MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304 · see citing works

Alzheimer's disease: the amyloid cascade hypothesis

Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534 · see citing works

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science · doi:10.1126/science.1079469 · Cited by 4,064 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works

Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002 · see citing works

Microglial physiology: unique stimuli, specialized responses

Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

Serbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658 · see citing works

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

Lue, L.-F., Kuo, Y.-M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., & Rogers, J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65184-x · Cited by 1,530 · see citing works

Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease

Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works

Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

Lacor, P. N., Buniel, M. C., Furlow, P. W., Sanz Clemente, A., Velasco, P. T., Wood, M., Viola, K. L., & Klein, W. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3501-06.2007 · Cited by 1,188 · see citing works

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience · doi:10.1038/nn2015 · Cited by 1,089 · see citing works

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease

El Khoury, J., Toft, M., Hickman, S. E., Means, T. K., Terada, K., Geula, C., & Luster, A. D. (2007) · Nature Medicine · doi:10.1038/nm1555 · Cited by 915 · see citing works

Regulation of innate immune responses in the brain

Rivest, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2565 · Cited by 843 · see citing works

Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

Rogers, D. C., Fisher, E. M. C., Brown, S. D. M., Peters, J., Hunter, A. J., & Martin, J. E. (1997) · Mammalian Genome · doi:10.1007/s003359900551 · Cited by 795 · see citing works

Inflammatory processes in Alzheimer's disease

Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works

MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis

Delano, M. J., Scumpia, P. O., Weinstein, J. S., Coco, D. P., Nagaraj, S., Kelly‐Scumpia, K. M., O’Malley, K. A., Wynn, J. L., Antonenko, S. V., Al‐Quran, S. Z., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062602 · Cited by 656 · see citing works

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation

Reed-Geaghan, E. G., Savage, J. C., Hise, A. G., & Landreth, G. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3158-09.2009 · Cited by 591 · see citing works

Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)

Izikson, L., Klein, R. S., Charo, I. F., Weiner, H. L., & Luster, A. D. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1075 · Cited by 584 · see citing works

Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease

Walter, S., Letiembre, M., Liu, Y., Heine, H., Penke, B., Hao, W., Bode, B., Manietta, N., Walter, J., Schulz-Schüffer, W., et al. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110455 · Cited by 543 · see citing works

Role of toll-like receptor signalling in A uptake and clearance

Tahara, K., Kim, H.-D., Jin, J.-J., Maxwell, J. A., Li, L., & Fukuchi, K.-I. (2006) · Brain · doi:10.1093/brain/awl249 · Cited by 493 · see citing works

Chemokine Expression by Glial Cells Directs Leukocytes to Sites of Axonal Injury in the CNS

Babcock, A. A., Kuziel, W. A., Rivest, S., & Owens, T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07922.2003 · Cited by 472 · see citing works

Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., Miller, J.-N. H., Johnson, R. E., & O’Banion, M. K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31450 · Cited by 433 · see citing works

Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models

Cheng, I. H.-J., Scearce-Levie, K. A., Legleiter, J. A., Palop, J. J., Gerstein, H., Bien‐Ly, N., Puolivaöli, J., Lesné, S., Ashe, K. H., Muchowski, P. J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701078200 · Cited by 403 · see citing works

Fibril Fragmentation Enhances Amyloid Cytotoxicity

Xue, W., Hellewell, A. L., Gosal, W. S., Homans, S. W., Hewitt, E. W., & Radford, S. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.049809 · Cited by 379 · see citing works

Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

Getts, D. R., Terry, R. L., Getts, M. T., Müller, M., Rana, S., Shrestha, B., Radford, J., Van Rooijen, N., Campbell, I. L., & King, N. J. C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080421 · Cited by 360 · see citing works

Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice

Méziane, H., Dodart, J., Mathis, C., Little, S. H., Clemens, J. A., Paul, S. M., & Ungerer, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12683 · Cited by 355 · see citing works

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide

Liu, Y., Walter, S., Stagi, M., Cherny, D., Letièmbre, M., Schulz‐Schaeffer, W., Heine, H., Penke, B., Neumann, H., & Fassbender, K. C. (2005) · Brain · doi:10.1093/brain/awh531 · Cited by 344 · see citing works

Microglial activation and amyloid‐β clearance induced by exogenous heat‐shock proteins

