Cited by 377Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

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Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders

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Baskerville, Tracey A., Douglas, Alison J.·2010·CNS Neuroscience & Therapeutics

DOI 10.1111/j.1755-5949.2010.00154.xPMC PMC6493805

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Abstract

Dopamine is an important neuromodulator that exerts widespread effects on the central nervous system (CNS) function. Disruption in dopaminergic neurotransmission can have profound effects on mood and behavior and as such is known to be implicated in various neuropsychiatric behavioral disorders including autism and depression. The subsequent effects on other neurocircuitries due to dysregulated dopamine function have yet to be fully explored. Due to the marked social deficits observed in psychiatric patients, the neuropeptide, oxytocin is emerging as one particular neural substrate that may be influenced by the altered dopamine levels subserving neuropathologic‐related behavioral diseases. Oxytocin has a substantial role in social attachment, affiliation and sexual behavior. More recently, it has emerged that disturbances in peripheral and central oxytocin levels have been detected in some patients with dopamine‐dependent disorders. Thus, oxytocin is proposed to be a key neural substrate that interacts with central dopamine systems. In addition to psychosocial improvement, oxytocin has recently been implicated in mediating mesolimbic dopamine pathways during drug addiction and withdrawal. This bi‐directional role of dopamine has also been implicated during some components of sexual behavior. This review will discuss evidence for the existence dopamine/oxytocin positive interaction in social behavioral paradigms and associated disorders such as sexual dysfunction, autism, addiction, anorexia/bulimia, and depression. Preliminary findings suggest that whilst further rigorous testing has to be conducted to establish a dopamine/oxytocin link in human disorders, animal models seem to indicate the existence of broad and integrated brain circuits where dopamine and oxytocin interactions at least in part mediate socio‐affiliative behaviors. A profound disruption to these pathways is likely to underpin associated behavioral disorders. Central oxytocin pathways may serve as a potential therapeutic target to improve mood and socio‐affiliative behaviors in patients with profound social deficits and/or drug addiction.

