Dietary intervention with edible medicinal plants and derived products for prevention of Alzheimer's disease: A compendium of time-tested strategy
Open accessAbstract
Alzheimer’s disease (AD) is acccounting for over 50% of all cases of dementia worldwide. Currently there are no effective treatments available for AD. Plant-based medications and dietary interventions have attracted increasing research interest as an alternative strategy for the protection and treatment of AD. Thereby, this review aims to summarize different medical interventions with dietary materials such as edible medicinal plants and ways to capitalize on the therapeutic advantages of their components to provide an alternative approach to enhance their long-term pleiotropic benefits in AD. Given the established mechanisms in AD pathogenesis, we elucidate different pathophysiological changes associated with lowering the disease incidence with these mainly plant-based dietary materials, providing laboratory evidence on the feasibility and potential of dietary intervention in the prevention and treatment of AD. In particular, we highly recommend the concept of dietary intervention as an alternative or supplementary therapeutic strategy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A wide range of medicinal plants and their bioactive plant compounds and crude extracts seem to have significant potential to treat and prevent Alzheimer's disease.
“A wide range of medicinal plants and their bioactive plant compounds and crude extracts seem to have significant potential to treat and prevent AD [22,23].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588 · see citing works
Bloom (2014) · doi:10.1001/jamaneurol.2013.5847 · Cited by 2,194 · see citing works
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024 · see citing works
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., et al. (2012) · Nature · doi:10.1038/nature11283 · Cited by 1,738 · see citing works
Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works
The distribution of tau in the mammalian central nervous system.
Binder, L. I., Frankfurter, A., & Rebhun, L. I. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.4.1371 · Cited by 1,588 · see citing works
Alzheimer's disease: Targeting the Cholinergic System
H. Ferreira-Vieira, T., M. Guimaraes, I., R. Silva, F., & M. Ribeiro, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666150716165726 · Cited by 1,551 · see citing works
Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., & Lannfelt, L. (1992) · Nature Genetics · doi:10.1038/ng0892-345 · Cited by 1,513 · see citing works
Tau is a candidate gene for chromosome 17 frontotemporal dementia
Poorkaj, P., Bird, T. D., Wijsman, E., Nemens, E., Garruto, R. M., Anderson, L., Andreadis, A., Wiederholt, W. C., Raskind, M., & Schellenberg, G. D. (1998) · Annals of Neurology · doi:10.1002/ana.410430617 · Cited by 1,374 · see citing works
Wang, X., Sun, G., Feng, T., Zhang, J., Huang, X., Wang, T., Xie, Z., Chu, X., Yang, J., Wang, H., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0216-x · Cited by 1,144 · see citing works
A Meta-Analysis of Cytokines in Alzheimer's Disease
Swardfager, W., Lanctôt, K., Rothenburg, L., Wong, A., Cappell, J., & Herrmann, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.012 · Cited by 1,108 · see citing works
Microglia and neuroinflammation: a pathological perspective
Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works
Gut microbes and the brain: paradigm shift in neuroscience
Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F., & Tillisch, K. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3299-14.2014 · Cited by 1,033 · see citing works
Neurotoxicity of Amyloid -Protein: Synaptic and Network Dysfunction
Mucke, L., & Selkoe, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006338 · Cited by 1,000 · see citing works
The microbiome-gut-brain axis: from bowel to behavior
Cryan, J. F., & O’Mahony, S. M. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01664.x · Cited by 990 · see citing works
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867 · see citing works
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804 · see citing works
Liu, F., Grundke‐Iqbal, I., Iqbal, K., & Gong, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04391.x · Cited by 759 · see citing works
Mesulam, M. M., Guillozet-Bongaarts, A. L., Shaw, P. L., Levey, A. I., Duysen, E. G., & Lockridge, O. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00613-3 · Cited by 654 · see citing works
Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?
