Cited by 377Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 300 of the 301 references it cites were found in a registry or an index.

Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders

Open access

Baskerville, Tracey A., Douglas, Alison J.·2010·CNS Neuroscience & Therapeutics

DOI 10.1111/j.1755-5949.2010.00154.xPMC PMC6493805

Open this paper in CoChat — free account Open PDF

Abstract

Dopamine is an important neuromodulator that exerts widespread effects on the central nervous system (CNS) function. Disruption in dopaminergic neurotransmission can have profound effects on mood and behavior and as such is known to be implicated in various neuropsychiatric behavioral disorders including autism and depression. The subsequent effects on other neurocircuitries due to dysregulated dopamine function have yet to be fully explored. Due to the marked social deficits observed in psychiatric patients, the neuropeptide, oxytocin is emerging as one particular neural substrate that may be influenced by the altered dopamine levels subserving neuropathologic‐related behavioral diseases. Oxytocin has a substantial role in social attachment, affiliation and sexual behavior. More recently, it has emerged that disturbances in peripheral and central oxytocin levels have been detected in some patients with dopamine‐dependent disorders. Thus, oxytocin is proposed to be a key neural substrate that interacts with central dopamine systems. In addition to psychosocial improvement, oxytocin has recently been implicated in mediating mesolimbic dopamine pathways during drug addiction and withdrawal. This bi‐directional role of dopamine has also been implicated during some components of sexual behavior. This review will discuss evidence for the existence dopamine/oxytocin positive interaction in social behavioral paradigms and associated disorders such as sexual dysfunction, autism, addiction, anorexia/bulimia, and depression. Preliminary findings suggest that whilst further rigorous testing has to be conducted to establish a dopamine/oxytocin link in human disorders, animal models seem to indicate the existence of broad and integrated brain circuits where dopamine and oxytocin interactions at least in part mediate socio‐affiliative behaviors. A profound disruption to these pathways is likely to underpin associated behavioral disorders. Central oxytocin pathways may serve as a potential therapeutic target to improve mood and socio‐affiliative behaviors in patients with profound social deficits and/or drug addiction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1755-5949.2010.00154.x

Cites

300 of 300 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
(1943) · The Nervous child · Cited by 8,870
The rat nervous system
Paxinos, G. (1985) · Cited by 3,715
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Autistic disturbances of affective contact.
Kanner, L. (1968) · PubMed · Cited by 2,282
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · cited 1×
“In addition to the NA [84], the VTA also supplies dopaminergic fibers to the hippocampus and amygdala [85] suggesting that dopamine–oxytocin interactions within these nuclei may also have a bi-directional role.”
Background
Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence
Mattick, R. P., Breen, C., Kimber, J., & Davoli, M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002209.pub2 · Cited by 1,654
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,497 · cited 1×
“, SN) [214], and increased CSF or plasma oxytocin levels [26,215] are evident compared to women who are not mothers.”
Background
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356

Show all 301 references

Research works printed but not linked: 13

10.1016/0306-4522(93)90285-N · DOI · Paper page
10.1210/jc.75.3.855 · DOI
Kendirci M, 2004, Intranasall apomorphine Nastech pharmaceutical, Idrugs, 7, 483
10.1038/35053579 · DOI · Paper page
Everitt BJ, 1998, Differential induction of C‐FOS in limbic and hypothalamic structures by primary and secondary reinforcers, Eur J Neurosci, 10, 157
10.1038/35053579 · DOI · Paper page
10.1016/0028-3908(90)90095-9 · DOI · Paper page
10.1016/0306-4530(94)90062-0 · DOI
10.1016/j.physbeh.2007.04.012 · DOI
10.1016/j.physbeh.2007.04.012 · DOI
Leng G, 2009, The handbook of behaviour, diet and nutrition
Ingram CD, 2005, Techniques in the behavioural and neural sciences series, 609
10.1016/j.pbb.2008.07.002 · DOI

