Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study

Miyaoka, Tsuyoshi; Wake, Rei; Furuya, Motohide; Liaury, Kristian; Ieda, Masa; Kawakami, Kazunori; Tsuchie, Keiko; Taki, Michiyo; Ishihara, Kotomi; Araki, Tomoko; Horiguchi, Jun

doi:10.1016/j.pnpbp.2012.02.002

Cited by 212Treatment of Major DepressionTryptophan and brain disordersSchizophrenia research and treatment

Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study

Miyaoka, Tsuyoshi, Wake, Rei, Furuya, Motohide, Liaury, Kristian, Ieda, Masa, Kawakami, Kazunori, Tsuchie, Keiko, Taki, Michiyo +3 more·2012·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2012.02.002

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Abstract

Background Approximately 25% of patients admitted to a hospital as a result of depression are actually suffering from psychotic depression. Psychotic symptoms can be present in patients with either unipolar depression or bipolar depression and can be difficult to treat. It was reported the second-generation tetracycline may exert potential antidepressant effects through its robust neuroprotective activities, which include neurogenesis, antioxidation, and anti-glutamate excitotoxicity, and may direct regulation of pro-inflammatory agents.Methods This was a 6-week, open-label study to evaluate the efficacy and safety of minocycline in combination with antidepressants in adult inpatients (n=25) diagnosed with major depression with psychotic features (psychotic depression) according to DSM-IV-TR. The primary endpoint was the change from baseline in the Hamilton Depression Rating Scale (HAM-D-21) score from baseline to week 6. Secondary endpoints were changes in the Brief Psychiatric Rating Scale (BPRS) and the Clinical Global Impression (CGI) Scale scores from baseline to week 6. Spontaneously reported adverse events were recorded.Results The patients' average age was 46.9±10.2 years. Minocyline (150 mg/day) in combination with antidepressants (fulvoxamine, paroxetine, and sertraline) provided significant improvement in depression. Mean (± SD) HAM-D-21 was reduced to 6.7±1.9 at week 6 from a baseline value of 40.4±2.5. Significant improvement of psychotic symptoms (mean±SD) was indicated by the decrease in BPRS scores from baseline (63.3±8.7) to week 6 (4.6±2.4). No serious adverse events occurred.Conclusions These preliminary data suggest that minocycline in combination with antidepressants is effective and well tolerated in the treatment of unipolar psychotic depression. Further studies using larger, double-blind, parallel-group design are warranted to confirm these findings.

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Minocycline may reduce depressive symptoms.
“and may reduce depressive symptoms (294).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [294]
Certain antibiotics, such as β-lactams and tetracyclines have potential antidepressant properties in rodents and humans.
“Conversely, certain antibiotics, such as β-lactams and tetracyclines have potential antidepressant properties in rodents and humans [161,162].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [162]
Preliminary findings from an open-label study confirmed minocycline antidepressant potential in individuals with unipolar psychotic depression.
“Preliminary findings from an open-label study confirmed minocycline antidepressant potential in individuals with unipolar psychotic depression [108].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [108]

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,767 · see citing works
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090 · see citing works
Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works
Evidence for an immune response in major depression: A review and hypothesis
Maes, M. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)00101-m · Cited by 1,003 · see citing works
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression
Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894 · see citing works
Increased Levels of Glutamate in Brains from Patients with Mood Disorders
Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works
Antidepressant-Induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates
Perera, T. D., Coplan, J. D., Lisanby, S. H., Lipira, C. M., Arif, M., Carpio, C., Spitzer, G., Santarelli, L., Scharf, B., Hen, R., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0237-07.2007 · Cited by 461 · see citing works
Minocycline and Neurodegenerative Diseases
Kim, H.-S., & Suh, Y.-H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.040 · Cited by 447 · see citing works
What causes the hippocampal volume decrease in depression?: Are neurogenesis, glial changes and apoptosis implicated?
