Cited by 274Gastrointestinal motility and disordersPain Mechanisms and TreatmentsIon Channels and Receptors

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract

Berthoud, H. R., Blackshaw, L. A., Brookes, S. J. H., Grundy, D.·2004·Neurogastroenterology & Motility

DOI 10.1111/j.1743-3150.2004.00471.x

Open this paper in CoChat — free account

Abstract

Here we discuss the neuroanatomy of extrinsic gastrointestinal (GI) afferent neurones, the relationship between structure and function and the role of afferents in disease. Three pathways connect the gut to the central nervous system: vagal afferents signal mainly from upper GI regions, pelvic afferents mainly from the colorectal region and splanchnic afferents from throughout. Vagal afferents mediate reflex regulation of gut function and behaviour, operating mainly at physiological levels. There are two major functional classes − tension receptors, responding to muscular contraction and distension, and mucosal receptors. The function of vagal endings correlates well with their anatomy: tracing studies show intramuscular arrays (IMAs) and intraganglionic laminar endings (IGLEs); IGLEs are now known to respond to tension. Functional mucosal receptors correlate with endings traced to the lamina propria. Pelvic afferents serve similar functions to vagal afferents, and additionally mediate both innocuous and noxious sensations. Splanchnic afferents comprise mucosal and stretch‐sensitive afferents with low thresholds in addition to high‐threshold serosal/mesenteric afferents suggesting diverse roles. IGLEs, probably of pelvic origin, have been identified recently in the rectum and respond similarly to gastric vagal IGLEs. Gastrointestinal afferents may be sensitized or inhibited by chemical mediators released from several cell types. Whether functional changes have anatomical correlates is not known, but it is likely that they underlie diseases involving visceral hypersensitivity.

Integrity signals

Registry

Crossref · 10.1111/j.1743-3150.2004.00471.x

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Functional and chemical anatomy of the afferent vagal system
Berthoud, H.-R., & Neuhuber, W. L. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00215-0 · Cited by 1,280
Self-citation
The organization of projections from the cortes, amygdala, and hypothalamus to the nucleus of the solitary tract in rat
van der Kooy, D., Koda, L. Y., McGinty, J. F., Gerfen, C. R., & Bloom, F. E. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902240102 · Cited by 733
Sensory innervation of the viscera: peripheral basis of visceral pain
Cerveró, F. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.95 · Cited by 526
Tension receptors in the stomach and the urinary bladder
Iggo, A. (1955) · The Journal of Physiology · doi:10.1113/jphysiol.1955.sp005327 · Cited by 515
Vagal afferent innervation of the rat fundic stomach: Morphological characterization of the gastric tension receptor
Berthoud, H., & Powley, T. L. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190206 · Cited by 295
Self-citation
Intraganglionic laminar endings are mechano‐transduction sites of vagal tension receptors in the guinea‐pig stomach
Zagorodnyuk, V. P., Chen, B. N., & Brookes, S. J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00255.x · Cited by 267
Self-citation
Neuroanatomy of visceral nociception: vagal and splanchnic afferent
Grundy, D. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i2 · Cited by 251
Self-citation
Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract
Ward, S. M., Bayguinov, J. R., Won, K., Grundy, D., & Berthoud, H. R. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10801 · Cited by 243
Self-citation
Visceral nociceptive input into the ventral posterolateral nucleus of the thalamus: a new function for the dorsal column pathway
Al–Chaer, E. D., Lawand, N., Westlund, K. N., & Willis, W. D. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.4.2661 · Cited by 241
Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo DiI-tracing
Berthoud, H., Kressel, M., Raybould, H., & Neuhuber, W. (1995) · Anatomy and Embryology · doi:10.1007/bf00187819 · Cited by 216
Self-citation

Show all 39 references

Research works printed but not linked: 1

Coldwell JR, 2002, Colonic lumbar splanchnic afferents respond to histamine, Gastroenterology, 122, A528

