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Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies
Open accessAbstract
Aims/Introduction: The aim of the present study was to investigate the association between diabetes and the risk of all type dementia ( ATD ), A lzheimer's disease ( AD ) and vascular dementia ( VaD ). Materials and Methods: Prospective observational studies describing the incidence of ATD , AD and VaD in patients with diabetes mellitus were extracted from PubMed, EMBASE and other databases up to January 2012. Pooled relative risk ( RR ) estimates and 95% confidence intervals ( CI s) were calculated using the random‐effects model. Subgroup analyses and sensitivity analysis were also carried out. Results: A total of 28 studies contributed to the analysis. Pooled RR of developing ATD ( n = 20) was 1.73 (1.65–1.82, I 2 = 71.2%), AD ( n = 20) was 1.56 (1.41–1.73, I 2 = 9.8%) and VaD ( n = 13) was 2.27 (1.94–2.66, I 2 = 0%) in patients with diabetes mellitus. Higher and medium quality studies did not show any significant difference for pooled RR for ATD , AD or VaD . Sensitivity analyses showed robustness of pooled RR among ATD , AD and VaD , showing no single study had a major impact on pooled RR . Conclusions: The results showed a 73% increased risk of ATD , 56% increase of AD and 127% increase of VaD in diabetes patients.
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“These factors include hypertension 85,[105][106][107] and diabetes.[108][109][110]”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [108]
In the citing paper
“A meta-analysis of prospective and observational studies in PWD showed a 73% increased risk of all types of dementia, a 56% increased risk of Alzheimer dementia, and a 127% increased risk of vascular dementia compared with individuals without diabetes (115).”
From Psychosocial care for people with diabetes: a position statement of the American Diabetes Association (2016) · cites this paper as [115]
In the citing paper
“A meta-analysis of prospective and observational studies in PWD showed a 73% increased risk of all types of dementia, a 56% increased risk of Alzheimer dementia, and a 127% increased risk of vascular dementia compared with individuals without diabetes (115).”
From Psychosocial care for people with diabetes: a position statement of the American Diabetes Association (2016) · cites this paper as [115]
In the citing paper
“A meta-analysis of prospective and observational studies in PWD showed a 73% increased risk of all types of dementia, a 56% increased risk of Alzheimer dementia, and a 127% increased risk of vascular dementia compared with individuals without diabetes (115).”
From Psychosocial care for people with diabetes: a position statement of the American Diabetes Association (2016) · cites this paper as [115]
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“Several experimental and clinical studies have investigated the effect of diabetes and hyperglycemia on synaptic plasticity and cognition (Gudala et al. 2013; Gupta et al. 2022; Li et al. 2018; Schernhammer et al. 2011).”
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Metadata
- Authors
- Gudala, K., Bansal, D., Schifano, F., & Bhansali, A.
- Affiliations
- National Institute of Pharmaceutical Education and Research (IN)
- University of Hertfordshire (GB)
- Post Graduate Institute of Medical Education and Research (IN)
- Corresponding author
- Bansal, Dipika
- Venue
- Journal of Diabetes Investigation
- Publisher
- Wiley
- Published
- 2013-04-26
- Volume
- 4
- Issue
- 6
- Pages
- 640-650
- ISSN
- 2040-1116 (ISSN-L)
- 2040-1124
- PMC
- PMC4020261
- OpenAlex
- W2035873080
- Cited by
- 727
- References
- 57
- Citations by year
- 2026: 69 · 2025: 90 · 2024: 73 · 2023: 61 · 2022: 84 · 2021: 61 · 2020: 80 · 2019: 66 · 2018: 37 · 2017: 44 · 2016: 35 · 2015: 20 · 2014: 5
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Diabetes Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- diabetes mellitus, dementia, Alzheimer's disease, vascular dementia, dementia risk, incidence, type 2 diabetes
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