Kakimura, J., Kitamura, Y., Takata, K., Umeki, M., Suzuki, S., Shibagaki, K., Taniguchi, T., Nomura, Y., Gebicke‐Haerter, P. J., Smith, M. A., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0530fje · Cited by 331 · see citing works

Fibrillar Amyloid-β Peptides Activate Microglia via TLR2: Implications for Alzheimer’s Disease

Jana, M., Palencia, C. A., & Pahan, K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7254 · Cited by 330 · see citing works

The LPS receptor (CD14) links innate immunity with Alzheimer's disease

Fassbender, K., Walter, S., Kühl, S., Landmann, R., Ishii, K., Bertsch, T., Stalder, A. K., Muehlhauser, F., Liu, Y., Ulmer, A. J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0364fje · Cited by 307 · see citing works

Inflammatory factors are elevated in brain microvessels in Alzheimer's disease

Grammas, P. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00276-7 · Cited by 292 · see citing works

Improved Real-Time RT-PCR Method for High-Throughput Measurements using Second Derivative Calculation and Double Correction

Luu-The, V., Paquet, N., Calvo, E. L., & Cumps, J. (2005) · BioTechniques · doi:10.2144/05382rr05 · Cited by 284 · see citing works

Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid β_1–42and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

Richard, K. L., Filali, M., Préfontaine, P., & Rivest, S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1146-08.2008 · Cited by 261 · see citing works

Monocyte Chemoattractant Protein‐1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

Sokolova, A., Hill, M. D., Rahimi, F., Warden, L. A., Halliday, G. M., & Shepherd, C. E. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00188.x · Cited by 249 · see citing works

Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease

ISHIZUKA, K., KIMURA, T., IGATA‐YI, R., KATSURAGI, S., TAKAMATSU, J., & MIYAKAWA, T. (1997) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1997.tb02375.x · Cited by 245 · see citing works

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

Letiembre, M., Liu, Y., Walter, S., Hao, W., Pfander, T., Wrede, A., Schulz-Schaeffer, W., & Fassbender, K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.018 · Cited by 228 · see citing works

Activation of Toll-like Receptor 2 on Microglia Promotes Cell Uptake of Alzheimer Disease-associated Amyloid β Peptide

Chen, K., Iribarren, P., Hu, J., Chen, J., Gong, W., Cho, E. H., Lockett, S., Dunlop, N. M., & Wang, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508125200 · Cited by 214 · see citing works

Selective neuronal degeneration induced by soluble oligomeric amyloid beta‐protein

Kim, H., Chae, S., Lee, D., Chromy, B. A., Lee, S. C., Park, Y., Klein, W. L., Krafft, G. A., & Hong, S. (2002) · The FASEB Journal · doi:10.1096/fj.01-0987fje · Cited by 210 · see citing works

Adult-derived neural precursors transplanted into multiple regions in the adult brain

Herrera, D. G., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199912)46:6 · Cited by 204 · see citing works

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

Taylor, C. J., Ireland, D. R., Ballagh, I. H., Bourne, K., Marechal, N. M., Turner, P. R., Bilkey, D. K., Tate, W. P., & Abraham, W. C. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.04.011 · Cited by 204 · see citing works

Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology

Scholtzova, H., Kascsak, R. J., Bates, K. A., Boutajangout, A., Kerr, D. J., Meeker, H. C., Mehta, P. D., Spinner, D. S., & Wisniewski, T. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5715-08.2009 · Cited by 166 · see citing works

Role of IL-1 and TNF in the brain: Twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system

Gosselin, D., & Rivest, S. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.004 · Cited by 130 · see citing works

MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis

Kang, J., & Rivest, S. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705046 · Cited by 94 · see citing works

Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice

Frank, S., Copanaki, E., Burbach, G. J., Müller, U. C., & Deller, T. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.075 · Cited by 86 · see citing works

MyD88 and Type I Interferon Receptor-Mediated Chemokine Induction and Monocyte Recruitment during Listeria monocytogenes Infection

Jia, T., Leiner, I. M., Dorothée, G., Brandl, K., & Pamer, E. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900460 · Cited by 78 · see citing works

CpG‐containing oligodeoxynucleotide promotes microglial cell uptake of amyloid β 1–42 peptide by up‐regulating the expression of the G‐protein‐coupled receptor mFPR2

