The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats
Abstract
Chronic exposure to stress is associated with increased incidence of depression, generalized anxiety, and PTSD. However, stress induces vulnerability to such disorders only in a sub-population of individuals, as others remain resilient. Inflammation has emerged as a putative mechanism for promoting stress vulnerability. Using a rodent model of social defeat, we have previously shown that rats with short-defeat latencies (SL/vulnerable rats) show increased anxiety- and depression-like behaviors, and these behaviors are mediated by inflammation in the ventral hippocampus. The other half of socially defeated rats show long-latencies to defeat (LL/resilient) and are similar to controls. Because gut microbiota are important activators of inflammatory substances, we assessed the role of the gut microbiome in mediating vulnerability to repeated social defeat stress. We analyzed the fecal microbiome of control, SL/vulnerable, and LL/resilient rats using shotgun metagenome sequencing and observed increased expression of immune-modulating microbiota, such as Clostridia, in SL/vulnerable rats. We then tested the importance of gut microbiota to the SL/vulnerable phenotype. In otherwise naive rats treated with microbiota from SL/vulnerable rats, there was higher microglial density and IL-1β expression in the vHPC, and higher depression-like behaviors relative to rats that received microbiota from LL/resilient rats, non-stressed control rats, or vehicle-treated rats. However, anxiety-like behavior during social interaction was not altered by transplant of the microbiome of SL/vulnerable rats into non-stressed rats. Taken together, the results suggest the gut microbiome contributes to the depression-like behavior and inflammatory processes in the vHPC of stress vulnerable individuals.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Rats receiving FMT from SL/vulnerable rats displayed depressive-like behaviours in the forced swim test, while LL/resilient recipients were not significantly different from control.
“It was found that rats receiving FMT from the SL/vulnerable group displayed depressive-like behaviours when asses with the forced swim test while the LL/resilient group was not significantly different than control [24].”
From Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review (2020) · cites this paper as [24]
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
Fast and accurate long-read alignment with Burrows-Wheeler transform.
Li, H., & Durbin, R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp698 · Cited by 12,063 · see citing works
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979 · see citing works
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works
The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661 · see citing works
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · cited 4× · see citing works
“Considerable evidence shows a link between the gut microbiome and immune system function and regulation [17, 19].”
BackgroundInfluentialThe Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083 · see citing works
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works
Detke, M. J., Rickels, M. R., & Lucki, I. (1995) · Psychopharmacology · doi:10.1007/bf02245592 · Cited by 1,438 · see citing works
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Cryan, J. F., Valentino, R. J., & Lucki, I. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.008 · Cited by 1,115 · see citing works
Microglia and neuroinflammation: a pathological perspective
Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works
Forced swimming test in mice: A review of antidepressant activity
Petit-Demouliere, B., Chenu, F., & Bourin, M. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2048-7 · Cited by 1,003 · see citing works
From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works
Systemic inflammation and microglial activation: systematic review of animal experiments
Hoogland, I. C. M., Houbolt, C., van Westerloo, D. J., van Gool, W. A., & van de Beek, D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0332-6 · Cited by 957 · see citing works
Burokas, A., Arboleya, S., Moloney, R. D., Peterson, V. L., Murphy, K., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.031 · Cited by 952 · see citing works
CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?
File, S. E., & Hyde, J. R. G. (1978) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1978.tb07001.x · Cited by 808 · see citing works
Inflammatory Mediators and Modulation of Blood–Brain Barrier Permeability
Abbott, N. J. (2000) · Cellular and Molecular Neurobiology · doi:10.1023/a:1007074420772 · Cited by 803 · see citing works
Commensal clostridia: Leading players in the maintenance of gut homeostasis
Lopetuso, L. R., Scaldaferri, F., Petito, V., & Gasbarrini, A. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-23 · Cited by 753 · see citing works
Norden, D. M., Trojanowski, P. J., Villanueva, E., Navarro, E., & Godbout, J. P. (2015) · Glia · doi:10.1002/glia.22930 · Cited by 596 · see citing works
Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity
Xanthos, D. N., & Sandkühler, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3617 · Cited by 580 · see citing works
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568 · see citing works
Tynan, R. J., Naicker, S., Hinwood, M., Nalivaiko, E., Buller, K. M., Pow, D. V., Day, T. A., & Walker, F. R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.02.001 · Cited by 531 · see citing works
Is depression an inflammatory disorder?
