Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction

Pierce, R. Christopher; Vanderschuren, Louk J.M.J.

doi:10.1016/j.neubiorev.2010.01.007

Cited by 115Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSubstance Abuse Treatment and Outcomes

Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction

Open access

Pierce, R. Christopher, Vanderschuren, Louk J.M.J.·2010·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2010.01.007PMC PMC2903634

Open this paper in CoChat — free account

Abstract

Cocaine addiction is a complex and multifaceted process encompassing a number of forms of behavioral plasticity. The process of acquiring and consuming drugs can be sufficiently risky and complicated that the casual drug user may choose not to act on every motivation to use drugs. The repetition of drug seeking and taking, however, often results in the gradual development of drug craving and compulsive drug seeking associated with addiction. Moreover, the complex sets of behaviors associated with drug addiction can become ingrained to such an extent that, when activated by drug-associated stimuli or exposure to the drug itself, the processes underlying drug seeking and taking are automatically engaged and very difficult to suppress. Here, we examine the hypothesis that aspects of cocaine seeking and taking become ingrained with repetition, thereby contributing to continued drug use despite a conscious desire to abstain. We also review emerging evidence indicating that neuronal circuits including the dorsolateral striatum play a particularly important role in the habitual aspects of drug seeking and taking.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2010.01.007

Cites

119 of 119 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A move to automaticity corresponds to increased weight of control taken by the dorsal striatum relative to the ventral striatum.
“A move to automaticity corresponds to increased weight of control taken by the dorsal striatum relative to the ventral striatum (Everitt & Robbins, 2005;Pierce and Vanderschuren, 2010).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Pierce and Vanderschuren, 2010
Impairments in frontal-executive function prevent effective inhibitory control of overlearned automatic drug use action schemas.
“Impairments in frontal-executive function prevent effective inhibitory control of overlearned, highly stereotyped, cognitive and behavioral repertoires for drug seeking and consumption, also known as automatic drug use action schemas, 15,16”
From Restructuring reward processing with Mindfulness‐Oriented Recovery Enhancement: novel therapeutic mechanisms to remediate hedonic dysregulation in addiction, stress, and pain (2016) · cites this paper as [15]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works
Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.
Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990) · PubMed · Cited by 2,422 · see citing works
The role of the basal ganglia in habit formation
Yin, H. H., & Knowlton, B. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1919 · Cited by 2,402 · see citing works
Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum
Kelly, P. H., Seviour, P. W., & Iversen, S. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90233-4 · Cited by 1,740 · see citing works
Learning and Memory Functions of the Basal Ganglia
Packard, M. G., & Knowlton, B. J. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142937 · Cited by 1,717 · see citing works
Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610 · see citing works
A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes
Tiffany, S. T. (1990) · Psychological Review · doi:10.1037/0033-295x.97.2.147 · Cited by 1,554 · see citing works
The primate basal ganglia: Parallel and integrative networks
Haber, S. N. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.10.003 · Cited by 1,479 · see citing works
The organization of the projection from the cerebral cortex to the striatum in the rat
McGeorge, A. J., & Faull, R. L. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90128-0 · Cited by 1,345 · see citing works
Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies
Vanderschuren, L. J. M. J., & Kalivas, P. W. (2000) · Psychopharmacology · doi:10.1007/s002130000493 · Cited by 1,337 · see citing works
Self-citation
Development of a rational scale to assess the harm of drugs of potential misuse
Nutt, D., King, L. A., Saulsbury, W., & Blakemore, C. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60464-4 · Cited by 1,302 · see citing works
A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
Pierce, R. C., & Kalivas, P. W. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00021-0 · Cited by 1,239 · see citing works
Self-citation
Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03095.x · Cited by 1,226 · see citing works
Specificity in the projection patterns of accumbal core and shell in the rat
