Cited by 377Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

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Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders

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Baskerville, Tracey A., Douglas, Alison J.·2010·CNS Neuroscience & Therapeutics

DOI 10.1111/j.1755-5949.2010.00154.xPMC PMC6493805

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Abstract

Dopamine is an important neuromodulator that exerts widespread effects on the central nervous system (CNS) function. Disruption in dopaminergic neurotransmission can have profound effects on mood and behavior and as such is known to be implicated in various neuropsychiatric behavioral disorders including autism and depression. The subsequent effects on other neurocircuitries due to dysregulated dopamine function have yet to be fully explored. Due to the marked social deficits observed in psychiatric patients, the neuropeptide, oxytocin is emerging as one particular neural substrate that may be influenced by the altered dopamine levels subserving neuropathologic‐related behavioral diseases. Oxytocin has a substantial role in social attachment, affiliation and sexual behavior. More recently, it has emerged that disturbances in peripheral and central oxytocin levels have been detected in some patients with dopamine‐dependent disorders. Thus, oxytocin is proposed to be a key neural substrate that interacts with central dopamine systems. In addition to psychosocial improvement, oxytocin has recently been implicated in mediating mesolimbic dopamine pathways during drug addiction and withdrawal. This bi‐directional role of dopamine has also been implicated during some components of sexual behavior. This review will discuss evidence for the existence dopamine/oxytocin positive interaction in social behavioral paradigms and associated disorders such as sexual dysfunction, autism, addiction, anorexia/bulimia, and depression. Preliminary findings suggest that whilst further rigorous testing has to be conducted to establish a dopamine/oxytocin link in human disorders, animal models seem to indicate the existence of broad and integrated brain circuits where dopamine and oxytocin interactions at least in part mediate socio‐affiliative behaviors. A profound disruption to these pathways is likely to underpin associated behavioral disorders. Central oxytocin pathways may serve as a potential therapeutic target to improve mood and socio‐affiliative behaviors in patients with profound social deficits and/or drug addiction.

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Untitled work
(1943) · The Nervous child · Cited by 8,870
The rat nervous system
Paxinos, G. (1985) · Cited by 3,715
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Autistic disturbances of affective contact.
Kanner, L. (1968) · PubMed · Cited by 2,282
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · cited 1×
“In addition to the NA [84], the VTA also supplies dopaminergic fibers to the hippocampus and amygdala [85] suggesting that dopamine–oxytocin interactions within these nuclei may also have a bi-directional role.”
Background
Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence
Mattick, R. P., Breen, C., Kimber, J., & Davoli, M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002209.pub2 · Cited by 1,654
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,497 · cited 1×
“, SN) [214], and increased CSF or plasma oxytocin levels [26,215] are evident compared to women who are not mothers.”
Background
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356

Show all 301 references

Research works printed but not linked: 13

10.1016/0306-4522(93)90285-N · DOI · Paper page
10.1210/jc.75.3.855 · DOI
Kendirci M, 2004, Intranasall apomorphine Nastech pharmaceutical, Idrugs, 7, 483
10.1038/35053579 · DOI · Paper page
Everitt BJ, 1998, Differential induction of C‐FOS in limbic and hypothalamic structures by primary and secondary reinforcers, Eur J Neurosci, 10, 157
10.1038/35053579 · DOI · Paper page
10.1016/0028-3908(90)90095-9 · DOI · Paper page
10.1016/0306-4530(94)90062-0 · DOI
10.1016/j.physbeh.2007.04.012 · DOI
10.1016/j.physbeh.2007.04.012 · DOI
Leng G, 2009, The handbook of behaviour, diet and nutrition
Ingram CD, 2005, Techniques in the behavioural and neural sciences series, 609
10.1016/j.pbb.2008.07.002 · DOI