Czéh, B., & Lucassen, P. J. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0728-0 · Cited by 419 · see citing works
A Double-Blind, Randomized Study of Minocycline for the Treatment of Negative and Cognitive Symptoms in Early-Phase Schizophrenia
Levkovitz, Y., Mendlovich, S., Riwkes, S., Braw, Y., Levkovitch-Verbin, H., Gal, G., Fennig, S., Treves, I., & Kron, S. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04666yel · Cited by 387 · see citing works
Emerging role of glutamate in the pathophysiology of major depressive disorder
Hashimoto, K. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.005 · Cited by 381 · see citing works
Escitalopram versus citalopram: the surprising role of the R-enantiomer
S�nchez, C., B�ges�, K. P., Ebert, B., Reines, E. H., & Bræstrup, C. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1865-z · Cited by 247 · see citing works
A Double-blind Randomized Controlled Trial of Olanzapine Plus Sertraline vs Olanzapine Plus Placebo for Psychotic Depression
Meyers, B. S. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.79 · Cited by 233 · see citing works
Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine
Zhang, L., Kitaichi, K., Fujimoto, Y., Nakayama, H., Shimizu, E., Iyo, M., & Hashimoto, K. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.05.015 · Cited by 159 · see citing works
Psychotic (delusional) depression: a meta-analysis of physical treatments
Parker, G. B., Roy, K., Hadži-Pavlović, D., & Pedic, F. (1992) · Journal of Affective Disorders · doi:10.1016/0165-0327(92)90056-c · Cited by 158 · see citing works
Minocycline as Adjunctive Therapy for Schizophrenia: An Open-Label Study
Miyaoka, T., Yasukawa, R., Yasuda, H., Hayashida, M., Inagaki, T., & Horiguchi, J. (2008) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3181593d45 · Cited by 146 · see citing works
Self-citation
Pharmacological treatment for psychotic depression
Wijkstra, J., Lijmer, J. G., Burger, H., Cipriani, A., Geddes, J. R., & Nolen, W. A. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004044.pub4 · Cited by 141 · see citing works
Psychotic Depression and Mortality
Vythilingam, M., Chen, J., Bremner, J. D., Mazure, C. M., Maciejewski, P. K., & Nelson, J. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.574 · Cited by 141 · see citing works
Outcome in Schizoaffective, Psychotic, and Nonpsychotic Depression
Coryell, W. H. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790190061008 · Cited by 118 · see citing works
Antidepressant-like actions of minocycline combined with several glutamate antagonists
Molina-Hernández, M., Téllez-Alcántara, N. P., Pérez-García, J., Olivera-Lopez, J. I., & Jaramillo, M. T. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.004 · Cited by 115 · see citing works
Current Issues in the Classification of Psychotic Major Depression
Keller, J., Schatzberg, A. F., & Maj, M. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm065 · Cited by 112 · see citing works
Does minocycline have antidepressant effect?
Pae, C., Marks, D. M., Han, C., & Patkar, A. A. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2007.12.005 · Cited by 108 · see citing works
Possible antipsychotic effects of minocycline in patients with schizophrenia
Miyaoka, T., Yasukawa, R., YASUDA, H., Hayashida, M., Inagaki, T., & Horiguchi, J. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.08.013 · Cited by 105 · see citing works
Self-citation
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline
Fujita, Y., Ishima, T., Kunitachi, S., Hagiwara, H., Zhang, L., Iyo, M., & Hashimoto, K. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.031 · Cited by 99 · see citing works
Drug Induced Weight Gain, an Impediment to Successful Pharmacotherapy: Focus on Antipsychotics
Baptista, T., Zarate, J. M., Joober, R., Colasante, C., Beaulieu, S., Páez, X., & Hernandez, L. (2004) · Current Drug Targets · doi:10.2174/1389450043490514 · Cited by 99 · see citing works
Treatment of unipolar psychotic depression: a randomized, double‐blind study comparing imipramine, venlafaxine, and venlafaxine plus quetiapine
Wijkstra, J., Burger, H., van den Broek, W. W., Birkenhäger, T. K., Janzing, J., Boks, M. P., Bruijn, J. A., van der Loos, M. L. M., Breteler, L. M. T., RAMAEKERS, G. M. G. I., et al. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01464.x · Cited by 99 · see citing works
Pharmacological treatment for unipolar psychotic depression
Wijkstra, J., Lijmer, J. G., Balk, F. J., Geddes, J. R., & Nolen, W. A. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.010470 · Cited by 96 · see citing works
Possible antidepressant effect of minocycline
Levine, J. S., Cholestoy, A., & Zimmerman, J. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.4.582b · Cited by 60 · see citing works
Pharmacological treatment for psychotic depression
Wijkstra, J., Lijmer, J. G., Balk, F. J., Geddes, J. R., & Nolen, W. A. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004044.pub2 · Cited by 53 · see citing works
