Hypocretin as a Hub for Arousal and Motivation

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The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

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Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

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Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

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Nucleus basalis and thalamic control of neocortical activity in the freely moving rat

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Distribution of orexin receptor mRNA in the rat brain

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Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

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Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

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Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons

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Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

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To Eat or to Sleep? Orexin in the Regulation of Feeding and Wakefulness

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Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine

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HYPOTHALAMIC REGULATION OF SLEEP IN RATS. AN EXPERIMENTAL STUDY

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Fos Expression in Orexin Neurons Varies with Behavioral State

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Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice

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The neurobiology, investigation, and treatment of chronic insomnia

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Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins

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VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors

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Afferents to the orexin neurons of the rat brain

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Neural regulation of immunity: molecular mechanisms and clinical translation

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Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

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Orexin/Hypocretin Excites the Histaminergic Neurons of the Tuberomammillary Nucleus

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Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish

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Anatomical substrates of orexin–dopamine interactions: lateral hypothalamic projections to the ventral tegmental area

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AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in Finland

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SCN Outputs and the Hypothalamic Balance of Life

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Hypocretin/Orexin Excites Hypocretin Neurons via a Local Glutamate Neuron—A Potential Mechanism for Orchestrating the Hypothalamic Arousal System

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Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway

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A key role for orexin in panic anxiety

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Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

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Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland

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HLA DQB1*0602 is Associated With Cataplexy in 509 Narcoleptic Patients

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Hypocretins (Orexins) Regulate Serotonin Neurons in the Dorsal Raphe Nucleus by Excitatory Direct and Inhibitory Indirect Actions

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Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation

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Changes in the composition of brain interstitial ions control the sleep-wake cycle

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Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

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Paroxysmal Panting

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Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior

Florido, A., Curtis, V. R., Pégard, N. C., & Rodríguez-Romaguera, J. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_539 · Cited by 3 · see citing works

Food restriction induces functional resilience to sleep restriction in rats

Loomis, S., McCarthy, A. P., Dijk, D., Gilmour, G., & Winsky‐Sommerer, R. (2020) · SLEEP · doi:10.1093/sleep/zsaa079 · Cited by 3 · see citing works

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System

Somach, R. T., Lim, M. M., & Cohen, A. S. (2025) · Neurotrauma Reports · doi:10.1089/neur.2024.0111 · Cited by 2 · see citing works

Prefrontal cortex-to-hypothalamic outputs orchestrate cue-potentiated palatable food consumption via AMPKβ2 signaling

Xiang, J., Shi, M., Kang, J., Zhang, X., Ling, J., Zhan, W., Li, D., Hu, R. K., & Xu, H. (2026) · Cell Discovery · doi:10.1038/s41421-025-00857-2 · Cited by 2 · see citing works

Changes in sensorimotor cortex oscillatory activity by orexin‐A in the ventrolateral preoptic area of the hypothalamus reflect increased muscle tone

Mavanji, V., Teske, J. A., Kotz, C. M., & Pellizzer, G. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25195 · Cited by 2 · see citing works

Neural bases of freedom and responsibility

Gruart, A., & Delgado-Garcia, J. M. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1191996 · Cited by 2 · see citing works

Neuroethics beyond the laboratory door: The new state-level brain research projects and the problem of dual use

Dando, M. (2020) · Ethics Medicine and Public Health · doi:10.1016/j.jemep.2020.100513 · Cited by 2 · see citing works

Motivational Processes in the Regulation of Sleep/Wake States

Eban-Rothschild, A. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00035-9 · Cited by 2 · see citing works

Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice

Bjorness, T. E., & Greene, R. W. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.868049 · Cited by 1 · see citing works

Hypothalamic CRH neurons in stress induced psychopathology: revaluation of endocrine and neural mechanismsPreprint

Stanton, L. M., Price, A. J., & Manning, E. E. (2022) · doi:10.31234/osf.io/2z9gw · Cited by 1 · see citing works

Lateral Hypothalamic Control of Sleep in the Context of Cancer

Borniger, J. C., & Nevárez, N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816658-1.00012-0

The US BRAIN Initiative

Dando, M. (2020) · Advanced sciences and technologies for security applications · doi:10.1007/978-3-030-53790-6_6

Ghrelin-dependent mechanisms of food reward. Part 1. Ghrelin and dopamine

Reikhardt, B. A., & Shabanov, P. D. (2022) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf20129-54

Genetics of Chronotype and Circadian Rhythm Disorders

Kunorozva, L., & Lane, J. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-62723-1_11

Identifying Arousal Inputs to the Intergeniculate Leaflet in HamstersPreprint

Moshirpour, M., Horsley, K. G., Saud, S. P., McCance, C., Scotland, M., & Antle, M. C. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5139171

Agonists for glutamate, acetylcholine, and orexin cause non-photic phase shifts when applied to the intergeniculate leaflet

Moshirpour, M., Horsley, K. G., Saud, S. P., McCance, C., Scotland, M., & Antle, M. C. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.04.007

The Scientific and Medical Communities’ Role in Preventing Weaponization of CNS-acting Chemical Agents and Broader Misuse of Neuroscience

(2025) · Royal Society of Chemistry eBooks · doi:10.1039/9781837678174-00401

Altérations anatomo-fonctionnelles des interneurones à parvalbumine dans un modèle murin de la maladie d'Alzheimer

Cattaud, V. (2018) · theses.fr (ABES) · doi:10.70675/ab9d6bfaz7490z4ae6zb7f3z525493f6bba4

Chronic fatigue syndrome in MS: an endogenous response pattern to an immunological challenge mediated by orexin/hypocretin?

Hildebrandt, H., & Stuke, H. (2026) · Brain Disorders · doi:10.1016/j.dscb.2026.100318

Multisensory dysfunction across sleep disorders: A systematic review of 31 human modalities

Biabani, N., Ferri, R., Naismith, S. L., Mutti, C., Puligheddu, M., Parrino, L., Goadsby, P. J., & Rosenzweig, I. (2026) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2026.102363

Effort-based decision-making:A value-based dissection and arousal-focused synthesis

Clairis, N., & Tobler, P. N. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.107062

Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour

Bonnavion, P., Mickelsen, L. E., Fujita, A., de Lecea, L., & Jackson, A. C. (2016) · The Journal of Physiology · doi:10.1113/jp271946 · Cited by 271 · see citing works

The Hypocretin Arousal Network

Borniger, J. C., & de Lecea, L. (2019) · Oxford Research Encyclopedia of Neuroscience · doi:10.1093/acrefore/9780190264086.013.29 · Cited by 7 · see citing works

Functional wiring of hypocretin and LC-NE neurons: implications for arousal

Carter, M. E., de Lecea, L., & Adamantidis, A. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00043 · Cited by 81 · see citing works

Coordination of metabolism, arousal, and reward by orexin/hypocretin neurons

Michael, N. J., & Elmquist, J. K. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140585 · Cited by 10 · see citing works

Addiction and Arousal: Alternative Roles of Hypothalamic Peptides: Figure 1.

de Lecea, L., Jones, B. E., Boutrel, B., Borgland, S. L., Nishino, S., Bubser, M., & Dileone, R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3118-06.2006 · Cited by 85 · see citing works