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Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans
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Release of oxytocin within the supraoptic nucleus during the milk ejection reflex in rats
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Both oxytocin and vasopressin may influence alloparental behavior in male prairie voles
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Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits
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Randomized Placebo-Controlled Trial of Baclofen for Cocaine Dependence
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Oxytocin and Vasopressin Receptors and Species-Typical Social Behaviors
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Central neural regulation of penile erection.
Giuliano, F., & Rampin, O. (2000) · Neuroscience and Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00020-8 · Cited by 210
Brief vs. long maternal separations in infancy: contrasting relationships with adult maternal behavior and lactation levels of aggression and anxiety
Boccia, M. L., & Pedersen, C. A. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00019-1 · Cited by 210
The chronoarchitecture of the human brain—natural viewing conditions reveal a time-based anatomy of the brain
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Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male rats
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Role of monoamines in the control of hormones of sexual receptivity in the female rat.
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Chapter 1 Brain preparations for maternity — adaptive changes in behavioral and neuroendocrine systems during pregnancy and lactation. An overview
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The role of oxytocin in relation to female sexual arousal
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Metabolic hormones, dopamine circuits, and feeding
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The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals
Argiolas, A., & Melis, M. R. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.019 · Cited by 179
The main olfactory system and social learning in mammals
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Reproduction‐Induced Neuroplasticity: Natural Behavioural and Neuronal Alterations Associated with the Production and Care of Offspring
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Neurochemistry of the paraventricular nucleus of the hypothalamus: Implications for cardiovascular regulation
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Genes Controlling Affiliative Behavior as Candidate Genes for Autism
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Paraventricular nucleus lesion prevents yawning and penile erection induced by apomorphine and oxytocin but not by ACTH in rats
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Brain circuits regulating energy homeostasis
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Emotional Stress Triggers Intrahypothalamic But Not Peripheral Release of Oxytocin in Male Rats
Engelmann, Ebner, Landgraf, Holsboer, & Wotjak (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00403.x · Cited by 170
Chapter 10 Alterations in behavioral and neuroendocrine stress coping strategies in pregnant, parturient and lactating rats
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Six-Month Trial of Bupropion With Contingency Management for Cocaine Dependence in a Methadone-Maintained Population
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Has dopamine a physiological role in the control of sexual behavior?
Paredes, R. G., & Ågmo, A. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.001 · Cited by 163
Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders
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Paternal care in rodents: Weakening support for hormonal regulation of the transition to behavioral fatherhood in rodent animal models of biparental care
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Localization of oxytocin receptor messenger ribonucleic acid in the rat brain.
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Oxytocin improves male copulatory performance in rats
Arletti, R., Bazzani, C., Castelli, M., & Bertolini, A. (1985) · Hormones and Behavior · doi:10.1016/0018-506x(85)90002-9 · Cited by 155
Neuronal activation in the hypothalamus and brainstem during feeding in rats
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In vivo imaging of synaptic function in the central nervous system
Nikolaus, S., Antke, C., & Müller, H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.008 · Cited by 153
EXTRAHYPOTHALAMIC NEUROPHYSIN-CONTAINING PERIKARYA, FIBER PATHWAYS AND FIBER CLUSTERS IN THE RAT BRAIN
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Autoantibodies against neuropeptides are associated with psychological traits in eating disorders
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Chapter 22 Cardiovascular effects of oxytocin
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EFFECTS OF MESOLIMBIC DOPAMINE DEPLETION ON RESPONDING MAINTAINED BY COCAINE AND FOOD
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Focal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis study
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Role of oxytocin in the neuroadaptation to drugs of abuse
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Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat
Véronneau-Longueville, F., Rampin, O., Freund‐Mercier, M. J., Tang, Y., Calas, A., Marson, L., McKenna, K. E., Stoeckel, M. E., Benoît, G., & Giuliano, F. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00262-6 · Cited by 140
Increased anxiety and impaired memory in rats 3 months after administration of 3,4-methylenedioxymethamphetamine (“Ecstasy”)
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Peripheral Pulses of Oxytocin Increase Partner Preferences in Female, but Not Male, Prairie Voles
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Release of oxytocin in the hypothalamic paraventricular nucleus, but not central amygdala or lateral septum in lactating residents and virgin intruders during maternal defence
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Paraventricular oxytocin neurons are involved in neural modulation of breathing
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Tiagabine increases cocaine‐free urines in cocaine‐dependent methadone‐treated patients: results of a randomized pilot study
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The Size and Distribution of Midbrain Dopaminergic Populations are Permanently Altered by Perinatal Glucocorticoid Exposure in a Sex- Region- and Time-Specific Manner
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Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges
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Oxytocinergic and serotonergic innervation of identified lumbosacral nuclei controlling penile erection in the male rat.
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Central neuropharmacological agents and mechanisms in erectile dysfunction: the role of dopamine
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Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin
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An Effect on the Subjective Sexual Response in Premenopausal Women with Sexual Arousal Disorder by Bremelanotide (PT-141), a Melanocortin Receptor Agonist
Diamond, L. E., Earle, D. C., Heiman, J. R., Rosen, R. C., Perelman, M. A., & Harning, R. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00268.x · Cited by 115
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Oxytocin Involvement in SSRI-Induced Delayed Ejaculation: A Review of Animal Studies
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Neuroendocrine mechanisms of change in food intake during pregnancy: A potential role for brain oxytocin
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Oxytocin for Induction of Labor
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A microdialysis study of ventral striatal dopamine during sexual behavior in female Syrian hamsters
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Increased Fos Expression in Oxytocin Neurons Following Masculine Sexual Behavior
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Light microscopic autoradiographic localization of [3H]oxytocin binding sites in the rat brain, pituitary and mammary gland
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See all 377

Authors: Baskerville, T. A., & Douglas, A. J.
Affiliations: University of Glasgow (GB)
University of Edinburgh (GB)
Corresponding author: Baskerville, Tracey A.
Venue: CNS Neuroscience & Therapeutics
Publisher: Wiley
Published: 2010-05-06
Volume: 16
Issue: 3
Pages: e92-123
ISSN: 1755-5930 (ISSN-L)
1755-5949
DOI: 10.1111/j.1755-5949.2010.00154.x
PMC: PMC6493805
OpenAlex: W1556392272
Cited by: 377
References: 301
Citations by year: 2026: 18 · 2025: 24 · 2024: 30 · 2023: 15 · 2022: 19 · 2021: 39 · 2020: 23 · 2019: 29 · 2018: 21 · 2017: 26 · 2016: 26 · 2015: 19 · 2014: 22 · 2013: 28 · 2012: 22
FWCI: 2.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: CNS Neuroscience & Therapeutics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Pfizer
Wellcome Trust
Medical Research Council
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: dopamine, oxytocin, social behavior, autism spectrum disorder, depression, drug addiction, anorexia nervosa, bulimia nervosa, sexual dysfunction, mesolimbic dopamine system, social attachment
MeSH terms: Animals, Behavior, Behavior, Animal, Behavioral Symptoms, Central Nervous System, Dopamine, Female, Humans, Male, Neurochemistry, Oxytocin, Pair Bond, Receptors, Dopamine, Sexual Behavior, Social Behavior

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Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders

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