A Novel Target of Action of Minocycline in NGF-Induced Neurite Outgrowth in PC12 Cells: Translation Initiation Factor eIF4AI
Hashimoto, K., & Ishima, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015430 · Cited by 50 · see citing works
Differential Response to Combined Treatment in Patients With Psychotic Versus Nonpsychotic Major Depression
Gaudiano, B. A., Beevers, C. G., & Miller, I. W. (2005) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000177791.33649.69 · Cited by 47 · see citing works
Desipramine or glutamate antagonists synergized the antidepressant-like actions of intra-nucleus accumbens infusions of minocycline in male Wistar rats
Molina-Hernández, M., Téllez-Alcántara, N. P., Pérez-García, J., Olivera-Lopez, J. I., & Jaramillo, M. T. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.06.010 · Cited by 46 · see citing works
Possible anti-catatonic effects of minocycline in patients with schizophrenia
Ahuja, N., & Carroll, B. T. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.01.018 · Cited by 41 · see citing works
Clinical Potential of Minocycline for Schizophrenia
Miyaoka, T. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708786441858 · Cited by 38 · see citing works
Self-citation
Microglial activation in schizophrenia and minocycline treatment
Hashimoto, K. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.06.012 · Cited by 35 · see citing works
The treatment of psychotic major depression: Is there a role for adjunctive psychotherapy?
Gaudiano, B. A., Miller, I. W., & Herbert, J. D. (2007) · Psychotherapy and Psychosomatics · doi:10.1159/000104703 · Cited by 31 · cited 1× · see citing works
“The latter findings, however, have been viewed as based only on limited data (Gaudiano et al., 2007).”
Background
An Open Study of Aripiprazole and Escitalopram for Psychotic Major Depressive Disorder
Matthews, J., Siefert, C. J., Dording, C. M., Denninger, J. W., Park, L., van Nieuwenhuizen, A. O., Sklarsky, K. G., Hilliker, S. E., Homberger, C. H., Rooney, K., et al. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318193dfb4 · Cited by 20 · see citing works
Effectiveness of Quetiapine in the Management of Psychotic Depression in an Adolescent Boy with Bipolar Disorder, Mixed, with Psychosis
Catapano-Friedman, L. (2001) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/104454601750284144 · Cited by 12 · see citing works
Psychotic depression.
Coryell, W. H. (1996) · PubMed · Cited by 12 · see citing works
Macrophages-mediated neurotoxic effects of intra-nigral manganese administration are attenuated by minocycline
Ponzoni, S. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.10.066 · Cited by 10 · see citing works

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Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works
The central nervous system and the gut microbiome
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513 · see citing works
Depression as a Microglial Disease
Yirmiya, R., Rimmerman, N., & Reshef, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.001 · Cited by 944 · see citing works
Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects: A Systematic Review and Meta-analysis of Randomized Clinical Trials
Köhler, O., Benros, M. E., Nordentoft, M., Farkouh, M. E., Iyengar, R. L., Mors, O., & Krogh, J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1611 · Cited by 941 · see citing works
Inflamed moods: A review of the interactions between inflammation and mood disorders
Rosenblat, J. D., Cha, D. S., Mansur, R. B., & McIntyre, R. S. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.013 · Cited by 609 · see citing works
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · see citing works
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568 · see citing works
Inflammation in Depression and the Potential for Anti-Inflammatory Treatment
Kohler, O., Krogh, J., Mors, O., & Eriksen Benros, M. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666151208113700 · Cited by 516 · see citing works
Efficacy of anti‐inflammatory treatment on major depressive disorder or depressive symptoms: meta‐analysis of clinical trials
Köhler‐Forsberg, O., N. Lydholm, C., Hjorthøj, C., Nordentoft, M., Mors, O., & Benros, M. E. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13016 · Cited by 432 · see citing works
Melancholic microbes: a link between gut microbiota and depression
Dinan, T. G., & Cryan, J. F. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12198 · Cited by 424 · see citing works
Gut microbiota in autism and mood disorders
Mangiola, F. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.361 · Cited by 413 · see citing works
Immune targets for therapeutic development in depression: towards precision medicine
Drevets, W. C., Wittenberg, G. M., Bullmore, E. T., & Manji, H. K. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00368-1 · Cited by 348 · see citing works
Irritable bowel syndrome: A microbiome-gut-brain axis disorder?