Sorted by citations

Items 201–300 of 376

Role of central oxytocin and dopamine systems in nociception and their possible interactions: suggested hypotheses
Gamal‐Eltrabily, M., & Manzano-García, A. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0068 · Cited by 14
Precision medicine in substance use disorders: Integrating behavioral, environmental, and biological insights
Guerrin, C. G. J., Tesselaar, D. R. M., Booij, J., Schellekens, A., & Homberg, J. R. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106311 · Cited by 15
“For example, baseline oxytocin levels or their reactivity to social stimuli may reflect the functioning of the oxytocin-dopamine system, a key neurobiological pathway underlying social bonding and motivation (Baskerville and Douglas, 2010; Vitale and Smith, 2022).”
An epistasis between dopaminergic and oxytocinergic systems confers risk of post-traumatic stress disorder in a traumatized Chinese cohort
Zhang, K., Li, G., Wang, L., Cao, C., Fang, R., Luo, S., Liu, P., & Zhang, X. (2019) · Scientific Reports · doi:10.1038/s41598-019-55936-8 · Cited by 14
Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder
Siecinski, S. K., Giamberardino, S. N., Spanos, M., Hauser, A. C., Gibson, J., Chandrasekhar, T., Trelles, M. D. P., Rockhill, C., Palumbo, M. L., Cundiff, A. W., et al. (2023) · Autism Research · doi:10.1002/aur.2884 · Cited by 15
Paradigm shift in consciousness research: the child′s self‐awareness and abnormalities in autism, ADHD and schizophrenia
Lou, H. C. (2011) · Acta Paediatrica · doi:10.1111/j.1651-2227.2011.02456.x · Cited by 14
“dysfunctional oxytocin ⁄ dopamine interaction in the pathophysiology of autism (42).”
Background
Oxytocinergic modulation of brain activation to cues related to reproduction and attachment: differences and commonalities during the perception of erotic and fearful social scenes
Sauer, C., Montag, C., Reuter, M., & Kirsch, P. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.06.005 · Cited by 13
The Role of Oxytocin and Vasopressin in Drug-Induced Reward—Implications for Social and Non-Social Factors
Wronikowska‐Denysiuk, O., Mrozek, W., & Budzyńska, B. (2023) · Biomolecules · doi:10.3390/biom13030405 · Cited by 13
Acupuncture and oxytocinergic system: The promising treatment for autism
Su, T., & Pei, L. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2021-0011 · Cited by 13
“Animal studies have shown that OT acts on serotoninergic and dopaminergic neurons and participates in many forms of social behaviors [54].”
Background
Intracranial Self-stimulation of the Paraventricular Nucleus of the Hypothalamus
Ewan, E. E., & Martin, T. J. (2012) · Anesthesiology · doi:10.1097/aln.0b013e3182518be3 · Cited by 13
“These effects likely arise from release of oxytocin from the PVN into limbic and forebrain regions, where oxytocin may interact with dopamine neurotransmission to modulate aspects of drug addiction.(5) For instance, PVN oxytocin fibers project to the VTA,(8) which expresses oxytocin receptor messenger RNA,(9) and intr…”
Background
Salsolinol Up‐Regulates Oxytocin Expression and Release During Lactation in Sheep
Górski, K., Marciniak, E., Zielińska-Górska, M. K., & Misztal, T. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12362 · Cited by 13
Acute oxytocin effects in inferring others’ beliefs and social emotions in people at clinical high risk for psychosis
Schmidt, A., Davies, C., Paloyelis, Y., Meyer, N., Micheli, A. D., Ramella‐Cravaro, V., Provenzani, U., Aoki, Y. Y., Rutigliano, G., Cappucciati, M., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00885-4 · Cited by 14
Effects of Metabolic Programming on Juvenile Play Behavior and Gene Expression in the Prefrontal Cortex of Rats
Hehar, H., Ma, I., & Mychasiuk, R. (2016) · Developmental Neuroscience · doi:10.1159/000444015 · Cited by 13
Effect of Natural Rewards on Substance Use Disorder: An Incentive Sensitization Perspective
Zheng, W., Liu, X., Lu, T., Yuan, K., Li, X., Xue, Y.-X., Yin, Q., Shi, J., Zou, G., Grimm, J. W., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.05.026 · Cited by 11
When Your Body Tells You to Not Breastfeed—The Connivance of Oxytocin, Prolactin, and Dopamine
Kraus, V., Čižmárová, B., & Birková, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125909 · Cited by 16
The Mediating Role of Positive Attitudes on the Relationship Between Esports Gaming Hours and Psychological Well-Being During the COVID-19 Pandemic
Shan, D., Dai, Z., Ge, F., Zhang, Y., Zheng, Y., Gao, X., & Han, J. (2023) · Cureus · doi:10.7759/cureus.36334 · Cited by 12
“The resulting social connections can either be newly established or consolidated, helping release neurotransmitters such as dopamine and oxytocin, which can enhance emotional functions and promote personal well-being [34-36].”
Background
Schizophrenia and alcohol dependence: Diverse clinical effects of oxytocin and their evolutionary origins