Iribarren, P., Chen, K., Hu, J., Gong, W., Cho, E. H., Lockert, S., Uranchimeg, B., & Wang, J. M. (2005) · The FASEB Journal · doi:10.1096/fj.05-4578fje · Cited by 73 · see citing works

Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimers Disease

Balistreri, C. R., Grimaldi, M., Chiappelli, M., Licastro, F., Castiglia, L., Listı̀, F., Vasto, S., Lio, D., Caruso, C., & Candore, G. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786264089 · Cited by 65 · see citing works

Aβ promotes Alzheimer’s disease‐like cytoskeleton abnormalities with consequences to APP processing in neurons

Henriques, A. G., Vieira, S. I., Silva, E. F. D. C. E., & Silva, O. A. B. D. C. E. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06643.x · Cited by 60 · see citing works

Toll-Like Receptor 2-Independent and MyD88-Dependent Gene Expression in the Mouse Brain

Naert, G., Laflamme, N., & Rivest, S. (2009) · Journal of Innate Immunity · doi:10.1159/000225990 · Cited by 15 · see citing works

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

Minter, M. R., Taylor, J. M., & Crack, P. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13411 · Cited by 451 · see citing works

Cell Densities in the Mouse Brain: A Systematic Review

Keller, D., Erö, C., & Markram, H. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00083 · Cited by 380 · see citing works

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

Grubman, A., Choo, X. Y., Chew, G., Ouyang, J. F., Sun, G., Croft, N. P., Rossello, F. J., Simmons, R., Buckberry, S., Landin, D. V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23111-1 · Cited by 357 · see citing works

Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models

Rom, S., Zuluaga‐Ramirez, V., Gajghate, S., Seliga, A., Winfield, M., Heldt, N. A., Kolpakov, M. A., Bashkirova, Y. V., Sabri, A. K., & Persidsky, Y. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1195-5 · Cited by 329 · see citing works

Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment

Lampron, A., ElAli, A., & Rivest, S. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.005 · Cited by 282 · see citing works

Microglia in Brain Development, Homeostasis, and Neurodegeneration

Bohlen, C. J., Friedman, B. A., Dejanovic, B., & Sheng, M. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043515 · Cited by 212 · see citing works

Innate Immunity and Neuroinflammation

Shastri, A., Bonifati, D. M., & Kishore, U. (2013) · Mediators of Inflammation · doi:10.1155/2013/342931 · Cited by 201 · see citing works

Clearance of Amyloid-β Peptides By Microglia and Macrophages: the Issue of What, When and Where

Lai, A. Y., & McLaurin, J. (2012) · Future Neurology · doi:10.2217/fnl.12.6 · Cited by 161 · see citing works

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

Saba, R., Gushue, S., Huzarewich, R. L. C. H., Manguiat, K., Medina, S., Robertson, C., & Booth, S. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030832 · Cited by 151 · see citing works

Inflammasomes as therapeutic targets for A lzheimer's disease

White, C., Lawrence, C. B., Brough, D., & Rivers‐Auty, J. (2016) · Brain Pathology · doi:10.1111/bpa.12478 · Cited by 131 · see citing works

Modulation of inflammation in transgenic models of Alzheimer’s disease

Birch, A. M., Katsouri, L., & Sastre, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-25 · Cited by 119 · see citing works

Toll-like receptors are key players in neurodegeneration

Arroyo, D. S., Soria, J. A., Gaviglio, E. A., Rodriguez‐Galán, M. C., & Iribarren, P. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.05.006 · Cited by 117 · see citing works

A deficiency in CCR2+ monocytes: the hidden side of Alzheimer’s disease

Naert, G., & Rivest, S. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt028 · Cited by 123 · see citing works

Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease

Keene, C. D., Cudaback, E., Li, X., Montine, K. S., & Montine, T. J. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.08.002 · Cited by 103 · see citing works

Type-I interferon pathway in neuroinflammation and neurodegeneration: focus on Alzheimer’s disease

Taylor, J. M., Moore, Z., Minter, M. R., & Crack, P. J. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1745-4 · Cited by 91 · see citing works

The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer’s disease

Pimentel‐Coelho, P. M., & Rivest, S. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08126.x · Cited by 85 · see citing works

Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype

Minter, M. R., Moore, Z., Zhang, M., Brody, K. M., Jones, N. C., Shultz, S. R., Taylor, J. M., & Crack, P. J. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0341-4 · Cited by 79 · see citing works