Bourassa, M. W., Alim, I., Bultman, S. J., & Ratan, R. R. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.009 · Cited by 636 · see citing works
Homeostasis of the gut barrier and potential biomarkers
Wells, J. M., Brummer, R. J., Derrien, M., MacDonald, T. T., Troost, F. J., Cani, P. D., Théodorou, V., Dekker, J. P., Méheust, A., de Vos, W. M., et al. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00048.2015 · Cited by 616 · see citing works
Evaluation of CSF-tau and CSF-Aβ42 as diagnostic markers for Alzheimer disease in clinical practice
Andreasen, N., Minthon, L., Davidsson, P., Vanmechelen, E., Vanderstichele, H., Winblad, B., & Blennow, K. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.373 · Cited by 573 · see citing works
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568 · see citing works
Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis
Westfall, S., Lomis, N., Kahouli, I., Dia, S. Y., Singh, S. P., & Prakash, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2550-9 · Cited by 551 · see citing works
Anti-inflammatory effects of phytochemicals from fruits, vegetables, and food legumes: A review
Zhu, F., Du, B., & Xu, B. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1251390 · Cited by 495 · see citing works
Hanger, D. P., Byers, H. L., Wray, S., Leung, K.-Y., Saxton, M. J., Seereeram, A., Reynolds, C. H., Ward, M. A., & Anderton, B. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703269200 · Cited by 455 · see citing works
Singh, A. K., Cabral, C., Kumar, R., Ganguly, R., Rana, H. K., Gupta, A., Lauro, M. R., Carbone, C., Reis, F., & Pandey, A. K. (2019) · Nutrients · doi:10.3390/nu11092216 · Cited by 444 · see citing works
Cruts, M., van Duijn, C. M., Backhovens, H., den Broeck, M. V., Wehnert, A., Serneels, S., Sherrington, R., Hutton, M., Hardy, J., George‐Hyslop, P. S., et al. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.1.43 · Cited by 429 · see citing works
Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline
vom Berg, J., Prokop, S., Miller, K. R., Obst, J., Kälin, R. E., Lopategui-Cabezas, I., Wegner, A., Mair, F., Schipke, C. G., Peters, O., et al. (2012) · Nature Medicine · doi:10.1038/nm.2965 · Cited by 416 · see citing works
Microbial metabolism of dietary phenolic compounds in the colon
Aura, A. (2008) · Phytochemistry Reviews · doi:10.1007/s11101-008-9095-3 · Cited by 412 · see citing works
Tomiyama, T., Matsuyama, S., Iso, H., Umeda, T., Takuma, H., Ohnishi, K., Ishibashi, K., Teraoka, R., Sakama, N., Yamashita, T., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5825-09.2010 · Cited by 396 · see citing works
Total and phosphorylated tau protein as biological markers of Alzheimer’s disease
Hampel, H., Blennow, K., Shaw, L. M., Hoessler, Y. C., Zetterberg, H., & Trojanowski, J. Q. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.010 · Cited by 389 · see citing works
Ho, L., Ono, K., Tsuji, M., Mazzola, P., Singh, R., & Pasinetti, G. M. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1400909 · Cited by 376 · see citing works
Bacterial Neuroactive Compounds Produced by Psychobiotics
Wall, R., Cryan, J. F., Ross, R. P., Fitzgerald, G. F., Dinan, T. G., & Stanton, C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_10 · Cited by 362 · see citing works
Towards microbial fermentation metabolites as markers for health benefits of prebiotics
Verbeke, K. A., Boobis, A. R., Chiodini, A., Edwards, C. A., Franck, A., Kleerebezem, M., Nauta, A., Raes, J., van Tol, E. A. F., & Tuohy, K. M. (2015) · Nutrition Research Reviews · doi:10.1017/s0954422415000037 · Cited by 343 · see citing works
Papandreou, M. A., Kanakis, C. D., Polissiou, M. G., Efthimiopoulos, S., Cordopatis, P. A., Margarity, M., & Lamari, F. N. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061932a · Cited by 342 · see citing works