Pedersen, C. A. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.050 · Cited by 11
The role of schizotypal traits and the OXTR gene in theory of mind in schizophrenia: A family-based study
Giralt‐López, M., Miret, S., Soler, J., Campanera, S., Parellada, M., Fañanás, L., & Fatjó‐Vilas, M. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2019.17 · Cited by 12
“Also, animal models of psychosis have shown that OXT administration reduces dopaminergic hyperactivity in the striatum and nucleus accumbens [19] in a similar manner to antipsychotic medications [20,21].”
Background
Oxytocin does not stand alone
Putnam, P. T., & Chang, S. W. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0047 · Cited by 13
“However, links between oxytocin and the dopaminergic system are arguably the most well understood [64].”
Background
Different Oxytocin Responses to Acute Methamphetamine Treatment in Juvenile Female Rats Perinatally Exposed to Stress and/or Methamphetamine Administration
Holubová, A., Poništ, S., Jur̀čovičová, J., & Šlamberová, R. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00305 · Cited by 13
Environmental enrichment enhances ethanol preference over social reward in male swiss mice: Involvement of oxytocin-dopamine interactions
Rae, M. B., Gomes, I., Spelta, L. E. W., Bailey, A., Marcourakis, T., Devi, L. A., & Camarini, R. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109971 · Cited by 11
Pengaruh Hypnobreastfeeding Terhadap Produksi ASI
Pratiwi, Y. S., Handayani, S., & Alfarizi, L. M. (2018) · Jurnal Kesehatan Qamarul Huda · doi:10.37824/jkqh.v6i2.2018.45 · Cited by 11
Artificially elevated oxytocin concentrations in pet dogs are associated with higher proximity-maintenance and gazing towards the owners
Pedretti, G., Wirobski, G., Range, F., & Marshall‐Pescini, S. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113451 · Cited by 11
“Oxytocin may interact with the dopaminergic system during social interactions [81], increasing the individual’s intrinsic social motivation [9].”
Background
Oxytocin receptor genotype and low economic privilege reverses ventral striatum-social anxiety association
Gonzalez, M. Z., Puglia, M. H., Morris, J. P., & Connelly, J. J. (2017) · Social Neuroscience · doi:10.1080/17470919.2017.1403954 · Cited by 10
“…available in high economic privilege environments may help C-carriers mitigate risk either by epigenetically tuning OXTR expression (Puglia, Lillard, Morris, & Connelly, 2015) in the VS or via indirect action on other neurotransmitter systems, like dopamine (Baskerville & Douglas, 2010).”
Background
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Lin, S., Chen, P. S., Lee, L.-T., Lee, S.-Y., Tsai, H. C., Chen, W. T., Chen, K. C., Lee, I. H., Lu, R., & Yang, Y. K. (2018) · European Addiction Research · doi:10.1159/000485563 · Cited by 11
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Hansen, N. C., & Keller, P. E. (2021) · Behavioral and Brain Sciences · doi:10.1017/s0140525x20001235 · Cited by 11
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Ingrosso, C., Corricelli, M., Testolin, A., Pifferi, V., Bettazzi, F., Bianco, G. V., Depalo, N., Fanizza, E., Striccoli, M., Palchetti, I., et al. (2023) · Materials Advances · doi:10.1039/d3ma00785e · Cited by 11
Postnatal genistein administration selectively abolishes sexual dimorphism in specific hypothalamic dopaminergic system in mice
Ponti, G., Farinetti, A., Marraudino, M., Panzica, G., & Gotti, S. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146434 · Cited by 11
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Reese, M. A., Bryant, D. J., & Ethridge, L. E. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.009 · Cited by 14
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Kovatsi, L., & Nikolaou, K. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.05.003 · Cited by 9
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McPartland, J. C., Tillman, R. M., Yang, D. Y. ‐., Bernier, R., & Pelphrey, K. A. (2014) · Wiley eBooks · doi:10.1002/9781118911389.hautc20 · Cited by 10
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Cantabella, E., Camilleri, V., Cavalié, I., Dubourg, N., Gagnaire, B., Charlier, T. D., Adam‐Guillermin, C., Cousin, X., & Armant, O. (2022) · Cancers · doi:10.3390/cancers14153793 · Cited by 11
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Chen, Y., Sun, J., Tao, J., & Sun, T. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1322486 · Cited by 14
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Reybrouck, M., Podlipniak, P., & Welch, D. (2024) · Behavioral Sciences · doi:10.3390/bs14090825 · Cited by 9
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Matsushita, H., & Nishiki, T. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.02.026 · Cited by 11
