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Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders
Open accessAbstract
Dopamine is an important neuromodulator that exerts widespread effects on the central nervous system (CNS) function. Disruption in dopaminergic neurotransmission can have profound effects on mood and behavior and as such is known to be implicated in various neuropsychiatric behavioral disorders including autism and depression. The subsequent effects on other neurocircuitries due to dysregulated dopamine function have yet to be fully explored. Due to the marked social deficits observed in psychiatric patients, the neuropeptide, oxytocin is emerging as one particular neural substrate that may be influenced by the altered dopamine levels subserving neuropathologic‐related behavioral diseases. Oxytocin has a substantial role in social attachment, affiliation and sexual behavior. More recently, it has emerged that disturbances in peripheral and central oxytocin levels have been detected in some patients with dopamine‐dependent disorders. Thus, oxytocin is proposed to be a key neural substrate that interacts with central dopamine systems. In addition to psychosocial improvement, oxytocin has recently been implicated in mediating mesolimbic dopamine pathways during drug addiction and withdrawal. This bi‐directional role of dopamine has also been implicated during some components of sexual behavior. This review will discuss evidence for the existence dopamine/oxytocin positive interaction in social behavioral paradigms and associated disorders such as sexual dysfunction, autism, addiction, anorexia/bulimia, and depression. Preliminary findings suggest that whilst further rigorous testing has to be conducted to establish a dopamine/oxytocin link in human disorders, animal models seem to indicate the existence of broad and integrated brain circuits where dopamine and oxytocin interactions at least in part mediate socio‐affiliative behaviors. A profound disruption to these pathways is likely to underpin associated behavioral disorders. Central oxytocin pathways may serve as a potential therapeutic target to improve mood and socio‐affiliative behaviors in patients with profound social deficits and/or drug addiction.
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“Anatomically, there is a close relationship between OXT and DA pathways in the brain (Baskerville and Douglas, 2010).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Baskerville and Douglas, 2010
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“Oxytocin may also interact with dopamine to modulate socio-affiliative behaviors and central oxytocin pathways may serve as therapeutic targets to improve mood and social behaviors [168].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [168]
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“Oxytocin-rich hypothalamic nuclei are innervated by dopamine fibrils and regulated by DA via D2-like dopaminergic receptors (30,31).”
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“Moreover, DA receptors have been found on OXT cells in the hypothalamus [15].”
BackgroundSex differences in motivated behaviors in animal models
Song, Z., Kalyani, M., & Becker, J. B. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.04.009 · Cited by 21
Shieh, K., & Yang, S.-C. (2020) · The Chinese Journal of Physiology · doi:10.4103/cjp.cjp_47_19 · Cited by 21
“Central DAergic systems play an important role in the regulation of locomotion and aggressive, social, and reward-directed behaviors.[44-46] For example, chronic social stress in mice blunts DA turnover in the NA and reduces reward-directed behavior.”
BackgroundHopkins, W. D., Mulholland, M. M., Reamer, L. A., Mareno, M. C., & Schapiro, S. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-64051-y · Cited by 21
Lin, S., Lee, L.-T., Tsai, H. C., Chen, K. C., Chen, W. T., Lee, I. H., Lu, R., Chen, P. S., & Yang, Y. K. (2015) · Neuropsychobiology · doi:10.1159/000371637 · Cited by 20
Kelly, A. M., & Goodson, J. L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.004 · Cited by 21
Adversity impacting on oxytocin and behaviour: timing matters
Johnson, J. L., & Buisman‐Pijlman, F. T. A. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000269 · Cited by 21
“Work in animal models suggests broad integration of the oxytocin and dopaminergic brain circuits, where dopamine–oxytocin interactions mediate socioaffiliative behaviours, at least in part (Baskerville and Douglas, 2010), and although further studies are required to establish an equivalent link in humans conclusively,…”
BackgroundDecreased lymphocyte dopamine transporter in romantic lovers
Marazziti, D., Baroni, S., Giannaccini, G., Piccinni, A., Mucci, F., Catena-Dell’Osso, M., Rutigliano, G., Massimetti, G., & Dell’Osso, L. (2016) · CNS Spectrums · doi:10.1017/s109285291600050x · Cited by 20
“Recent data suggest that oxytocin and DA are positively related, so that increased or decreasedDA levels would lead to similar fluctuations of oxytocin and vice versa.(38) Therefore, if increased DA (and oxytocin) concentrations, coupled with low 5-HT levels, might be related to romantic love,(2,6) our findings would…”
Wang, J., Zhuang, J.-Y., Fu, L., Lei, Q., Fan, M., & Zhang, W. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237032 · Cited by 19
“Unlike the VTA-NAc projection pathway, the SN pathway has more interaction with the prefrontal cortex and is responsible for the reward-related cognition and involves in the initiation and movement of muscle [14].”