<i>APOE</i> ε4: The most prevalent yet understudied risk factor for Alzheimer's disease
Michaelson, D. M. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.06.015 · Cited by 331 · see citing works
Skovronsky, D., Moore, D. B., Milla, M. E., Doms, R. W., & Lee, V. M. ‐. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2568 · Cited by 325 · see citing works
Gut microbiota in neurodegenerative disorders
Sarkar, S. R., & Banerjee, S. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.01.004 · Cited by 319 · see citing works
Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice
Carvalho, B. M., Guadagnini, D., Tsukumo, D. M. L., Schenka, A. A., Latuf-Filho, P., Vassallo, J., Dias, J. C., Kubota, L. T., Carvalheira, J. B. C., & Saad, M. J. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2648-4 · Cited by 314 · see citing works
Hu, J., Akama, K. T., Krafft, G. A., Chromy, B. A., & Eldik, L. J. V. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01318-8 · Cited by 313 · see citing works
Butyrylcholinesterase in the life cycle of amyloid plaques
Guillozet-Bongaarts, A. L., Mesulam, M. M., Smiley, J. F., & Mash, D. C. (1997) · Annals of Neurology · doi:10.1002/ana.410420613 · Cited by 312 · see citing works
Neurochemical diagnosis of Alzheimer’s dementia by CSF Aβ42, Aβ42/Aβ40 ratio and total tau
Lewczuk, P., Esselmann, H., Otto, M., Maler, J. M., Henkel, A. W., Henkel, M. K., Eikenberg, O., Antz, C., Krause, W., Reulbach, U., et al. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00086-1 · Cited by 309 · see citing works
Álvarez, A., Opazo, C., Alarcón, R., Garrido, J., & Inestrosa, N. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1245 · Cited by 308 · see citing works
Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases
Paul, B., Barnes, S., Demark-Wahnefried, W., Morrow, C., Salvador, C., Skibola, C., & Tollefsbol, T. O. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0144-7 · Cited by 306 · see citing works
Yarandi, S., Peterson, D. A., Treisman, G. J., Moran, T. H., & Pasricha, P. J. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15146 · Cited by 294 · see citing works
Hashimoto, M., Tanabe, Y., Fujii, Y., Kikuta, T., Shibata, H., & Shido, O. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.549 · Cited by 288 · see citing works
Lost after translation: missorting of Tau protein and consequences for Alzheimer disease
Zempel, H., & Mandelkow�, E. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.004 · Cited by 272 · see citing works
Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics
Carmody, R. N., & Turnbaugh, P. J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72335 · Cited by 268 · see citing works
The Critical Roles of Polysaccharides in Gut Microbial Ecology and Physiology
Porter, N. T., & Martens, E. C. (2017) · Annual Review of Microbiology · doi:10.1146/annurev-micro-102215-095316 · Cited by 251 · see citing works
Sokolova, A., Hill, M. D., Rahimi, F., Warden, L. A., Halliday, G. M., & Shepherd, C. E. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00188.x · Cited by 249 · see citing works
Serafini, M., & Peluso, I. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666161123094235 · Cited by 246 · see citing works
Goozee, K. G., Shah, T. M., Sohrabi, H. R., Rainey‐Smith, S. R., Brown, B. M., Verdile, G., & Martins, R. N. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515004687 · Cited by 245 · see citing works
Pasinetti, G. M., Wang, J., Ho, L., Zhao, W., & Dubner, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.006 · Cited by 238 · see citing works