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
The serotonin signaling system: from basic understanding to drug development for functional GI disorders
Gershon, M. D., & Tack, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.002 · Cited by 1,563
The enteric nervous system and gastrointestinal innervation: integrated local and central control
Furness, J. B., Callaghan, B. P., Rivera, L. R., & Cho, H.-J. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_3 · Cited by 827
The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753
Sensory neurons that detect stretch and nutrients in the digestive system
Williams, E. K., Chang, R. B., Strochlic, D. E., Umans, B. D., Lowell, B. B., & Liberles, S. D. (2016) · Cell · doi:10.1016/j.cell.2016.05.011 · Cited by 645
The Brain, Appetite, and Obesity
Berthoud, H., & Morrison, C. D. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093551 · Cited by 699
Self-citation
Genetic identification of vagal sensory neurons that control feeding
Bai, L., Mesgarzadeh, S., Ramesh, K. S., Huey, E. L., Liu, Y., Gray, L. A., Aitken, T. J., Chen, Y., Beutler, L. R., Ahn, J. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.031 · Cited by 494
Hindbrain Neurons as an Essential Hub in the Neuroanatomically Distributed Control of Energy Balance
Grill, H. J., & Hayes, M. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.015 · Cited by 501
Brainstem circuits regulating gastric function
Travagli, R. A., Hermann, G. E., Browning, K. N., & Rogers, R. C. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040504.094635 · Cited by 498
The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm
Palmiter, R. D. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.03.007 · Cited by 461
Gut Microbiota in Hypertension and Atherosclerosis: A Review
Verhaar, B. J. H., Prodan, A., Nieuwdorp, M., & Muller, M. (2020) · Nutrients · doi:10.3390/nu12102982 · Cited by 425
The Lipid Messenger OEA Links Dietary Fat Intake to Satiety
Schwartz, G. J., Fu, J., Astarita, G., Li, X., Gaetani, S., Campolongo, P., Cuomo, V., & Piomelli, D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.005 · Cited by 370
Vagal neurocircuitry and its influence on gastric motility
Travagli, R. A., & Anselmi, L. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.76 · Cited by 323
The vagus nerve, food intake and obesity
Berthoud, H.-R. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2007.08.024 · Cited by 316
Self-citation
Bile acid signaling pathways from the enterohepatic circulation to the central nervous system
Mertens, K. L., Kalsbeek, A., Soeters, M. R., & Eggink, H. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00617 · Cited by 287
Toll-like Receptors 3, 4, and 7 Are Expressed in the Enteric Nervous System and Dorsal Root Ganglia
Barajon, I., Serrao, G., Arnaboldi, F., Opizzi, E., Ripamonti, G., Balsari, A., & Rumio, C. (2009) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2009.953539 · Cited by 287
The intestinal barrier and its regulation by neuroimmune factors: Intestinal barrier and neuroimmune regulation
Keita, Å. V., & Söderholm, J. D. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01498.x · Cited by 286
Sensory transmission in the gastrointestinal tract
Blackshaw, L. A., Brookes, S. J., Grundy, D., & Schemann, M. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00871.x · Cited by 285
Self-citation
Intrameal Hepatic Portal and Intraperitoneal Infusions of Glucagon-Like Peptide-1 Reduce Spontaneous Meal Size in the Rat via Different Mechanisms
Rüttimann, E. B., Arnold, M., Hillebrand, J. J., Geary, N., & Langhans, W. (2008) · Endocrinology · doi:10.1210/en.2008-1221 · Cited by 259
Imaging and modelling of digestion in the stomach and the duodenum
Schulze, K. S. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00759.x · Cited by 256
A multidimensional coding architecture of the vagal interoceptive system
Zhao, Q., Yu, C. D., Wang, R., Xu, Q. J., Pra, R. D., Zhang, L., & Chang, R. B. (2022) · Nature · doi:10.1038/s41586-022-04515-5 · Cited by 243
Psychoactive bacteria Lactobacillus rhamnosus (JB-1) elicits rapid frequency facilitation in vagal afferents
Perez-Burgos, A., Wang, B., Mao, Y.-K., Mistry, B., Neufeld, K.-A. M., Bienenstock, J., & Kunze, W. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00128.2012 · Cited by 235
Integrative neurocircuits that control metabolism and food intake
Brüning, J. C., & Fenselau, H. (2023) · Science · doi:10.1126/science.abl7398 · Cited by 214
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism
Borgmann, D., Ciglieri, E., Biglari, N., Brandt, C., Cremer, A. L., Backes, H., Tittgemeyer, M., Wunderlich, F. T., Brüning, J. C., & Fenselau, H. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.002 · Cited by 212
Necrotizing enterocolitis: It’s not all in the gut
Meister, A. L., Doheny, K. K., & Travagli, R. A. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219891971 · Cited by 226
The gut, its microbiome, and the brain: connections and communications
Gershon, M. D., & Margolis, K. G. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143768 · Cited by 219
An inter-organ neural circuit for appetite suppression
Zhang, T., Perkins, M. H., Chang, H., Han, W., & de Araujo, I. E. (2022) · Cell · doi:10.1016/j.cell.2022.05.007 · Cited by 192
Harnessing Gut Microbes for Mental Health: Getting From Here to There
Bruce‐Keller, A. J., Salbaum, J. M., & Berthoud, H. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.014 · Cited by 192
Self-citation
Physiology of Visceral Pain
Gebhart, G. F., & Bielefeldt, K. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150049 · Cited by 238
Signalling from the periphery to the brain that regulates energy homeostasis
Kim, K., Seeley, R. J., & Sandoval, D. A. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.8 · Cited by 188
Hypothalamic detection of macronutrients via multiple gut-brain pathways
Goldstein, N., McKnight, A. D., Carty, J. R. E., Arnold, M., Betley, J. N., & Alhadeff, A. L. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.018 · Cited by 182
Basic and clinical aspects of gastrointestinal pain
Knowles, C. H., & Aziz, Q. (2009) · Pain · doi:10.1016/j.pain.2008.12.011 · Cited by 170
A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration
Tavakoli, P., Vollmer-Conna, U. S., Hadzi-Pavlovic, D., & Grimm, M. (2021) · Public health reviews · doi:10.3389/phrs.2021.1603990 · Cited by 173
Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications
Checa-Ros, A., Jeréz-Calero, A., Molina-Carballo, A., Campoy, C., & Muñoz-Hoyos, A. (2021) · Nutrients · doi:10.3390/nu13010249 · Cited by 164
The Paraventricular Nucleus of the Hypothalamus: Development, Function, and Human Diseases
Qin, C., Li, J., & Tang, K. (2018) · Endocrinology · doi:10.1210/en.2018-00453 · Cited by 170
Review article: endocannabinoids and their receptors in the enteric nervous system
Duncan, M., Davison, J. S., & Sharkey, K. A. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02648.x · Cited by 156
Mechanisms of CCK signaling from gut to brain
Raybould, H. E. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.09.006 · Cited by 151
Vagal afferent nerves with nociceptive properties in guinea‐pig oesophagus
Yu, S., Undem, B. J., & Kollárik, M. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.079574 · Cited by 147
Fundamentals of Neurogastroenterology: Physiology/Motility – Sensation
Boeckxstaens, G., Camilleri, M., Sifrim, D., Houghton, L. A., Elsenbruch, S., Lindberg, G., Azpiroz, F., & Parkman, H. P. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.030 · Cited by 142
The gut-to-brain axis for toxin-induced defensive responses
Xie, Z., Zhang, X., Zhao, M., Huo, L., Huang, M., Li, D., Zhang, S., Cheng, X., Gu, H., Zhang, C., et al. (2022) · Cell · doi:10.1016/j.cell.2022.10.001 · Cited by 139
The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938
Perez‐Burgos, A., Wang, L., McVey Neufeld, K., Mao, Y., Ahmadzai, M., Janssen, L. J., Stanisz, A. M., Bienenstock, J., & Kunze, W. A. (2015) · The Journal of Physiology · doi:10.1113/jp270229 · Cited by 123
The Role of PVH Circuits in Leptin Action and Energy Balance
Sutton, A. K., Myers, M. G., & Olson, D. P. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105347 · Cited by 126
Inflammation-induced hyperexcitability of nociceptive gastrointestinal DRG neurones: the role of voltage-gated ion channels
Beyak, M. J., & Vanner, S. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00596.x · Cited by 121
Characterization of silent afferents in the pelvic and splanchnic innervations of the mouse colorectum
Feng, B., & Gebhart, G. F. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00406.2010 · Cited by 118
Regulation of enteric functions by adenosine: Pathophysiological and pharmacological implications
Antonioli, L., Fornai, M., Colucci, R., Ghisu, N., Tuccori, M., Tacca, M. D., & Blandizzi, C. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.08.010 · Cited by 116
Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system