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Kankaynar, M., Sulukan, E., Yıldırım, S., Şenol, O., Atakay, M., Baran, A., Kılıçlıoğlu, M., Bolat, İ., Yildiz, E., Ceyhun, H. A., et al. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.127229 · Cited by 9
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Morales, J. M., Skipwith, C. G., & Clark, H. A. (2015) · Sensors · doi:10.3390/s150819912 · Cited by 9
“of neurodegenerative disorders, such as Alzheimer’s, Huntington’s, and Parkinson’s disease [3,4].”
Background
SKF83959, an agonist of phosphatidylinositol-linked dopamine receptors, prevents renewal of extinguished conditioned fear and facilitates extinction
Chen, F.-F., Wang, C., Chen, H., Wang, J., Han, Q.-Q., Cao, Y., Shen, T., Yang, Y., Hu, Z., Wang, F., et al. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147136 · Cited by 9
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Blum, K., Badgaiyan, R. D., & Gold, M. S. (2015) · Cureus · doi:10.7759/cureus.290 · Cited by 11
“Hypersexuality-induced withdrawal symptoms have been reported by some investigators with varying degrees of severity and co-morbid substance abuse [41-45].”
Background
Retracted
The potential of oxytocin as a therapeutic target for psychiatric disorders
Martinetz, S., & Neumann, I. D. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1129403 · Cited by 9
“social interactions.[13] Moreover, there is also evidence for OXT interactions with the glutamatergic system, specifically with mGluR5 in the septum.”
Background
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Scarboro, S. M., López, M. F., & Becker, H. C. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.08.006 · Cited by 7
The role of the Oxytocin-Neurophysin I gene in contributing to human personality traits promoting sociality
Chong, A., Chew, S. H., Lai, P. S., Ebstein, R. P., & Gouin, J. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.02.015 · Cited by 8
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Haas, B. W., Smith, A. K., & Nishitani, S. (2018) · Personality Neuroscience · doi:10.1017/pen.2018.7 · Cited by 8
“Interestingly, the OT and dopamine systems have been shown to interact with one another to influence the way many social and cognitive tasks are performed (Baskerville & Douglas, 2010; Love et al., 2012; Rosenfeld, Lieberman, & Jarskog, 2011).”
Exploratory and agile behaviors with central dopaminergic activities in open field tests in Formosan wood mice (Apodemus semotus)
Shieh, K., & Yang, S.-C. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.199356 · Cited by 8
Oxytocin and dopamine in psychostimulant-induced changes in social behaviour
Díaz, F. C., Neumann, I. D., & Rappeneau, V. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101200 · Cited by 8
“Anatomically, OXT and DA signalling components co-localise in key reward and social cognition regions, including the VTA, NAc, hypothalamus, and amygdala (Baskerville and Douglas, 2010; Buijs et al., 1984).”
Emerging role of substance and energy metabolism associated with neuroendocrine regulation in tumor cells
Liu, Y., Gu, R., Gao, M., Wei, Y., Shi, Y., Wang, X., Gu, Y.-H., Gu, X., & Zhang, H. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1126271 · Cited by 9
Functional Polymorphisms in Oxytocin and Dopamine Pathway Genes and the Development of Dispositional Compassion Over Time: The Young Finns Study
Dobewall, H., Saarinen, A. I. L., Lyytikäinen, L., Keltikangas‐Järvinen, L., Lehtimäki, T. J., & Hintsanen, M. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.576346 · Cited by 13
“Oxytocin and dopamine are known to interact (Baskerville and Douglas, 2010; Feldman et al., 2012).”
Background
Disturbance of the reciprocal-interaction between the OXTergic and DAergic systems in the CNS causes atypical social behavior in syntaxin 1A knockout mice
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Neuroimaging genetics of oxytocin: A transcriptomics-informed systematic review
Prata, D. P., & Silva, M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104912 · Cited by 7
“…animal evidence demonstrating OT to regulate the amount of dopamine that is released in response to rewarding stimuli and support the current robust hypothesis of an OT-dopamine interplay in the human brain (Baskerville and Douglas, 2010), which for now is still in requirement of direct evidence.”
Psychometric Properties, Factor Structure, and Validity of the Sensitivity to Threat and Affiliative Reward Scale in Children and Adults
Perlstein, S., Wagner, N. J., Domínguez-Álvarez, B., Fraguela, J. A. G., Romero, E., López‐Romero, L., & Waller, R. E. (2022) · Assessment · doi:10.1177/10731911221128946 · Cited by 8
“Similarly, distinct genetically mediated neurotransmitter pathways are thought to differentially give rise to the processing of fear-related (Holsboer & Ising, 2009) versus affiliative cues (Baskerville & Douglas, 2010; Panksepp et al., 1994).”