Loef, M., & Walach, H. (2012) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0097-x · Cited by 225 · see citing works
Polyphenols-gut microbiota interplay and brain neuromodulation
Filosa, S., Meo, F. D., & Crispi, S. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.241429 · Cited by 225 · see citing works
Mrak, R. E., Sheng, J. G., & Griffin, W. S. T. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199603000-00002 · Cited by 224 · see citing works
Shih, P., Chan, Y., Liao, J., Wang, M.-F., & Yen, G. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.03.008 · Cited by 220 · see citing works
Berry Fruit Supplementation and the Aging Brain
Shukitt‐Hale, B., Lau, F. C., & Joseph, J. A. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072505f · Cited by 218 · see citing works
Bellucci, A., Westwood, A. J., Ingram, E., Casamenti, F., Goedert, M., & Spillantini, M. G. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63421-9 · Cited by 215 · see citing works
Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease
Lyte, M., & Cryan, J. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4 · Cited by 212 · see citing works
Grape Juice, Berries, and Walnuts Affect Brain Aging and Behavior
Joseph, J. A., Shukitt‐Hale, B., & Willis, L. (2009) · Journal of Nutrition · doi:10.3945/jn.109.108266 · Cited by 202 · see citing works
Parvathy, S., Hussain, I., Karran, E. H., Turner, A. J., & Hooper, N. M. (1999) · Biochemistry · doi:10.1021/bi9906827 · Cited by 200 · see citing works
Geromichalos, G. D., Lamari, F. N., Papandreou, M. A., Trafalis, D. T., Margarity, M., Papageorgiou, T., & Sinakos, Z. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300589c · Cited by 189 · see citing works
The NF-κB/Rel family of proteins mediates Aβ-induced neurotoxicity and glial activation
Bales, K. R., Du, Y., Dodel, R. C., Yan, G.-M., Hamilton‐Byrd, E., & Paul, S. M. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00066-7 · Cited by 186 · see citing works
Wiley, N., Dinan, T. G., Ross, R. P., Stanton, C., Clarke, G. A., & Cryan, J. F. (2017) · Journal of Animal Science · doi:10.2527/jas.2016.1256 · Cited by 180 · see citing works
Thomas, J., Thomas, C. J., Radcliffe, J., & Itsiopoulos, C. (2015) · BioMed Research International · doi:10.1155/2015/172801 · Cited by 173 · see citing works
Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission
Zimmerman, G., & Soreq, H. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0239-8 · Cited by 168 · see citing works
Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study
Schuitemaker, A., Kropholler, M. A., Boellaard, R., van der Flier, W. M., Kloet, R. W., van der Doef, T. F., Knol, D. L., Windhorst, A. D., Luurtsema, G., Barkhof, F., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.021 · Cited by 167 · see citing works
Khatoon, S., Grundke, I., & Iqbal, K. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00829-9 · Cited by 167 · see citing works
Alzheimer disease γ-secretase: a complex story of GxGD-type presenilin proteases
Haass, C., & Steiner, H. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02394-2 · Cited by 165 · see citing works
Farber, N. B., Rubin, E. H., Newcomer, J. W., Kinscherf, D. A., Miller, J. P., Morris, J. C., Olney, J. W., & McKeel, D. W. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1165 · Cited by 162 · see citing works
Tau Oligomers and Fibrils Induce Activation of Microglial Cells
Morales, I., Jiménez, J. M., Mancilla, M., & Maccioni, R. B. (2013) · Journal of Alzheimer’s Disease · doi:10.3233/jad-131843 · Cited by 160 · see citing works
Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease
Rinne, J. O. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.1.113 · Cited by 153 · see citing works
RANTES upregulation in the Alzheimer's disease brain: A possible neuroprotective role