Heimer, L., Zahm, D. S., Churchill, L., Kalivas, P. W., & Wohltmann, C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90202-y · Cited by 1,219 · see citing works
Putting a spin on the dorsal-ventral divide of the striatum
Voorn, P., Vanderschuren, L. J. M. J., Groenewegen, H. J., Robbins, T. W., & Pennartz, C. M. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.006 · Cited by 1,188 · see citing works
Self-citation
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Childress, A.-R., Jayne, M., Ma, Y., & Wong, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1544-06.2006 · Cited by 1,164 · see citing works
Evidence for Addiction-like Behavior in the Rat
Deroche-Gamonet, V., Belin, D., & Piazza, P. V. (2004) · Science · doi:10.1126/science.1099020 · Cited by 1,135 · see citing works
The role of the dorsomedial striatum in instrumental conditioning
Yin, H. H., Ostlund, S. B., Knowlton, B. J., & Balleine, B. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04218.x · Cited by 1,099 · see citing works
On the significance of subterritories in the “accumbens” part of the rat ventral striatum
Zahm, D. S., & Brog, J. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90202-d · Cited by 1,040 · see citing works
Incubation of cocaine craving after withdrawal
Grimm, J. W., Hope, B. T., Wise, R. A., & Shaham, Y. (2001) · Nature · doi:10.1038/35084134 · Cited by 1,003 · see citing works
Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli
Garavan, H., Pankiewicz, J., Bloom, A., Cho, J.-K., Sperry, L., Ross, T. J., Salmeron, B. J., Risinger, R., Kelley, D., & Stein, E. A. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1789 · Cited by 931 · see citing works
The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of abuse?
Pierce, R. C., & Kumaresan, V. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.016 · Cited by 913 · see citing works
Self-citation
Multiple Parallel Memory Systems in the Brain of the Rat
White, N. M., & McDonald, R. J. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2001.4008 · Cited by 888 · see citing works
Prefrontal Glutamate Release into the Core of the Nucleus Accumbens Mediates Cocaine-Induced Reinstatement of Drug-Seeking Behavior
McFarland, K., Lapish, C. C., & Kalivas, P. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03531.2003 · Cited by 884 · see citing works
The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics
Heidbreder, C. A., & Groenewegen, H. J. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.09.003 · Cited by 882 · see citing works
Neurobiology of relapse to heroin and cocaine seeking: a review
Shalev, U., Grimm, J. W., & Shaham, Y. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.1 · Cited by 880 · see citing works
Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat
Berendse, H. W., Graaf, Y. G.-D., & Groenewegen, H. J. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903160305 · Cited by 847 · see citing works
Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
Yin, H. H., Mulcare, S. P., Hilário, M. R. F., Clouse, E., Holloway, T., Davis, M. I., Hansson, A. C., Lovinger, D. M., & Costa, R. M. (2009) · Nature Neuroscience · doi:10.1038/nn.2261 · Cited by 818 · see citing works
Cognitive Strategies Dependent on the Hippocampus and Caudate Nucleus in Human Navigation: Variability and Change with Practice
Iaria, G., Petrides, M., Dagher, A., Pike, G. B., & Bohbot, V. D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05945.2003 · Cited by 799 · see citing works
A specific role for posterior dorsolateral striatum in human habit learning
Tricomi, E., Balleine, B. W., & O’Doherty, J. P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06796.x · Cited by 769 · see citing works
Coordination of Actions and Habits in the Medial Prefrontal Cortex of Rats
Killcross, S. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.4.400 · Cited by 748 · see citing works
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
Baker, D. L., McFarland, K., LAKE, R. W., Shen, H., Tang, X., Toda, S., & Kalivas, P. W. (2003) · Nature Neuroscience · doi:10.1038/nn1069 · Cited by 740 · see citing works
Drug Seeking Becomes Compulsive After Prolonged Cocaine Self-Administration
Vanderschuren, L. J. M. J., & Everitt, B. J. (2004) · Science · doi:10.1126/science.1098975 · Cited by 733 · see citing works
Self-citation
Striatal dopamine nerve terminal markers in human, chronic methamphetamine users
Wilson, J. M., Kalasinsky, K. S., Levey, A. I., Bergeron, C., Reiber, G. D., Anthony, R. M., Schmunk, G. A., Shannak, K. S., Haycock, J. W., & Kish, S. J. (1996) · Nature Medicine · doi:10.1038/nm0696-699 · Cited by 718 · see citing works
Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems
EVERITT, B. J., PARKINSON, J. A., OLMSTEAD, M. C., ARROYO, M., ROBLEDO, P., & ROBBINS, T. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09280.x · Cited by 708 · see citing works
Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
Belin, D., & Everitt, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.019 · Cited by 697 · see citing works
Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission
Kalivas, P. W., Volkow, N., & Seamans, J. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.005 · Cited by 657 · see citing works
Expectation of reward modulates cognitive signals in the basal ganglia
Kawagoe, R., Takikawa, Y., & Hikosaka, O. (1998) · Nature Neuroscience · doi:10.1038/1625 · Cited by 632 · see citing works
Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization
Pierce, R. C., Bell, K., Duffy, P., & Kalivas, P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01550.1996 · Cited by 624 · see citing works
Self-citation
Drug addiction: bad habits add up
Robbins, T. W., & Everitt, B. J. (1999) · Nature · doi:10.1038/19208 · Cited by 599 · see citing works
Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics
Gr�sser, S. M., Wrase, J., Klein, S., Hermann, D., Smolka, M. N., Ruf, M., Weber-Fahr, W., Flor, H., Mann, K., Braus, D. F., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1828-4 · Cited by 598 · see citing works
The pharmacological and anatomical substrates of the amphetamine response in the rat
Creese, I., & Iversen, S. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90834-3 · Cited by 583 · see citing works
Inactivation of dorsolateral striatum enhances sensitivity to changes in the action–outcome contingency in instrumental conditioning
YIN, H., KNOWLTON, B., & BALLEINE, B. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.07.012 · Cited by 532 · see citing works
Neuroplasticity in the mesolimbic dopamine system and cocaine addiction
Thomas, M. J., Kalivas, P. W., & Shaham, Y. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.77 · Cited by 513 · see citing works
Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
Ito, R., Robbins, T. W., & Everitt, B. J. (2004) · Nature Neuroscience · doi:10.1038/nn1217 · Cited by 501 · see citing works
An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens
Zahm, D. S. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00065-2 · Cited by 487 · see citing works
Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
Ito, R., Dalley, J. W., Robbins, T. W., & Everitt, B. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06247.2002 · Cited by 463 · see citing works
Incubation of cocaine craving after withdrawal: a review of preclinical data
Lü, L., Grimm, J. W., Hope, B. T., & Shaham, Y. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.027 · Cited by 446 · see citing works
Amphetamine Exposure Enhances Habit Formation
Nelson, A., & Killcross, S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4305-05.2006 · Cited by 445 · see citing works
Dissociation in Conditioned Dopamine Release in the Nucleus Accumbens Core and Shell in Response to Cocaine Cues and during Cocaine-Seeking Behavior in Rats
Ito, R., Dalley, J. W., Howes, S. R., Robbins, T. W., & Everitt, B. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07489.2000 · Cited by 441 · see citing works
The accumbens: beyond the core-shell dichotomy
Heimer, L., Alheid, G. F., de Olmos, J. S., Groenewegen, H. J., Haber, S. N., Harlan, R. E., & Zahm, D. S. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.3.354 · Cited by 418 · see citing works
Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats
Wise, R. A., Leeb, K., Pocock, D., Newton, P., Burnette, B., & Justice, J. B. (1995) · Psychopharmacology · doi:10.1007/bf02246140 · Cited by 406 · see citing works
Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation
Faure, A., Haberland, U., Condé, F., & Massioui, N. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3894-04.2005 · Cited by 402 · see citing works
Involvement of the dorsal striatum in cue-controlled cocaine seeking
Vanderschuren, L. J. M. J., Di Ciano, P., & Everitt, B. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0925-05.2005 · Cited by 393 · see citing works
Self-citation
Limbic-Striatal Memory Systems and Drug Addiction
Robbins, T. W. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4103 · Cited by 379 · see citing works
Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking
Wang, B., Shaham, Y., Zitzman, D., Azari, S., Wise, R. A., & You, Z.-B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0955-05.2005 · Cited by 369 · see citing works
Inactivation of the infralimbic prefrontal cortex reinstates goal-directed responding in overtrained rats
Coutureau, E., & Killcross, S. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.025 · Cited by 342 · see citing works
Amphetamine‐Induced time‐dependent sensitization of dopamine neurotransmission in the dorsal and ventral striatum: A microdialysis study in behaving rats
Paulson, P. E., & Robinson, T. E. (1995) · Synapse · doi:10.1002/syn.890190108 · Cited by 337 · see citing works
Direct Interactions between the Basolateral Amygdala and Nucleus Accumbens Core Underlie Cocaine-Seeking Behavior by Rats
Ciano, P. D., & Everitt, B. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1581-04.2004 · Cited by 333 · see citing works
Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex
Carlezon, & Wise, R. A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03112.1996 · Cited by 327 · see citing works
Compulsive drug seeking by rats under punishment: effects of drug taking history
Pelloux, Y., Everitt, B. J., & Dickinson, A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0805-0 · Cited by 323 · see citing works
Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving
Wong, D. F., Kuwabara, H., Schretlen, D. J., Bonson, K. R., Zhou, Y., Nandi, A., Brašić, J. R., Kimes, A. S., Maris, M. A., Kumar, A., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301194 · Cited by 311 · see citing works
Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens
Park, W.-K., Bari, A., Jey, A. R., Anderson, S. M., Spealman, R. D., Rowlett, J. K., & Pierce, R. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02916.2002 · Cited by 310 · see citing works
Self-citation
Cocaine Dependence and D2 Receptor Availability in the Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior
Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Frankel, W. G., Cooper, T., Kleber, H. D., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300420 · Cited by 306 · see citing works
Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen
Fuchs, R. A., Branham, R. K., & See, R. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5146-05.2006 · Cited by 298 · see citing works
Psychomotor stimulants and neuronal plasticity
Wolf, M. E., Sun, X., Mangiavacchi, S., & Chao, S. Z. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.006 · Cited by 288 · see citing works
Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior
Ciano, P. D. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00235-4 · Cited by 287 · see citing works
Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat
Caine, S. B., Heinrichs, S. C., Coffin, V. L., & Koob, G. F. (1995) · Brain Research · doi:10.1016/0006-8993(95)00598-k · Cited by 286 · see citing works
Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains
Porrino, L. J., Lyons, D., Smith, H. R., Daunais, J. B., & Nader, M. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5578-03.2004 · Cited by 276 · see citing works
Alcohol seeking by rats: action or habit?
Dickinson, A., Wood, N., & Smith, J. W. (2002) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/0272499024400016 · Cited by 268 · see citing works
Inhibitory Control in Rats Performing a Stop-Signal Reaction-Time Task: Effects of Lesions of the Medial Striatum and d-Amphetamine.
Eagle, D. M., & Robbins, T. W. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1302 · Cited by 252 · see citing works
Acquisition, maintenance and reinstatement of intravenous cocaine self-administration under a second-order schedule of reinforcement in rats: effects of conditioned cues and continuous access to cocaine
Arroyo, M., Markou, A., Robbins, T. W., & Everitt, B. J. (1998) · Psychopharmacology · doi:10.1007/s002130050774 · Cited by 251 · see citing works
24-h smoking abstinence potentiates fMRI-bold activation to smoking cues in cerebral cortex and dorsal striatum
McClernon, F. J., Kozink, R. V., Lutz, A. M., & Rose, J. E. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1436-9 · Cited by 244 · see citing works
Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys
Letchworth, S. R., Nader, M. A., Smith, H. R., Friedman, D. P., & Porrino, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02799.2001 · Cited by 239 · see citing works
Neural correlates of high and craving during cocaine self-administration using BOLD fMRI
Risinger, R. C., Salmeron, B. J., Ross, T. J., Amen, S. L., Sanfilipo, M., Hoffmann, R. G., Bloom, A. S., Garavan, H., & Stein, E. A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.03.030 · Cited by 234 · see citing works
Increased Responsiveness of Ventral Tegmental Area Dopamine Neurons to Glutamate after Repeated Administration of Cocaine or Amphetamine Is Transient and Selectively Involves AMPA Receptors
Zhang, X. F., Hu, X.-T., White, F. J., & Wolf, M. E. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36671-6 · Cited by 210 · see citing works
Enduring Resistance to Extinction of Cocaine-Seeking Behavior Induced by Drug-Related Cues
Weiss, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00238-x · Cited by 207 · see citing works
Effects of Cocaine Self-administration on Striatal Dopamine Systems in Rhesus Monkeys Initial and Chronic Exposure
Nader, M. A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00427-4 · Cited by 206 · see citing works
Why does the rapid delivery of drugs to the brain promote addiction?
Samaha, A., & Robinson, T. E. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.12.007 · Cited by 204 · see citing works
Cocaine-induced alterations in dopamine receptor signaling: Implications for reinforcement and reinstatement
Anderson, S. M., & Pierce, R. C. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.12.004 · Cited by 200 · see citing works
