Cited by 235Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

Physiopathological Mechanism of Sarcopenia

Walrand, Stéphane, Guillet, Christelle, Salles, Jérome, Cano, Noël, Boirie, Yves·2011·Clinics in Geriatric Medicine

Abstract

The etiology of sarcopenia is multifactorial but still poorly understood, and the sequelae of this phenomenon represent a major public health issue. Age-related loss of muscle mass can be counteracted by adequate metabolic interventions including nutritional intake and exercise training. Other strategies including changes in daily protein pattern, the speed of protein digestion, or specific amino acid supplementation may be beneficial to improve short-term muscle anabolic response in elderly people. A multimodal approach combining nutrition, exercise, hormones, and specific anabolic drugs may be an innovative treatment for limiting the development of sarcopenia with aging.

Integrity signals

Registry

Crossref · 10.1016/j.cger.2011.03.005

Cites

147 of 147 references verified0 citation errors · 0 not checkable

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Authors
Walrand, S., Guillet, C., Salles, J., Cano, N., & Boirie, Y.
Affiliations
Unité de Nutrition Humaine (FR)
Venue
Clinics in Geriatric Medicine
Publisher
Elsevier BV
Published
2011-08
Volume
27
Issue
3
Pages
365-385
ISSN
0749-0690 (ISSN-L)
OpenAlex
W2081978729
Cited by
235
References
150
Citations by year
2026: 4 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 19 · 2020: 17 · 2019: 23 · 2018: 23 · 2017: 18 · 2016: 16 · 2015: 29 · 2014: 19 · 2013: 13 · 2012: 15
FWCI
11.78
Type
journal article
Language
en
Open access
closed
Locations
  • Clinics in Geriatric Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
sarcopenia, muscle mass loss, aging, muscle anabolism, protein intake, amino acid supplementation, exercise training, dietary intervention, anabolic agents, hormonal regulation, multimodal therapy
MeSH terms
Age Factors, Aged, Aged, 80 and over, Aging, Body Composition, Dietary Proteins, Female, Hormones, Humans, Life Style, Male, Middle Aged, Obesity, Exercise, Muscle, Skeletal, Sarcopenia

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