Cited by 137Mindfulness and Compassion InterventionsSubstance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index; none of the 64 sources its claims cite is checked for support yet.

Restructuring reward processing with Mindfulness‐Oriented Recovery Enhancement: novel therapeutic mechanisms to remediate hedonic dysregulation in addiction, stress, and pain

Open access
Garland, Eric L.·2016·Annals of the New York Academy of Sciences

Abstract

Though valuation processes are fundamental to survival of the human species, hedonic dysregulation is at the root of an array of maladies, including addiction, stress, and chronic pain, as evidenced by the allostatic shift in the relative salience of natural reward to drug reward observed among persons with severe substance use disorders. To address this crucial problem, novel interventions are needed to restore hedonic regulatory processes gone awry in persons exhibiting addictive behaviors. This article describes a theoretical rationale and empirical evidence for the effects of one such new intervention, Mindfulness‐Oriented Recovery Enhancement (MORE), on top‐down and bottom‐up mechanisms implicated in cognitive control and hedonic regulation. MORE is innovative and distinct from extant mindfulness‐based interventions in that it unites traditional mindfulness meditation with reappraisal and savoring strategies designed to reverse the downward shift in salience of natural reward relative to drug reward, representing a crucial tipping point to disrupt the progression of addiction—a mechanistic target that no other behavioral intervention has been designed to address. Though additional studies are needed, clinical and biobehavioral data from several completed and ongoing trials suggest that MORE may exert salutary effects on addictive behaviors and the neurobiological processes that underpin them.

Overview

Integrity signals

Registry

Crossref · 10.1111/nyas.13034

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

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Claims the paper makes

43 Not checked yet · 16 Own interpretation · 3 Own result · 2 Own method · 1 No basis given

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Show all 51 claims

  • It may state two separate claims as one. 9
  • Probably not a substantial claim. 6
14 of 14
  • The paper relies on this without support.

    No other behavioral intervention has been designed to reverse the downward shift in salience of natural reward relative to drug reward.

    “representing a crucial tipping point to disrupt the progression of addiction, which no other behavioral intervention has been designed to do.”
  • The paper relies on this without support.

    Extant MBIs use mindfulness to disrupt elaborative processing rather than to guide and potentiate it.

    “extant MBIs ostensibly use mindfulness to disrupt elaborative processing rather than to guide and potentiate it.b”
  • The paper relies on this without support.

    Many existing MBIs eschew an explicit focus on promoting evaluative processing and therefore do not directly or intentionally engage in restructuring of learned responses.

    “While many existing MBIs use mindfulness to disrupt patterns of maladaptive associative learning, they eschew an explicit focus on promoting evaluative processing and therefore do not directly or intentionally engage in restructuring of learned responses.”
  • The paper relies on this without support.

    Few of the mechanistic targets examined in the MORE research program have been studied in other behavioral addiction treatments.

    “few of the mechanistic targets (e.g., reward responsiveness, addiction attentional bias) studied in the MORE research program have been explored in studies of other behavioral treatments for addiction (e.g., CBT, motivational interviewing).”
  • The paper relies on this without support.

    The range of treatment conditions against which MORE has been tested has been limited so far.

    “the range of treatment conditions to which this intervention has been compared has been limited to date.”
  • The paper relies on this without support.

    MORE combines mindfulness training with reappraisal and savoring techniques in one multimodal treatment.

    “MORE is a multimodal intervention that combines mindfulness training with reappraisal and savoring techniques”
6 of 6

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Citations

Cites

Show all 57 references

Research works printed but not linked: 3

  1. Garland E.L., 2013, Mindfulness‐Oriented Recovery Enhancement for Addiction, Stress, and Pain
  2. Cabanac M., 2010, Pleasures of the Brain, 113
  3. Garland E.L. A.Beck P.Hansen et al.2015.Integrated Mindfulness‐oriented recovery enhancement and physical health intervention for obese cancer survivors: preliminary results from a pilot randomized controlled trial. Poster presentation. 12th International Conference of the Society for Integrative Oncology. November 15 2015. Boston MA.

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Metadata

Authors
Garland, E. L.
Affiliations
University of Utah (US)
Corresponding author
Garland, Eric L.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2016-04
Volume
1373
Issue
1
Pages
25-37
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2314235134
Cited by
137
References
57
Citations by year
2026: 9 · 2025: 8 · 2024: 14 · 2023: 15 · 2022: 18 · 2021: 18 · 2020: 13 · 2019: 14 · 2018: 12 · 2017: 11 · 2016: 5
FWCI
2.07
Type
journal article
Language
en
Open access
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (NIH) (R34DA037005)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
Mindfulness-Oriented Recovery Enhancement, reward processing, addiction, substance use disorders, cognitive control, cognitive reappraisal, savoring, natural reward, drug reward, stress, chronic pain, mindfulness meditation
MeSH terms
Humans, Reward, Stress, Psychological, Behavior, Addictive, Treatment Outcome, Meditation, Chronic Pain, Mindfulness

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