Raison, C. L., & Miller, A. H. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0232-0 · Cited by 524 · see citing works
MacFabe, D. F. (2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.19260 · Cited by 432 · see citing works
Role of microglia in CNS inflammation
Graeber, M. B., Li, W., & Rodriguez, M. L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.033 · Cited by 392 · see citing works
van Praag, H. M. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.05.031 · Cited by 378 · see citing works
Interleukin‐1: A master regulator of neuroinflammation
Basu, A., Krady, J. K., & Levison, S. W. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20266 · Cited by 367 · see citing works
Reshaping the gut microbiome with bacterial transplantation and antibiotic intakePreprint
Manichanh, C., Reeder, J., Gibert, P., Varela, E., Llopis, M., Antolı́n, M., Guigó, R., Knight, R. D., & Guarner, F. (2010) · Genome Research · doi:10.1101/gr.107987.110 · Cited by 332 · see citing works
Coping style and immunity in animals: Making sense of individual variation
Koolhaas, J. M. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.11.006 · Cited by 300 · see citing works
Structural & functional consequences of chronic psychosocial stress on the microbiome & host
Bharwani, A., Mian, M. F., Foster, J. A., Surette, M. G., Bienenstock, J., & Forsythe, P. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.001 · Cited by 293 · see citing works
Umesaki, Y., Setoyama, H., Matsumoto, S., Imaoka, A., & Itoh, K. (1999) · Infection and Immunity · doi:10.1128/iai.67.7.3504-3511.1999 · Cited by 271 · see citing works
The microbiome, immunity, and schizophrenia and bipolar disorder.
Dickerson, F., Severance, E., & Yolken, R. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.010 · Cited by 268 · cited 1× · see citing works
“Furthermore, differences in gut microbiota have been identified in humans with a variety of psychiatric diseases, including depression, anxiety, and schizophrenia [20, 21], and several animal models of psychiatric diseases show disturbances in the gut microbiome [17].”
BackgroundWood, S. K., Walker, H. E., Valentino, R. J., & Bhatnagar, S. (2010) · Endocrinology · doi:10.1210/en.2009-1026 · Cited by 251 · see citing works
Self-citationStanley, D., Geier, M. S., Chen, H., Hughes, R., & Moore, R. J. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0388-6 · Cited by 246 · see citing works
Blood biomarkers for brain injury: What are we measuring?
Kawata, K., Liu, C. Y., Merkel, S. F., Ramirez, S. H., Tierney, R., & Langford, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.009 · Cited by 237 · see citing works
Antibiotic Exposure and the Risk for Depression, Anxiety, or Psychosis: A Nested Case-Control Study
Lurie, I., Yang, Y.-X., Haynes, K., Mamtani, R., & Boursi, B. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15m09961 · Cited by 231 · see citing works
Interleukin-10: Biology, Role in Inflammation and Autoimmunity
Lalani, I., Bhol, K. C., & Ahmed, A. R. (1997) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63052-9 · Cited by 230 · see citing works
Validation of Serum Markers for Blood-Brain Barrier Disruption in Traumatic Brain Injury
Blyth, B. J., Farhavar, A., Gee, C., Hawthorn, B., He, H., Nayak, A., Stöcklein, V., & Bazarian, J. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0738 · Cited by 227 · see citing works
Gonzalez, L. E., Andrews, N., & File, S. E. (1996) · Brain Research · doi:10.1016/0006-8993(96)00517-3 · Cited by 204 · see citing works
Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases
Huang, E. Y., Inoue, T., Leone, V. A., Dalal, S., Touw, K., Wang, Y., Musch, M. W., Theriault, B., Higuchi, K., Donovan, S., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000332 · Cited by 204 · see citing works
Wood, S. K., & Bhatnagar, S. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.11.002 · Cited by 194 · see citing works
Self-citationvan Praag, H. M. (2005) · The World Journal of Biological Psychiatry · doi:10.1080/15622970510030018 · Cited by 184 · see citing works
Brain Inflammation and Microglia: Facts and Misconceptions
Jeong, H., Ji, K., Min, K., & Joe, E.-H. (2013) · Experimental Neurobiology · doi:10.5607/en.2013.22.2.59 · Cited by 182 · see citing works
Maukonen, J., Satokari, R., Mättö, J., Söderlund, H., Mattila-Sandholm, T., & Saarela, M. (2006) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46134-0 · Cited by 156 · see citing works
Stress Vulnerability during Adolescent Development in Rats
Jankord, R., Solomon, M. B., Albertz, J., Flak, J. N., Zhang, R., & Herman, J. P. (2010) · Endocrinology · doi:10.1210/en.2010-0658 · Cited by 154 · see citing works