Tripathy, D., Thirumangalakudi, L., & Grammas, P. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.009 · Cited by 150 · see citing works
Targeting Multiple Neurodegenerative Diseases Etiologies with Multimodal-Acting Green Tea Catechins
Mandel, S. A., Amit, T., Kalfon, L., Reznichenko, L., & Youdim, M. B. H. (2008) · Journal of Nutrition · doi:10.1093/jn/138.8.1578s · Cited by 148 · see citing works
DHA May Prevent Age-Related Dementia
Cole, G. M., & Frautschy, S. A. (2010) · Journal of Nutrition · doi:10.3945/jn.109.113910 · Cited by 143 · see citing works
Li, T., & Paudel, H. K. (2006) · Biochemistry · doi:10.1021/bi051634r · Cited by 140 · see citing works
Green tea catechins prevent cognitive deficits caused by Aβ1–40 in rats
Haque, A. M., Hashimoto, M., Katakura, M., Hara, Y., & Shido, O. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.08.008 · Cited by 139 · see citing works
Chauhan, N. B. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.05.030 · Cited by 138 · see citing works
Ren, H., Luo, C., Feng, Y., Yao, X., Shi, Z., Liang, F., Kang, J. X., Wan, J., Pei, Z., & Su, H. (2016) · The FASEB Journal · doi:10.1096/fj.201600896 · Cited by 136 · see citing works
Self-citationBerry Fruit Enhances Beneficial Signaling in the Brain
Miller, M. G., & Shukitt‐Hale, B. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2036033 · Cited by 135 · see citing works
Liu, X., Liu, D., Lin, G., Wu, Y., Gao, L., Ai, C., Huang, Y., Wang, M.-F., El-Seedi, H. R., Chen, X., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.07.195 · Cited by 125 · see citing works
A Role for Transforming Growth Factor α as an Inducer of Astrogliosis
Rabchevsky, A. G., Weinitz, J. M., Coulpier, M., et al. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10541.1998 · Cited by 124 · see citing works
Vincent, V. A. M., Tilders, F. J. H., & van Dam, A.-M. (1997) · Glia · doi:10.1002/(sici)1098-1136(199703)19:3 · Cited by 123 · see citing works
The decline in synapses and cholinergic activity is asynchronous in Alzheimer’s disease
Tiraboschi, P., Hansen, L. A., Alford, M. F., Masliah, E., Thal, L. J., & Corey‐Bloom, J. (2000) · Neurology · doi:10.1212/wnl.55.9.1278 · Cited by 121 · see citing works
Deciphering the tête-à-tête between the microbiota and the immune system
Surana, N. K., & Kasper, D. L. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72332 · Cited by 120 · see citing works
Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer’s Disease and Related Tauopathies
Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., et al. (2017) · Aging and disease · doi:10.14336/ad.2017.0112 · Cited by 118 · see citing works
Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease
Davinelli, S., Sapere, N., Zella, D., Bracale, R., Intrieri, M., & Scapagnini, G. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/386527 · Cited by 111 · see citing works
Orhan, İ. E., & Aslan, M. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.12.026 · Cited by 107 · see citing works
Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice
Qosa, H., Mohamed, L. A., Batarseh, Y. S., Alqahtani, S., Ibrahim, B. A., LeVine, H., Keller, J. N., & Kaddoumi, A. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.07.022 · Cited by 106 · see citing works
Okello, E. J., Savelev, S. U., & Perry, E. K. (2004) · Phytotherapy Research · doi:10.1002/ptr.1519 · Cited by 96 · see citing works
Yin, X., Jin, N., Gu, J., Shi, J., Zhou, J., Gong, C., Iqbal, K., Grundke, I., & Liu, F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.355412 · Cited by 93 · see citing works
O'Sullivan, E., Barrett, E., Grenham, S., Fitzgerald, P., Stanton, C., Ross, R., Quigley, E., Cryan, J., & Dinan, T. (2011) · Beneficial Microbes · doi:10.3920/bm2011.0015 · Cited by 92 · see citing works
