Cited by 727Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

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Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies

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Gudala, Kapil, Bansal, Dipika, Schifano, Fabrizio, Bhansali, Anil·2013·Journal of Diabetes Investigation

DOI 10.1111/jdi.12087PMC PMC4020261

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Abstract

Aims/Introduction: The aim of the present study was to investigate the association between diabetes and the risk of all type dementia ( ATD ), A lzheimer's disease ( AD ) and vascular dementia ( VaD ). Materials and Methods: Prospective observational studies describing the incidence of ATD , AD and VaD in patients with diabetes mellitus were extracted from PubMed, EMBASE and other databases up to January 2012. Pooled relative risk ( RR ) estimates and 95% confidence intervals ( CI s) were calculated using the random‐effects model. Subgroup analyses and sensitivity analysis were also carried out. Results: A total of 28 studies contributed to the analysis. Pooled RR of developing ATD ( n = 20) was 1.73 (1.65–1.82, I 2 = 71.2%), AD ( n = 20) was 1.56 (1.41–1.73, I 2 = 9.8%) and VaD ( n = 13) was 2.27 (1.94–2.66, I 2 = 0%) in patients with diabetes mellitus. Higher and medium quality studies did not show any significant difference for pooled RR for ATD , AD or VaD . Sensitivity analyses showed robustness of pooled RR among ATD , AD and VaD , showing no single study had a major impact on pooled RR . Conclusions: The results showed a 73% increased risk of ATD , 56% increase of AD and 127% increase of VaD in diabetes patients.

