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Cited by 120Hormonal and reproductive studiesNutrition and Health in AgingMuscle Physiology and Disorders

Muscle strength and serum testosterone, cortisol and SHBG concentrations in middle-aged and elderly men and women

HÄKKINEN, K., PAKARINEN, A.·1993·Acta Physiologica Scandinavica
DOI 10.1111/j.1748-1716.1993.tb09549.x
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Abstract

Forty healthy males (M) and females (F) divided into two different age groups i.e. M50 years (range 44–57; n= 9), F50 years (range 43–54; n= 9), M70 years (range 64–73; n= 11) and F70 years (range 63–73; n= 11) volunteered as subjects for examination of muscle cross‐sectional area (CSA) and maximal voluntary isometric force production characteristics of the leg extensor muscles and serum androgen and sex hormone binding globulin (SHBG) concentrations. The CSA in the male groups was greatly larger (P < 0.01) than in the female groups and both elderly groups demonstrated slightly (n.s.) smaller values in the CSA than the two middle‐aged groups. Maximal force of 2854 ± 452 N in M50 was greater (P < 0.05) than that of 2627 ± 752 N recorded for F50 as well as the force of 2787 ± 843 in M70 was greater (P < 0.001) than that of 1849 ± 295 recorded for F70. The force between F50 and F70 differed significantly (P < 0.05) from each other. The maximal rate of force production in M50 was greater (P < 0.01) than in F50 as well as in M70 greater (P < 0.001) than in F70. Both middle‐aged groups demonstrated greater (P < 0.05) values than the respective elderly groups of the same sex. The individual values in the CSA correlated with the values in maximal force both in the middle‐aged subjects (r= 0.66; P < 0.01) and in the elderly subjects (r= 0.69; P < 0.01). The mean concentration of serum testosterone in M50 was slightly (n.s.) greater than in M70 and in F50 significantly (P < 0.05) greater than in F70. Serum SHBG levels were lower in the males (P < 0.01) than in the females and serum testosterone/SHBG ratio in M70 and in F70 were lower (P < 0.05) than in M50 and in F50, respectively. In the females significant positive correlations were observed between the individual values in serum testosterone concentration and the values both in the CSA (r= 0.46; P < 0.05) and in maximal force (r= 0.62; P < 0.01) as well as between serum testosterone/SHBG ratio and both the CSA (r= 0.55; P < 0.05) and maximal force (r= 0.68; P < 0.01). The present results imply that the decreasing basal level of blood testosterone over the years in aging people, especially in females, may lead to decreasing anabolic effects on muscles thus having an association with age‐related declines in the maximal voluntary neuromuscular performance capacity in aging people.

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Authors
HÄKKINEN, K., & PAKARINEN, A.
Affiliations
  • University of Jyväskylä (FI)
  • University of Oulu (FI)
Corresponding author
HÄKKINEN, K.
Venue
Acta Physiologica Scandinavica
Publisher
Wiley
Published
1993-06
Volume
148
Issue
2
Pages
199-207
ISSN
  • 0001-6772 (ISSN-L)
  • 1365-201X
DOI
10.1111/j.1748-1716.1993.tb09549.x
OpenAlex
W2068219898
Cited by
120
References
34
Citations by year
2026: 3 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 5
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5671 d)
Locations
  • Acta Physiologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
muscle strength, leg extensor muscles, muscle cross-sectional area, serum testosterone, cortisol, sex hormone-binding globulin, aging, sex differences, middle-aged adults, older adults, androgens, healthy volunteers
MeSH terms
Adult, Aged, Aging, Female, Humans, Hydrocortisone, Male, Middle Aged, Muscles, Osmolar Concentration, Sex Characteristics, Sex Hormone-Binding Globulin, Testosterone

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