Mudd, A. T., Berding, K., Wang, M., Donovan, S. M., & Dilger, R. N. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1353849 · Cited by 134 · see citing works
Timing the Microbes: The Circadian Rhythm of the Gut Microbiome
Liang, X., & FitzGerald, G. A. (2017) · Journal of Biological Rhythms · doi:10.1177/0748730417729066 · Cited by 132 · see citing works
Pro-inflammatory biomakers in depression: Treatment with venlafaxine
Piletz, J. E., Halaris, A. E., Iqbal, O., Hoppensteadt, D., Fareed, J., Zhu, H., Sinacore, J. M., & DeVane, C. L. (2009) · The World Journal of Biological Psychiatry · doi:10.3109/15622970802573246 · Cited by 130 · see citing works
Wood, S. K., Wood, C. S., Lombard, C. M., Lee, C. S., Zhang, X.-Y., Finnell, J. E., & Valentino, R. J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.026 · Cited by 129 · see citing works
Yu, H., Chen, K., Sun, Y., Carter, M., Garey, K. W., Savidge, T., Devaraj, S., Tessier, M. E. M., von Rosenvinge, E. C., Kelly, C. P., et al. (2017) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00037-17 · Cited by 126 · see citing works
Fecal Microbiota Analysis: An Overview of Sample Collection Methods and Sequencing Strategies
Thomas, V., Clark, J. R., & Dore, J. M. (2015) · Future Microbiology · doi:10.2217/fmb.15.87 · Cited by 122 · see citing works
Pearson-Leary, J., Eacret, D., Chen, R. J., Takano, H., Nicholas, B., & Bhatnagar, S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.122 · Cited by 114 · see citing works
Self-citationBlood-brain barrier integrity may be threatened by exercise in a warm environment
Watson, P., Shirreffs, S. M., & Maughan, R. J. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00676.2004 · Cited by 110 · see citing works
Lee, J., Yang, W., Hostetler, A., Schultz, N., Suckow, M. A., Stewart, K. L., Kim, D. D., & Kim, H. S. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0686-7 · Cited by 107 · see citing works
Venkatesan, C., Chrzaszcz, M., Choi, N., & Wainwright, M. S. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-32 · Cited by 103 · see citing works
MicroRNAs as biomarkers of resilience or vulnerability to stress
Chen, R. J., Kelly, G., Sengupta, A., Heydendael, W., Nicholas, B., Beltrami, S., Luz, S., Peixoto, L., Abel, T. G., & Bhatnagar, S. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.045 · Cited by 100 · see citing works
Self-citationThe neurobiology of the stress-resistant brain
Fleshner, M., Maier, S. F., Lyons, D. M., & Raskind, M. A. (2011) · Stress · doi:10.3109/10253890.2011.596865 · Cited by 98 · see citing works
Li, H., Zhang, L., Chen, L., Zhu, Q. R., Wang, W., & Qiao, J. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0862-9 · Cited by 82 · see citing works
Proteins released from stimulated neutrophils contain very high levels of oxidized methionine
Beck‐Speier, I., Leuschel, L., Luippold, G., & Maier, K. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)81401-7 · Cited by 78 · see citing works
Acute and chronic effects of three benzodiazepines in the social interaction anxiety test in mice
Angelis, L. D., & File, S. E. (1979) · Psychopharmacology · doi:10.1007/bf00496051 · Cited by 75 · see citing works
Animal inflammation-based models of depression and their application to drug discovery
Ma, L., Demin, K. A., Kolesnikova, T. O., Kharsko, S. L., Zhu, X., Yuan, X., Song, C., Мешалкина, Д. А., Leonard, B. E., Tian, L., et al. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1362385 · Cited by 68 · see citing works
The Systemic Inflammatory Response to Clostridium difficile Infection
Rao, K. K., Erb‐Downward, J. R., Walk, S. T., Micić, D., Falkowski, N. R., Santhosh, K., Mogle, J. A., Ring, C., Young, V. B., Huffnagle, G. B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092578 · Cited by 66 · see citing works
IL-4/10 prevents stress vulnerability following imipramine discontinuation
Han, A., Yeo, H.-L., Park, M.-J., Kim, S. H., Choi, H. J., Hong, C.-W., & Kwon, M. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0416-3 · Cited by 59 · see citing works
Klein, R., & Roggendorf, W. (2001) · Acta Neuropathologica · doi:10.1007/s004010000286 · Cited by 58 · see citing works
Interferon-induced depression: Strategies in treatment
Asnis, G. M., & Garza, R. D. L. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.006 · Cited by 57 · see citing works
Archer, A. C., Peddha, M. S., & Halami, P. M. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.08.044 · Cited by 54 · see citing works
Is Peripheral Immunity Regulated by Blood-Brain Barrier Permeability Changes?