Yoshimura, Y., Ichinose, T., & Yamauchi, T. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.037 · Cited by 89 · see citing works
Bharathi, M. D., Thenmozhi, A. J., & Manivasagam, T. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.05.001 · Cited by 88 · see citing works
Takahashi, S., Saito, T., Hisanaga, S.-I., Pant, H. C., & Kulkarni, A. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211964200 · Cited by 86 · see citing works
Food therapy and medical diet therapy of Traditional Chinese Medicine
Wu, Q., & Liang, X. (2018) · Clinical Nutrition Experimental · doi:10.1016/j.yclnex.2018.01.001 · Cited by 86 · see citing works
Amelioration of early cognitive deficits by aged garlic extract in Alzheimer's transgenic mice
Chauhan, N. B., & Sandoval, J. (2007) · Phytotherapy Research · doi:10.1002/ptr.2122 · Cited by 84 · see citing works
Yang, S., Gong, Q., Wu, Q., et al. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.10.026 · Cited by 84 · see citing works
Strada, O., Vyas, S., Hirsch, É. C., et al. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9549 · Cited by 81 · see citing works
Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP)
Grimm, M. O. W., Rothhaar, T. L., Grösgen, S., Burg, V. K., Hundsdörfer, B., Haupenthal, V. J., Frieß, P., Kins, S., Grimm, H. S., & Hartmann, T. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.06.015 · Cited by 78 · see citing works
Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment
Theuns, J., Marjaux, E., Vandenbulcke, M., Laere, K. V., Kumar‐Singh, S., Bormans, G. M., Brouwers, N., den Broeck, M. V., Vennekens, K. M., Corsmit, E., et al. (2006) · Human Mutation · doi:10.1002/humu.20402 · Cited by 78 · see citing works
Cholinergic Basis of Memory-Strengthening Effect of Foeniculum vulgare Linn.
Joshi, H., & Parle, M. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.413 · Cited by 77 · see citing works
Inhibition of acetylcholinesterase by green and white tea and their simulated intestinal metabolites
Okello, E. J., Leylabi, R., & McDougall, G. J. (2012) · Food & Function · doi:10.1039/c2fo10174b · Cited by 77 · see citing works
Takechi, R., Galloway, S., Pallebage‐Gamarallage, M. M., Wellington, C. L., Johnsen, R. D., Dhaliwal, S. S., & Mamo, J. C. L. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992194 · Cited by 76 · see citing works
Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
Timm, T., Marx, A., Panneerselvam, S., Mandelkow�, E., & Mandelkow, E. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-s2-s9 · Cited by 76 · see citing works
Mani, V., Ramasamy, K., Ahmad, A., Parle, M., Shah, S. A. A., & Majeed, A. B. A. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.11.037 · Cited by 75 · see citing works
del Río, R., Noubade, R., Saligrama, N., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101498 · Cited by 72 · see citing works
Gupta, V. B., Indi, S. S., & Rao, K. S. J. (2008) · Phytotherapy Research · doi:10.1002/ptr.2574 · Cited by 70 · see citing works
Kang, I., Jeon, Y. E., Yin, X. F., Nam, J., You, S. G., Hong, M. S., Jang, B. G., & Kim, M.-J. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.06.023 · Cited by 68 · see citing works
Hashimoto, M., Hossain, S., Tanabe, Y., Kawashima, A., Harada, T., Yano, T., Mizuguchi, K., & Shido, O. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.08.009 · Cited by 64 · see citing works
Lee, C.-L., Kuo, T., Wu, C.-L., et al. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf904027y · Cited by 64 · see citing works
Xu, P., Wang, K., Lu, C., Dong, L., Gao, L., Yan, M., Aibai, S., & Liu, X. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.08.030 · Cited by 64 · see citing works