KUWAHARA, A., MATSUDA, K., KUWAHARA, Y., ASANO, S., INUI, T., & MARUNAKA, Y. (2020) · Biomedical Research · doi:10.2220/biomedres.41.199 · Cited by 112
Mechanisms of Disease: the pathological basis of gastroparesis—a review of experimental and clinical studies
Vittal, H., Farrugia, G., Gomez, G., & Pasricha, P. J. (2007) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0838 · Cited by 109
Acid-sensitive vagal sensory pathways and cough
Kollárik, M., Ru, F., & Undem, B. J. (2006) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2006.11.010 · Cited by 106
Electrogastrography for psychophysiological research: Practical considerations, analysis pipeline, and normative data in a large sample
Wolpert, N., Rebollo, I., & Tallon‐Baudry, C. (2020) · Psychophysiology · doi:10.1111/psyp.13599 · Cited by 96
Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis
Tan, C., Yan, Q., Ma, Y., Fang, J., & Yang, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1015175 · Cited by 120
A Western Diet Increases Serotonin Availability in Rat Small Intestine
Bertrand, R. L., Senadheera, S. N., Markus, I., Liu, L., Howitt, L., Chen, H., Murphy, T. V., Sandow, S. L., & Bertrand, P. P. (2010) · Endocrinology · doi:10.1210/en.2010-0377 · Cited by 100
Considerations on pig models for appetite, metabolic syndrome and obese type 2 diabetes: From food intake to metabolic disease
Koopmans, S. J., & Schuurman, T. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.044 · Cited by 102
The critical role of CCK in the regulation of food intake and diet-induced obesity
Cawthon, C. R., & Serre, C. B. D. L. (2021) · Peptides · doi:10.1016/j.peptides.2020.170492 · Cited by 99
Helicobacter pylori Infection and Extragastric Diseases—A Focus on the Central Nervous System
Baj, J., Forma, A., Flieger, W., Morawska, I., Michalski, A., Buszewicz, G., Sitarz, R., Portincasa, P., Garruti, G., Flieger, M., et al. (2021) · Cells · doi:10.3390/cells10092191 · Cited by 100
Enteric nervous system: reflexes, pattern generators and motility
Wood, J. D. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f56125 · Cited by 108
The gut-brain axis rewired: adding a functional vagal nicotinic “sensory synapse”
Perez‐Burgos, A., Mao, Y., Bienenstock, J., & Kunze, W. A. (2014) · The FASEB Journal · doi:10.1096/fj.13-245282 · Cited by 91
Stimulating the Central Nervous System to Prevent Intestinal Dysfunction After Traumatic Brain Injury
Bansal, V., Costantini, T. W., Ryu, S. Y., Peterson, C. Y., Loomis, W. H., Putnam, J., Elicieri, B. P., Baird, A., & Coimbra, R. S. M. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181d87373 · Cited by 93
Visceral versus somatic pain: an educational review of anatomy and clinical implications
Boezaart, A. P., Smith, C. R., Chembrovich, S., Zasimovich, Y., Server, A., Morgan, G., Theron, A., Booysen, K., & Reina, M. Á. (2021) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2020-102084 · Cited by 98
Mechanosensitive Piezo Channels in the Gastrointestinal Tract
Alcaino, C., Farrugia, G., & Beyder, A. (2017) · Current topics in membranes · doi:10.1016/bs.ctm.2016.11.003 · Cited by 89
The gut–brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders
Richards, P., Thornberry, N. A., & Pinto, S. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101175 · Cited by 89
Obesity surgery and gut–brain communication
Berthoud, H., Shin, A. C., & Zheng, H. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.01.023 · Cited by 85
Self-citation
Intraperitoneal Local Anesthetic Improves Recovery After Colon Resection
Kahokehr, A. A., Sammour, T., Zargar‐Shoshtari, K., Taylor, M., & Hill, A. G. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e318221f0cf · Cited by 83
The role of purinergic pathways in the pathophysiology of gut diseases: Pharmacological modulation and potential therapeutic applications
Antonioli, L., Colucci, R., Pellegrini, C., Giustarini, G., Tuccori, M., Blandizzi, C., & Fornai, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.04.002 · Cited by 81
Human resident gut microbe Bacteroides thetaiotaomicron regulates colonic neuronal innervation and neurogenic function
Aktar, R., Parkar, N., Stentz, R., Baumard, L., Parker, A., Goldson, A. J., Brion, A., Carding, S. R., Blackshaw, L. A., & Peiris, M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1766936 · Cited by 89
Self-citation
The Functional and Neurobiological Properties of Bad Taste
Schier, L. A., & Spector, A. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2017 · Cited by 77
Exploring relationships for visceral and somatic pain with autonomic control and personality