Sorted by citations

Integrating psychological and neurobiological considerations regarding the development and maintenance of specific Internet-use disorders: An Interaction of Person-Affect-Cognition-Execution (I-PACE) model
Brand, M., Young, K. S., Laier, C., Wölfling, K., & Potenza, M. N. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.033 · Cited by 2,416
“One biological correlate of insecure attachment style is lower evels of oxytocin, which have also been associated with developng addictive behaviors (Baskerville and Douglas, 2010; Sarnyai and ovács, 2014).”
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
“In rats, OXTergic and dopaminergic fibers often exist in close apposition to each other (129), with dopamine D2 receptors being expressed directly on OXT neurons (61), suggesting a close interaction between OXT and dopamine systems (62).”
Background
The Social Salience Hypothesis of Oxytocin
Shamay-Tsoory, S. G., & Abu-Akel, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.020 · Cited by 904
“key regions within this system [for reviews see (6, 97-99)].”
Consensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723
“Oxytocin may also interact with dopamine to modulate socio-affiliative behaviors and central oxytocin pathways may serve as therapeutic targets to improve mood and social behaviors [168].”
Background
Biased Oxytocinergic Modulation of Midbrain Dopamine Systems
Xiao, L., Priest, M. F., Nasenbeny, J., Lu, T., & Kozorovitskiy, Y. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.003 · Cited by 292
Maternal neglect: oxytocin, dopamine and the neurobiology of attachment
Strathearn, L. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02228.x · Cited by 268
Breaking the loop: Oxytocin as a potential treatment for drug addiction
McGregor, I. S., & Bowen, M. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.001 · Cited by 268
“However, the exact interaction between dopamine and oxytocin in regulating drug and social reward is complex and poorly understood, and may vary according to behavioral context (Baskerville and Douglas, 2010).”
Background
Empathy as a “risky strength”: A multilevel examination of empathy and risk for internalizing disorders
Tone, E. B., & Tully, E. C. (2014) · Development and Psychopathology · doi:10.1017/s0954579414001199 · Cited by 253
“The data primarily from preclinical studies indicate that the oxytocin and dopamine systems may interact to influence a range of social cognitive and interpersonal outcomes (Young & Wang, 2004; for a review, see Baskerville & Douglas, 2010).”
Oxytocin and social motivation
Gordon, I., Martin, C., Feldman, R., & Leckman, J. F. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.007 · Cited by 211
“…of movement), tuberinfiundibular (regulation of prolactin secretion from the anterior pituitary), incertohypothalamic (innervation of the SON and PVN and related regions for control of endocrine function and sexual behavior) and diencephalospinal (spinal reflexes) (Baskerville and Douglas, 2010).”
Influence of stress associated with chronic alcohol exposure on drinking
Becker, H. C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.028 · Cited by 191
“…behaviors, oxytocin also regulates a number of behaviors that involve social interactions (e.g., pair-bonding, social reward processing, aggression) and nonsocial behaviors, including anxiety and stress responses (Baskerville and Douglas, 2010; Bowen et al., 2011; Neumann and Landgraf, 2012).”
Influential
Hydrothermal synthesis of nitrogen and boron co-doped carbon quantum dots for application in acetone and dopamine sensors and multicolor cellular imaging
Liu, Y., Li, W. H., Wu, P. T., Ma, C., Wu, X., Xu, M., Luo, S., Xu, Z., & Liu, S. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.10.075 · Cited by 188
The biology of trust: Integrating evidence from genetics, endocrinology, and functional brain imaging.
Riedl‬, R., & Javor, A. (2011) · Journal of Neuroscience Psychology and Economics · doi:10.1037/a0026318 · Cited by 193
“In line with this argumentation, a recent review (Baskerville & Douglas, 2010) indicates the existence of a positive interaction between DOP and OXT.”
Result
Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies
Wigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179
Born to lead? A twin design and genetic association study of leadership role occupancy
Jan-emmanuel De Neve, A., Mikhaylov, S., Dawes, C. T., Christakis, N. A., & Fowler, J. H. (2012) · The Leadership Quarterly · doi:10.1016/j.leaqua.2012.08.001 · Cited by 184
“…studies in neurobiology have provided more direct evidence for the link between dopamine and leadership (Lee et al., 2009), and separately for the hormone oxytocin (Nowack, 2009), which has been shown to interact with dopamine to mediate socio-affiliative behaviors (Baskerville & Douglas, 2010).”
Background
Making room for oxytocin in understanding depression
McQuaid, R. J., McInnis, O. A., Abizaid, A. B., & Anisman, H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.005 · Cited by 175
What Guides Us to Neurally and Behaviorally Align With Anyone Specific? A Neurobiological Model Based on fNIRS Hyperscanning Studies
Gvirts, H. Z., & Perlmutter, R. (2019) · The Neuroscientist · doi:10.1177/1073858419861912 · Cited by 166