Background
Molecular cloning, expression and variation analyses of the dopamine D2 receptor gene in pig breeds in China
Xu, H. P., He, X., Fang, M., Hu, Y., Jia, X. Z., Nie, Q. H., & Zhang, X. Q. (2011) · Genetics and Molecular Research · doi:10.4238/2011.december.5.6 · Cited by 7
Prolonged functional cerebral asymmetry as a consequence of dysfunctional parvocellular paraventricular hypothalamic nucleus signaling: An integrative model for the pathophysiology of bipolar disorder
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Emerging therapeutic landscape on delivery of oxytocin to brain for treating neurological disorders
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Pregnancy and the Opioid Epidemic
Saia, K., Jones, H. E., & Terplan, M. (2017) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-017-0116-y · Cited by 6
Interaction between central GABAA receptor and dopaminergic system on food intake in neonatal chicks: role of D1and GABAAreceptors
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“Dopamine (DA) is a main catecholamine neurotransmitter in the CNS. Dopaminergic (DAergic) neurons expressed in different nucleus of the brain include the substantia nigra, ventral tegmental area (VTA), nucleus accumbance (NAcc) and hypothalamus [10].”
BackgroundInfluential
Human-Human and Human-Animal Interaction : Some Common Physiological and Psychological Effects
Handlin, L. (2010) · Cited by 6
Group singing and its effect on cortisol, alpha amylase, oxytocin, and pain threshold in patients with Parkinson's disease
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“The anxiolytic effect of oxytocin would be given by an action via serotoninergic pathways, which are also involved in depressive disorders; these findings are inherent in animal models only (Baskerville and Douglas, 2010).”
Background
Modulation of empathic abilities by the interplay between estrogen receptors and arginine vasopressin
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“…’ perception and resonance with others ’ emotions by modulating brain levels of neuro-transmitters such as dopamine and oxytocin, as well as gene expressions related to social cognition and behavior, thereby influencing empathy, sympathy, and prosocial behaviors (Baskerville and Douglas, 2010).”
Background
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“OT modulates several key systems involved in addiction processes, including opioid and dopamine mesolimbic reward circuitry, and hypothalamic – pituitary – adrenal (HPA) axis and corticotrophin-releasing factor (CRF) stress systems [3, 4].”
Background
Neural systems supporting and affecting economically relevant behavior
Braeutigam, S. (2012) · Neuroscience and Neuroeconomics · doi:10.2147/nan.s25038 · Cited by 6
“Although progress is clearly being made (eg, in the area of dopamine and oxytocin interactions 65 ), still very little is known about the precise nature of the mutual actions of such systems.”
Individual variation in the attribution of incentive salience to social cues
Fitzpatrick, C. J., & Morrow, J. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-59378-5 · Cited by 5
“OXT was measured because it modulates DA release in response to social stimuli (Baskerville and Douglas, 2010) and regulates the salience of social cues (Shamay-Tsoory and Abu-Akel, 2016).”
Background
Distinct promoter regions of the oxytocin receptor gene are hypomethylated in Prader-Willi syndrome and in Prader-Willi syndrome associated psychosis
Heseding, H. M., Jahn, K., Eberlein, C. K., Wieting, J., Maier, H. B., Proskynitopoulos, P. J., Glahn, A., Bleich, S., Frieling, H., & Deest, M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02014-9 · Cited by 5
“Nonetheless, plasma OT levels do not necessarily reflect central OT levels, as OT is secreted both centrally via axon terminals and peripherally into the bloodstream via the neurohypophysis [37].”
Background
Hypothesis on supine sleep, sudden infant death syndrome reduction and association with increasing autism incidence
Bergman, N. (2016) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v5.i3.330 · Cited by 7
Female Sexual Function
Marson, L., & Wesselmann, U. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00045-0 · Cited by 5
Sex and Sexual Addiction in the United States of America: An Overview of Its Epidemiology, Management and Prevention Strategies
Bk, A., Oti, V. B., & Usman, B. A. (2018) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.1000366 · Cited by 5
Human-human and human-animal interaction
Handlin, L. (2010) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) · Cited by 5
Improvised herding: Mapping biobehavioral mechanisms that underlie group efficacy during improvised social interaction