Self-citation
Time course of the development of the enhanced behavioral and biochemical responses to amphetamine after pretreatment with amphetamine
Kolta, M. G., Shreve, P. E., DESOUZA, V., & Uretsky, N. J. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90032-2 · Cited by 199 · see citing works
Conditioned reinforcing properties of stimuli paired with self-administered cocaine, heroin or sucrose: implications for the persistence of addictive behaviour
Ciano, P. D., & Everitt, B. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.005 · Cited by 193 · see citing works
The orbital cortex in rats topographically projects to central parts of the caudate-putamen complex
Schilman, E. A., Uylings, H. B. M., Graaf, Y. G.-D., Joel, D., & Groenewegen, H. J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.024 · Cited by 187 · see citing works
Repeated Cocaine Administration Alters Extracellular Glutamate in the Ventral Tegmental Area
Kalivas, P. W., & Duffy, P. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041497.x · Cited by 187 · see citing works
Involvement of the Olfactory Tubercle in Cocaine Reward: Intracranial Self-Administration Studies
Ikemoto, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09305.2003 · Cited by 183 · see citing works
The effects of cocaine: A shifting target over the course of addiction
Porrino, L. J., Smith, H. R., Nader, M. A., & Beveridge, T. J. R. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.040 · Cited by 178 · see citing works
Oral cocaine seeking by rats: Action or habit?
Miles, F. J., Everitt, B. J., & Dickinson, A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.5.927 · Cited by 175 · see citing works
Pharmacological and Environmental Determinants of Relapse to Cocaine-Seeking Behavior
Spealman, R. D., Barrett-Larimore, R. L., Rowlett, J. K., Platt, D. M., & Khroyan, T. V. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00049-0 · Cited by 173 · see citing works
Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking
Schmidt, H. D., Anderson, S. M., Famous, K. R., Kumaresan, V., & Pierce, R. C. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.068 · Cited by 170 · see citing works
Self-citation
Pattern of Intake and Drug Craving Predict the Development of Cocaine Addiction-like Behavior in Rats
Belin, D., Balado, É., Piazza, P. V., & Deroche‐Gamonet, V. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.031 · Cited by 165 · see citing works
The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats
See, R. E., Elliott, J. C., & Feltenstein, M. W. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0850-8 · Cited by 150 · see citing works
Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats
Rodd-Henricks, Z. A., McKinzie, D. L., Li, T.-K., Murphy, J. M., & McBride, W. J. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.038950 · Cited by 150 · see citing works
Augmented reinforcer value and accelerated habit formation after repeated amphetamine treatment
Nordquist, R. E., Voorn, P., Malsen, J. G. D. M., Joosten, R. N. J. M. A., Pennartz, C. M. A., & Vanderschuren, L. J. M. J. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.12.005 · Cited by 144 · see citing works
Self-citation
Striatal Dopamine Responses to Intranasal Cocaine Self-Administration in Humans
Cox, S. M. L., Benkelfat, C., Dagher, A., Delaney, J. S., Durand, F., McKenzie, S. A., Kolivakis, T., Casey, K. F., & Leyton, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.021 · Cited by 138 · see citing works
Effect of cocaine self-administration on dopamine D2 receptors in rhesus monkeys
Moore, R. J., Vinsant, S. L., Nader, M. A., Porrino, L. J., & Friedman, D. P. (1998) · Synapse · doi:10.1002/(sici)1098-2396(199809)30:1 · Cited by 134 · see citing works
D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement
Bari, A., & Pierce, R. C. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.048 · Cited by 131 · see citing works
Self-citation
Differential Effects of Nucleus Accumbens Core, Shell, or Dorsal Striatal Inactivations on the Persistence, Reacquisition, or Reinstatement of Responding for a Drug-Paired Conditioned Reinforcer
Ciano, P. D., Robbins, T., & Everitt, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301522 · Cited by 129 · see citing works
Inactivation of the Lateral But Not Medial Dorsal Striatum Eliminates the Excitatory Impact of Pavlovian Stimuli on Instrumental Responding
Corbit, L. H., & Janak, P. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4097-07.2007 · Cited by 122 · see citing works
6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: Effect on amphetamine-induced stereotyped behavior in rats
Asher, I. M., & Aghajanian, G. K. (1974) · Brain Research · doi:10.1016/0006-8993(74)90888-9 · Cited by 117 · see citing works
The Rate of Cocaine Administration Alters Gene Regulation and Behavioral Plasticity: Implications for Addiction