Birth practices: Maternal‐neonate separation as a source of toxic stress
Bergman, N. (2019) · Birth Defects Research · doi:10.1002/bdr2.1530 · Cited by 186
“It is involved in sexual and reproductive behaviors (Baskerville & Douglas, 2010).”
Background
The Resilience handbook: approaches to stress and trauma
(2014) · Choice Reviews Online · doi:10.5860/choice.51-5313 · Cited by 162
Sex differences in methamphetamine seeking in rats: Impact of oxytocin
Cox, B. M., Young, A. B., See, R. E., & Reichel, C. M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.005 · Cited by 159
“Although the underlying mechanisms are beyond the scope of this study, one suggestion relies on the interaction of oxytocin with the dopamine system (Baskerville and Douglas, 2010).”
Influential
The role of oxytocin in male and female reproductive behavior
Veening, J. G., A, T. R. D. J., Waldinger, M. D., Korte, S. M., & Olivier, B. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.045 · Cited by 156
Why social attachment and oxytocin protect against addiction and stress: Insights from the dynamics between ventral and dorsal corticostriatal systems
Mattie Tops, A., Koole, S. L., IJzerman, H., & Buisman‐Pijlman, F. T. A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.07.015 · Cited by 146
Adolescent oxytocin exposure causes persistent reductions in anxiety and alcohol consumption and enhances sociability in rats
Bowen, M. T., Carson, D. S., Spiro, A., Arnold, J. C., & McGregor, I. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027237 · Cited by 143
“The anxiolytic and prosocial effects of OT evident in these animal models have led to worldwide interest in exogenous OT as a potential therapeutic for human psychiatric disorders [2,16–23].”
Background
Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system
Buisman‐Pijlman, F. T. A., Sumracki, N. M., Gordon, J. J., Hull, P. R., Carter, C. S., & Tops, M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.005 · Cited by 147
Gene expression links functional networks across cortex and striatum
Anderson, K. M., Krienen, F. M., Choi, E. Y., Reinen, J. M., Yeo, B. T. T., & Holmes, A. J. (2018) · Nature Communications · doi:10.1038/s41467-018-03811-x · Cited by 138
A general approach-avoidance hypothesis of Oxytocin: Accounting for social and non-social effects of oxytocin
Harari-Dahan, O., & Bernstein, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.007 · Cited by 143
Neural Circuits for Social Cognition: Implications for Autism
Fernández, M. C., Mollinedo-Gajate, I., & Peñagarikano, O. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.013 · Cited by 143
“14 catechol-O-methyl transferase that end up yielding the inactive homovanillic acid (HVA) (Baskerville and Douglas, 2010).”
Influential
Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests
Clipperton‐Allen, A. E., & Page, D. T. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu057 · Cited by 134
“The DA system is known to influence social behavior, along with other behaviors altered in germline Pten+/2 mice (64, 85).”
Background
Intranasal oxytocin increases covert attention to positive social cues
Domes, G., Sibold, M., Schulze, L., Lischke, A., Herpertz, S. C., & Heinrichs, M. (2013) · Psychological Medicine · doi:10.1017/s0033291712002565 · Cited by 130
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129
Interaction between Oxytocin Genotypes and Early Experience Predicts Quality of Mothering and Postpartum Mood
Mileva‐Seitz, V. R., Steiner, M. S., Atkinson, L. R., Meaney, M. J., Levitan, R. D., Kennedy, J. L., Sokolowski, M. B., & Fleming, A. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061443 · Cited by 134
“Oxytocin neurons express DRD2-like receptors in the rat brain [72].”
Background
Roles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
Onaka, T., Takayanagi, Y., & Yoshida, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02300.x · Cited by 123
Association between Oxytocin Receptor Gene Polymorphisms and Self-Rated ‘Empathic Concern’ in Schizophrenia
Montag, C., Brockmann, E.-M., Lehmann, A. I., Müller, D. J., Rujescu, D., & Gallinat, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051882 · Cited by 128
“Of note, OXT interacts with the dopaminergic system and thus stimulates the attribution of salience to social and emotional stimuli [43–46].”
Background
The Role of Intranasal Oxytocin in Anxiety and Depressive Disorders: A Systematic Review of Randomized Controlled Trials
Cagna, F. D., Fusar‐Poli, L., Damiani, S., Rocchetti, M., Giovanna, G., Mori, A., Politi, P., & Brondino, N. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.1.1 · Cited by 121
Oxytocin in schizophrenia: a review of evidence for its therapeutic effects
MacDonald, K. S., & Feifel, D. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00634.x · Cited by 117
Marijuana: Current Concepts†
Greydanus, D. E., Hawver, E. K., Greydanus, M. M., & Merrick, J. (2013) · Frontiers in Public Health · doi:10.3389/fpubh.2013.00042 · Cited by 112
A Review of Oxytocin’s Effects on the Positive, Negative, and Cognitive Domains of Schizophrenia
Feifel, D., Shilling, P. D., & MacDonald, K. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.025 · Cited by 110
Nonsocial Functions of Hypothalamic Oxytocin
Yang, H.-P., Wang, L., Han, L., & Wang, S. C. (2013) · ISRN Neuroscience · doi:10.1155/2013/179272 · Cited by 116