Bargerstock, E., Puvenna, V., Iffland, P. H., Falcone, T., Hossain, M. S., Vetter, S., Man, S., Dickstein, L. P., Marchi, N., Ghosh, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101477 · Cited by 49 · see citing works
Bowen, M. T., Dass, S. A. H., Booth, J., Suraev, A. S., Vyas, A., & McGregor, I. S. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.08.004 · Cited by 41 · see citing works
Wood, S. K. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120224413 · Cited by 41 · see citing works
Felger, J. C., Haroon, E., & Miller, A. H. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.017 · Cited by 32 · see citing works
Blon, D. L., Hoornaert, C., Daans, J., Santermans, E., Hens, N., Goossens, H., Berneman, Z. N., & Ponsaerts, P. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.49 · Cited by 31 · see citing works
Active coping with stress suppresses glucose metabolism in the rat hypothalamus
Ono, Y., Lin, H.-C., Tzen, K., Chen, H.-H., Yang, P., Lai, W., Chen, J., Onozuka, M., & Yen, C. (2011) · Stress · doi:10.3109/10253890.2011.614296 · Cited by 29 · see citing works
Пискунов, А. К., Stepanichev, M. Y., Тишкина, А. О., Novikova, M. R., Levshina, I. P., & Gulyaeva, N. V. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-015-9785-7 · Cited by 27 · see citing works
Meeker, H. C., Chadman, K. K., Heaney, A. T., & Carp, R. I. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.05.003 · Cited by 20 · see citing works
Lopez, P., Halary, S., & Bapteste, É. (2015) · Biology Direct · doi:10.1186/s13062-015-0092-3 · Cited by 16 · see citing works
Flagged first, then by citations
3 of the 82 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857 · see citing works
Wang, Z., Chen, W.-H., Li, S.-X., He, Z.-M., Zhu, W.-L., Ji, Y.-B., Wang, Z., Zhu, X.-M., Yuan, K., Bao, Y.-P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01113-1 · Cited by 307 · see citing works
D’Amato, A., Di Cesare Mannelli, L., Lucarini, E., Man, A. L., Le Gall, G., Branca, J. J. V., Ghelardini, C., Amedei, A., Bertelli, E., Regoli, M., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00914-w · Cited by 269 · see citing works
Han, Y., Wang, B., Gao, H., He, C., Hua, R., Liang, C., Zhang, S., Wang, Y., Xin, S., & Xu, J. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s384949 · Cited by 265 · see citing works
Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review
Chinna Meyyappan, A., Forth, E., Wallace, C. J. K., & Milev, R. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02654-5 · Cited by 254 · see citing works
Wu, M., Tian, T., Mao, Q., Zou, T., Zhou, C., Xie, J., & Chen, J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01038-3 · Cited by 235 · see citing works
The microbiota-immune axis as a central mediator of gut-brain communication
Fung, T. C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104714 · Cited by 228 · see citing works
Zheng, P., Wu, J., Zhang, H., Perry, S. W., Yin, B., Tan, X., Chai, T., Liang, W., Huang, Y., Li, Y., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0744-2 · Cited by 202 · see citing works
Intestinal epithelial barrier functions in ageing
Branca, J. J. V., Gulisano, M., & Nicoletti, C. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100938 · Cited by 157 · see citing works
Bertollo, A. G., Santos, C. F., Bagatini, M. D., & Ignácio, Z. M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1541075 · Cited by 177 · see citing works
Cancer and stress: NextGen strategies
Cui, B., Peng, F., Lu, J., He, B., Su, Q., Luo, H., Deng, Z., Jiang, T., Su, K., Huang, Y., et al. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.005 · Cited by 152 · see citing works
Gheorghe, C. E., Ritz, N. L., Martin, J. A., Wardill, H. R., Cryan, J. F., & Clarke, G. A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1941711 · Cited by 149 · see citing works
Microbiota‐gut‐brain axis as a regulator of reward processes
García‐Cabrerizo, R., Carbia, C., O’Riordan, K. J., Schellekens, H., & Cryan, J. F. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15284 · Cited by 147 · see citing works