BackgroundWang, Y., Xu, H., Chen, S., Chen, J., Zheng, Q., Ma, Y., Zhao, X., Shi, Y., & Xiao, L. (2024) · Advanced Science · doi:10.1002/advs.202310244 · Cited by 18
Kang, J. I., Kim, H. W., Kim, C. H., Hwang, E. H., & Kim, S. J. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.09.011 · Cited by 19
“In particular, the oxytocin system is also reported to interact anatomically and functionally with the serotonin and dopamine systems (Baskerville and Douglas, 2010; Dolen et al., 2013; Lefevre et al., 2017).”
BackgroundG Protein-Coupled Receptor Heteromers as Putative Pharmacotherapeutic Targets in Autism
DelaCuesta-Barrutia, J., Peñagarikano, O., & Erdozain, A. M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.588662 · Cited by 18
“The co-activation of D2R and OXTR in NAcc has been reported to be necessary for pair bond formation in female voles (Baskerville and Douglas, 2010).”
BackgroundThe potential role of oxytocin in addiction: What is the target process?
Sanna, F., & Luca, M. A. D. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.03.002 · Cited by 18
Genetic variation in the oxytocin system and its link to social motivation in human infants
Krol, K. M., Namaky, N., Monakhov, M. V., Lai, P. S., Ebstein, R. P., & Großmann, T. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105290 · Cited by 18
“For example, the oxytocinergic system has strong links with other neuromodulatory systems, including dopamine and serotonin, which play critical roles in reward processing and mood (Baskerville and Douglas, 2010).”
BackgroundDo dopamine gene variants and prenatal smoking interactively predict youth externalizing behavior?
O’Brien, T. C., Mustanski, B. S., Skol, A. D., Cook, E. H., & Wakschlag, L. S. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.09.002 · Cited by 18
“Dopamine is expressed at higher concentrations in the brain than most other neurotransmitters and has a broad receptor distribution, making it an excellent candidate for genetic studies (Baskerville & Douglas, 2010; Bell & Deater-Deckard, 2007).”
BackgroundPrajapati, S. K., Bhaseen, S., Krishnamurthy, S., & Sahu, A. N. (2020) · Neurochemical Research · doi:10.1007/s11064-019-02944-9 · Cited by 17
High Plasma Oxytocin Levels in Men With Hypersexual Disorder
Flanagan, J. N., Chatzittofis, A., Boström, A. E. D., Hallberg, J., Öberg, K. G., Arver, S., & Jokinen, J. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac015 · Cited by 19
Wu, Y. H., Veerareddy, A., Lee, M. R., Bellucci, G., Camilleri, J. A., Eickhoff, S. B., & Krüeger, F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.053 · Cited by 17
Weber, A. M., Harrison, T. M., Sinnott, L. T., Shoben, A. B., & Steward, D. K. (2018) · Advances in Neonatal Care · doi:10.1097/anc.0000000000000452 · Cited by 18
Out of the box: A psychedelic model to study the creative mind
Kuypers, K. P. C. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.03.010 · Cited by 21
Yuan, W., Li, L., Hou, W., He, Z., Wang, L., Zhang, J., Yang, Y., Cai, W., Guo, Q., Zhang, X., et al. (2019) · Neuroendocrinology · doi:10.1159/000501798 · Cited by 17
Molecular characterization and differential expression of multiple goose dopamine D2 receptors
Wang, C., Liu, Y., Wang, H., Wu, H., Gong, S., Chen, W., & He, D. (2013) · Gene · doi:10.1016/j.gene.2013.11.037 · Cited by 16
“In mammals, dopamine is involved in a wide variety of behavioral and physiology functions, such as locomotor activity, cognition, emotion and motivation (Baskerville and Douglas, 2010; Blasi et al., 2009; Korchounov et al., 2010;Missale et al., 1998).”
BackgroundBlending oxytocin and dopamine with everyday creativity
Chong, A., Tolomeo, S., Yue, X., Angeles, D. C., Cheung, M. W. ‐., Becker, B., Lai, P. S., Lei, Z., Malavasi, F., Tang, Q., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-95724-x · Cited by 16
Beta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid Depression
Roschina, O. V., Levchuk, L. A., Boiko, A. S., Викторовна, М. Е., Epimakhova, E. V., Losenkov, I. S., Simutkin, G. G., LOONEN, A. J. M., Bokhan, N. A., & Ivanova, S. А. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10235696 · Cited by 16
“This includes an important role for oxytocin in addiction to alcohol (and other drugs) [22–26], supporting theories invariably paying close attention to the interaction of oxytocin with dopaminergic neurotransmission [22,23,26].”
BackgroundBorie, A. M., Young, L. J., & Liu, R. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0057 · Cited by 17
“Instead, the physiological actions of oxytocin in different contexts—defined by both external factors and internal biological conditions—need to be carefully examined, with particular attention to the wide diversity of other neuromodulators such as dopamine [57], serotonin [33], vasopressin [58] or eCBs [34,59] with w…”
BackgroundFu, Y., & Depue, R. A. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.026 · Cited by 18
The effect of intranasal oxytocin on social reward processing in humans: a systematic review
Kraus, J., Výborová, E., & Silani, G. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1244027 · Cited by 16
“Only one study found a significant effect of oxytocin treatment (63), which was conducted on female participants and precisely, increased VTA activity during social reward anticipation after the treatment.”
BackgroundOxytocin, GABA, and dopamine interplay in autism
Havránek, T., Bačová, Z., & Bakoš, J. (2024) · Endocrine Regulations · doi:10.2478/enr-2024-0012 · Cited by 16
Parasitic Manipulations of the Host Phenotype: Effects in Internal and External Environments
Gopko, M., & Mikheev, V. N. (2019) · Biology Bulletin Reviews · doi:10.1134/s2079086419010018 · Cited by 15
“Indeed, an increase in the dopamine concentration in certain parts of the central nervous system weakens the sense of danger and increases animal libido (Baskerville and Douglas, 2010).”
BackgroundMaternal responsivity and oxytocin in opioid‐dependent mothers
Daigle, K. M., Heller, N. A., Sulinski, E., Shim, J., Lindblad, W. J., Brown, M. S., Gosse, J. A., & Hayes, M. J. (2019) · Developmental Psychobiology · doi:10.1002/dev.21897 · Cited by 17
Paletta, P., Bass, N., Kavaliers, M., & Choleris, E. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0058 · Cited by 15
Chronic central oxytocin infusion impairs sociability in mandarin voles
Du, P., He, Z., Cai, Z., Hao, X., Dong, N., Yuan, W., Hou, W., Yang, J., Jia, R., & Tai, F. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.09.006 · Cited by 14
“10 a marked increase in mesolimbic DA activity, suggesting an interaction between OT and DA (Baskerville and Douglas, 2010).”
Metadata
- Authors
- Baskerville, T. A., & Douglas, A. J.
- Affiliations
- University of Glasgow (GB)
- University of Edinburgh (GB)
- Corresponding author
- Baskerville, Tracey A.
- Venue
- CNS Neuroscience & Therapeutics
- Publisher
- Wiley
- Published
- 2010-05-06
- Volume
- 16
- Issue
- 3
- Pages
- e92-123
- ISSN
- 1755-5930 (ISSN-L)
- 1755-5949
- PMC
- PMC6493805
- OpenAlex
- W1556392272
- Cited by
- 377
- References
- 301
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 30 · 2023: 15 · 2022: 19 · 2021: 39 · 2020: 23 · 2019: 29 · 2018: 21 · 2017: 26 · 2016: 26 · 2015: 19 · 2014: 22 · 2013: 28 · 2012: 22
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- CNS Neuroscience & Therapeutics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- Pfizer
- Wellcome Trust
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- dopamine, oxytocin, social behavior, autism spectrum disorder, depression, drug addiction, anorexia nervosa, bulimia nervosa, sexual dysfunction, mesolimbic dopamine system, social attachment
- MeSH terms
- Animals, Behavior, Behavior, Animal, Behavioral Symptoms, Central Nervous System, Dopamine, Female, Humans, Male, Neurochemistry, Oxytocin, Pair Bond, Receptors, Dopamine, Sexual Behavior, Social Behavior
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