Neuroprotective effect of Alpinia galanga (L.) fractions on Aβ(25–35) induced amnesia in mice
Chellammal, H. S. J., Alagarsamy, V., Diwan, P. V., Kumar, S. S., Nisha, J. C., & Reddy, Y. N. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.08.048 · Cited by 57 · see citing works
Koivisto, H., Grimm, M. O. W., Rothhaar, T. L., Berkecz, R., Lütjohann, D., Giniatullina, R., Takalo, M., Miettinen, P. O., Lahtinen, H.-M., Giniatullin, R. A., et al. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.015 · Cited by 57 · see citing works
Xu, Y. (2001) · International Journal of Food Science & Technology · doi:10.1046/j.1365-2621.2001.t01-1-00461.x · Cited by 56 · see citing works
Takalo, M., Haapasalo, A., Martiskainen, H., Kurkinen, K. M. A., Koivisto, H., Miettinen, P., Khandelwal, V. K. M., Kemppainen, S., Kamińska, D., Mäkinen, P. M., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.02.003 · Cited by 54 · see citing works
Influence of the Green Tea Leaf Extract on Neurotoxicity of Aluminium Chloride in Rats
Jelenković, A., Jovanović, M., Stevanović, I. D., Petronijević, N., Bokonjić, D., Živković, J., & Igic, R. P. (2013) · Phytotherapy Research · doi:10.1002/ptr.4962 · Cited by 51 · see citing works
Yeon, S.-W., You, Y., Kwon, H.-S., Yang, E. H., Ryu, J.-S., Kang, B. H., & Kang, J. (2010) · Journal of Functional Foods · doi:10.1016/j.jff.2010.04.002 · Cited by 51 · see citing works
Yang, H. J., Hwang, J. T., Kwon, D. Y., Kim, M. J., Kang, S., Moon, N. R., & Park, S. (2013) · Journal of Nutrition · doi:10.3945/jn.112.173401 · Cited by 51 · see citing works
Choi, J. Y., Lee, J. M., Lee, D. G., Cho, S., Yoon, Y.-H., Cho, E. J., & Lee, S. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3292 · Cited by 50 · see citing works
Choi, J. Y., Cho, E. J., Lee, H. S., Lee, J. M., Yoon, Y.-H., & Lee, S. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.11.002 · Cited by 50 · see citing works
Wen, M., Xu, J., Ding, L., Zhang, L., Du, L., Wang, J., Wang, Y., & Xue, C. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.04.034 · Cited by 50 · see citing works
Self-citationThenmozhi, A. J., Dhivyabharathi, M., Manivasagam, T., & Essa, M. M. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.08.047 · Cited by 49 · see citing works
Lee, A. Y., Choi, J. M., Lee, J., Lee, M. H., Lee, S., & Cho, E. J. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2016.3737 · Cited by 43 · see citing works
Shetty, A. K., Upadhya, R., Madhu, L. N., & Kodali, M. (2019) · Aging and Disease · doi:10.14336/ad.2019.0330 · Cited by 39 · see citing works
Kuo, P.-H., Lin, C.-I., Chen, Y., Chiu, W., & Lin, S. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000732 · Cited by 38 · see citing works
Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease–Induced Rats
Ahmed, H. H., Salem, A. M. H., Sabry, G. M., Husein, A. A., & Kotob, S. E. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0165 · Cited by 37 · see citing works
Giridharan, V. V., Thandavarayan, R. A., Mani, V., Dundapa, T. A., Watanabe, K., & Konishi, T. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1516 · Cited by 35 · see citing works
PKA Phosphorylations on Tau: Developmental Studies in the Mouse
Andorfer, C. A., & Davies, P. (2000) · Developmental Neuroscience · doi:10.1159/000017454 · Cited by 34 · see citing works
Ademosun, A. O., & Oboh, G. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2011.0226 · Cited by 32 · see citing works
Wang, P.-Y., Chen, J.-J., & Su, H. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.01.012 · Cited by 30 · see citing works
Self-citationHashimoto, M., Tozawa, R., Katakura, M., Shahdat, H., Haque, A. M., Tanabe, Y., Gamoh, S., & Shido, O. (2011) · Food & Function · doi:10.1039/c1fo00002k · Cited by 30 · see citing works