Greenberg, D. M., Milstein, N., Gilboa, A., Cohen, S., Haimovich, N., Siegman, S., Pinhasi, S., & Gordon, I. (2023) · Psychophysiology · doi:10.1111/psyp.14307 · Cited by 4
Increased social reward behavior in adolescent male and female rats exposed prenatally to alcohol is associated with altered dopamine receptor expression
Sheehan, A. C., Leonetti, A. M., Murray, S. H., Dhaliwal, R., Stamp, M. A., Holman, P. J., McCormick, C. M., & Raineki, C. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107705 · Cited by 6
“Furthermore, OT can enhance dopamine release in regions such as the VTA and NAcc during social behaviors such as pup grooming in female rats (Shahrokh et al., 2010), thereby amplifying the salience of social cues (Baskerville and Douglas, 2010).”
Reducing social media use decreases loneliness regardless of gender or level of social comparisons in youth with anxiety and depression: A randomized controlled trial
Goldfield, G. S., Lopes, M. V., Mahboob, W., Perry, S., & Davis, C. G. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121331 · Cited by 4
Music Listening as Kangaroo Mother Care: From Skin-to-Skin Contact to Being Touched by the Music
Reybrouck, M. (2024) · Acoustics · doi:10.3390/acoustics6010003 · Cited by 5
Is It in Our Genes: Oxytocin, Dopamine, Stress, and Sex
Abi‐Dargham, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.007 · Cited by 4
Prolonged efavirenz exposure reduces peripheral oxytocin and vasopressin comparable to known drugs of addiction in male Sprague Dawley rats
Roux, M. L., Möller, M., & Harvey, B. H. (2021) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2021.06.003 · Cited by 4
Differential temporal decline of cerebral oxytocin and μ‐opioid receptor density during the aging process in mice
Effah, F., Nidadavolu, P., Silva, N. K. D. G. T., Wojtowicz, M., Camarini, R., Zimmer, A., & Bailey, A. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16578 · Cited by 4
“Given the well-characterised OT interaction with the dopamine system, which is implicated in regulating socioemotional and sexual behaviour (Baskerville & Douglas, 2010), it is conceivable that this age-related OTR decline may be related to the age-related changes in the dopaminergic system.”
A computational perspective on social attachment
Chumbley, J. R., & Steinhoff, A. (2019) · Infant Behavior and Development · doi:10.1016/j.infbeh.2018.12.001 · Cited by 4
Oxytocin and addiction
McGregor, I. S., & Bowen, M. T. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.018 · Cited by 4
The role of intranasal oxytocin in anxiety and depressive disorders: a systematic review of randomized controlled trials
Cagna, F. D., Fusar‐Poli, L., Damiani, S., & Mori, A. (2018) · doi:10.26226/morressier.5b681764b56e9b005965c55b · Cited by 4
Neuroendocrine Effects of Short-Bout Aerobic Exercises in Individuals With Alcohol Use Disorder: A Quasi-experimental Study
Shaik, R., Ravada, V. R. A., Yeddu, P., & Lalitha, D. L. (2025) · Cureus · doi:10.7759/cureus.78921 · Cited by 3
“In drug-addicted individuals, oxytocin can be considered a therapeutic target to improve mood and socio ‐ affiliative behaviors [32-34].”
Oxytocin and opioid antagonists: A dual approach to improving social behavior
Monte, O. D., Gangopadhyay, P., Putnam, P. T., & Chang, S. W. C. (2025) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15376 · Cited by 3
“27,28 OTmodulatesdopaminergicactivityinkeyreward-related regions, including the ventral tegmental area (VTA), nucleus accumbens (NAcc), ventral pallidum, and dorsal and ventral striatum.”
Oxytocin as a treatment for high-risk psychosis or early stages of psychosis: a mini review
Bargiota, S. I., Papakonstantinou, A., & Christodoulou, G. N. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1232776 · Cited by 3
Epistatic interactions between oxytocin- and dopamine-related genes and trust
Koyama, Y., Nawa, N., Ochi, M., Surkan, P. J., & Fujiwara, T. (2024) · PLoS ONE · doi:10.1371/journal.pone.0308728 · Cited by 3
“Oxytocin and dopamine receptors are co-expressed in regions of the brain related to social functioning, such as the striatum and pre-frontal cortex, and are associated with similar social and affiliative behaviors [23,24].”
Epigenetic Control in Schizophrenia
D’Addario, C., & Bartolomeo, M. D. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-75980-2_5 · Cited by 3
Oxytocin Neuropeptide in the Control of Drug Dependence: A Review of Past Studies and Future Challenges
Esmaili‐Shahzade‐Ali‐Akbari, P., Bozorgnia, A., Shaterian, M., Jandaghian, S., & Shahri, S. M. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70197 · Cited by 3
“Hence, it seems that OXT can be a potential therapeutic target for improving mood and behaviors of social dependence and drug addiction (Baskerville and Douglas 2010; Sundar et al. 2021).”
Interaction Between Oxytocin and Dopamine Signaling: Focus on the Striatum