Tian, T., Mao, Q., Xie, J., Wang, Y., Shao, W., Zhong, Q., & Chen, J. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.10.002 · Cited by 146 · see citing works
Yang, Z., Li, J., Gui, X., Shi, X., Bao, Z., Han, H., & Li, M. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0729-1 · Cited by 138 · see citing works
Stress and cancer: The mechanisms of immune dysregulation and management
Liu, Y., Tian, S., Ning, B., Huang, T., Li, Y., & Wei, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1032294 · Cited by 135 · see citing works
Microbiota-brain interactions: Moving toward mechanisms in model organisms
Nagpal, J. K., & Cryan, J. F. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.036 · Cited by 107 · see citing works
Matsuda, Y., Ozawa, N., Shinozaki, T., Wakabayashi, K.-I., Suzuki, K., Kawano, Y., Ohtsu, I., & Tatebayashi, Y. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0855-1 · Cited by 105 · see citing works
Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses
Zhu, X., Sakamoto, S., Ishii, C., Smith, M. D., Ito, K., Obayashi, M., Unger, L., Hasegawa, Y., Kurokawa, S., Kishimoto, T., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01447-8 · Cited by 99 · see citing works
Chen, H., Zhang, F., Li, R., Liu, Y., Wang, X., Zhang, X., Xu, C., Li, Y., Guo, Y., & Yao, Q. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109829 · Cited by 98 · see citing works
Purging and the body in the therapeutic use of ayahuasca
Fotiou, E., & Gearin, A. K. (2019) · Social Science & Medicine · doi:10.1016/j.socscimed.2019.112532 · Cited by 93 · see citing works
Volatility as a Concept to Understand the Impact of Stress on the Microbiome
Bastiaanssen, T. F. S., Gururajan, A., van de Wouw, M., Moloney, G. M., Ritz, N. L., Long-Smith, C. M., Wiley, N., Murphy, A., Lyte, J. M., Fouhy, F., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105047 · Cited by 92 · see citing works
Interactions between central nervous system and peripheral metabolic organs
Zeng, W., Yang, F., Shen, W. L., Zhan, C., Zheng, P., & Hu, J. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2103-5 · Cited by 96 · see citing works
The change of gut microbiota in MDD patients under SSRIs treatment
Shen, Y., Yang, X., Li, G., Gao, J., & Liang, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-94481-1 · Cited by 90 · see citing works
Shan, B., Ai, Z., Zeng, S., Song, Y., Song, J., Zeng, Q., Liao, Z., Wang, T., Huang, C. C., & Su, D. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104699 · Cited by 86 · see citing works
Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats
Lv, W., Liu, C., Yu, L., Zhou, J., Li, Y., Xiong, Y., Guo, A., Chao, L., Qu, Q., Guang-wei, W., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1241894 · Cited by 85 · see citing works
The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
Sarubbo, F., Cavallucci, V., & Pani, G. (2022) · Cells · doi:10.3390/cells11030382 · Cited by 82 · see citing works
Bajaj, J. S., Sikaroodi, M., Fagan, A., Heuman, D. M., Gilles, H., Gavis, E. A., Fuchs, M. A., González‐Maeso, J., Nizam, S., Gillevet, P. M., et al. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00194.2019 · Cited by 81 · see citing works
cAMP-PKA cascade: An outdated topic for depression?
Gao, F., Yang, S., Wang, J., & Zhu, G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113030 · Cited by 77 · see citing works
Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases
Yuan, C., He, Y., Xie, K., Feng, L., Gao, S., & Cai, L. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1282431 · Cited by 82 · see citing works
Song, Y., Shan, B., Zeng, S., Zhang, J., Chen, J., Liao, Z., Wang, T., Zeng, Q., He, H., Wei, F.-Q., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113426 · Cited by 77 · see citing works
Dandekar, M. P., Palepu, M. S. K., Satti, S., Jaiswal, Y., Singh, A. A., Dash, S. P., Gajula, S. N. R., & Sonti, R. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00143 · Cited by 75 · see citing works
Agranyoni, O., Meninger-Mordechay, S., Uzan-Yulzari, A., Oren, Z., Salmon‐Divon, M., Rodin, D., Raz, O., Koman, I. E., Koren, O., Pinhasov, A., et al. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00193-9 · Cited by 73 · see citing works
