinat, T., Ramón-Krauel, M., Ribó, S., & Plösch, T. (2012) · Biochimie · doi:10.1016/j.biochi.2012.06.012 · Cited by 266
Blake, B. E., Cope, H. A., Hall, S., Keys, R. D., Mahler, B. W., McCord, J. P., Scott, B., Stapleton, H. M., Strynar, M. J., Elmore, S. A., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6233 · Cited by 271
“Additionally, it is known that low birth weight is associated with adult diseases, including metabolic syndrome in both humans and animals (Barker 2004).”
Early-Life Risk Factors for Alzheimer Disease
Borenstein, A. R., Copenhaver, C. I., & Mortimer, J. A. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000201854.62116.d7 · Cited by 260
“Intrauterine Environment The intrauterine environment has been postulated to contribute to late-life chronic diseases independently of genetics and environmental risk factors experienced throughout the life course.(39,40) Barker’s ‘‘fetal origins hypothesis’’ postulates that chronic diseases may result in part from ch…”
BackgroundHagadorn, J. I., Furey, A., Nghiem‐Rao, T. H., Schmid, C. H., Phelps, D. L., Pillers, D. M., Cole, C. H., & and the AVIOx Study Group (2006) · PEDIATRICS · doi:10.1542/peds.2005-0413 · Cited by 257
de Rooij, S. R., Painter, R. C., Roseboom, T. J., Phillips, D. I. W., Osmond, C., Barker, D. J. P., Tanck, M. W. T., Michels, R. P. J., Bossuyt, P. M., & Bleker, O. P. (2006) · Diabetologia · doi:10.1007/s00125-005-0136-9 · Cited by 237
“Reduced early growth has been shown to be associated with later IGT and type 2 diabetes [20, 21].”
BackgroundLoomans, E. M., van Dijk, A. E., Vrijkotte, T. G. M., van Eijsden, M., Stronks, K., Gemke, R. J. B. J., & Van den Bergh, B. R. H. (2013) · European Journal of Public Health · doi:10.1093/eurpub/cks097 · Cited by 212
Castellano, J. M., Overgaard, A., Sanchez-Garrido, M. A., Ruíz-Pino, F., Romero, M., García-Galiano, D., Aguilar, E., Pinilla, L., Diéguez, C., Mikkelsen, J. D., et al. (2011) · Endocrinology · doi:10.1210/en.2010-1415 · Cited by 206
“Early Metabolic Programming of Kiss1 System and Puberty Endocrinology, September 2011, 152(9):3396–3408”
BackgroundInfluentialGuidelines for Implementing Culturally Competent Nursing Care
Douglas, M. K., Rosenkoetter, M. M., Pacquiao, D. F., Callister, L. C., Hattar‐Pollara, M., Lauderdale, J. L., Milstead, J. A., Nardi, D. A., & Purnell, L. D. (2014) · Journal of Transcultural Nursing · doi:10.1177/1043659614520998 · Cited by 248
Holmes, M. C., Abrahamsen, C. T., French, K. L., Paterson, J. M., Mullins, J. J., & Seckl, J. R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4464-05.2006 · Cited by 200
“An adverse prenatal environment “programs” lifelong susceptibility to adult disorders such as hypertension, diabetes/insulin resistance, heart disease, as well as depression and schizophrenia (Barker, 2004; Eriksson et al., 2004; Huizink et al., 2004).”
Bakulski, K. M., Rozek, L. S., Dolinoy, D. C., Paulson, H. L., & Hu, H. (2012) · Current Alzheimer Research · doi:10.2174/156720512800617991 · Cited by 199
“role in the developmental origins of adult health and disease (DOHaD) by providing a mechanism underlying the latent effects of adverse fetal, infant, and childhood environments on late-life chronic disease [102-104].”
BackgroundSharp, A., Cornforth, C., Jackson, R., Harrold, J. A., Turner, M. A., Kenny, L. C., Baker, P. N., Johnstone, E., Khalil, A. A., von Dadelszen, P., et al. (2017) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(17)30173-6 · Cited by 196
Long-term influence of normal variation in neonatal characteristics on human brain development
Walhovd, K. B., Fjell, A. M., Brown, T. T., Kuperman, J. M., Chung, Y., Hagler, D. J., Roddey, J. C., Erhart, M., McCabe, C., Akshoomoff, N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208180109 · Cited by 187
“This adaptation has been coined fetal programming or developmental plasticity (7).”