Loss of Interleukin Receptor-Associated Kinase 4 Signaling Suppresses Amyloid Pathology and Alters Microglial Phenotype in a Mouse Model of Alzheimer's Disease

Cameron, B., Tse, W., Lamb, R., Li, X., Lamb, B. T., & Landreth, G. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1729-12.2012 · Cited by 75 · see citing works

Inflammation and neurodegeneration: the story ‘retolled’

Drouin‐Ouellet, J., & Cicchetti, F. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.07.002 · Cited by 70 · see citing works

The neuroendocrine control of the innate immune system in health and brain diseases

Bellavance, M., & Rivest, S. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01129.x · Cited by 60 · see citing works

Review: Experimental manipulations of microglia in mouse models of <scp>A</scp>lzheimer's pathology: activation reduces amyloid but hastens tau pathology

Lee, D. C., Rizer, J., Hunt, J. B., Selenica, M. ‐. B., Gordon, M. N., & Morgan, D. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12002 · Cited by 57 · see citing works

Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice

Pimentel‐Coelho, P. M., Michaud, J.-P., & Rivest, S. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.025 · Cited by 49 · see citing works

Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis

McFarland, K. N., & Chakrabarty, P. (2022) · Neurotherapeutics · doi:10.1007/s13311-021-01179-3 · Cited by 48 · see citing works

IKKβ Deficiency in Myeloid Cells Ameliorates Alzheimer's Disease-Related Symptoms and Pathology

Liu, Y., Liu, X., Hao, W., Decker, Y., Schomburg, R., Fülöp, L., Pasparakis, M., Menger, M. D., & Fassbender, K. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1348-14.2014 · Cited by 44 · see citing works

Targeting innate immunity to protect and cure Alzheimer’s disease: opportunities and pitfalls

Cisbani, G., & Rivest, S. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01083-4 · Cited by 43 · see citing works

Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APPSwe/PS1 mice

Naert, G., & Rivest, S. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00051 · Cited by 39 · see citing works

Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro

Minter, M. R., Main, B. S., Brody, K. M., Zhang, M., Taylor, J. M., & Crack, P. J. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0263-2 · Cited by 35 · see citing works

Hematopoietic MyD88-adaptor Protein Acts as a Natural Defense Mechanism for Cognitive Deficits in Alzheimer’s Disease

Michaud, J.-P., Richard, K. L., & Rivest, S. (2012) · Stem Cell Reviews and Reports · doi:10.1007/s12015-012-9356-9 · Cited by 32 · see citing works

Brain-borne IL-1 adjusts glucoregulation and provides fuel support to astrocytes and neurons in an autocrine/paracrine manner

del Rey, A., Verdenhalven, M., Lörwald, A. C., Meyer, C., Hernangómez, M., Randolf, A., Roggero, E., König, A., Heverhagen, J. T., Guaza, C., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.174 · Cited by 27 · see citing works

Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice

Heuss, N. D., Pierson, M. J., Montaniel, K. R. C., McPherson, S. W., Lehmann, U., Hussong, S. A., Ferrington, D. A., Low, W. C., & Gregerson, D. S. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0143-1 · Cited by 26 · see citing works

Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer’s disease?

Sbai, O., Bazzani, V., Tapaswi, S., McHale, J., Vascotto, C., & Perrone, L. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1166879 · Cited by 24 · see citing works

Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders

Miller, S., & Blanco, M.-J. (2021) · RSC Medicinal Chemistry · doi:10.1039/d1md00036e · Cited by 21 · see citing works

Haploinsufficiency of microglial MyD88 ameliorates Alzheimer's pathology and vascular disorders in APP / PS1 ‐transgenic mice

Quan, W., Luo, Q., Hao, W., Tomic, I., Furihata, T., Schulz‐Schaeffer, W., Menger, M. D., Fassbender, K. C., & Liu, Y. (2021) · Glia · doi:10.1002/glia.24007 · Cited by 19 · see citing works

MyD88 Is Dispensable for Cerebral Amyloidosis and Neuroinflammation in APP/PS1 Transgenic Mice

Weitz, T. M., Gate, D., Rezai-Zadeh, K. P., & Town, T. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.07.004 · Cited by 17 · see citing works

Modulation of Innate Immunity by Amyloidogenic Peptides

Westwell-Roper, C. Y., & Verchere, C. B. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.06.005 · Cited by 17 · see citing works