Kim, H. G., Park, G., Lim, S., Park, H., Choi, J. G., Jeong, H. U., Kang, M. S., Lee, M. K., & Oh, M. S. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.05.054 · Cited by 28 · see citing works
Ren, J., Li, X., Sun, J., et al. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-006572 · Cited by 28 · see citing works
Jang, J., Kim, C., Lim, S. H., et al. (2009) · Phytotherapy Research · doi:10.1002/ptr.2871 · Cited by 27 · see citing works
Roy, N. B. A., Zaal, A., Hall, G. W., et al. (2019) · Lara D. Veeken · doi:10.1093/rheumatology/kez317 · Cited by 26 · see citing works
Wang, X., Blanchard, J., Tung, Y. C., Grundke, I., & Iqbal, K. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142403 · Cited by 25 · see citing works
Ballard, C. G., Morris, C. M., Kalaria, R. N., McKeith, I. G., Perry, R., & Perry, E. K. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000084705 · Cited by 23 · see citing works
Chang, Y., Mori, E., Suzuki, M., Ikeda, M., Huang, C., Lee, J., Chang, W., & Chang, C. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.101621 · Cited by 18 · see citing works
Ipomoea batatas Attenuates Amyloid β Peptide-Induced Neurotoxicity in ICR Mice
Kim, J. K., Choi, S. J., Cho, H. Y., Kim, Y. J., Lim, S.-T., Kim, C., Kim, E. K., Kim, H. K., Trudo, S. P., & Shin, D.-H. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0047 · Cited by 16 · see citing works
P3‐067: ELEVATED ACETYLCHOLINESTERASE LEVELS BY HYPERPHOSPHORYLATED TAU OVEREXPRESSION
García‐Ayllón, M., Llorens, E., Ávila, J., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.05.1155 · Cited by 2 · see citing works
Khan (2000) · doi:10.1002/1531-8249(200008)48:2
Flagged first, then by citations
Research works printed but not linked: 5
- Garcia-Ayllón, M.-S., Llorens, E., Avila, J., Alom, J., & Saez-Valero, J. (2014). Elevated acetylcholinesterase levels by hyperphosphorylated tau overexpression. Alzheimer's & Dementia, 10(4), P651.
- Inestrosa, N. C., Sagal, J. P., & Colombres, M. (2005). Acetylcholinesterase interaction with Alzheimer amyloid β Alzheimer's Disease (pp. 299-317). Springer.
- Kisling, L. A., & Stiegmann, R. A. Alternative Medicine. Klein, M. A., Möller, J. C., Jones, L. L., Bluethmann, H., Kreutzberg, G. W., & Raivich, G. (1997). Impaired neuroglial activation in interleukin-6 deficient mice. Glia, 19(3), 227-233.
- Mesulam, M.-M. (1994). Butyrylcholinesterase in Alzheimer's disease Alzheimer Disease (pp. 79-83). Springer.
- Shinotoh, H., Namba, H., Fukushi, K., Nagatsuka, S. I., Tanaka, N., Aotsuka, A., … Irie, T. (2000). Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: A positron emission tomography study. Annals of Neurology, 48(2), 194-200.
Cited by
Sorted by citations
Nagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61 · see citing works
- Authors
- Peng, Y., Tao, H., Wang, S., Xiao, J., Wang, Y., & Su, H.
- Affiliations
- University of Macau (MO)
- Corresponding author
- Su, Huanxing
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 81
- Pages
- 104463
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W3156628315
- Cited by
- 31
- References
- 147
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 6 · 2023: 9 · 2022: 3 · 2021: 3
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Universidade de Macau (MYRG2018-00242-ICMS, MYRG2019-00160-ICMS)
- University of Macau Institute of Chinese Medical Science
- Science and Technology Development Fund (0049/2019/A1)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, dietary intervention, edible medicinal plants, plant products, dementia prevention, plant-derived drugs, Alzheimer's disease pathogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review