“OXT is involved in drug addiction and withdrawal by regulating mesolimbic dopamine pathways [133].”
Background
The social neuroscience of music: Understanding the social brain through human song.
Greenberg, D. M., Decety, J., & Gordon, I. (2021) · American Psychologist · doi:10.1037/amp0000819 · Cited by 111
Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions
Song, Z., Borland, J. M., Larkin, T. E., O’Malley, M., & Albers, H. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.001 · Cited by 101
“There is a limited but growing body of evidence that OT and AVP can act within the mesolimbic DA system to influence the expression of social behaviors (Baskerville and Douglas, 2010; Caldwell and Albers, 2016; Lim and Young, 2004; Numan and Young, 2015; Young et al., 2011).”
Background
A brief history of oxytocin and its role in modulating psychostimulant effects
Carson, D. S., Guastella, A. J., Taylor, E. R., & McGregor, I. S. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112473788 · Cited by 105
“…dopamine (DA), for promoting behaviors such as pair bonding, and sexual arousal and appetite, and highlights a potential therapeutic benefit of OT in a number of DA-related disorders such as sexual dysfunction, autism, schizophrenia, and addiction (see Baskerville and Douglas, 2010 for review).”
Background
Oxytocin for the treatment of drug and alcohol use disorders
Lee, M. R., & Weerts, E. M. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000258 · Cited by 105
“…and motivational processes is believed to be because of the important role of OT to shift salience to social, affiliative processes, both by increasing the salience itself of rewarding stimuli and/or by reducing stress, allowing for attention to social bonding (Baskerville and Douglas, 2010).”
Background
Oxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99
Mice Heterozygous for the Oxytocin Receptor Gene (Oxtr+/−) Show Impaired Social Behaviour but not Increased Aggression or Cognitive Inflexibility: Evidence of a Selective Haploinsufficiency Gene Effect
Sala, M., Braida, D., Donzelli, A., Martucci, R., Busnelli, M., Bulgheroni, E., Rubino, T., Parolaro, D., Nishimori, K., & Chini, B. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02385.x · Cited by 104
Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference
Baracz, S. J., Rourke, P. I., Pardey, M. C., Hunt, G. E., McGregor, I. S., & Cornish, J. L. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.11.038 · Cited by 100
Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand
Cox, B. M., Bentzley, B. S., Regen-Tuero, H. C., See, R. E., Reichel, C. M., & Aston‐Jones, G. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.011 · Cited by 98
“Systemic oxytocin decreases neuronal activation in NAc core Oxytocin in NAc modulates reward behaviors (4, 8, 9, 13, 17, 36-41, 46).”
Influential
Medications for alcohol use disorders: An overview
Akbar, M. D., Egli, M., Cho, Y., Song, B., & Noronha, A. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.11.007 · Cited by 101
“The effects of oxytocin (OT) have been reported by many laboratories in alcohol addiction as well as in some neuropsychiatric disorders and social behaviors (Baskerville & Douglas, 2010; Lee & Weerts, 2016).”
Research Review: Social motivation and oxytocin in autism – implications for joint attention development and intervention
Stavropoulos, K. K. M., & Carver, L. J. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12061 · Cited by 104
“Oxytocin has been implicated in several aspects of social behavior in animals (e.g. Liu & Wang, 2003) and humans (e.g. Guastella, Mitchell & Dadds, 2008), and likely plays a role in social reward systems (e.g. Baskerville & Douglas, 2010).”
Background
Genetic Influences on Social Cognition
Skuse, D., & Gallagher, L. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212f562 · Cited by 105
Oxytocin reduces ethanol self-administration in mice
King, C. E., Griffin, W. C., Luderman, L. N., Kates, M. M., McGinty, J. F., & Becker, H. C. (2017) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13359 · Cited by 89
“A growing body of literature suggests that oxytocin plays a role in several neuropsychiatric disorders that involve deficits in social behaviors, including drug and alcohol addiction (Baskerville and Douglas, 2010; Lee and Weerts, 2016).”
BackgroundInfluential
Effects of a Common Variant in the CD38 Gene on Social Processing in an Oxytocin Challenge Study: Possible Links to Autism
Sauer, C., Montag, C., Wörner, C., Kirsch, P., & Reuter, M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.333 · Cited by 90
“The dopamine system is supposed to have a crucial role for rewarding social affiliative behaviors (which are in turn regulated by OT) and could thereby contribute to ASD’s social disinterest and deficits (Baskerville and Douglas, 2010; Skuse and Gallagher, 2009).”
Background
Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction
Neisewander, J. L., Peartree, N. A., & Pentkowski, N. S. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2853-3 · Cited by 87
“For instance, the peptide neurotransmitter oxytocin is released in response to appetitive social stimuli (Baskerville and Douglas 2010; Insel 1992) and causes a decrease in anxiety (Bowen et al. 2011; McGregor et al. 2008; Windle et al. 1997) and an increase in trust in humans (Kosfeld et al. 2005).”