Samaha, A., Mallet, N. P., Ferguson, S. M., Gonon, F., & Robinson, T. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1205-04.2004 · Cited by 115 · see citing works
Transient role of the rat prelimbic cortex in goal‐directed behaviour
Tran‐Tu‐Yen, D. A. S., Marchand, A. R., Pape, J., Scala, G. D., & Coutureau, É. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06834.x · Cited by 114 · see citing works
Dynamic Encoding of Action Selection by the Medial Striatum
Kimchi, E. Y., & Laubach, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5206-08.2009 · Cited by 114 · see citing works
A Role for Conditioned Ventral Tegmental Glutamate Release in Cocaine Seeking
You, Z., Wang, B., Zitzman, D. L., Azari, S., & Wise, R. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2967-07.2007 · Cited by 106 · see citing works
The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration
Porrino, L. J., Daunais, J. B., Smith, H. R., & Nader, M. A. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.013 · Cited by 103 · see citing works
Behavioral and Neural Evidence of Incentive Bias for Immediate Rewards Relative to Preference-Matched Delayed Rewards
LUO, S. H., Ainslie, G. W., Giragosian, L., & Monterosso, J. R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4261-09.2009 · Cited by 94 · see citing works
An ethopharmacological approach to the development of drug addiction
Wolffgramm, J. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80142-3 · Cited by 92 · see citing works
Metabolic Mapping of the Effects of Cocaine during the Initial Phases of Self-Administration in the Nonhuman Primate
Porrino, L. J., Huston-Lyons, D., Miller, M. D., Smith, H. R., Friedman, D. P., Daunais, J. B., & Nader, M. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07687.2002 · Cited by 89 · see citing works
Effect of medial prefrontal cortex injections of SCH 23390 on intravenous cocaine self-administration under both a fixed and progressive ratio schedule of reinforcement
McGregor, A., & Roberts, D. C. S. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00106-p · Cited by 86 · see citing works
Role of dopamine D1-family receptors in dorsolateral striatum in context-induced reinstatement of heroin seeking in rats
Bossert, J. M., Wihbey, K. A., Pickens, C. L., Nair, S. G., & Shaham, Y. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1580-x · Cited by 78 · see citing works
Brain Dopamine Transporter Messenger RNA and Binding Sites in Cocaine Users
Little, K. Y., McLaughlin, D. P., Zhang, L., McFinton, P. R., Dalack, G. W., Cook, E. H., Cassin, B. J., & Watson, S. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.9.793 · Cited by 76 · see citing works
Cocaine self-administration appears to be mediated by dopamine uptake inhibition
Ritz, M. C., Lamb, R. J., Goldberg, S. R., et al. (1988) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(88)90040-1 · Cited by 75 · see citing works
Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration
Parsons, L. H., KOOB, G. E., & Weiss, F. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00101-5 · Cited by 71 · see citing works
Chronic cocaine self‐administration is associated with altered functional activity in the temporal lobes of non human primates
Beveridge, T. J. R., Smith, H. R., Daunais, J. B., Nader, M. A., & Porrino, L. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04788.x · Cited by 57 · see citing works
Human Cocaine-Seeking Behavior and its Control by Drug-Associated Stimuli in the Laboratory
Panlilio, L. V., Yaşar, S., Nemeth-Coslett, R., Katz, J. L., Henningfield, J. E., Solinas, M., Heishman, S. J., Schindler, C. W., & Goldberg, S. R. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300599 · Cited by 49 · see citing works
Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition
Wassum, K. M., Cely, I. C., Maidment, N. T., & Balleine, B. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.071 · Cited by 46 · see citing works
Both the shell of the nucleus accumbens and the central nucleus of the amygdala support amphetamine self-administration in rats
Chevrette, J., Stellar, J. R., Hesse, G. W., & Markou, A. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00686-4 · Cited by 41 · see citing works
Stimulus-response functions of the lateral dorsal striatum and regulation of behavior studied in a cocaine maintenance/cue reinstatement model in rats
Kantak, K. M., Black, Y. D., Valencia, E., Green-Jordan, K., & Eichenbaum, H. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1036-z · Cited by 32 · see citing works
Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the rat
Schmidt, H. D., & Pierce, R. C. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.009 · Cited by 27 · see citing works
Self-citation
Long-term voluntary d-amphetamine consumption and behavioral predictors for subsequent d-amphetamine addiction in rats
Galli, G., & Wolffgramm, J. (2003) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2003.09.003 · Cited by 21 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