BackgroundNandi, A. A., Chen, Z., Patel, R., & Poretsky, L. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.10.003 · Cited by 189
Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants
Stanislawski, M. A., Dabelea, D., Wagner, B. D., Sontag, M. K., Lozupone, C., & Eggesbø, M. Å. (2017) · Microbiome · doi:10.1186/s40168-017-0332-0 · Cited by 190
“The fetal programming hypothesis sets forth the notion that exposures in utero, at birth and in early life may have longterm effects on adult health [52].”
BackgroundRole of the hypothalamic–pituitary–adrenal axis in developmental programming of health and disease
Xiong, F., & Zhang, L. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.11.002 · Cited by 177
“weight with higher risk of coronary heart disease, diabetes, and hypertension in later life in multiple populations [11,13,12], programming of adult disease by adverse early life environments has been extensively studied in humans.”
BackgroundPUFAs in Fish: Extraction, Fractionation, Importance in Health
Sahena, F., Zaidul, I. S. M., Jinap, S., Saari, N., Jahurul, M. H. A., Abbas, K. A., & Rahman, N. N. N. A. (2009) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2009.00069.x · Cited by 176
Gill, J. M. R., & Malkova, D. (2006) · Clinical Science · doi:10.1042/cs20050207 · Cited by 173
The Role of Microbes in Developmental Immunologic Programming
Kaplan, J. L., Shi, H. N., & Walker, W. A. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318217638a · Cited by 171
“are credited with the “developmental origins of adult disease” or “fetal programming” hypothesis (9), which grew from epidemiologic observations linking LBW and prenatal under-nutrition to adult diseases such as coronary artery disease (10), type 2 diabetes (11), hypertension (12), and stroke.”
BackgroundEpigenome Mapping in Normal and Disease States
Maunakea, A. K., Chepelev, I., & Zhao, K. (2010) · Circulation Research · doi:10.1161/circresaha.110.222463 · Cited by 165
Guo, L., Choufani, S., Ferreira, J., Smith, A. C., Chitayat, D., Shuman, C., Uxa, R., Keating, S., Kingdom, J., & Weksberg, R. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.04.025 · Cited by 176
Epigenetic Transgenerational Inheritance of Obesity Susceptibility
King, S. E., & Skinner, M. K. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.02.009 · Cited by 177
Childhood obesity and cardiovascular disease
Bridger, T. (2009) · Paediatrics & Child Health · doi:10.1093/pch/14.3.177 · Cited by 163
“Studies (44-47) have demonstrated an association between low birth weight (and high birth weight in some studies) and hypertension, dyslipidemia, insulin resistance and the metabolic syndrome.”
BackgroundSchlotz, W., Jones, A., Phillips, D. I. W., Gale, C. R., Robinson, S. M., & Godfrey, K. M. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02182.x · Cited by 165
“alterations and influence risk for disease later in life (Barker, 2004).”
The role of microorganisms in achieving the sustainable development goals
Akinsemolu, A. A. (2018) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2018.02.081 · Cited by 170
“Furthermore, maternal dietary factors and hygiene highly in fl uence the immune development of the foetus, and prenatal undernutrition can lead to the development of adult diseases like coronary heart illnesses, type 2 diabetes and stroke (Barker, 2004).”