Guidolin, D., Tortorella, C., Cervetto, C., Marcoli, M., Maura, G., & Agnati, L. F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178711 · Cited by 3
Are We missing out the role of oxytocin in overactive bladder syndrome?
Cangüven, Ö., & Talib, R. A. (2019) · The Aging Male · doi:10.1080/13685538.2019.1577376 · Cited by 3
“It has emerged that disturbances in peripheral and central OT levels have been detected in some patients with dopamine-dependent disorders [32].”
Background
Lack of association between severity of ADHD symptoms and salivary oxytocin levels
Boyle, D., Levi-Shachar, O., Gvirts, H. Z., Zagoory‐Sharon, O., Feldman, R., Bloch, Y., Nitzan, U., & Maoz, H. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105293 · Cited by 4
Lack of Association between Parental ABO Blood Type and Autism Spectrum Disorders
Wu, Z.-T., Zhang, W., Zhang, S., Yu, J., Lei, H., Wang, W.-Z., & Liu, X. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00342.x · Cited by 3
“These risk factors include genetics, environmental factors, prenatal and perinatal factors, and neuroanatomical abnormalities [2].”
Background
Savant Skills, Special Skills, and Intelligence Vary Widely in Autism
Waterhouse, L. H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-415961-7.00006-x · Cited by 3
The Creative Mind: Blending Oxytocinergic, Dopaminergic and PersonalityPreprint
Chong, A., Becker, B., Angeles, D. C., Matos, M. G., Yue, X., Lai, P. S., Cheung, M. W. ‐., Lei, Z., Malavasi, F., Chew, S. H., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/700807 · Cited by 3
Nesfatin1 attenuates autism-like behavior via antioxidant, anti-inflammatory activities in a prenatal valproic acid-induced rat model of autism
Farbin, M., Hajisoltani, R., Baluchnejadmojarad, T., Hejazi, A., Ahmed, T., Parsian, H., & Mehrabi, S. (2025) · Neuropeptides · doi:10.1016/j.npep.2025.102561 · Cited by 2
Emotional Intelligence: A Human-Centred AI Perspective
Gámez, M. E. (2026) · Springer eBooks · doi:10.1007/978-981-97-8440-0_109-1 · Cited by 2
Serum Oxytocin Level Among Male Patients With Opioid Dependence and Its Relation to Craving
Mobasher, M. W., Fathy, H., Soliman, A., El-Hanafi, H., & El-Makawi, S. M. (2020) · Addictive Disorders & Their Treatment · doi:10.1097/adt.0000000000000231 · Cited by 3
“It is therefore likely that OT interferedwith thedevelopment ofphysical dependence and a lower degree of physical dependence resulted in the appearance of less severewithdrawal signs.(14) As stress has been found to be an important factor influencing heroin and other substance abuse behaviors such as craving, it is pl…”
BackgroundResult
Raga Therapy for Autism
Chauhan, N. B., Kale, M., & Naik, N. (2022) · MedPress Neurology and Neurosurgery · doi:10.33582/mpnns.2022.202201002 · Cited by 2
Gut Microbiome-Mediated Mechanisms in Alleviating Opioid Addiction with Aqueous Extract of Anacyclus pyrethrum
Baslam, A., Kabdy, H., Chait, Y., Azraida, H., Yazouli, L. E., Aboufatima, R., Chait, A., & Baslam, M. (2024) · Biomedicines · doi:10.3390/biomedicines12061152 · Cited by 3
“…with previous studies that have consistently reported the presence of depressive-and anxious-like behaviors as common withdrawal Furthermore, the dependent groups displayed a depressive-like behavior, characterized by an increased immobility time in the FST. symptoms associated with OUD [38–41].”
Background
Hormonal imprinting in the central nervous system: causes and consequences
Csaba, G. (2013) · Orvosi Hetilap · doi:10.1556/oh.2013.29533 · Cited by 3
Molecular characterization, expression profile, and polymorphism of goose dopamine D1 receptor gene
Wang, C., Liu, Y. T., Wang, H., Wu, H., Gong, S., & He, D. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3149-y · Cited by 2
“DA is a vital neurotransmitter in the central nervous system and an important hormone in the periphery, exerts widespread effects on the neuroendocrine secretion, behavioral and physiological functions, such as the control of movement, cognition and emotion [6–8].”
Background
Oxytocin ameliorates the deleterious effect of pain in adult male rats
Nessren, M. A. E.-R., Omyma, G. A., Ebtihal, A. A. E.-A., Ayman, M., & Amel, T. (2017) · Journal of Physiology and Pathophysiology · doi:10.5897/jpap2016.0107 · Cited by 2
“For many years, OXT was widely known for its peripheral role in milk letdown and uterine contractions (Baskerville and Douglas, 2010).”
Background
The relation of stress coping strategies and self-handicapping strategies to the process of opiate addicts behavior changes
Jovanović, M., Dickov, A., Kajtez, M., Dickov, V., & Dragisic, T. (2017) · Vojnosanitetski pregled · doi:10.2298/vsp170222047j · Cited by 4
“Some recent biological studies also indicate that social attachments protect against addiction and health consequences of stress, whereas drug abuse and chronic stress can undermine social attachments (28,29).”
Background

