micro RNA Let‐7b: A Novel treatment for endometriosis
Open accessAbstract
Endometriosis is an oestrogen-dependent, chronic inflammatory disease that affects 10% of reproductive-aged women. Current treatment options depend on female sex steroid hormone modulation; however, all have side effects and are not useful in women who want to conceive. microRNAs treatments have provided promising results for some chronic diseases and cancers. We have previously shown the microRNA Let-7b is repressed in endometriosis and that loss of Let-7 contributes to the pathophysiology of the disease. Here, we propose using microRNA Let-7b for the treatment of endometriosis in a murine model. Endometriosis was treated using microRNA Let-7b or a scrambled control microRNA. Let-7b treatment resulted in reduced endometriosis lesion size. Decreased gene expression was noted in several genes known to promote endometriosis growth including ER-α, ER-ß, Cyp19a, KRAS 4A, KRAS 4B and IL-6. These results indicate that microRNA Let-7b has a pleiotropic role in endometriosis pathophysiology affecting oestrogen signalling, inflammation and growth factor receptors. Local treatment of endometriosis with Let-7b is a promising therapy for endometriosis that simultaneously affects multiple pathways driving endometriosis without systemic hormonal side effects.
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Altered expression of miR449b3p in endometriosis affects development of the disease.
“Liu et al. suggested that miR449b3p altered expression in endometriosis affects the development of the disease [159].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [159]
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- Authors
- Sahin, C., Mamillapalli, R., Yi, K. W., & Taylor, H. S.
- Affiliations
- Department of Obstetrics, Gynecology and Reproductive Sciences Yale School of Medicine New Haven Connecticut
- Yale University (US)
- Corresponding author
- Taylor, Hugh S.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2018-07-31
- Volume
- 22
- Issue
- 11
- Pages
- 5346-5353
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC6201226
- OpenAlex
- W2886983271
- Cited by
- 64
- References
- 49
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 10 · 2023: 6 · 2022: 5 · 2021: 13 · 2020: 6 · 2019: 8 · 2018: 1
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NIH R01 HD076422, NIH U54 HD052668)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- endometriosis, miRNA-based therapy, estrogen signaling, estrogen receptor alpha, estrogen receptor beta, cyp19a, KRAS, interleukin-6, inflammation, local therapy, mouse model
- MeSH terms
- Animals, Aromatase, Disease Models, Animal, Endometriosis, Female, Gene Expression Regulation, Humans, Inflammation, Signal Transduction, Interleukin-6, Proto-Oncogene Proteins p21(ras), MicroRNAs, Estrogen Receptor alpha, Estrogen Receptor beta, Mice
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