Kennedy, P. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14105 · Cited by 335 · see citing works
Microglial Dysregulation in Psychiatric Disease
Frick, L. R., Williams, K., & Pittenger, C. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/608654 · Cited by 299 · see citing works
Microglia in depression: current perspectives
Jia, X., Gao, Z., & Hu, H. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1815-6 · Cited by 283 · see citing works
Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness
Macêdo, D. S., Filho, A. J. M. C., de Sousa, C. N. S., Quevedo, J., Barichello, T., Júnior, H. V. N., & de Lucena, D. F. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.012 · Cited by 264 · see citing works
Bipolar Disorder and Immune Dysfunction: Epidemiological Findings, Proposed Pathophysiology and Clinical Implications
Rosenblat, J., & McIntyre, R. (2017) · Brain Sciences · doi:10.3390/brainsci7110144 · Cited by 258 · see citing works
Role of Inflammation in Suicide: From Mechanisms to Treatment
Brundin, L., Bryleva, E. Y., & Thirtamara Rajamani, K. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.116 · Cited by 257 · see citing works
“Preliminary data from an open-label study of patients with MDD suggest that adjunctive minocycline treatment is able to reduce the severity of depressive and psychotic symptoms (Miyaoka et al , 2012).”
Microbes, immunity, and behavior: psychoneuroimmunology meets the microbiome
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Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial
Nettis, M. A., Lombardo, G., Hastings, C., Zajkowska, Z., Mariani, N., Nikkheslat, N., Worrell, C., Enache, D., McLaughlin, A., Kose, M., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00948-6 · Cited by 235 · see citing works
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Laskaris, L., Biase, M. A. D., Everall, I., Chana, G., Christopoulos, A., Skafidas, E. S., Cropley, V., & Pantelis, C. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13364 · Cited by 227 · see citing works
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Tay, T. L., Béchade, C., D’Andrea, I., St‐Pierre, M., Henry, M. S., Roumier, A., & Tremblay, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00421 · Cited by 211 · see citing works
Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms
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Teichman, E. M., O’Riordan, K. J., Gahan, C. G. M., Dinan, T. G., & Cryan, J. F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.008 · Cited by 198 · see citing works
Novel therapeutic targets in depression: Minocycline as a candidate treatment
Soczynska, J. K., Mansur, R. B., Brietzke, E. M., Swardfager, W., Kennedy, S. H., Woldeyohannes, H. O., Powell, A. M., Manierka, M. S., & McIntyre, R. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.026 · Cited by 190 · see citing works
Efficacy and tolerability of minocycline for depression: A systematic review and meta-analysis of clinical trials
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Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: A meta-analysis
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Maurya, P. K., Noto, C. D. S., Rizzo, L. B., Rios, A. C., Nunes, S. O. V., Barbosa, D. S., Sethi, S., Zeni‐Graiff, M., Mansur, R. B., Maes, M. H. J., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.016 · Cited by 170 · see citing works
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Burke, N. N., Kerr, D. M., Moriarty, O., Finn, D. P., & Roche, M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.015 · Cited by 168 · see citing works
Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia
Hui, C. W., St-Pierre, A., Hajj, H. E., Remy, Y., Hébert, S. S., Luheshi, G. N., Srivastava, L. K., & Tremblay, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00013 · Cited by 158 · see citing works
On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death
Kell, D. B., & Pretorius, E. (2015) · Integrative Biology · doi:10.1039/c5ib00158g · Cited by 160 · see citing works
What is behind the non-antibiotic properties of minocycline?
