The interplay between glutamatergic circuits and oxytocin neurons in the hypothalamus and its relevance to neurodevelopmental disorders
Open accessAbstract
Oxytocin (OXT) neurons of the hypothalamus are at the center of several physiological functions, including milk ejection, uterus contraction, and maternal and social behavior. In lactating females, OXT neurons show a pattern of burst firing and inter-neuron synchronization during suckling that leads to pulsatile release of surges of OXT into the bloodstream to stimulate milk ejection. This pattern of firing and population synchronization may be facilitated in part by hypothalamic glutamatergic circuits, as has been observed in vitro using brain slices obtained from male rats and neonates. However, it remains unknown how hypothalamic glutamatergic circuits influence OXT cell activity outside the context of lactation. In this review, we summarize the in vivo and in vitro studies that describe the synchronized burst firing pattern of OXT neurons and the implication of hypothalamic glutamate in this pattern of firing. We also make note of the few studies that have traced glutamatergic afferents to the hypothalamic paraventricular and supraoptic nuclei. Finally, we discuss the genetic findings implicating several glutamatergic genes in neurodevelopmental disorders, including autism spectrum disorder, thus underscoring the need for future studies to investigate the impact of these mutations on hypothalamic glutamatergic circuits and the OXT system.
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Glutamatergic circuits within the hypothalamus play a role in the release of oxytocin.
“given the role of glutamatergic circuits within the hypothalamus in the release of oxytocin (52)”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [52]
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- Authors
- Leithead, A. B., Tasker, J. G., & Harony‐Nicolas, H.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Tulane University (US)
- Corresponding author
- Harony‐Nicolas, Hala
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2021-11-16
- Volume
- 33
- Issue
- 12
- Pages
- e13061-e13061
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- PMC
- PMC8951898
- OpenAlex
- W3212146801
- Cited by
- 26
- References
- 186
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 1 · 2021: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroendocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH116108)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin neurons, hypothalamus, glutamatergic circuits, glutamate, burst firing, neuronal synchronization, paraventricular nucleus, supraoptic nucleus, glutamatergic afferents, neurodevelopmental disorders, autism spectrum disorder, lactation, milk ejection, social behavior
- MeSH terms
- Animals, Cell Communication, Female, Humans, Hypothalamus, Male, Nerve Net, Neurons, Oxytocin, Glutamic Acid, Rats, Neurodevelopmental Disorders
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