BackgroundEpigenetic Regulation of Human Trophoblastic Cell Migration and Invasion
Rahnama, F., Shafiei, F., Gluckman, P. D., Mitchell, M. D., & Lobie, P. E. (2006) · Endocrinology · doi:10.1210/en.2006-0288 · Cited by 160
Environmental epigenetic inheritance through gametes and implications for human reproduction
Wei, Y., Schatten, H., & Sun, Q. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu061 · Cited by 162
de Waal, E., Vrooman, L. A., Fischer, E., Ord, T. S., Mainigi, M. A., Coutifaris, C., Schultz, R. M., & Bartolomei, M. S. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv400 · Cited by 157
Oluwasanmi, J. O. (1974) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)32271-9 · Cited by 156
Pediatrics Consequences of Caesarean Section—A Systematic Review and Meta-Analysis
Słabuszewska-Jóźwiak, A., Szymański, J. K., Ciebiera, M., Sarecka‐Hujar, B., & Jakiel, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218031 · Cited by 162
Gene expression in the placenta: maternal stress and epigenetic responses
Gheorghe, C. P., Goyal, R., Mittal, A., & Longo, L. D. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082770cg · Cited by 156
Chapter 5 Biomarkers Related To Aging In Human Populations
Crimmins, E. M., Vasunilashorn, S. M., Kim, J. K., & Alley, D. E. (2008) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)00405-8 · Cited by 159
A second look at the influence of birth weight on carcass and meat quality in pigs
Rehfeldt, C., Tuchscherer, A., Hartung, M., & Kuhn, G. (2007) · Meat Science · doi:10.1016/j.meatsci.2007.05.029 · Cited by 151
“When both sexes were included, it tended to be lower in LW pigs (Rehfeldt & Kuhn, 2006) or it was equal in LW and HW pigs (Bee, 2004) as seen in the present study. Thus, the inconsistency may results from the influence of gender on lean meat percentage. Poore and Fowden (2004a) also observed stronger effects of birth…”
ResultLung-function trajectories: relevance and implementation in clinical practice
Melén, E., Faner, R., Allinson, J. P., Bui, D., Bush, A., Čustović, A., García‐Aymerich, J., Guerra, S., Breyer‐Kohansal, R., Hallberg, J., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00016-3 · Cited by 151
Roche, J. R., Blache, D., Kay, J. K., Miller, D. R., Sheahan, A. J., & Miller, D. W. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138744 · Cited by 154
Human Milk and Allergic Diseases: An Unsolved Puzzle
Munblit, D., Peroni, D. G., Boix-Amorós, A., Hsu, P. S., Land, B. V., Gay, M. C. L., Kolotilina, A., Skevaki, C. L., Boyle, R. J., Collado, M. C., et al. (2017) · Nutrients · doi:10.3390/nu9080894 · Cited by 165
“Keeping in mind the “Developmental Origins of Health and Disease” (DOHaD) hypothesis, which suggests fetal developmental ‘plasticity’ and discordance between intra- and extra-uterine exposures produces the greatest adverse effects [240].”
Ślusarczyk, J., Trojan, E., Głombik, K., Budziszewska, B., Kubera, M., Lasoń, W., Popiołek-Barczyk, K., Mika, J., Wędzony, K., & Basta‐Kaim, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00082 · Cited by 143
“In addition, maternal stress in humans leads to neuro-immuno-endocrine disturbances that enhance susceptibility to some immune-related diseases (e.g., asthma, allergy or diabetes) in adult life (Barker, 2004; Knackstedt et al., 2005).”
BackgroundLi, Y., Ley, S. H., Tobias, D. K., Chiuve, S. E., VanderWeele, T. J., Rich-Edwards, J. W., Curhan, G. C., Willett, W. C., Manson, J. E., Hu, F. B., et al. (2015) · BMJ · doi:10.1136/bmj.h3672 · Cited by 135
Lane, M., McPherson, N. O., Fullston, T., Spillane, M., Sandeman, L., Kang, W. X., & Zander‐Fox, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100832 · Cited by 140
“Through epidemiological studies the impact of low birth weight was initially correlated to an increased risk of non-communicable adult onset diseases such as stroke, high blood pressure, diabetes and heart disease [45,46].”
BackgroundEarly life programming as a target for prevention of child and adolescent mental disorders
Lewis, A. J., Galbally, M., Gannon, T., & Symeonides, C. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-33 · Cited by 149
“Such research has been largely inspired by the developmental origins of health and disease (DOHaD) model, which proposes a link between fetal development and non-communicable diseases emerging in adulthood such as cardiovascular disease and diabetes [1].”
BackgroundEffect of Maternal Cardiovascular Conditions and Risk Factors on Offspring Cardiovascular Disease
Palinski, W. (2014) · Circulation · doi:10.1161/circulationaha.113.001805 · Cited by 133
Regulation of Placental Amino Acid Transport and Fetal Growth
Vaughan, O. R., Rosario, F. J., Powell, T. L., & Jansson, T. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.008 · Cited by 133
Can We Modify the Intrauterine Environment to Halt the Intergenerational Cycle of Obesity?
Adamo, K. B., Ferraro, Z. M., & Brett, K. (2012) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph9041263 · Cited by 131
“Overall, despite animal [102,236,242] and human [234,242,251–258] studies that have examined the effects of maternal over-nutrition and obesity on offspring obesity and Type 2 diabetes, our knowledge concerning the precise mechanisms mediating childhood pathologies are far from complete.”
BackgroundFjell, A. M., Westlye, L. T., Amlien, I. K., Tamnes, C. K., Grydeland, H., Engvig, A., Espeseth, T., Reinvang, I., Lundervold, A. J., Lundervold, A. J., et al. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht201 · Cited by 126
Bergvall, N., Iliadou, A. N., Johansson, S., Fairé, U. D., Kramer, M. S., Yudi Pawitan, Y., Pedersen, N. L., Lichtenstein, P., & Cnattingius, S. (2007) · Circulation · doi:10.1161/circulationaha.106.674812 · Cited by 126
Complementary Foods and Flavor Experiences: Setting the Foundation
Mennella, J. A., & Trabulsi, J. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000335337 · Cited by 127
Morris, R. K., Cnossen, J. S., Langejans, M., Robson, S. C., Kleijnen, J., ter Riet, G., Mol, B. W., van der Post, J., & Khan, K. S. (2008) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-8-33 · Cited by 124
Ali, Z., Saaka, M., Adams, A.-G., Kamwininaang, S. K., & Abizari, A. (2017) · BMC Nutrition · doi:10.1186/s40795-017-0154-2 · Cited by 123
“Stunting in children, especially in the first 2 years of life has long term effects on adult height, income, school attainment [4], and a predisposition to adult chronic diseases [5].”
BackgroundNutritional manipulations in the perinatal period program adipose tissue in offspring
Lukaszewski, M., Eberlé, D., Vieau, D., & Breton, C. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00231.2013 · Cited by 128
Infant regulation of intake: the effect of free glutamate content in infant formulas
Ventura, A. K., Beauchamp, G. K., & Mennella, J. A. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.024919 · Cited by 122
“Several recent studies have shown that accelerated weight gain during the first year of life increases the risk of later obesity (1), metabolic syndrome (2), and mortality from cardiovascular disease (3), which leads some to argue that early life should be the focus for both preventive intervention and further scienti…”
BackgroundMaternal exercise improves insulin sensitivity in mature rat offspring
CARTER, L. G., QI, N. R., CABO, R. D., & PEARSON, K. J. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31827de953 · Cited by 121
“This is not surprising given that numerous developmental programming studies, in animals as well as humans, do not detect differences in offspring until advanced age (3,18).”
Mäkelä, J., Linderborg, K. M., Niinikoski, H., Yang, B., & Lagström, H. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0378-5 · Cited by 120
“According to a variant of Barker hypothesis, excessive maternal body weight or weight gain during pregnancy disturbs the intrauterine environment during fetal development [2].”
BackgroundHPA axis programming by maternal undernutrition in the male rat offspring
Vieau, D., Sebaai, N., Léonhardt, M., Dutriez-Casteloot, I., Molendi‐Coste, O., Laborie, C., Breton, C., DELOOF, S., & Lésage, J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.014 · Cited by 125
“Epidemiological studies suggest that babies born at term with low weight will develop with high prevalence several pathologies including type 2 diabetes and hypertension during the adult life (Barker, 2004).”
BackgroundPeri-conception parental obesity, reproductive health, and transgenerational impacts
Lane, M., Zander‐Fox, D., Robker, R. L., & McPherson, N. O. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.11.005 · Cited by 118
Kazemier, B. M., Buijs, P. E., Mignini, L. E., Limpens, J., de Groot, C. J. M., Mol, B. W., & CONNECT, E. (2014) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12896 · Cited by 116
Standards of Practice for Culturally Competent Nursing Care
Douglas, M. K., Pierce, J. U., Rosenkoetter, M. M., Pacquiao, D. F., Callister, L. C., Hattar‐Pollara, M., Lauderdale, J. L., Milstead, J. A., Nardi, D. A., & Purnell, L. D. (2011) · Journal of Transcultural Nursing · doi:10.1177/1043659611412965 · Cited by 115
Booij, L., Wang, D., Lévesque, M. L., Tremblay, R. E., & Szyf, M. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0251 · Cited by 122
Tan, J. M., Loganath, A., Chong, Y. S., & Obbard, J. P. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.09.045 · Cited by 115
Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea
Polychronaki, N., Wild, C. P., Mykkänen, H. M., Amra, H., Abdel-Wahhab, M. A., Sylla, A., Diallo, M. S., El-Nezami, H. S., & Turner, P. C. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.08.034 · Cited by 113
“Children are a particularly susceptible population to environmental hazards (Wild and Kleinjans, 2003) and there are strong links between growth and health of the fetus and infant, and disease risk in later life (Barker, 2004; Delisle, 2002; Firestone and Amler, 2003).”