Stevens, B. R., Roesch, L. F. W., Dobbler, P. T., Russell, J. T., Pepine, C. J., Holbert, R. C., Raizada, M. K., & Triplett, E. W. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0652-5 · Cited by 70 · see citing works
The emerging role of the gut microbiome in posttraumatic stress disorder
Ke, S., Hartmann, J., Ressler, K. J., Liu, Y., & Koenen, K. C. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.005 · Cited by 70 · see citing works
Bifidobacterium: a probiotic for the prevention and treatment of depression
Li, J., Wang, J., Wang, M., Zheng, L., Cen, Q., Wang, F., Li, Z., Pang, R., & Zhang, A. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1174800 · Cited by 75 · see citing works
Mathee, K., Cickovski, T., Deoraj, A., Stollstorff, M., & Narasimhan, G. (2019) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001112 · Cited by 68 · see citing works
Song, X., Wang, W., Ding, S., Liu, X., Wang, Y., & Ma, H. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.04.037 · Cited by 66 · see citing works
Wang, Q., Jia, M., Zhao, Y., Yan, H., Pan, J., Yu, H., Yan, S., Dai, X., Liu, X., & Liu, Z. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b03652 · Cited by 66 · see citing works
Zhang, M., Zhang, M., Kou, G., & Li, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1159771 · Cited by 63 · see citing works
Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation
Ge, T., Yao, X., Zhao, H., Yang, W., Zou, X., Peng, F., Li, B., & Cui, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105909 · Cited by 62 · see citing works
Madison, A. A., & Bailey, M. T. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.10.014 · Cited by 67 · see citing works
Lv, W.-J., Wu, X.-L., Chen, W.-Q., Li, Y.-F., Zhang, G.-F., Chao, L.-M., Zhou, J.-H., Guo, A., Liu, C., & Guo, S.-N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7902874 · Cited by 61 · see citing works
Miyanishi, H., & Nitta, A. (2021) · Pharmaceuticals · doi:10.3390/ph14090889 · Cited by 57 · see citing works
He, H., He, H., Mo, L., You, Z., & Zhang, J. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.031 · Cited by 61 · see citing works
Alterations of the Gut Microbiota in Response to Total Sleep Deprivation and Recovery Sleep in Rats
Wang, Z., Yuan, K., Ji, Y.-B., Li, S.-X., Shi, L., Wang, Z., Zhou, X.-Y., Bao, Y.-P., Xie, W., Han, Y., et al. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s334985 · Cited by 56 · see citing works
Kuti, D., Winkler, Z., Horváth, K., Juhász, B., Paholcsek, M., Stágel, A., Gulyás, G., Czeglédi, L., Ferenczi, S., & Kovács, K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.12.004 · Cited by 56 · see citing works
Xie, C., & Prasad, A. A. (2020) · Microorganisms · doi:10.3390/microorganisms8111661 · Cited by 56 · see citing works
Schmidt, E. K. A., Raposo, P. J. F., Espin, A. T., Fenrich, K. K., & Fouad, K. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02123-0 · Cited by 53 · see citing works
Laudani, S., Torrisi, S. A., Alboni, S., Bastiaanssen, T. F. S., Benatti, C., Rivi, V., Moloney, R. D., Fuochi, V., Furneri, P. M., Drago, F., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.11.004 · Cited by 52 · see citing works
Gut Microbiome and Neurodevelopmental Disorders: A Link Yet to Be Disclosed
Iliodromiti, Z., Triantafyllou, A., Tsaousi, M., Pouliakis, A., Petropoulou, C., Sokou, R., Volaki, P., Boutsikou, Τ., & Iacovidou, N. M. (2023) · Microorganisms · doi:10.3390/microorganisms11020487 · Cited by 52 · see citing works
Inflamed brain: Targeting immune changes and inflammation for treatment of depression
Sakamoto, S., Zhu, X., Hasegawa, Y., Karma, S., Obayashi, M., Alway, E., & Kamiya, A. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13286 · Cited by 51 · see citing works
Chen, C.-Y., Wang, Y., Lei, L., & Zhang, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122815 · Cited by 53 · see citing works
Resilience or susceptibility to traumatic stress: Potential influence of the microbiome
Tanelian, A., Nankova, B. B., Miari, M., Nahvi, R. J., & Sabban, E. L. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100461 · Cited by 51 · see citing works
Review of multi-omics data resources and integrative analysis for human brain disorders
Dong, X., Liu, C., & Dozmorov, M. (2021) · Briefings in Functional Genomics · doi:10.1093/bfgp/elab024 · Cited by 47 · see citing works
The hippocampus in stress susceptibility and resilience: Reviewing molecular and functional markers
Larosa, A., & Wong, T. P. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110601 · Cited by 47 · see citing works
Impact of gut microbiota on neurogenesis and neurological diseases during infancy
Cerdó, T., Diéguez, E., & Campoy, C. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.11.006 · Cited by 45 · see citing works
Liu, J., Fang, Y., Cui, L.-X., Wang, Z., Luo, Y., Gao, C., Ge, W., Huang, T., Wen, J., & Zhou, T. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112861 · Cited by 46 · see citing works
Jiang, Z., Wang, F., Zhao, Y., Lu, L.-F., Jiang, X., Huang, T., Yang, L., Guo, L., Weng, Z., & Liu, E. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155847 · Cited by 44 · see citing works
Han, H., Yao, J., Wu, J., Mao, S., Pan, H., Qv, L., Zhu, G., Ren, J., Yu, Y., Xuan, F., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03044-7 · Cited by 46 · see citing works
The emerging roles of neuroactive components produced by gut microbiota
Dezfouli, M. A., Rashidi, S. K., Yazdanfar, N., Khalili, H., Goudarzi, M., Saadi, A., & Kiani, A. A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-10097-4 · Cited by 45 · see citing works
He, H., Zhao, Z., Xiao, C., Li, L., Liu, Y., Fu, J., Liao, H., Zhou, T., & Zhang, J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106396 · Cited by 41 · see citing works
Hou, X., Rong, C., Wang, F., Liu, X., Sun, Y., & Zhang, H. (2020) · Neural Plasticity · doi:10.1155/2020/8858415 · Cited by 41 · see citing works
Fitzgerald, E., Parent, C. I., Kee, M. Z. L., & Meaney, M. J. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.635304 · Cited by 39 · see citing works
Resilience to the effects of social stress on vulnerability to developing drug addiction
Calpe-López, C., Martínez-Caballero, M. Á., García-Pardo, M. P., & Aguilar, M. A. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i1.24 · Cited by 38 · see citing works
Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence
Dai, W., Liu, J., Yan, Q., Teng, Z., Li, S., Yuan, H., Huang, J., Xiang, H., Tang, H., Wang, B., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.893567 · Cited by 41 · see citing works
Chen, C., Xiao, Q., Wen, Z., Gong, F., Zhan, H., Liu, J., Li, H., & Jiao, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107654 · Cited by 38 · see citing works
Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis
Kelly, J. R., Clarke, G. A., Harkin, A., Corr, S. C., Galvin, S. D., Pradeep, V., Cryan, J. F., O’Keane, V., & Dinan, T. G. (2022) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2022.100349 · Cited by 38 · see citing works
Stress, inflammation, microbiome and depression
Medina-Rodriguez, E. M., Cruz, A. A., Abreu, J. C. D., & Beurel, E. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173561 · Cited by 37 · see citing works
PTSD, Immune System, and Inflammation
Pivac, N., Vuić, B., Šagud, M., Erjavec, G. N., Perković, M. N., Konjevod, M., Tudor, L., Štrac, D. Š., Uzun, S., Kozumplik, O., et al. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_11 · Cited by 38 · see citing works
Sah, R. K., Nandan, A., Athira, K. V., Prashant, S. K., Sankaran, S., Jose, A., Venkidasamy, B., & Nile, S. H. (2023) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2023.103861 · Cited by 35 · see citing works
The Microbiota‐Gut‐Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders
Faysal, M. F., Zehravi, M., Sutradhar, B., Amin, M. A., Shanmugarajan, T. S., Arjun, U. V. N. V., Ethiraj, S., Durairaj, A., Dayalan, G., Ahamad, S. K., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70593 · Cited by 37 · see citing works
Zhu, Z., Cheng, Y., Liu, X., Xu, X., Ding, W., Ling, Z., Liu, J., & Cai, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1644160 · Cited by 39 · see citing works
SCI and depression: Does inflammation commandeer the brain?
Brakel, K., & Hook, M. A. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112977 · Cited by 34 · see citing works
Pick fecal microbiota transplantation to enhance therapy for major depressive disorder
Meng, Y., Sun, J., & Zhang, G. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110860 · Cited by 31 · see citing works
Scanes, E., Parker, L. M., Seymour, J. R., Siboni, N., King, W. L., Wegner, K. M., Dove, M. C., O’Connor, W. A., & Ross, P. M. (2021) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiab099 · Cited by 31 · see citing works
Benefits of animal models to understand the pathophysiology of depressive disorders
Czéh, B., & Simon, M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110049 · Cited by 30 · see citing works
de Jong, I. C., Schokker, D., Gunnink, H., van Wijhe, M., & Rebel, J. M. J. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.977359 · Cited by 29 · see citing works
Depression-associated gut microbes, metabolites and clinical trials
Wang, M., Song, Z., Lai, S., Tang, F., Dou, L., & Yang, F. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1292004 · Cited by 29 · see citing works
Stallmach, A., Quickert, S., Puta, C., & Reuken, P. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1352744 · Cited by 29 · see citing works
Microcystis toxin-mediated tumor promotion and toxicity lead to shifts in mouse gut microbiome
Lee, J., Lee, S., Mayta, A., Mrdjen, I., Weghorst, C. M., & Knobloch, T. J. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111204 · Cited by 29 · see citing works
Zhang, D., Li, H., Luo, X., Liu, D., Wei, Q., & Ye, X. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154300 · Cited by 29 · see citing works
Zhang, F., Chen, H., Zhang, R.-X., Liu, Y., Kong, N., Guo, Y., & Xu, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165884 · Cited by 29 · see citing works
He, H., He, H., Mo, L., Yuan, Q., Xiao, C., Ma, Q., Yi, S., Zhou, T., You, Z., & Zhang, J. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100729 · Cited by 29 · see citing works
Effect of gut microbiota early in life on aggressive behavior in mice
Watanabe, N., Mikami, K., Hata, T., Kimoto, K., Nishino, R., Akama, F., Yamamoto, K., Sudo, N., Koga, Y., & Matsumoto, H. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.01.005 · Cited by 28 · see citing works
Zhang, Y., Zhang, J., Wu, J., Zhu, Q., Chen, C., & Li, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1124454 · Cited by 28 · see citing works
Han, Y., Sun, C.-Y., Meng, S., Tabarak, S., Yuan, K., Cao, L., Yan, W., Xu, L., Deng, J., Zhu, W., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0470-9 · Cited by 25 · see citing works
Chen, Y., An, Q., Yang, S., Chen, Y.-L., Tong, L., & Ji, L.-L. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114154 · Cited by 27 · see citing works
Zhao, N., 东南大学医学院神经内科, 江. 南. 2., Xiu, C., Chen, Q.-G., Liu, X.-T., Geng, F., Zhu, M., Yan, F., Zhang, Z., Ren, Q., et al. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2024.085 · Cited by 25 · see citing works
Miyanishi, H., Muramatsu, S., & Nitta, A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01033-2 · Cited by 24 · see citing works
Vasiliu, O. (2022) · Current Medical Research and Opinion · doi:10.1080/03007995.2022.2124071 · Cited by 25 · see citing works
Tanelian, A., Nankova, B. B., Cheriyan, A., Arens, C., Hu, F., & Sabban, E. L. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100533 · Cited by 25 · see citing works
Microbiota-Gut-Brain Axis in Major Depression: A New Therapeutic Approach
Kim, I. B., Park, S., & Kim, Y. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_10 · Cited by 26 · see citing works
Chen, H., Xu, C., Zhang, F., Liu, Y., Guo, Y., & Yao, Q. (2020) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-020-04060-w · Cited by 24 · see citing works
Fouesnard, M., Zoppi, J., Pétéra, M., Gléau, L. L., Migné, C., Devime, F., Durand, S., Bénani, A., Chaffron, S., Douard, V., et al. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00796-4 · Cited by 24 · see citing works
A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h
Jing, W., Zhang, T., Liu, J., Huang, X., Yu, Q., Yu, H., Zhang, Q., Li, H., Deng, M., Zhu, L., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110177 · Cited by 25 · see citing works
Nohesara, S., Abdolmaleky, H. M., Zhou, J., & Thiagalingam, S. (2023) · Genes · doi:10.3390/genes14122217 · Cited by 24 · see citing works
Song, A., Ru, C., Jiang, J., Qu, H., Wu, Z., Qian, F., Shen, S., Zhang, L., Wang, Z., Zhao, W., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.03.017 · Cited by 23 · see citing works
Pearson-Leary, J., Eacret, D., & Bhatnagar, S. (2019) · Stress · doi:10.1080/10253890.2019.1673360 · Cited by 21 · see citing works
Self-citation
- Authors
- Pearson-Leary, J., Zhao, C., Bittinger, K., Eacret, D., Luz, S., Vigderman, A. S., Dayanim, G., & Bhatnagar, S.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Bhatnagar, Seema
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 2019-03-04
- Volume
- 25
- Issue
- 5
- Pages
- 1068-1079
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2918256091
- Cited by
- 206
- References
- 82
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 30 · 2023: 25 · 2022: 33 · 2021: 37 · 2020: 30 · 2019: 15
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Army Research Office
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- gut microbiota, depression-like behavior, anxiety-like behavior, social defeat stress, stress vulnerability, ventral hippocampus, neuroinflammation, microglia, IL-1β, Clostridia, fecal microbiota transplantation, resilience
- MeSH terms
- Gastrointestinal Microbiome, Animals, Anxiety, Behavior, Animal, Depression, Hippocampus, Stress, Psychological, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review