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.006 · Cited by 158 · see citing works
The influence of stress on neuroinflammation and alterations in brain structure and function in major depressive disorder
Kim, Y., & Won, E. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.020 · Cited by 157 · see citing works
Therapeutic Strategies for Treatment of Inflammation-related Depression
Adžić, M., Brkic, Z., Mitić, M., Francija, E., Jovicic, M. J., Radulović, J., & Marić, N. P. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170828163048 · Cited by 156 · see citing works
The ketone body metabolite β‐hydroxybutyrate induces an antidepression‐associated ramification of microglia via HDACs inhibition‐triggered Akt‐small RhoGTPase activation
Huang, C., Wang, P., Xu, X., Zhang, Y., Gong, Y. L., Hu, W., Gao, M., Wu, Y. H., Ling, Y., Zhao, X., et al. (2017) · Glia · doi:10.1002/glia.23241 · Cited by 149 · see citing works
Minocycline as an adjunct for treatment-resistant depressive symptoms: A pilot randomised placebo-controlled trial
Husain, M. I., Chaudhry, I. B., Husain, N., Khoso, A. B., Rahman, R. R., Hamirani, M. M., Hodsoll, J. P., Qurashi, I., Deakin, J. F. W., & Young, A. H. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117724352 · Cited by 146 · see citing works
Stress induced microglial activation contributes to depression
Li, B., Yang, W., Ge, T., Wang, Y., & Cui, R. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106145 · Cited by 147 · see citing works
The neurobiological correlates of childhood adversity and implications for treatment
Tyrka, A. R., Burgers, D. E., Philip, N. S., Price, L. H., & Carpenter, L. L. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12143 · Cited by 142 · see citing works
The Involvement of TNF-&#945; in Cognitive Dysfunction Associated with Major Depressive Disorder: An Opportunity for Domain Specific Treatments
Bortolato, B., F. Carvalho, A., K. Soczynska, J., I. Perini, G., & S. McIntyre, R. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150630171433 · Cited by 142 · see citing works
Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression
Won, E., Na, K., & Kim, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010305 · Cited by 146 · see citing works
Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial
Savitz, J. B., Teague, T. K., Misaki, M., Macaluso, M., Wurfel, B. E., Meyer, M., Drevets, D. A., Yates, W. R., Gleason, O. C., Drevets, W. C., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0073-7 · Cited by 138 · see citing works
Anti-inflammatory treatments for mood disorders: Systematic review and meta-analysis
Husain, M. I., Strawbridge, R., Stokes, P. R., & Young, A. H. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725711 · Cited by 139 · see citing works
Ketamine interactions with gut-microbiota in rats: relevance to its antidepressant and anti-inflammatory properties
Getachew, B., Aubee, J. I., Schottenfeld, R. S., Csoka, A. B., Thompson, K. M., & Tizabi, Y. (2018) · BMC Microbiology · doi:10.1186/s12866-018-1373-7 · Cited by 137 · see citing works
Novel neuroimmunologic therapeutics in depression: A clinical perspective on what we know so far
Roman, M., & Irwin, M. R. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.09.016 · Cited by 132 · see citing works
Disease-Induced Neuroinflammation and Depression
Benatti, C., Blom, J. M. C., Rigillo, G., Alboni, S., Zizzi, F., Torta, R., Brunello, N., & Tascedda, F. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160321104749 · Cited by 121 · see citing works
Inflammatory Mediators in Mood Disorders: Therapeutic Opportunities
Pfau, M. L., Ménard, C., & Russo, S. J. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052823 · Cited by 116 · see citing works
Developmental minocycline treatment reverses the effects of neonatal immune activation on anxiety- and depression-like behaviors, hippocampal inflammation, and HPA axis activity in adult mice
Majidi, J., Kosari-Nasab, M., & Salari, A.-A. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.10.009 · Cited by 109 · see citing works
Inflammation as a treatment target in mood disorders: review
Jones, B. D. M., Daskalakis, Z. J., Carvalho, A. F., Strawbridge, R., Young, A. H., Mulsant, B. H., & Husain, M. I. (2020) · BJPsych Open · doi:10.1192/bjo.2020.43 · Cited by 106 · see citing works
Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation
Han, Y., Zhang, L., Wang, Q., Zhang, D.-D., Zhao, Q., Zhang, J., Xie, L., Liu, G., & You, Z. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.021 · Cited by 105 · see citing works
Adjunctive minocycline treatment for major depressive disorder: A proof of concept trial
Dean, O. M., Kanchanatawan, B., Ashton, M. M., Mohebbi, M., Ng, C. H., Maes, M. H. J., Berk, L., Sughondhabirom, A., Tangwongchai, S., Singh, A., et al. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867417709357 · Cited by 106 · see citing works
