Cited by 727Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

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Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies

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Gudala, Kapil, Bansal, Dipika, Schifano, Fabrizio, Bhansali, Anil·2013·Journal of Diabetes Investigation

DOI 10.1111/jdi.12087PMC PMC4020261

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Abstract

Aims/Introduction: The aim of the present study was to investigate the association between diabetes and the risk of all type dementia ( ATD ), A lzheimer's disease ( AD ) and vascular dementia ( VaD ). Materials and Methods: Prospective observational studies describing the incidence of ATD , AD and VaD in patients with diabetes mellitus were extracted from PubMed, EMBASE and other databases up to January 2012. Pooled relative risk ( RR ) estimates and 95% confidence intervals ( CI s) were calculated using the random‐effects model. Subgroup analyses and sensitivity analysis were also carried out. Results: A total of 28 studies contributed to the analysis. Pooled RR of developing ATD ( n = 20) was 1.73 (1.65–1.82, I 2 = 71.2%), AD ( n = 20) was 1.56 (1.41–1.73, I 2 = 9.8%) and VaD ( n = 13) was 2.27 (1.94–2.66, I 2 = 0%) in patients with diabetes mellitus. Higher and medium quality studies did not show any significant difference for pooled RR for ATD , AD or VaD . Sensitivity analyses showed robustness of pooled RR among ATD , AD and VaD , showing no single study had a major impact on pooled RR . Conclusions: The results showed a 73% increased risk of ATD , 56% increase of AD and 127% increase of VaD in diabetes patients.

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Authors: Gudala, K., Bansal, D., Schifano, F., & Bhansali, A.
Affiliations: National Institute of Pharmaceutical Education and Research (IN)
University of Hertfordshire (GB)
Post Graduate Institute of Medical Education and Research (IN)
Corresponding author: Bansal, Dipika
ORCID: Bansal, Dipika
Schifano, Fabrizio
Bhansali, Anil
Venue: Journal of Diabetes Investigation
Publisher: Wiley
Published: 2013-04-26
Volume: 4
Issue: 6
Pages: 640-650
ISSN: 2040-1116 (ISSN-L)
2040-1124
DOI: 10.1111/jdi.12087
PMC: PMC4020261
OpenAlex: W2035873080
Cited by: 727
References: 57
Citations by year: 2026: 69 · 2025: 90 · 2024: 73 · 2023: 61 · 2022: 84 · 2021: 61 · 2020: 80 · 2019: 66 · 2018: 37 · 2017: 44 · 2016: 35 · 2015: 20 · 2014: 5
FWCI: 14.22
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Diabetes Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: diabetes mellitus, dementia, Alzheimer's disease, vascular dementia, dementia risk, incidence, type 2 diabetes

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Diabetes mellitus and risk of dementia: A meta‐analysis of prospective observational studies

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