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Cited by 55

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CAX1 suppresses Cd‐induced generation of reactive oxygen species in Arabidopsis halleri

Ahmadi, Hassan, Corso, Massimiliano, Weber, Michael, Verbruggen, Nathalie, Clemens, Stephan·2018·Plant, Cell & Environment
DOI 10.1111/pce.13362
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Abstract

The molecular analysis of metal hyperaccumulation in species such as Arabidopsis halleri offers the chance to gain insights into metal homeostasis and into the evolution of adaptation to extreme habitats. A prerequisite of metal hyperaccumulation is metal hypertolerance. Genetic analysis of a backcross population derived from Arabidopsis lyrata × A. halleri crosses revealed three quantitative trait loci for Cd hypertolerance. A candidate gene for Cdtol2 is AhCAX1, encoding a vacuolar Ca 2+/H+ antiporter. We developed a method for the transformation of vegetatively propagated A. halleri plants and generated AhCAX1‐silenced lines. Upon Cd 2+ exposure, several‐fold higher accumulation of reactive oxygen species (ROS) was detectable in roots of AhCAX1‐silenced plants. In accordance with the dependence of Cdtol2 on external Ca 2+ concentration, this phenotype was exclusively observed in low Ca 2+ conditions. The effects of external Ca 2+ on Cd accumulation cannot explain the phenotype as they were not influenced by the genotype. Our data strongly support the hypothesis that higher expression of CAX1 in A. halleri relative to other Arabidopsis species represents a Cd hypertolerance factor. We propose a function of AhCAX1 in preventing a positive feedback loop of Cd‐elicited ROS production triggering further Ca 2+‐dependent ROS accumulation.

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Metadata

Authors
Ahmadi, H., Corso, M., Weber, M., Verbruggen, N., & Clemens, S.
Affiliations
  • University of Bayreuth Department of Plant Physiology, and Bayreuth Center of Ecology and Environmental Research Bayreuth Germany
  • Université Libre de Bruxelles Laboratory of Plant Physiology and Molecular Genetics Brussels Belgium
ORCID
Venue
Plant, Cell & Environment
Publisher
Wiley
Published
2018-07-13
Volume
41
Issue
10
Pages
2435-2448
ISSN
  • 0140-7791
  • 1365-3040
DOI
10.1111/pce.13362
Cited by
55
References
9
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • Fonds De La Recherche Scientifique - FNRS (PDR T.0206.13)
  • Deutsche Forschungsgemeinschaft (SPP1529 ADAPTOMICS, CL152/9‐1, 9‐2)

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CoChat. (2026). Citation check: CAX1 suppresses Cd‐induced generation of reactive oxygen species in Arabidopsis halleri. https://app.cochat.ai/papers/10.1111/pce.13362
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Ahmadi, H., Corso, M., Weber, M., Verbruggen, N., & Clemens, S. (2018). CAX1 suppresses Cd‐induced generation of reactive oxygen species in Arabidopsis halleri. Plant, Cell & Environment. https://doi.org/10.1111/pce.13362

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