Background
Early adverse experience and substance addiction: Dopamine, oxytocin, and glucocorticoid pathways
Kim, S., Kwok, S., Mayes, L. C., Potenza, M. N., Rutherford, H. J. V., & Strathearn, L. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13140 · Cited by 85
Potential of Oxytocin in the Treatment of Schizophrenia
Shilling, P. D., & Feifel, D. (2016) · CNS Drugs · doi:10.1007/s40263-016-0315-x · Cited by 84
Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues
Song, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114647 · Cited by 88
Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain
Qi, J., Han, W., Yang, J., Wang, L., Dong, Y., Wang, F., Song, M., & Wu, C. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00439.x · Cited by 83
“Furthermore, OT is thought to act as a neuromodulator on dopaminergic neurotransmission in limbic-basal forebrain structures to regulate adaptive processes (Qi et al. 2008b; Baskerville & Douglas 2010; Sarnyai 2011).”
Background
Oxytocin: a therapeutic target for mental disorders
Matsuzaki, M., Matsushita, H., Tomizawa, K., & Matsui, H. (2012) · The Journal of Physiological Sciences · doi:10.1007/s12576-012-0232-9 · Cited by 79
“The OT receptor (OTR), a member of the G protein-coupled receptor family, is expressed widely in the central nervous system (CNS), especially in the ventromedial nucleus of the hypothalamus, the central nucleus of the amygdala, the head of the caudate-putamen and the hippocampus [2, 5].”
Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL/6 mice caused by chronic high-fat diet intake
Krishna, S., Lin, Z., Serre, C. B. D. L., Wagner, J. J., Harn, D. A., Pepples, L. M., Djani, D. M., Weber, M., Srivastava, L., & Filipov, N. M. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.007 · Cited by 77
“Different forebrain regions, such as PFC, dHIP and vHIP, regulate mood and anxiety [95, 109, 110]; dopaminergic, noradrenergic and/or serotonergic dysregulations have been implicated in emotional disorders, such as anxiety and/or depression [109, 111, 112].”
Neural modulation of social reinforcement learning by intranasal oxytocin in male adults with high-functioning autism spectrum disorder: a randomized trial
Kruppa, J. A., Gossen, A., Oberwelland Weiß, E., Kohls, G., Großheinrich, N., Cholemkery, H., Freitag, C. M., Karges, W., Wölfle, E., Sinzig, J., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0258-7 · Cited by 69
“For example, OXT modulates social learning, such as establishing social preference and bonding, and acts specifically as a social reinforcement signal within the NAcc [6, 7].”
Background
Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia
Loth, M. K., & Donaldson, Z. R. (2020) · Endocrinology · doi:10.1210/endocr/bqaa223 · Cited by 80
“However, it is important to note that D2-like receptors include D2, D3, and D4 receptors and that D1-like refers to D1 and D5 receptors (49).”
Background
Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment
Goh, K. K., Chen, C.-H., & Lane, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042146 · Cited by 84
Oxytocin and vasopressin: signalling, behavioural modulation and potential therapeutic effects
Rae, M., Lemos Duarte, M., Gomes, I., Camarini, R., & Devi, L. A. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15481 · Cited by 72
“Medium expression of OT receptors is found in the basolateral amygdala, hippocampus and ventral tegmental area (VTA).”
Influential
A New Generation of Sexual Addiction
Riemersma, J., & Sytsma, M. (2013) · Sexual Addiction & Compulsivity The Journal of Treatment and Prevention · doi:10.1080/10720162.2013.843067 · Cited by 68
“The neurotransmitters dopamine and oxytocin, implicated in behavior disorders such as sexual addiction, are both involved in sociosexual behaviors as well as erotic presentation (Baskerville & Douglas, 2010).”
Background
Oxytocin and Serotonin Brain Mechanisms in the Nonhuman Primate
Lefèvre, A., Richard, N., Jazayeri, M., Beuriat, P.-A., Fieux, S., Zimmer, L., Duhamel, J., & Sirigu, A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0659-17.2017 · Cited by 73
Autistic-like behavioural and neurochemical changes in a mouse model of food allergy
de Theije, C. G. M., Wu, J., Koelink, P. J., Korte-Bouws, G. A. H., Borre, Y. E., Kas, M. J., da Silva, S. L., Korte, S. M., Olivier, B., Garssen, J., et al. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.008 · Cited by 71
High-fat diet exacerbates cognitive rigidity and social deficiency in the BTBR mouse model of autism
Zilkha, N., Kuperman, Y., & Kimchi, T. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.070 · Cited by 72
“Following behavioral testing, we measured hypothalamic mRNA expression levels of several genes involved in dopamine and oxytocin signaling, as these factors have been implicated both in obesity and feeding behavior (Meguid et al., 2000; Kelley et al., 2005; Baskerville and Douglas, 2010; Mason et al., 2013) as well as…”
Influential
The role of oxytocin in alcohol and drug abuse
King, C. E., Gano, A., & Becker, H. C. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146761 · Cited by 69
May oxytocin be a trait marker for bipolar disorder?