Adams CD Variations in the sensitivity of instrumental responding to renforcer devaluation Quarterly Journal of Experimental Psychology 1982 34B 77 98
American Psychiatric Association Diagnostic and Statistical Manual of Mential Disorders DSM-IV-TR Fourth Edition (Text Revision) 2000
Drug Addiction and Drug Abuse O'Brien CP Hardman JG Limbird LE Gilman AG Goodman and Gilman's the pharmacological basis of therapeutics 2001 New York, NY McGraw-Hill 621 642

Sorted by citations

Natural rewards, neuroplasticity, and non-drug addictions
Olsen, C. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.010 · Cited by 339 · see citing works
The downward spiral of chronic pain, prescription opioid misuse, and addiction: Cognitive, affective, and neuropsychopharmacologic pathways
Garland, E. L., Froeliger, B., Zeidan, F., Partin, K., & Howard, M. O. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.08.006 · Cited by 277 · see citing works
Multiple roles for orexin/hypocretin in addiction
Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59489-1.00007-0 · Cited by 215 · see citing works
Binge-like consumption of a palatable food accelerates habitual control of behavior and is dependent on activation of the dorsolateral striatum
Furlong, T. M., Jayaweera, H. K., Balleine, B. W., & Corbit, L. H. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3707-13.2014 · Cited by 186 · see citing works
Restructuring reward processing with Mindfulness‐Oriented Recovery Enhancement: novel therapeutic mechanisms to remediate hedonic dysregulation in addiction, stress, and pain
Garland, E. L. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13034 · Cited by 137 · see citing works
Effects of Repeated Cocaine Exposure on Habit Learning and Reversal by N-Acetylcysteine
Corbit, L. H., Chieng, B. C., & Balleine, B. W. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.37 · Cited by 134 · see citing works
Feed-forward mechanisms: Addiction-like behavioral and molecular adaptations in overeating
Alsiö, J., Olszewski, P. K., Levine, A. S., & Schiöth, H. B. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.01.002 · Cited by 81 · see citing works
Opioid attentional bias and cue-elicited craving predict future risk of prescription opioid misuse among chronic pain patients
Garland, E. L., & Howard, M. O. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.09.014 · Cited by 55 · see citing works
A motivation model of sex addiction – Relevance to the controversy over the concept
Toates, F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104872 · Cited by 25 · see citing works
“” A move to automaticity corresponds to increased weight of control taken by the dorsal striatum relative to the ventral striatum (Everitt & Robbins, 2005; Pierce and Vanderschuren, 2010).”
Background

Authors: Pierce, R. C., & Vanderschuren, L. J. M. J.
Affiliations: University of Pennsylvania (US)
University Medical Center Utrecht (NL)
Corresponding author: Pierce, R. Christopher
ORCID: Pierce, R. Christopher
Vanderschuren, Louk J.M.J.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2010-11
Volume: 35
Issue: 2
Pages: 212-219
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2010.01.007
PMC: PMC2903634
OpenAlex: W2082268474
Cited by: 115
References: 119
Citations by year: 2026: 4 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 14 · 2013: 10 · 2012: 15
FWCI: 4.66
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA015214, R01DA022339, K02DA018678)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: cocaine dependence, compulsive drug seeking, drug craving, behavioral plasticity, dorsolateral striatum, habit formation
MeSH terms: Animals, Corpus Striatum, Humans, Models, Neurological, Neuronal Plasticity, Signal Transduction, Behavior, Addictive, Cocaine-Related Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Record

About these checks