Putative neuroprotective agents in neuropsychiatric disorders
Dodd, S., Maes, M. H. J., Anderson, G., Dean, O. M., Moylan, S., & Berk, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.11.007 · Cited by 105 · see citing works
Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial
Hellmann-Regen, J., Clemens, V., Grözinger, M., Kornhuber, J., Reif, A., Prvulovic, D., Goya-Maldonado, R., Wiltfang, J., Gruber, O., Schüle, C., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.30367 · Cited by 100 · see citing works
Faster, better, stronger: Towards new antidepressant therapeutic strategies
O’Leary, O. F., Dinan, T. G., & Cryan, J. F. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.046 · Cited by 100 · see citing works
Depression after myocardial infarction: TNF-α-induced alterations of the blood–brain barrier and its putative therapeutic implications
Liu, H., Luiten, P. G. M., Eisel, U. L. M., DeJongste, M. J. L., & Schoemaker, R. G. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.004 · Cited by 98 · see citing works
Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects
Strong, R., Miller, R. A., Bogue, M. A., Fernández, E., Javors, M. A., Libert, S., Martinez, P. A., Murphy, M. P., Musi, N., Nelson, J. F., et al. (2020) · Aging Cell · doi:10.1111/acel.13269 · Cited by 99 · see citing works
Minocycline in neurodegenerative and psychiatric diseases: An update
Romero‐Miguel, D., Lamanna‐Rama, N., Casquero‐Veiga, M., Gómez‐Rangel, V., Desco, M., & Soto‐Montenegro, M. L. (2020) · European Journal of Neurology · doi:10.1111/ene.14642 · Cited by 95 · see citing works
Bibliometric and Visual Analysis of Research on the Links Between the Gut Microbiota and Depression From 1999 to 2019
Zhu, X., Hu, J., Deng, S., Tan, Y., Qiu, C., Zhang, M., Ni, X., Lu, H., Wang, Z., Li, L., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.587670 · Cited by 92 · see citing works
Immune-based strategies for mood disorders: facts and challenges
Colpo, G. D., Leboyer, M., Dantzer, R., Trivedi, M. H., & Teixeira, A. L. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1407242 · Cited by 90 · see citing works
Cytokine alterations and cognitive impairment in major depressive disorder: From putative mechanisms to novel treatment targets
Misiak, B., Beszłej, J. A., Kotowicz, K., Szewczuk-Bogusławska, M., Samochowiec, J., Kucharska–Mazur, J., & Frydecka, D. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.021 · Cited by 86 · see citing works
Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III – convergence toward clinical trials
Bested, A. C., Logan, A. C., & Selhub, E. M. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-4 · Cited by 84 · see citing works
Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways
Anderson, G., Maes, M. H. J., & Berk, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.016 · Cited by 83 · see citing works
Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro
Su, F., Yi, H., Xu, L., & Zhang, Z. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.028 · Cited by 81 · see citing works
Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation?
Fiore, N. T., & Austin, P. J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.04.012 · Cited by 80 · see citing works
Exploring the role of inflammation in major depressive disorder: beyond the monoamine hypothesis
Pastis, I., Santos, M. G., & Paruchuri, A. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1282242 · Cited by 80 · see citing works
Modulating Neuroinflammation to Treat Neuropsychiatric Disorders
Radtke, F., Chapman, G., Hall, J., & Syed, Y. A. (2017) · BioMed Research International · doi:10.1155/2017/5071786 · Cited by 76 · see citing works
Therapeutic effects of minocycline on mild-to-moderate depression in HIV patients
Emadi-Kouchak, H., Mohammadinejad, P., Asadollahi‐Amin, A., Rasoulinejad, M., Zeinoddini, A., Yalda, A., & Akhondzadeh, S. (2015) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000098 · Cited by 76 · see citing works
Investigational drugs in recent clinical trials for treatment-resistant depression
Garay, R. P., Zarate, C. A., Charpeaud, T., Citrome, L., Correll, C. U., Hameg, A., & Llorca, P. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1283217 · Cited by 74 · see citing works
Neuroinflammatory remodeling of the anterior cingulate cortex as a key driver of mood disorders in gastrointestinal disease and disorders
Matisz, C. E., & Gruber, A. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.020 · Cited by 70 · see citing works
Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder
Rahimian, R., Belliveau, C., Chen, R., & Mechawar, N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.871997 · Cited by 73 · see citing works
Gastrointestinal alterations in autism spectrum disorder: What do we know?