Turan, T., Uysal, C., Asdemir, A., & Kılıç, E. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.07.017 · Cited by 66
“Oxytocin is released to the hippocampus, amygdala, ventral tegmental area, and the spinal cord via axonal projections of magnocellular neurons within the PVN and SON and contributes to the regulation of several physiological and behavioral functions including reproductive and sexual behaviors, anxiety and social behav…”
Oxytocin via its receptor affects restraint stress-induced methamphetamine CPP reinstatement in mice: Involvement of the medial prefrontal cortex and dorsal hippocampus glutamatergic system.
Han, W.-Y., Du, P., Fu, S.-Y., Wang, F., Song, M.-H., Wu, C.-F., & Yang, J.-Y. (2014) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.014 · Cited by 61
Effects of formaldehyde exposure on anxiety-like and depression-like behavior, cognition, central levels of glucocorticoid receptor and tyrosine hydroxylase in mice
Li, Y., Song, Z., Ding, Y., Ye, X., Wu, T., Su, T., He, R., Tai, F., & Lian, Z. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.10.102 · Cited by 66
Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control
Subba, R., Sandhir, R., Singh, S. P., Mallick, B. N., & Mondal, A. C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15136 · Cited by 69
“2.3.2 | Dopamine Dopamine influences behavior encompassing the systems that drive motivation, reward, cognition, sleep, emotion, among many others (Baskerville & Douglas, 2010).”
BackgroundInfluential
Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 63
“performance apparent in sexual desire/arousal disorders (Baskerville and Douglas, 2010).”
Attachment, affective temperament, and personality disorders: A study of their relationships in psychiatric outpatients
MacDonald, K. S., Berlow, R., & Thomas, M. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.07.040 · Cited by 65
DNA Methylation and Schizophrenia: Current Literature and Future Perspective
Magwai, T., Shangase, K. B., Oginga, F. O., Chiliza, B., Mpofana, T., & Xulu, K. R. (2021) · Cells · doi:10.3390/cells10112890 · Cited by 68
Altered anxiety-related and abnormal social behaviors in rats exposed to early life seizures
Castelhano, A. S. S., Cassane, G. D. S. T., Scorza, F. A., & Cysneiros, R. M. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00036 · Cited by 58
“It is well-established that the dopamine found in the PFC originates from the ventral tegmental area, a structure involved in neural network of social behaviors (Goodson and Kabelik, 2009) is also involved in and emotional responses (Baskerville and Douglas, 2010). In this sense, dopamine reduction in PFC could lead t…”
Influential
Current findings on the role of oxytocin in the regulation of food intake
Spetter, M. S., & Hallschmid, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.007 · Cited by 61
Chronic methamphetamine treatment induces oxytocin receptor up-regulation in the amygdala and hypothalamus via an adenosine A2A receptor-independent mechanism
Zanos, P., Wright, S. R., Georgiou, P., Yoo, J. H., Ledent, C. A., Hourani, S. M. O., Kitchen, I., Winsky‐Sommerer, R., & Bailey, A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.05.009 · Cited by 57
Design and synthesis of fluorescent reagents for selective detection of dopamine
Suzuki, Y. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.08.019 · Cited by 56
Neuroendocrine Aspects of Tourette Syndrome
Martino, D., Macerollo, A., & Leckman, J. F. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-411546-0.00009-3 · Cited by 59
Genetic mechanisms of parenting
Mileva‐Seitz, V. R., Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.003 · Cited by 58
Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia
Bartholomeusz, C. F., Ganella, E. P., Labuschagne, I., Bousman, C., & Pantelis, C. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.06.007 · Cited by 54
“…administration reduces dopaminergic hyperactivity in the striatum and nucleus accumbens (Qi et al., 2008), as well as alleviating pre-pulse inhibition deficits (Caldwell et al., 2009), in a similarmanner to antipsychotic medications (for reviews see Baskerville and Douglas, 2010; Pedersen, 2014).”
Oxytocin receptor gene rs53576 polymorphism modulates oxytocin–dopamine interaction and neuroticism traits—A SPECT study
Chang, W. H., Lee, I. H., Chen, K. C., Chi, M. H., Chiu, N.-T., Yao, W. J., Lu, R., Yang, Y. K., & Chen, P. S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.020 · Cited by 54
Drug addiction: An affective-cognitive disorder in need of a cure
Fattore, L., & Diana, M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.006 · Cited by 58
What is orgasm? A model of sexual trance and climax via rhythmic entrainment
Safron, A. (2016) · Socioaffective Neuroscience & Psychology · doi:10.3402/snp.v6.31763 · Cited by 60
“Climax is also associated with elevated oxytocin and vasopressin, both of which have been associated with analgesic-type effects (Baskerville & Douglas, 2010; González-Hernández, Rojas-Piloni, & Condés-Lara, 2014; Mogil et al., 2011), as well as enhanced social learning (Freeman & Young, 2016).”
Background
Oxytocin-induced yawning: Sites of action in the brain and interaction with mesolimbic/mesocortical and incertohypothalamic dopaminergic neurons in male rats
