Supplement with whey protein hydrolysate in contrast to carbohydrate supports mitochondrial adaptations in trained runners

Hansen, Mette; Oxfeldt, Mikkel; Larsen, Anne E.; Thomsen, Lise S.; Rokkedal-Lausch, Torben; Christensen, Britt; Rittig, Nikolaj; De Paoli, Frank V.; Bangsbo, Jens; Ørtenblad, Niels; Madsen, Klavs

doi:10.1186/s12970-020-00376-3

Cited by 13Muscle metabolism and nutritionSports Performance and TrainingCardiovascular and exercise physiology

Supplement with whey protein hydrolysate in contrast to carbohydrate supports mitochondrial adaptations in trained runners

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Hansen, Mette, Oxfeldt, Mikkel, Larsen, Anne E., Thomsen, Lise S., Rokkedal-Lausch, Torben, Christensen, Britt, Rittig, Nikolaj, De Paoli, Frank V. +3 more·2020·Journal of the International Society of Sports Nutrition

DOI 10.1186/s12970-020-00376-3PMC PMC7487963

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Abstract

BACKGROUND: and performance in trained runners. METHODS: test pre, midway (only 6 K TT) and post intervention. RESULTS: and 6 K TT was significantly improved after training with no significant difference between groups. CONCLUSION: or 6 K TT performance. TRIAL REGISTRATION: clinicaltrials.gov , NCT03561337 . Registered 6 June 2018 - Retrospectively registered.

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Co-ingestion of carbohydrates and protein during post-exercise may confer additional benefits, including positive nitrogen balance leading to increased whole-body muscle protein synthesis, increased protein content related to mitochondrial biogenesis, reduced muscle damage markers, and accelerated post-exercise rehydration.
“it may confer additional benefits, including positive nitrogen balance leading to increased whole-body muscle protein synthesis [93], increased protein content related to mitochondrial biogenesis [94], reduced muscle damage markers [95], and accelerated post-exercise rehydration [96]”
From Nutritional Strategies to Improve Post-exercise Recovery and Subsequent Exercise Performance: A Narrative Review (2025) · cites this paper as [94]

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Authors: Hansen, M., Oxfeldt, M., Larsen, A. E., Thomsen, L. S., Rokkedal-Lausch, T., Christensen, B., Rittig, N., De Paoli, F. V., Bangsbo, J., Ørtenblad, N., & Madsen, K.
Affiliations: Aarhus University (DK)
University of Southern Denmark (DK)
Aalborg University (DK)
Aarhus University Hospital (DK)
Department of BiomedicineAarhus University Aarhus Denmark
University of Copenhagen (DK)
Corresponding author: Hansen, Mette
ORCID: Hansen, Mette
Oxfeldt, Mikkel
Rokkedal-Lausch, Torben
Christensen, Britt
Rittig, Nikolaj
Bangsbo, Jens
Ørtenblad, Niels
Madsen, Klavs
Venue: Journal of the International Society of Sports Nutrition
Publisher: Informa UK Limited
Published: 2020-01-03
Volume: 17
Issue: 1
Pages: 46-46
ISSN: 1550-2783 (ISSN-L)
DOI: 10.1186/s12970-020-00376-3
PMC: PMC7487963
OpenAlex: W3083649343
Cited by: 13
References: 50
Citations by year: 2026: 1 · 2025: 4 · 2023: 2 · 2022: 4 · 2021: 2
FWCI: 1.00
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (vor)
Locations: Journal of the International Society of Sports Nutrition (publishedVersion, cc-by)
Research Square (acceptedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
VBN Forskningsportal (Aalborg Universitet) (submittedVersion, cc-by)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
Funders: Arla Foods Ingredients Group P/S
Danish Ministry of Culture
Team Denmark
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: whey protein hydrolysate, carbohydrate supplementation, mitochondrial adaptation, trained runners, endurance performance, exercise training
MeSH terms: Whey, Prohibitins, Adaptation, Physiological, Adolescent, Adult, Beverages, Organelle Biogenesis, Body Composition, Dietary Carbohydrates, Female, Heart Rate, Humans, Male, Middle Aged, Mitochondria, Muscle, Oxygen Consumption, Physical Endurance, Protein Hydrolysates, Running, Dietary Supplements, Mitochondrial Proteins, Young Adult, Physical Conditioning, Human

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Supplement with whey protein hydrolysate in contrast to carbohydrate supports mitochondrial adaptations in trained runners

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