Paine, P., Kishor, J., Worthen, S. F., Gregory, L. J., & Aziz, Q. (2009) · Pain · doi:10.1016/j.pain.2009.02.022 · Cited by 79
Rectal Hyposensitivity
Burgell, R., & Scott, S. (2012) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2012.18.4.373 · Cited by 172
Neural signalling of gut mechanosensation in ingestive and digestive processes
Kim, M., Heo, G., & Kim, S. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00544-7 · Cited by 83
Learning of food preferences: mechanisms and implications for obesity & metabolic diseases
Berthoud, H., Morrison, C. D., Ackroff, K., & Sclafani, A. J. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00894-3 · Cited by 81
Self-citation
Basic and clinical aspects of visceral sensation: transmission in the CNS
Bielefeldt, K., Christianson, J. A., & Davis, B. M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00671.x · Cited by 72
Vagal Afferents Mediate Early Satiation and Prevent Flavour Avoidance Learning in Response to Intraperitoneally Infused Exendin‐4
Labouesse, M. A., Weber‐Stadlbauer, U., Weber, E., Arnold, M., Langhans, W., & Pacheco‐López, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02364.x · Cited by 71
Gastrointestinal Microbiome and Neurologic Injury
Panther, E. J., Dodd, W., Clark, A., & Lucke-Wold, B. P. (2022) · Biomedicines · doi:10.3390/biomedicines10020500 · Cited by 77
Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating
Langhans, W., Leitner, C., & Arnold, M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00610.2010 · Cited by 71
The CCK(-like) receptor in the animal kingdom: Functions, evolution and structures
Staljanssens, D., Azari, E. K., Christiaens, O., Beaufays, J., Lins, L., Camp, J. V., & Smagghe, G. J. (2010) · Peptides · doi:10.1016/j.peptides.2010.11.025 · Cited by 63
Up-regulation of calcitonin gene-related peptide and receptor tyrosine kinase TrkB in rat bladder afferent neurons following TNBS colitis
Qiao, L. Y., & Grider, J. R. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.12.024 · Cited by 63
The relationship between gastric motility and nausea: Gastric prokinetic agents as treatments
Sanger, G. J., Broad, J., & Andrews, P. L. R. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.06.031 · Cited by 62
Mouse colon sensory neurons detect extracellular acidosis via TRPV1
Sugiura, T., Bielefeldt, K., & Gebhart, G. F. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00440.2006 · Cited by 60
Exenatide reduces food intake and activates the enteric nervous system of the gastrointestinal tract and the dorsal vagal complex of the hindbrain in the rat by a GLP-1 receptor
Washington, M. C., Raboin, S. J., Thompson, W., Larsen, C. J., & Sayegh, A. I. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.002 · Cited by 58
Role of the intestinal microbiota in contributing to weight disorders and associated comorbidities
Hul, M. V., Neyrinck, A. M., Everard, A., Abot, A., Bindels, L. B., Delzenne, N. M., Knauf, C., & Cani, P. D. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00045-23 · Cited by 60
Gut microbes and food reward: From the gut to the brain
d’Oplinter, A. D. W., Huwart, S. J. P., Cani, P. D., & Everard, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.947240 · Cited by 57
Optogenetic and chemogenetic techniques for neurogastroenterology
Boesmans, W., Hao, M. M., & Berghe, P. V. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.151 · Cited by 55
Vagal influences over mast cells
Stead, R. H., Colley, E. C., Wang, B., Partosoedarso, E. R., Lin, J., STANISZ, A. M., & Hillsley, K. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.01.002 · Cited by 54
Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine
Wang, G., Wang, X.-Y., Liu, S., Qu, M., Xia, Y. L., NEEDLEMAN, B. J., Mikami, D. J., & Wood, J. D. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00125.2014 · Cited by 52
Detection of macronutrients in the intestinal wall
Raybould, H. E., Glatzle, J., Freeman, S. L., Whited, K. L., Darcel, N., Liou, A. P., & Bohan, D. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.01.016 · Cited by 53
Molecular profiling of murine sensory neurons in the nodose and dorsal root ganglia labeled from the peritoneal cavity
Peeters, P. J., Aerssens, J., Hoogt, R. D., STANISZ, A. M., Göhlmann, H. W. H., Hillsley, K., Meulemans, A., Grundy, D., Stead, R. H., & Coulie, B. J. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00169.2005 · Cited by 50
Self-citation
Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat
Xia, C., Gulick, M. A., Yu, S. J., Grider, J. R., Murthy, K. S., Kuemmerle, J. F., Akbarali, H. I., & Qiao, L. Y. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-30 · Cited by 49
Endogenous cholecystokinin reduces food intake and increases Fos-like immunoreactivity in the dorsal vagal complex but not in the myenteric plexus by CCK1 receptor in the adult rat
Sullivan, C. N., Raboin, S. J., Gulley, S., Sinzobahamvya, N. T., Green, G. M., Reeve, J. R., & Sayegh, A. I. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00490.2006 · Cited by 49
Molecular anatomy of the gut-brain axis revealed with transgenic technologies: implications in metabolic research
Udit, S., & Gautron, L. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00134 · Cited by 53
Changes in microglial activation within the hindbrain, nodose ganglia, and the spinal cord following subdiaphragmatic vagotomy
Gallaher, Z. R., Ryu, V., Herzog, T., Ritter, R. C., & Czaja, K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.01.079 · Cited by 47
Vagal afferents are not necessary for the satiety effect of the gut lipid messenger oleoylethanolamide
Azari, E. K., Ramachandran, D., Weibel, S., Arnold, M., Romano, A., Gaetani, S., Langhans, W., & Mansouri, A. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00067.2014 · Cited by 46
Gastric distension enhances CCK-induced Fos-like immunoreactivity in the dorsal hindbrain by activating 5-HT3 receptors
Hayes, M. R., & Covașă, M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.018 · Cited by 46
Gut Microbiome, Diet and Depression: Literature Review of Microbiological, Nutritional and Neuroscientific Aspects
Clerici, L., Bottari, D., & Bottari, B. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00619-2 · Cited by 54
Neural regulation of intestinal nutrient absorption
Mourad, F. H., & Saadé, N. E. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.07.010 · Cited by 46
Brainstem Control of the Gastric Function
Rogers, R., & Hermann, G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00031-2 · Cited by 28
Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass
Ye, Y., Haija, M. A. E., Morgan, D. A., Guo, D., Song, Y., Frank, A. P., Tian, L., Riedl, R. A., Burnett, C. M.-L., Gao, Z., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108270 · Cited by 43
Fatty acid oxidation in the energostatic control of eating—A new idea
Langhans, W. (2008) · Appetite · doi:10.1016/j.appet.2008.06.014 · Cited by 41
Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells
Peiris, M., Aktar, R., Reed, D. E., Cibert‐Goton, V., Zdanaviciene, A., Halder, W., Robinow, A. D., Corke, S., Dogra, H., Knowles, C. H., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323219 · Cited by 42
Self-citation
Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract
Beyak, M. J., Bulmer, D. C., Jiang, W. G., Keating, C., Rong, W., & Grundy, D. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50028-3 · Cited by 41
Self-citation
Macrophages regulate gastrointestinal motility through complement component 1q
Pendse, M., Selle, H. D., Vo, N., Quinn, G. M., Dende, C., Li, Y., Salinas, C. N., Srinivasan, T., Propheter, D. C., Crofts, A. A., et al. (2023) · eLife · doi:10.7554/elife.78558 · Cited by 37
Plasticity of vagal afferent signaling in the gut
Grabauskas, G., & Owyang, C. (2017) · Medicina · doi:10.1016/j.medici.2017.03.002 · Cited by 38

Authors: Berthoud, H. R., Blackshaw, L. A., Brookes, S. J. H., & Grundy, D.
Affiliations: Pennington Biomedical Research Center (US)
Royal Adelaide Hospital (AU)
Flinders University (AU)
University of Sheffield (GB)
Corresponding author: Berthoud, H. R.
ORCID: Berthoud, H. R.
Blackshaw, L. A.
Brookes, S. J. H.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2004-04
Volume: 16
Issue: s1
Pages: 28-33
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/j.1743-3150.2004.00471.x
OpenAlex: W1972094807
Cited by: 274
References: 39
Citations by year: 2026: 9 · 2025: 7 · 2024: 11 · 2023: 10 · 2022: 15 · 2021: 17 · 2020: 11 · 2019: 10 · 2018: 13 · 2017: 10 · 2016: 18 · 2015: 7 · 2014: 16 · 2013: 6 · 2012: 20
FWCI: 2.23
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5 d)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Flinders Academic Commons (Flinders University) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: neuroanatomy, vagal afferents, splanchnic afferents, tension receptors, visceral hypersensitivity, visceral sensation
MeSH terms: Animals, Digestive System, Humans, Nerve Endings, Neuronal Plasticity, Enteric Nervous System, Visceral Afferents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks