Intramuscular fat and physical performance at the Framingham Heart Study
Open accessAbstract
Intramuscular fat may mediate associations between obesity and physical disability. We examined the associations between muscle attenuation, a proxy for intramuscular fat, and physical function. Paraspinous muscle computed tomography attenuation was obtained on a Framingham Heart Study subgroup (n = 1152, 56 % women, mean age 66 years). Regressions modeled cross-sectional associations between muscle attenuation and mobility disability, grip strength, and walking speed with standard covariates; models additionally adjusted for body mass index (BMI) and visceral adipose tissue (VAT). Separate models investigated associations between VAT and subcutaneous adipose tissue (SAT) and physical function. Per 1 standard deviation decrement in muscle attenuation (i.e., more muscle fat), we observed 1.29 (95 % CI = 1.11, 1.50; p = 0.0009) increased odds of walking speed ≤1 m/s in women and men. This persisted after separate BMI and VAT adjustments (p < 0.02). In men, there was a 1.29 kg (95 % CI = 0.57, 2.01; p = 0.0005) decrement in grip strength, which persisted after BMI and VAT adjustments (p ≤ 0.0004). For VAT and SAT, similar associations were not observed. Intramuscular fat is associated with increased odds of walking speed ≤1 m/s in both sexes and lower grip strength in men. There were no similar associations for VAT and SAT, highlighting the specificity of intramuscular fat in association with physical function.
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- Authors
- Therkelsen, K. E., Pedley, A., Hoffmann, U., Fox, C. S., & Murabito, J. M.
- Affiliations
- Boston University (US)
- Framingham Heart Study (US)
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Murabito, Joanne M.
- Venue
- AGE
- Published
- 2016-02-22
- Volume
- 38
- Issue
- 2
- Pages
- 31-31
- ISSN
- 0161-9152 (ISSN-L)
- 1574-4647
- PMC
- PMC5005897
- OpenAlex
- W2278224300
- Cited by
- 77
- References
- 46
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 11 · 2023: 4 · 2022: 14 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 3
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- AGE (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (Contract N01-HC-25195)
- National Institute on Aging (R0129451)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- intramuscular fat, muscle attenuation, physical function, mobility impairment, walking speed, grip strength, visceral adipose tissue, subcutaneous adipose tissue, body mass index, obesity, older adults
- MeSH terms
- Adult, Aged, Aging, Biopsy, Cross-Sectional Studies, Disability Evaluation, Female, Follow-Up Studies, Humans, Male, Middle Aged, Motor Activity, Obesity, Retrospective Studies, Risk Factors, United States, Incidence, Muscle, Skeletal, Subcutaneous Fat, Adiposity, Mobility Limitation, Multidetector Computed Tomography
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