The hypocretins and sleep

de Lecea, Luis; Sutcliffe, J. Gregor

doi:10.1111/j.1742-4658.2005.04981.x

Cited by 105Sleep and Wakefulness ResearchNeuroscience of respiration and sleepRegulation of Appetite and Obesity

The hypocretins and sleep

de Lecea, Luis, Sutcliffe, J. Gregor·2005·The FEBS Journal

DOI 10.1111/j.1742-4658.2005.04981.x

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Abstract

The hypocretins (also called the orexins) are two neuropeptides derived from the same precursor whose expression is restricted to a few thousand neurons of the lateral hypothalamus. Two G-protein coupled receptors for the hypocretins have been identified, and these show different distributions within the central nervous system and differential affinities for the two hypocretins. Hypocretin fibers project throughout the brain, including several areas implicated in regulation of the sleep/wakefulness cycle. Central administration of synthetic hypocretin-1 affects blood pressure, hormone secretion and locomotor activity, and increases wakefulness while suppressing rapid eye movement sleep. Most human patients with narcolepsy have greatly reduced levels of hypocretin peptides in their cerebral spinal fluid and no or barely detectable hypocretin-containing neurons in their hypothalamus. Multiple lines of evidence suggest that the hypocretinergic system integrates homeostatic, metabolic and limbic information and provides a coherent output that results in stability of the states of vigilance.

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An upregulation of the activity of orexin neurons may be a primary mechanism linking sleep deprivation and adverse metabolic effects.
“An upregulation of the activity of orexin neurons may be a primary mechanism linking sleep deprivation and adverse metabolic effects [4, 5].”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [5]

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Authors: de Lecea, L., & Sutcliffe, J. G.
Affiliations: Scripps Research Institute (US)
Venue: The FEBS Journal
Publisher: Wiley
Published: 2005-11
Volume: 272
Issue: 22
Pages: 5675-5688
ISSN: 1742-464X (ISSN-L)
1742-4658
DOI: 10.1111/j.1742-4658.2005.04981.x
OpenAlex: W2151396935
Cited by: 105
References: 117
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 2 · 2018: 7 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 5
FWCI: 0.72
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7 d)
Locations: FEBS Journal (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01MH058543, MH 58543)
National Institute of General Medical Sciences (GM-32355, R01GM032355)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: orexin, sleep regulation, sleep-wake cycle, narcolepsy, orexin-A, hypocretin-2, G protein-coupled receptors, lateral hypothalamus, sustained attention, REM sleep suppression, blood pressure, locomotor activity, cerebrospinal fluid
MeSH terms: Animals, Blood Pressure, Hormones, Humans, Hypothalamus, Models, Neurological, Motor Activity, Narcolepsy, Neurons, Neuropeptides, Sleep, Sleep, REM, Tissue Distribution, Wakefulness, Neurotransmitter Agents, Receptors, G-Protein-Coupled

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