Authors: Baskerville, T. A., & Douglas, A. J.
Affiliations: University of Glasgow (GB)
University of Edinburgh (GB)
Corresponding author: Baskerville, Tracey A.
Venue: CNS Neuroscience & Therapeutics
Publisher: Wiley
Published: 2010-05-06
Volume: 16
Issue: 3
Pages: e92-123
ISSN: 1755-5930 (ISSN-L)
1755-5949
DOI: 10.1111/j.1755-5949.2010.00154.x
PMC: PMC6493805
OpenAlex: W1556392272
Cited by: 377
References: 301
Citations by year: 2026: 18 · 2025: 24 · 2024: 30 · 2023: 15 · 2022: 19 · 2021: 39 · 2020: 23 · 2019: 29 · 2018: 21 · 2017: 26 · 2016: 26 · 2015: 19 · 2014: 22 · 2013: 28 · 2012: 22
FWCI: 2.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: CNS Neuroscience & Therapeutics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Pfizer
Wellcome Trust
Medical Research Council
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: dopamine, oxytocin, social behavior, autism spectrum disorder, depression, drug addiction, anorexia nervosa, bulimia nervosa, sexual dysfunction, mesolimbic dopamine system, social attachment
MeSH terms: Animals, Behavior, Behavior, Animal, Behavioral Symptoms, Central Nervous System, Dopamine, Female, Humans, Male, Neurochemistry, Oxytocin, Pair Bond, Receptors, Dopamine, Sexual Behavior, Social Behavior

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Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders

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