Bjørklund, G., Pivina, L. M., Dadar, M., Meguid, N. A., Semenova, Y. M., Anwar, M., & Chirumbolo, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.033 · Cited by 70 · see citing works
Inflammation and Immune Regulation as Potential Drug Targets in Antidepressant Treatment
Schmidt, F. M., Kirkby, K. C., & Lichtblau, N. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160115130414 · Cited by 72 · see citing works
Antibiotics and mental health: the good, the bad and the ugly
Dinan, K., & Dinan, T. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13543 · Cited by 69 · see citing works
Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents
Chen, L., Lv, X., Guo, Q., Lv, S., Lü, N., Xu, W., Yu, J. M., & Zhang, Y. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15994 · Cited by 67 · see citing works
Microbiota-brain axis: Exploring the role of gut microbiota in psychiatric disorders - A comprehensive review
Singh, J., Vanlallawmzuali, Singh, A. K., Biswal, S., Zomuansangi, R., Lalbiaktluangi, C., Singh, B. P., Singh, P. K., Vellingiri, B., Iyer, M., et al. (2024) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2024.104068 · Cited by 70 · see citing works
Brain-immune crosstalk in the treatment of major depressive disorder
Branchi, I., Poggini, S., Capuron, L., Benedetti, F., Poletti, S., Tamouza, R., Drexhage, H. A., Penninx, B. W. J. H., & Pariante, C. M. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.11.016 · Cited by 64 · see citing works
Mind and body: how the health of the body impacts on neuropsychiatry
Renoir, T., Hasebe, K., & Gray, L. J. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00158 · Cited by 62 · see citing works
Minocycline prevents the development of depression-like behavior and hippocampal inflammation in a rat model of Alzheimer’s disease
Amani, M., Shokouhi, G., & Salari, A. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5137-8 · Cited by 62 · see citing works
Minocycline as Adjunctive Treatment to Risperidone in Children with Autistic Disorder: A Randomized, Double-Blind Placebo-Controlled Trial
Ghaleiha, A., Alikhani, R., Kazemi, M.-R., Mohammadi, M.-R., Mohammadinejad, P., Zeinoddini, A., Hamedi, M., Shahriari, M., Keshavarzi, Z., & Akhondzadeh, S. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0175 · Cited by 56 · see citing works
Novel investigational drugs targeting IL-6 signaling for the treatment of depression
Fonseka, T. M., McIntyre, R. S., Soczynska, J. K., & Kennedy, S. H. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.998334 · Cited by 53 · see citing works
Neuroinflammation Regulates Cognitive Impairment in Socially Defeated Mice
Pfau, M. L., & Russo, S. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.04.004 · Cited by 54 · see citing works
A pilot study of minocycline for the treatment of bipolar depression: Effects on cortical glutathione and oxidative stress in vivo
Murrough, J. W., Huryk, K. M., Mao, X., Iacoviello, B. M., Collins, K. A., Nierenberg, A. A., Kang, G., Shungu, D. C., & Iosifescu, D. V. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.12.067 · Cited by 54 · see citing works
Sleep and inflammatory markers in different psychiatric disorders
Krysta, K., Krzystanek, M., Bratek, A., & Krupka-Matuszczyk, I. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-015-1492-3 · Cited by 53 · see citing works
Matrix Metalloproteinase-9 as an Important Contributor to the Pathophysiology of Depression
Li, H., Sheng, Z., Khan, S., Zhang, R., Liu, Y., Zhang, Y., Yong, V. W., & Xue, M. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.861843 · Cited by 54 · see citing works
Immunotherapy for depression: Recent insights and future targets
Bai, Y., Cai, Y., Chang, D., Li, D., Huo, X., & Zhu, T. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108624 · Cited by 54 · see citing works
Putative neuroprotective pharmacotherapies to target the staged progression of mental illness
Robertson, O. D., Coronado, N. G., Sethi, R., Berk, M., & Dodd, S. (2019) · Early Intervention in Psychiatry · doi:10.1111/eip.12775 · Cited by 52 · see citing works
Inflamed brain: Targeting immune changes and inflammation for treatment of depression
Sakamoto, S., Zhu, X., Hasegawa, Y., Karma, S., Obayashi, M., Alway, E., & Kamiya, A. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13286 · Cited by 51 · see citing works
Innovative biomarkers in psychiatric disorders: a major clinical challenge in psychiatry
Lozupone, M., Seripa, D., Stella, E., Montagna, M. L., Solfrizzi, V., Quaranta, N. A. A., Veneziani, F., Cester, A., Sardone, R., Bonfiglio, C., et al. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1375857 · Cited by 51 · see citing works
The gut microbiome in psychiatry: A primer for clinicians
Ameringen, M. V., Turna, J., Patterson, B. A., Pipe, A., Mao, R. Q., Anglin, R., & Surette, M. G. (2019) · Depression and Anxiety · doi:10.1002/da.22936 · Cited by 51 · see citing works
The microbiome and childhood diseases: Focus on brain‐gut axis
O’Mahony, S. M., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2015) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21118 · Cited by 50 · see citing works
A pilot, open‐label, 8‐week study evaluating the efficacy, safety and tolerability of adjunctive minocycline for the treatment of bipolar I/II depression
Soczynska, J. K., Kennedy, S. H., Alsuwaidan, M. T., Mansur, R. B., Li, M., McAndrews, M. P., Brietzke, E. M., Woldeyohannes, H. O., Taylor, V. H., & McIntyre, R. S. (2017) · Bipolar Disorders · doi:10.1111/bdi.12496 · Cited by 49 · see citing works
Therapeutic Drug Monitoring of Second- and Third-Generation Antipsychotic Drugs—Influence of Smoking Behavior and Inflammation on Pharmacokinetics
Moschny, N., Hefner, G., Grohmann, R., Eckermann, G., Maier, H. B., Seifert, J., Heck, J., Francis, F., Bleich, S., Toto, S., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14060514 · Cited by 50 · see citing works
Microbiome and mental health in the modern environment
Deans, E. (2016) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-016-0101-y · Cited by 49 · see citing works
The antidepressant impact of minocycline in rodents: A systematic review and meta-analysis
Reis, D. J., Casteen, E. J., & Ilardi, S. S. (2019) · Scientific Reports · doi:10.1038/s41598-018-36507-9 · Cited by 44 · see citing works

Bowater plans US$220 million investment in mill
(1998) · Pump Industry Analyst · doi:10.1016/s1359-6128(98)90226-9
Minocycline as an adjunctive therapy for unipolar depression
Dean, O., Maes, M. H. J., Berk, L., Ashton, M. M., Kanchanatawan, B., Sughondhabirom, A., Tangwongchai, S., Ng, C. H., Dowling, N. L., Malhi, G. S., et al. (2016) · Figshare
Minocycline as an Adjunctive Treatment for Depression
Yager, J. (2020) · Journal watch · doi:10.1056/nejm-jw.na52744 · Cited by 1 · see citing works
Pharmacological treatment for unipolar psychotic depression
Wijkstra, J., Lijmer, J. G., Balk, F. J., Geddes, J. R., & Nolen, W. A. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.010470 · Cited by 96 · see citing works
Protocol and rationale-the efficacy of minocycline as an adjunctive treatment for major depressive disorder: a double blind, randomised, placebo controlled trial
Dean, O. M., Maes, M., Ashton, M., Berk, L., Kanchanatawan, B., Sughondhabirom, A., Tangwongchai, S., Ng, C., Dowling, N., Malhi, G. S., et al. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.3.180 · Cited by 58 · see citing works

Authors: Miyaoka, T., Wake, R., Furuya, M., Liaury, K., Ieda, M., Kawakami, K., Tsuchie, K., Taki, M., Ishihara, K., Araki, T., & Horiguchi, J.
Affiliations: Shimane University (JP)
Corresponding author: Miyaoka, Tsuyoshi
ORCID: Miyaoka, Tsuyoshi
Wake, Rei
Horiguchi, Jun
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2012-06
Volume: 37
Issue: 2
Pages: 222-226
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2012.02.002
OpenAlex: W2002519510
Cited by: 212
References: 42
Citations by year: 2026: 3 · 2025: 8 · 2024: 10 · 2023: 6 · 2022: 16 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 13 · 2017: 28 · 2016: 23 · 2015: 26 · 2014: 11 · 2013: 13 · 2012: 5
FWCI: 12.94
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: minocycline, psychotic depression, major depressive disorder, adjunctive therapy, antidepressants, paroxetine, sertraline, neuroprotection, neurogenesis, anti-inflammatory activity, antidepressant efficacy, drug safety
MeSH terms: Adult, Antidepressive Agents, Depressive Disorder, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Minocycline, Psychotic Disorders, Treatment Outcome

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Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study

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