MyD88 acts as an adaptor protein for inflammatory signalling induced by amyloid-β in macrophages

O’Halloran, S., O’Leary, A., Kuijper, T., & Downer, E. J. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.08.001 · Cited by 13 · see citing works

Purification, structural characterization and immunoregulatory mechanism of PSPW-3-a isolated from wine-processed Polygonatum sibiricum

Sun, T., Liu, Y., Huang, W., et al. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105159 · Cited by 12 · see citing works

Roles of Toll-Like Receptors in Pathophysiology of Alzheimer’s Disease and Multiple Sclerosis

Bir, S. C., Chernyshev, O. Y., & Minagar, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811709-5.00033-8 · Cited by 9 · see citing works

Toll-Like Receptor Signaling in Alzheimer?s Disease Progression

Downer, E. J. (2012) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.s10-006 · Cited by 9 · see citing works

Deletion of MyD88 in astrocytes prevents β‐amyloid‐induced neuropathology in mice

Huat, T. J., Onraet, T., Camats‐Perna, J., Newcombe, E. A., Ngo, K. C., Sue, A. N., Mirzaei, M., LaFerla, F. M., & Medeiros, R. (2022) · Glia · doi:10.1002/glia.24285 · Cited by 8 · see citing works

Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory

Downer, E. J., Jones, R. S., McDonald, C., Greco, E., Brennan, S., Connor, T. J., Robertson, I. H., & Lynch, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063194 · Cited by 8 · see citing works

Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1α

Grubman, A., Choo, X. Y., Chew, G., Ouyang, J. F., Sun, G., Croft, N. P., Rossello, F. J., Simmons, R., Buckberry, S., Landin, D. V., et al. (2019) · doi:10.1101/639054 · Cited by 7 · see citing works

Early ultrasonic vocalization deficits and related thyroarytenoid muscle pathology in the transgenic TgF344-AD rat model of Alzheimer’s disease

Rudisch, D. M., Krasko, M. N., Barnett, D. G. S., Mueller, K. D., Russell, J. A., Connor, N. P., & Ciucci, M. R. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1294648 · Cited by 7 · see citing works

Sustained Alzheimer's Amyloid Pathology in Myeloid Differentiation Protein-88-Deficient APPswe/PS1 Mice

Goll, Y., Bekenstein, U., Barbash, S., Greenberg, D., Zangen, R., Shoham, S., & Soreq, H. (2013) · Neurodegenerative Diseases · doi:10.1159/000353689 · Cited by 7 · see citing works

The role of MyD88 in the nervous system: Neuronal functions, implications in neurological diseases, and therapeutic potential

Pan, H.-L., Ge, J.-Y., Zhang, Z.-A., Xu, J., Wu, J., Ju, Y., Zhang, X.-Y., Jiang, Z.-J., Chen, Y., Xu, Y., et al. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109016 · Cited by 3 · see citing works

Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease

Hurst, T. P., Coleman-Vaughan, C., Patwal, I., & McCarthy, J. V. (2016) · AIMS molecular science · doi:10.3934/molsci.2016.2.138 · Cited by 2 · see citing works

Is Alzheimer's Associated Amyloid Beta an Innate Immune Protein

Kandel, R., White, M. R., Hseih, I.-N., & Hartshorn, K. L. (2016) · InTech eBooks · doi:10.5772/63021 · Cited by 1 · see citing works

Sex differences in microglia as a risk factor for Alzheimer’s disease

Delage, C. I., Rendina, D. N., Malacon, K. E., Tremblay, M., & Bilbo, S. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819344-0.00008-9 · Cited by 2 · see citing works

On the Theory of Social Mechanism

Cui-ping, K. (2007) · Journal of Nanyang Normal University

The future of neurology after the COVID-19 pandemic according to neurology residents

Ercoli, T., Barbato, F., Cuffaro, L., et al. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06450-9 · Cited by 5 · see citing works

A Study on Mechanism of Synergic Development of the Regional High -tech In dustries between Mainland and Taiwan

Zhu, B. (2002) · Zhongguo ruankexue

A Probe into the Development of Community Sports and the Innovation of Its System and Mechanism

Jun-qi, Z. (2011) · Journal of Changzhou Institute of Technology

What Educational Mechanism We Need

Cui-ping, K. (2007) · Journal of Jingmen Technical College