BackgroundParadis, A. N., Gay, M. S., & Zhang, L. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.10.019 · Cited by 118
“The long-term implications of this adverse environment have been well established [8,14].”
BackgroundA longitudinal assessment of aflatoxin M1 excretion in breast milk of selected Egyptian mothers
Polychronaki, N., West, R. M., Turner, P. C., Amra, H., Abdel-Wahhab, M. A., Mykkänen, H. M., & El-Nezami, H. S. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.01.001 · Cited by 110
The Association of Maternal Age with Birthweight and Gestational Age: A Cross‐Cohort Comparison
Restrepo–Méndez, M. C., Lawlor, D. A., Horta, B. L., Matijasevich, A., Santos, I. S., Menezes, A. M. B., Barros, F. C., & Victora, C. G. (2014) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12162 · Cited by 105
SOCIOECONOMIC STATUS AND ADVERSE BIRTH OUTCOMES: A POPULATION-BASED CANADIAN SAMPLE
Campbell, E. E., Gilliland, J., Dworatzek, P. D. N., de Vrijer, B., Penava, D., & Seabrook, J. A. (2017) · Journal of Biosocial Science · doi:10.1017/s0021932017000062 · Cited by 106
“Later-life health consequences include type 2 diabetes, hypertension and cardiovascular disease (World Health Organization, 2014; Barker, 2004).”
BackgroundNomura, Y., WICKRAMARATNE, P. J., Pilowsky, D. J., Newcorn, J. H., Bruder-Costello, B., Davey, C., Fifer, W. P., Jeanne Brooks-gunn, B., & Weissman, M. M. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2007.04.005 · Cited by 103
“Barker's fetal origins hypothesis [6] also suggests a link between LBWand adult hypertension, stroke [7], and diabetes mellitus [8].”
BackgroundBreton, C., Lukaszewski, M., Risold, P., Enache, M., Guillemot, J., Rivière, G., Delahaye, F., Lésage, J., Dutriez-Casteloot, I., Laborie, C., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90740.2008 · Cited by 109
“This has led to the concept of the developmental origin of adult diseases, also called “fetal programming,” or the Barker hypothesis (4).”
BackgroundŞanlı, E., & Kabaran, S. (2019) · Current Genomics · doi:10.2174/1389202920666191030092225 · Cited by 104
Coan, P. M., Ferguson‐Smith, A. C., & Burton, G. J. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00488.x · Cited by 94
“The recent realization that the intrauterine environment has a profound effect on predisposition to chronic illness in adult life (Barker, 2004) has led to a resurgence of interest in placental development and function.”
BackgroundThe Interplay between DNA Methylation, Folate and Neurocognitive Development
Irwin, R. E., Pentieva, K. D., Cassidy, T., Lees‐Murdock, D. J., McLaughlin, M., Prasad, G., McNulty, H., & Walsh, C. P. (2016) · Epigenomics · doi:10.2217/epi-2016-0003 · Cited by 98
Burggren, W. W., & Reyna, K. S. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.05.001 · Cited by 94
The developmental origins of adult disease
Joss‐Moore, L. A., & Lane, R. H. (2009) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e328326773b · Cited by 96
“The Developmental Origins of Adult Disease Hypothesis describes the origin of adult disease in terms of fetal developmental ‘plasticity’ or the ability of the fetus to respond to poor in-utero conditions [ 1 ].”
BackgroundBriana, D. D., & Malamitsi‐Puchner, A. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.019 · Cited by 91
Early immunological development and mortality from infectious disease in later life
Moore, S. E., Collinson, A. C., N’Gom, P. T., Aspinall, R., & Prentice, A. M. (2006) · Proceedings of The Nutrition Society · doi:10.1079/pns2006503 · Cited by 90
“The past two decades has seen much research and debate focused on the long-term health consequences of early-life exposures, with poor early nutrition now considered as an important risk factor for a number of chronic degenerative diseases such as heart disease and type 2 diabetes (Barker, 2004).”
BackgroundFranco, J. G., Lisboa, P. C., Lima, N. S., Amaral, T. A. S., Peixoto‐Silva, N., Resende, Â. C., OLIVEIRA, E. B. D., Passos, M. C. F., & de Moura, E. G. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.019 · Cited by 89
“Adverse conditions in critical periods (gestation and lactation) such as malnutrition could affect permanently the progeny in both humans and animals [1,2].”
BackgroundMorris, R. K., Malin, G. L., Robson, S. C., Kleijnen, J., Zamora, J., & Khan, K. S. (2010) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.7767 · Cited by 89
Ahmed, S. M., Hadi, A., Razzaque, A., Ashraf, A., Juvekar, S. K., Ng, N., Kanungsukkasem, U., Soonthornthada, K., Minh, H. V., & Bich, T. H. (2009) · Global Health Action · doi:10.3402/gha.v2i0.1986 · Cited by 89
“life (16), intrauterine origin of chronic NCDs (17),”
Guo, P., Chen, Y., Wu, H., Zeng, J., Zeng, Z., Li, W., Zhang, Q., Huo, X., Feng, W., Lin, J., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.105410 · Cited by 87
Cardiovascular Health Among Pregnant Women, Aged 20 to 44 Years, in the United States
Perak, A. M., Ning, H., Khan, S. S., Horn, L. V., Grobman, W. A., & Lloyd‐Jones, D. M. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015123 · Cited by 85
“Gestation is also increasingly recognized as a critical period for developmental programming of offspring CVD risk.(5,6) For example, maternal obesity in pregnancy has been associated with offspring CVD risk factors (adiposity, blood pressure, lipids, and insulin resistance), CVD events, and premature allcause mortali…”
BackgroundRobinson, D. L., Cafe, L. M., & Greenwood, P. L. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5799 · Cited by 85
Aaltonen, J., Ojala, T. H., Laitinen, K., Poussa, T. A., Ozanne, S. E., & Isolauri, E. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.225 · Cited by 85
“Evidence that overweight or obesity, heightened blood pressure and impaired glucose metabolism are programmed (Barker, 2004) by early nutrition points to fetal and early postnatal life as critical periods and intervention targets.”
BackgroundPredictors of low birth weight and preterm birth in rural Uganda: Findings from a birth cohort study
Bater, J., Lauer, J. M., Ghosh, S. A., Webb, P., Agaba, E., Bashaasha, B., Turyashemererwa, F., Shrestha, R., & Duggan, C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235626 · Cited by 84
“Finally, intrauterine programming and genetic modulation associated with LBW are postulated to increase risk of chronic diseases, including obesity, hypertension, and insulin resistance later in life [12, 13].”
BackgroundWemakor, A., & Mensah, K. A. (2016) · BMC Public Health · doi:10.1186/s12889-016-3558-z · Cited by 87
“The consequences of childhood stunting include delayed neurological development, permanent cognitive impairment, weakened immune systems [2], and a susceptibility to chronic diseases in adulthood [3].”
BackgroundPeng, S., Deyssenroth, M. A., Narzo, A. F. D., Cheng, H. M., Zhang, Z., Lambertini, L., Ruusalepp, A., Kovacic, J. C., Björkegren, J., Marsit, C. J., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007799 · Cited by 83
“The placenta, situated at the maternal-fetal interface, is a key organ for fetal growth and development; it performs a variety of functions including controlling fetal access to nutrients, hormone production, and mitigation of adverse effects from the environment [2,5,6].”
BackgroundClimate Change, Food Supply, and Dietary Guidelines
Binns, C. W., Lee, M. K., Maycock, B. R., Torheim, L. E., Nanishi, K., & Duong, D. T. T. (2021) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-012420-105044 · Cited by 91
Metadata
- Authors
- Barker, D.
- Affiliations
- Southampton General Hospital (GB)
- Corresponding author
- Barker, DJP
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2004-11
- Volume
- 93
- Issue
- s446
- Pages
- 26-33
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2143230895
- Cited by
- 790
- References
- 53
- Citations by year
- 2026: 19 · 2025: 38 · 2024: 49 · 2023: 42 · 2022: 36 · 2021: 63 · 2020: 55 · 2019: 42 · 2018: 39 · 2017: 37 · 2016: 33 · 2015: 40 · 2014: 37 · 2013: 40 · 2012: 45
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- developmental origins of health and disease, low birth weight, coronary artery disease, stroke, hypertension, type 2 diabetes, developmental plasticity, fetal growth restriction, gestational age, child weight gain, environmental influences on development
- MeSH terms
- Adult, Birth Weight, Cardiovascular Diseases, Child, Child Development, Child, Preschool, Chronic Disease, Diabetes Mellitus, Type 2, Female, Humans, Infant, Infant, Newborn, Male
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