Sanna, F., Argiolas, A., & Melis, M. R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.08.010 · Cited by 53
Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards
Damiano, C. R., Aloi, J. M., Dunlap, K., Burrus, C. J., Mosner, M. G., Kozink, R. V., McLaurin, R. E., Mullette-Gillman, O. A., Carter, R., Huettel, S. A., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-7 · Cited by 56
“The association between rs2268493 and mesolimbic response during reward anticipation is consistent with preclinical evidence that the OXT and mesolimbic dopamine systems act reciprocally and become linked through early social experiences [40,42,43,83-85] and that OXT modulation may directly result in increased firing…”
Result
Oxytocin and Eating Disorders: A Narrative Review on Emerging Findings and Perspectives
Giel, K. E., Zipfel, S., & Hallschmid, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171128143158 · Cited by 58
“These findings might be of particular relevance for behavioral disorders like autism and depression, but also for eating disorders [20].”
Background
Oxytocin attenuates stress-induced reinstatement of alcohol seeking behavior in male and female mice
King, C. E., & Becker, H. C. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05233-z · Cited by 53
Early life adversity and adult social behavior: focus on arginine vasopressin and oxytocin as potential mediators
Kompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00143 · Cited by 53
Validation of an enzyme-linked immunoassay (ELISA) for plasma oxytocin in a novel mammal species reveals potential errors induced by sampling procedure
Robinson, K. J., Hazon, N., Lonergan, M., & Pomeroy, P. P. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.01.019 · Cited by 52
Understanding the Biological Relationship between Migraine and Depression
Viudez‐Martínez, A., Torregrosa, A. B., Navarrete, F., & García‐Gutiérrez, M. S. (2024) · Biomolecules · doi:10.3390/biom14020163 · Cited by 57
“One promising finding is that oxytocin may be used as an adjunct drug to antidepressant treatment or to treat specific aspects of depressive disorders [355].”
Background
The Yin and Yang of the oxytocin and stress systems: opposites, yet interdependent and intertwined determinants of lifelong health trajectories
Uvnäs‐Moberg, K., Groß, M. M., Calleja‐Agius, J., & Turner, J. D. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1272270 · Cited by 61
Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species
Rappeneau, V., & Castillo Díaz, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105675 · Cited by 51
“Anatomically, there is a close relationship between OXT and DA pathways in the brain (Baskerville and Douglas, 2010).”
Background
Psychotropic effects of L-theanine and its clinical properties: from the management of anxiety and stress to a potential use in schizophrenia
Lopes Sakamoto, F., Metzker Pereira Ribeiro, R., Amador Bueno, A., & Oliveira Santos, H. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104395 · Cited by 49
Revealing the neurobiology underlying interpersonal neural synchronization with multimodal data fusion
Lotter, L. D., Kohl, S. H., Gerloff, C., Bell, L., Niephaus, A., Kruppa, J. A., Dukart, J., Schulte‐Rüther, M., Reindl, V., & Konrad, K. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105042 · Cited by 52
How does oxytocin modulate human behavior?
Yao, S., & Kendrick, K. M. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02898-1 · Cited by 61
“…this broad domain, OT, primarily informed by animal models, may mainly be acting to modulate dopamine, serotonin and opioid signaling [40, 42, 47, 48, 127, 128, 152] in fronto-striatal and amygdalo-striatal systems [102, 150, 151] as well as synaptic plasticity and neural excitability changes…”
Sex-Gender Comparisons in Comorbidities of Children and Adolescents With High-Functioning Autism Spectrum Disorder
Margari, L., Palumbi, R., Peschechera, A., Craig, F., de Giambattista, C., Ventura, P., & Margari, F. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00159 · Cited by 56
Father Absence in the Monogamous California Mouse Impairs Social Behavior and Modifies Dopamine and Glutamate Synapses in the Medial Prefrontal Cortex
Bambico, F. R., Lacoste, B., Hattan, P. R., & Gobbi, G. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht310 · Cited by 48
Oxytocin differentially affects sucrose taking and seeking in male and female rats
Zhou, L., Ghee, S. M., See, R. E., & Reichel, C. M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.01.050 · Cited by 45
The neurocircuitry involved in oxytocin modulation of methamphetamine addiction
Baracz, S. J., & Cornish, J. L. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.08.001 · Cited by 46
“…system and ventral tegmental area extend to oxytocin nuclei in the hypothalamus, hippocampus and amygdala (Baskerville et al., 2009) and oxytocinergic fibres innervate mesocorticolimbic DA cell bodies in the ventral tegmental area that then terminate in the NAc (Baskerville and Douglas, 2010).”
BackgroundInfluential
Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease
Sakakibara, R., Kishi, M., Ogawa, E., Tateno, F., Uchiyama, T., Yamamoto, T., & Yamanishi, T. (2011) · Parkinson's Disease · doi:10.4061/2011/924605 · Cited by 118
“Role of dopamine in female sexual function remains not completely clear [241].”
Background