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Additional file 5 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S. J. H., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746397
Additional file 11 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S. J. H., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746382
Additional file 3 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746391
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Additional file 6 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S. J. H., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746400
Additional file 1 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S. J. H., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746385
Additional file 8 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746406
Additional file 7 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S. J. H., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746403
Additional file 4 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S. J. H., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746394
Additional file 10 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S. J. H., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746379
Additional file 2 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S. J. H., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746388
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Additional file 1 of The relationship between diabetes and the dementia risk: a meta-analysis
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Additional file 9 of Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: ‘OPTIMISE your health’ trial protocol
Brakenridge, C. J., Gardiner, P. A., Grigg, R., WINKLER, E. A. H., Fjeldsoe, B. S., Schaumberg, M. A., Owen, N. G., Eakin, E., Biddle, S. J. H., Moodie, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19746409
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Kounatidis, D. C., & Rebelos, E. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00339-3
Cognitive Performance in Middle-Aged Adults with Type 2 Diabetes: Normative Comparisons and Associations with Medical and Psychological Variables
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Integrative Multimodal Subtyping, Risk of Incident Mild Cognitive Impairment, and Differential Cardiometabolic Treatment Effects: A Prospective Cohort Study in the All of Us Research ProgramPreprint
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Cognitive risk and resilience in diabetes involving APOE ε4 and alpha klotho: a narrative review
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“Gudala et al. [12] reported a 73% higher risk compared to non-diabetics, while Cao et al. [13] estimated a 59% higher risk.”
A neuroimaging functional connectivity signature of emotional conflict monitoring predicting cognitive decline in type 2 diabetes
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“…model for cognitive declination in type 2 diabetes patients based on common neural mechanisms emphasizing cognitive control regions observed across different clinical disorders reported in recent fMRI meta-analytical studies 15 , given their documented increased risk for all-cause dementia 24 .”
Cognitive decline and neurodegenerative risk in diabetes and aging
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Introduction of neurobiology and type 2 diabetes
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Etude génotypique et phénotypique des polymorphismes du récepteur du complément de type 1 (CR1,CD35) dans la maladie d’Alzheimer
Mahmoudi, A.-E.-R. (2015) · theses.fr (ABES) · doi:10.70675/5f05520ez1713z4991za6c8z055ab117e2bb
Integrating Plasma and Renal Biomarkers for Alzheimer’s Disease Diagnosis: A Systematic Review and Meta-Analysis of the Brain–Kidney AxisPreprint
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Développement de formes vectorisables innovantes dans le cadre de maladies liées à l'âge
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Diabète et risque de démence
Frison, É. (2019) · theses.fr (ABES) · doi:10.70675/a527bd03zb814z44e5z8848z942b662a0847
Étude épidémiologique de la relation entre exposome alimentaire et vieillissement cérébral : du nutriment candidat à une approche systémique
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Connexion des désordres métaboliques à l’émergence tumorale : régulation de l’acide gras synthase (FAS) par O-GlcNAcylation et mTOR au cours de la prolifération cellulaire hépatique
Raab, S. (2021) · theses.fr (ABES) · doi:10.70675/1a19d9c0z667az40c4za4daz0c728bbcb2ee
Caractérisation des mécanismes moléculaires impliqués dans la mise en place des altérations cérébrales dans un modèle préclinique de diabète de type 2
Hamzé, R. (2023) · theses.fr (ABES) · doi:10.70675/3ac7f72cz196fz4796z99a3z89271cd76677
Implications de la signalisation de la protéine kinase activée par l’AMP (AMPK) dans les dysfonctions mitochondriales, la pathologie amyloïde et Tau, et la neuroinflammation dans la maladie d’Alzheimer
Mary, A. (2022) · theses.fr (ABES) · doi:10.70675/868e288ezd237z49c1z866fzf618e1462aab
Contribution à l'étude des facteurs de risque pour la maladie d'Alzheimer : analyse de candidats identifiés par étude d'association pangénomique ou GWAS
Bauer, C. (2023) · theses.fr (ABES) · doi:10.70675/0d82043ezd7c7z4fb4z9fc8ze2d05d18b02b
SAGE-DM—Senescence-Associated Gluco-Endocrinopathy Diabetes Mellitus: comprehensive review
Szklarz, M., Wołos-Kłosowicz, K., Modzelewska, J., Górny, J. M., Modzelewski, R., & Matuszewski, W. (2026) · European journal of medical research · doi:10.1186/s40001-026-04445-2
“…A meta-analysis of more than 1 million people with diabetes estimated a pooled RR of dementia as 1․73 (95% CI 1․65–1․82), or a 73% increased risk [107]․ A second meta-analysis of 114 potential studies found that people with diabetes were 1․5 times more likely to develop AD, two times more likely…”
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Mehta, K., Gong, J. Y., Santoso, J. A., Salim, A., Stephan, B. C. M., Anstey, K. J., Shaw, J. E., & Magliano, D. J. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261442227
Exploring the Research Progress of Vascular Dementia and Key Regulatory Molecules: E2F1
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“…risk factors for cardiovascular and cerebrovascular diseases are also risk factors for vascular dementia, mainly including poor dietary habits [8], obesity [9], hypertension [10], hypercholesterolemia [11], excessive alcohol consumption [12], diabetes [13], smoking [14], and lack of exercise [15].”
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Revision of Energy Metabolism Adaptations in High-Level Athletes: From Physical Performance Enhancement to Potential Therapeutic Targets in Mental Disorders
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Impact of Microvascular Complication Burden on the Risk of Dementia and Cognitive Decline in Patients With Diabetes: A Systematic Review of Latest Evidence
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Authors: Gudala, K., Bansal, D., Schifano, F., & Bhansali, A.
Affiliations: National Institute of Pharmaceutical Education and Research (IN)
University of Hertfordshire (GB)
Post Graduate Institute of Medical Education and Research (IN)
Corresponding author: Bansal, Dipika
ORCID: Bansal, Dipika
Schifano, Fabrizio
Bhansali, Anil
Venue: Journal of Diabetes Investigation
Publisher: Wiley
Published: 2013-04-26
Volume: 4
Issue: 6
Pages: 640-650
ISSN: 2040-1116 (ISSN-L)
2040-1124
DOI: 10.1111/jdi.12087
PMC: PMC4020261
OpenAlex: W2035873080
Cited by: 727
References: 57
Citations by year: 2026: 69 · 2025: 90 · 2024: 73 · 2023: 61 · 2022: 84 · 2021: 61 · 2020: 80 · 2019: 66 · 2018: 37 · 2017: 44 · 2016: 35 · 2015: 20 · 2014: 5
FWCI: 14.22
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Diabetes Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: diabetes mellitus, dementia, Alzheimer's disease, vascular dementia, dementia risk, incidence, type 2 diabetes

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Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies

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