Authors: Baskerville, T. A., & Douglas, A. J.
Affiliations: University of Glasgow (GB)
University of Edinburgh (GB)
Corresponding author: Baskerville, Tracey A.
Venue: CNS Neuroscience & Therapeutics
Publisher: Wiley
Published: 2010-05-06
Volume: 16
Issue: 3
Pages: e92-123
ISSN: 1755-5930 (ISSN-L)
1755-5949
DOI: 10.1111/j.1755-5949.2010.00154.x
PMC: PMC6493805
OpenAlex: W1556392272
Cited by: 377
References: 301
Citations by year: 2026: 18 · 2025: 24 · 2024: 30 · 2023: 15 · 2022: 19 · 2021: 39 · 2020: 23 · 2019: 29 · 2018: 21 · 2017: 26 · 2016: 26 · 2015: 19 · 2014: 22 · 2013: 28 · 2012: 22
FWCI: 2.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: CNS Neuroscience & Therapeutics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Pfizer
Wellcome Trust
Medical Research Council
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: dopamine, oxytocin, social behavior, autism spectrum disorder, depression, drug addiction, anorexia nervosa, bulimia nervosa, sexual dysfunction, mesolimbic dopamine system, social attachment
MeSH terms: Animals, Behavior, Behavior, Animal, Behavioral Symptoms, Central Nervous System, Dopamine, Female, Humans, Male, Neurochemistry, Oxytocin, Pair Bond, Receptors, Dopamine, Sexual Behavior, Social Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks