Programming assembly of biomimetic exosomes: An emerging theranostic nanomedicine platform

The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes

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Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

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Engineering exosomes for targeted drug delivery

Liang, Y., Duan, L., Lu, J., & Xia, J. (2021) · Theranostics · doi:10.7150/thno.52570 · Cited by 1,547 · see citing works

&lt;p&gt;Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications&lt;/p&gt;

Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s264498 · Cited by 1,323 · see citing works

Engineering exosomes as refined biological nanoplatforms for drug delivery

Luan, X., Sansanaphongpricha, K., Myers, I., Chen, H., Yuan, H., & Sun, D. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.12 · Cited by 1,171 · see citing works

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

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Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells

Savina, A., Furlán, M., Vidal, M., & Colombo, M. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301642200 · Cited by 835 · see citing works

Engineering hybrid exosomes by membrane fusion with liposomes

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Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., & Takakura, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.03.013 · Cited by 729 · see citing works

Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake

Gebologlu, I. K., & Öncel, S. Ş. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.027 · Cited by 703 · see citing works

Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

Han, Q.-F., Li, W.-J., Hu, K., Gao, J., Zhai, W., Yang, J.-H., & Zhang, S. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01671-0 · Cited by 683 · see citing works

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: In vitro and in vivo evaluations

Kim, M. S., Haney, M. J., Zhao, Y., Yuan, D., Deygen, I., Klyachko, N. L., Kabanov, A. V., & Batrakova, E. V. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.09.011 · Cited by 663 · see citing works

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

Kooijmans, S. A. A., Fliervoet, L. A. L., van der Meel, R., Fens, M. H. A. M., Heijnen, H. F. G., Henegouwen, P. M. P. V. B. E., Vader, P., & Schiffelers, R. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.009 · Cited by 629 · see citing works

Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

Lin, Y., Wu, J., Gu, W., Huang, Y., Tong, Z., Huang, L., & Tan, J. (2018) · Advanced Science · doi:10.1002/advs.201700611 · Cited by 625 · see citing works

Surface Functionalization of Exosomes Using Click Chemistry

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M1 Macrophage-Derived Nanovesicles Potentiate the Anticancer Efficacy of Immune Checkpoint Inhibitors

Choo, Y. W., Kang, M., Kim, H. Y., Han, J., Kang, S., Lee, J., Jeong, G., Kwon, S. P., Song, S. Y., Go, S., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02446 · Cited by 466 · see citing works

Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems

Piffoux, M., Silva, A., Wilhelm, C., Gazeau, F., & Tareste, D. C. (2018) · ACS Nano · doi:10.1021/acsnano.8b02053 · Cited by 463 · see citing works

Biomimetic proteolipid vesicles for targeting inflamed tissues

Molinaro, R., Corbo, C., Martinez, J. O., Taraballi, F., Evangelopoulos, M., Minardi, S., Yazdi, I. K., Zhao, P., Rosa, E. D., Sherman, M. B., et al. (2016) · Nature Materials · doi:10.1038/nmat4644 · Cited by 453 · see citing works

Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment

Zhou, W., Zhou, Y., Chen, X., Ning, T., Chen, H., Guo, Q., Zhang, Y., Liu, P., Zhang, Y., Li, C., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120546 · Cited by 449 · see citing works

Macrophage-derived exosome-mimetic hybrid vesicles for tumor targeted drug delivery

Rayamajhi, S., Nguyen, T. D. T., Marasini, R., & Aryal, S. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.054 · Cited by 429 · see citing works

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

Chen, D. L., Love, K. T., Chen, Y., Eltoukhy, A. A., Kastrup, C. J., Sahay, G., Jeon, A., Dong, Y., Whitehead, K. A., & Anderson, D. G. (2012) · Journal of the American Chemical Society · doi:10.1021/ja301621z · Cited by 422 · see citing works

Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity

Ferguson, S. W., & Nguyen, J. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.037 · Cited by 419 · see citing works

Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools

Li, S.-P., Lin, Z., Jiang, X., & Yu, X. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.178 · Cited by 395 · see citing works

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

Liang, Y., Xu, X., Li, X., Xiong, J., Li, B., Duan, L., Wang, D., & Xia, J. (2020) · ACS Applied Materials &amp; Interfaces · doi:10.1021/acsami.0c10458 · Cited by 391 · see citing works

Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing

Zhigaltsev, I. V., Belliveau, N. M., Hafez, I. M., Leung, A. K. K., Huft, J., Hansen, C. L., & Cullis, P. R. (2012) · Langmuir · doi:10.1021/la204833h · Cited by 346 · see citing works

Artificial exosomes for translational nanomedicine

Li, Y., Wu, J., Liu, J., Xu, W., Qiu, X., Huang, S. Q., Hu, X.-B., & Xiang, D. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00986-2 · Cited by 337 · see citing works

In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9

Li, Z., Zhou, X., Wei, M., Gao, X., Zhao, L., Shi, R., Sun, W., Duan, Y., Yang, G., & Yuan, L. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b02689 · Cited by 318 · see citing works

Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins

Dorayappan, K. D. P., Wanner, R. A., Wallbillich, J. J., Saini, U., Zingarelli, R. A., Suarez, A. A., Cohn, D. E., & Selvendiran, K. (2018) · Oncogene · doi:10.1038/s41388-018-0189-0 · Cited by 309 · see citing works

Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy

Cheng, L., Zhang, X., Tang, J., Lv, Q., & Liu, J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120964 · Cited by 307 · see citing works

Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury

Cao, J., Wang, B., Tang, T., Lv, L., Ding, Z., Li, Z., Hu, R., Wei, Q., Shen, A., Fu, Y., et al. (2020) · Stem Cell Research &amp; Therapy · doi:10.1186/s13287-020-01719-2 · Cited by 264 · see citing works

Simulation of the Spontaneous Aggregation of Phospholipids into Bilayers

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Exosome-mediated delivery of gene vectors for gene therapy

Duan, L., Xu, L., Xu, X., Qin, Z., Zhou, X., Xiao, Y., Liang, Y., & Xia, J. (2021) · Nanoscale · doi:10.1039/d0nr07622h · Cited by 238 · see citing works

Camouflage strategies for therapeutic exosomes evasion from phagocytosis

Parada, N., Romero-Trujillo, A., Georges, N., & Alcayaga‐Miranda, F. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.01.001 · Cited by 237 · see citing works

Exosome-liposome hybrid nanoparticle codelivery of TP and miR497 conspicuously overcomes chemoresistant ovarian cancer

Li, L., He, D., Guo, Q., Zhang, Z., Ru, D., Wang, L., Gong, K., Liu, F., Duan, Y., & He, L. N. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01264-5 · Cited by 232 · see citing works

Functional siRNA Delivery by Extracellular Vesicle–Liposome Hybrid Nanoparticles

Evers, M. J. W., van de Wakker, S. I., de Groot, E. M., de Jong, O. G., Gitz-Francois, J. J., Seinen, C. W., Sluijter, J. P. G., Schiffelers, R. M., & Vader, P. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101202 · Cited by 221 · see citing works

Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation

Yang, Z., Xie, J., Zhu, J., Chen, K., Chiang, C., Wang, X., Wang, X., Kuang, T., Chen, F., Chen, Z., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.10.008 · Cited by 217 · see citing works

Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment

Liang, Y., Xu, X., Xu, L., Iqbal, Z., Ouyang, K., Zhang, H., Wen, C., Duan, L., & Xia, J. (2022) · Theranostics · doi:10.7150/thno.69368 · Cited by 217 · see citing works

Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges

Mehryab, F., Rabbani, S., Shahhosseini, S., Shekari, F., Fatahi, Y., Baharvand, H., & Haeri, A. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.06.036 · Cited by 216 · see citing works

Thermosensitive Exosome–Liposome Hybrid Nanoparticle‐Mediated Chemoimmunotherapy for Improved Treatment of Metastatic Peritoneal Cancer

Lv, Q., Cheng, L., Lu, Y., Zhang, X., Wang, Y., Deng, J., Zhou, J., Liu, B., & Liu, J. (2020) · Advanced Science · doi:10.1002/advs.202000515 · Cited by 210 · see citing works

The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer

Wang, X., Huang, J., Chen, W., Li, G., Li, Z., & Lei, J. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00855-4 · Cited by 190 · see citing works

Enhanced Loading of Functional miRNA Cargo via pH Gradient Modification of Extracellular Vesicles

Jeyaram, A., Lamichhane, T. N., Wang, S., Zou, L., Dahal, E., Kronstadt, S. M., Levy, D. H., Parajuli, B., Knudsen-Palmer, D. R., Chao, W., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.12.007 · Cited by 184 · see citing works

Boosting the Biogenesis and Secretion of Mesenchymal Stem Cell-Derived Exosomes

Wang, J., Bonacquisti, E. E., Brown, A., & Nguyen, J. (2020) · Cells · doi:10.3390/cells9030660 · Cited by 183 · see citing works

Cell membrane-formed nanovesicles for disease-targeted delivery

Gao, J., Chu, D., & Wang, Z. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.024 · Cited by 179 · see citing works

Exosome-mimetic nanoplatforms for targeted cancer drug delivery

Vázquez-Ríos, A. J., Molina-Crespo, Á., Bouzo, B. L., López‐López, R., Moreno‐Bueno, G., & de la Fuente, M. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0517-8 · Cited by 177 · see citing works

Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis

Sun, L., Fan, M., Huang, D., Li, B., Xu, R., Gao, F., & Chen, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120761 · Cited by 173 · see citing works

Clinical applications of exosome membrane proteins

Hu, Q., Su, H., Li, J., Lyon, C. J., Tang, W., Wan, M., & Hu, Y. (2020) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbaa007 · Cited by 172 · see citing works

Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers

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Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice

Nakamura, Y., Kita, S., Tanaka, Y., Fukuda, S., Obata, Y., Okita, T., Nishida, H., Takahashi, Y., Kawachi, Y., Tsugawa-Shimizu, Y., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.06.026 · Cited by 167 · see citing works

Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment

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Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering

Liang, Y., Iqbal, Z., Lu, J., Wang, J., Zhang, H., Chen, X., Duan, L., & Xia, J. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2022.10.008 · Cited by 162 · see citing works

Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system

Patel, D. B., Luthers, C. R., Lerman, M. J., Fisher, J. P., & Jay, S. M. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.024 · Cited by 152 · see citing works

Diversity of PEGylation methods of liposomes and their influence on RNA delivery

Nosova, A. S., Koloskova, O. O., Nikonova, A. A., Simonova, V. A., Vv, S., Kudlay, D. A., & Khaitov, M. R. (2019) · MedChemComm · doi:10.1039/c8md00515j · Cited by 149 · see citing works

Generation of nanovesicles with sliced cellular membrane fragments for exogenous material delivery

Yoon, J., Jo, W., Jeong, D., Kim, J., Jeong, H., & Park, J. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.028 · Cited by 133 · see citing works

Dual-targeting immunoliposomes using angiopep-2 and CD133 antibody for glioblastoma stem cells

Kim, J. S., Shin, D. H., & Kim, J. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.026 · Cited by 133 · see citing works

Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment

Zhang, L., Qin, Z., Sun, H., Chen, X. '., Dong, J. P., Shen, S., Zheng, L., Gu, N., & Jiang, Q. Y. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.02.017 · Cited by 132 · see citing works

Functionalized DNA Enables Programming Exosomes/Vesicles for Tumor Imaging and Therapy

Fan, Z., Xiao, K., Lin, J., Liao, Y., & Huang, X. (2019) · Small · doi:10.1002/smll.201903761 · Cited by 113 · see citing works

Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications

Zhang, X., Xu, Q., Zi, Z., Liu, Z., Wan, C., Crisman, L., Shen, J., & Liu, X. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.11.007 · Cited by 113 · see citing works

Strategies to overcome the main challenges of the use of exosomes as drug carrier for cancer therapy

Hussen, B. M., Faraj, G. S. H., Rasul, M. F., Hidayat, H. J., Salihi, A. B., Baniahmad, A., Taheri, M. N., & Ghafouri‐Fard, S. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02743-3 · Cited by 110 · see citing works

Cancer Cell-Derived, Drug-Loaded Nanovesicles Induced by Sulfhydryl-Blocking for Effective and Safe Cancer Therapy

Ingato, D., Edson, J. A., Zakharian, M., & Kwon, Y. J. (2018) · ACS Nano · doi:10.1021/acsnano.8b05377 · Cited by 105 · see citing works

Bottom-up assembly of biomedical relevant fully synthetic extracellular vesicles

Staufer, O., Dietrich, F., Rimal, R., Schröter, M., Fabritz, S., Boehm, H., Singh, S., Möller, M., Platzman, I., & Spatz, J. P. (2021) · Science Advances · doi:10.1126/sciadv.abg6666 · Cited by 104 · see citing works

Liposome‐bound APO2L/TRAIL is an effective treatment in a rabbit model of rheumatoid arthritis

Martínez‐Lostao, L., Garcí´a‐Alvarez, F., Basáñez, G., Alegre‐Aguarón, E., Desportes, P., Larrad, L., Naval, J., Martínez‐Lorenzo, M. J., & Anel, A. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27501 · Cited by 99 · see citing works

Harnessing knee joint resident mesenchymal stem cells in cartilage tissue engineering

Xu, X. G., Xu, L., Xia, J., Wen, C., Liang, Y., & Zhang, Y. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.07.024 · Cited by 92 · see citing works

Engineering exosome-based biomimetic nanovehicles for wound healing

Joorabloo, A., & Liu, T. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.013 · Cited by 91 · see citing works

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models

Liang, X., Niu, Z., Galli, V., Howe, N., Zhao, Y. H., Wiklander, O. P. B., Zheng, W., Wiklander, R. J., Corso, G., Davies, C., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12248 · Cited by 90 · see citing works

Nanovesicles engineered from ES cells for enhanced cell proliferation

Jeong, D., Jo, W., Yoon, J., Kim, J., Gianchandani, S., Gho, Y. S., & Park, J. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.07.047 · Cited by 88 · see citing works

Nanoparticle Delivery of Pooled siRNA for Effective Treatment of Non-Small Cell Lung Caner

Yang, Y., Hu, Y., Wang, Y., Li, J., Liu, F., & Huang, L. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300152v · Cited by 88 · see citing works

Fully Artificial Exosomes: Towards New Theranostic Biomaterials

García‐Manrique, P., Gutiérrez, G., & Blanco‐López, M. C. (2017) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.10.005 · Cited by 88 · see citing works

Low level electricity increases the secretion of extracellular vesicles from cultured cells

Fukuta, T., Nishikawa, A., & Kogure, K. (2019) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2019.100713 · Cited by 87 · see citing works

Advancement and obstacles in microfluidics-based isolation of extracellular vesicles

Havers, M., Broman, A., Lenshof, A., & Laurell, T. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-04362-3 · Cited by 84 · see citing works

Exosomes derived from umbilical cord mesenchymal stem cells in mechanical environment show improved osteochondral activity via upregulation of LncRNA H19

Yan, L., Liu, G., & Wu, X. (2020) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2020.03.005 · Cited by 83 · see citing works

Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing

Duan, L., Ouyang, K., Wang, J., Xu, L., Xu, X., Wen, C., Xie, Y., Liang, Y., & Xia, J. (2021) · ChemBioChem · doi:10.1002/cbic.202100359 · Cited by 82 · see citing works

Liposomes Decorated with Apo2L/TRAIL Overcome Chemoresistance of Human Hematologic Tumor Cells

de Miguel, D., Basáñez, G., Sánchez‐Martínez, D., Galán‐Malo, P., Marzo, I., Larrad, L., Naval, J., Pardo, J., Anel, A., & Martínez‐Lostao, L. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300258c · Cited by 81 · see citing works

Antibody-conjugated liposomes loaded with indocyanine green for oral targeted photoacoustic imaging-guided sonodynamic therapy of Helicobacter pylori infection

Wang, R., Song, C., Gao, A., Liu, Q., Guan, W., Mei, J., Ma, L., & Cui, D. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.02.031 · Cited by 77 · see citing works

Cell-free synthesis of connexin 43-integrated exosome-mimetic nanoparticles for siRNA delivery

Lu, M., Zhao, X., Xing, H., Liu, H., Lang, L., Yang, T., Xun, Z., Wang, D., & Ding, P. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.07.006 · Cited by 73 · see citing works

Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice

Gao, J., Wang, S., Dong, X., Leanse, L. G., Dai, T., & Wang, Z. (2020) · Communications Biology · doi:10.1038/s42003-020-01410-5 · Cited by 73 · see citing works

Cell-derived extracellular vesicles for CRISPR/Cas9 delivery: engineering strategies for cargo packaging and loading

Liang, Y., Iqbal, Z., Wang, J., Xu, L., Xu, X., Ouyang, K., Zhang, H., Lu, J., Duan, L., & Xia, J. (2022) · Biomaterials Science · doi:10.1039/d2bm00480a · Cited by 72 · see citing works

Biomaterial-assisted targeted and controlled delivery of CRISPR/Cas9 for precise gene editing

Iqbal, Z., Rehman, K., Xia, J., Shabbir, M., Zaman, M., Liang, Y., & Duan, L. (2023) · Biomaterials Science · doi:10.1039/d2bm01636b · Cited by 69 · see citing works

Serum deprivation elevates the levels of microvesicles with different size distributions and selectively enriched proteins in human myeloma cells in vitro

Sun, L., Wang, H., Zhu, X., Wu, P., Chen, W., Zou, P., Li, Q., & Chen, Z. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.166 · Cited by 67 · see citing works

Osteoclast-targeted delivery of anti-miRNA oligonucleotides by red blood cell extracellular vesicles

Xu, L., Xu, X., Liang, Y., Wen, C., Ouyang, K., Huang, J., Xiao, Y., Deng, X., Xia, J., & Duan, L. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.04.043 · Cited by 65 · see citing works

Attenuation of Tumor Necrosis Factor-α Induced Inflammation by Umbilical Cord-Mesenchymal Stem Cell Derived Exosome-Mimetic Nanovesicles in Endothelial Cells

Ko, K., Yoo, Y.-I., Kim, J. Y., Choi, B., Park, S.-B., Park, W., Rhim, W.-K., & Han, D. K. (2020) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-019-00234-7 · Cited by 63 · see citing works

A Facile Magnetic Extrusion Method for Preparing Endosome‐Derived Vesicles for Cancer Drug Delivery

Guo, P., Busatto, S., Huang, J., Morad, G., & Moses, M. A. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202008326 · Cited by 62 · see citing works

Microfluidics for extracellular vesicle separation and mimetic synthesis: Recent advances and future perspectives

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EXOPLEXs: Chimeric Drug Delivery Platform from the Fusion of Cell-Derived Nanovesicles and Liposomes

Goh, W. J., Zou, S., Lee, C. K., Ou, Y.-H., Wang, J., Czarny, B., & Pastorin, G. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01176 · Cited by 59 · see citing works

Extracellular blebs: Artificially-induced extracellular vesicles for facile production and clinical translation

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GE11 Peptide Conjugated Liposomes for EGFR-Targeted and Chemophotothermal Combined Anticancer Therapy

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Synergistic ferroptosis and macrophage re-polarization using engineering exosome-mimic M1 nanovesicles for cancer metastasis suppression

Li, P., Gao, M., Hu, Z., Xu, T., Chen, J., Ma, Y., Li, S., & Gu, Y. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.128217 · Cited by 45 · see citing works

A novel micro-emulsion and micelle assembling method to prepare DEC205 monoclonal antibody coupled cationic nanoliposomes for simulating exosomes to target dendritic cells

Li, K., Chang, S., Wang, Z., Zhao, X., & Chen, D. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.05.068 · Cited by 42 · see citing works

Uncovering temperature‐dependent extracellular vesicle secretion in breast cancer

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Surface protein engineering increases the circulation time of a cell membrane-based nanotherapeutic

Krishnamurthy, S., Muthukumaran, P., Jayakumar, M. K. G., Liße, D., Masurkar, N. D., Xu, C., Chan, J. M., & Drum, C. L. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.02.024 · Cited by 37 · see citing works

Electrical stimulation to optimize cardioprotective exosomes from cardiac stem cells

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Exosome‐Mimetic Supramolecular Vesicles with Reversible and Controllable Fusion and Fission**

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Development of rapamycin-encapsulated exosome-mimetic nanoparticles-in-PLGA microspheres for treatment of hemangiomas

Li, H., Wang, X., Guo, X., Wan, Q., Teng, Y., & Liu, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112737 · Cited by 33 · see citing works

Immunotherapy with liposome-bound TRAIL overcomes partial protection to soluble TRAIL-induced apoptosis offered by down-regulation of Bim in leukemic cells

de Miguel, D., Gallego-Lleyda, A., Galán‐Malo, P., Rodríguez‐Vigil, C., Marzo, I., Anel, A., & Martínez‐Lostao, L. (2015) · Clinical & Translational Oncology · doi:10.1007/s12094-015-1295-x · Cited by 32 · see citing works

Macrophage-derived hybrid exosome-mimic nanovesicles loaded with black phosphorus for multimodal rheumatoid arthritis therapy

Zhao, C., Song, W.-X., Ma, J., & Wang, N. (2022) · Biomaterials Science · doi:10.1039/d2bm01274j · Cited by 32 · see citing works

Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy

Zheng, Y., Kong, F., Liu, S., Liu, X., Pei, D., & Miao, X. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1983072 · Cited by 31 · see citing works

Cytochalasin B Treatment and Osmotic Pressure Enhance the Production of Extracellular Vesicles (EVs) with Improved Drug Loading Capacity

Nair, A., Bu, J., Rawding, P. A., Steven, C., Li, H., & Hong, S. (2021) · Nanomaterials · doi:10.3390/nano12010003 · Cited by 28 · see citing works

Investigation of the Antitumor Activity and Toxicity of Tumor-Derived Exosomes Fused with Long-Circulating and pH-Sensitive Liposomes Containing Doxorubicin

Gomes, E. R., Souza, F. R., Cassali, G. D., Sabino, A. D. P., de Barros, A. L. B., & Oliveira, M. C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112256 · Cited by 22 · see citing works

Biomimetic and immunomodulatory therapeutics as an alternative to natural exosomes for vascular and cardiac applications

Villarreal-Leal, R. A., Cooke, J. P., & Corradetti, B. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102385 · Cited by 21 · see citing works

Targeting Myd88 using peptide-loaded mesenchymal stem cell membrane-derived synthetic vesicles to treat systemic inflammation

Park, K., Bergqvist, M., Lässer, C., & Lötvall, J. O. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01660-x · Cited by 21 · see citing works

Examination of Effective Buccal Absorption of Salmon Calcitonin Using Cell-Penetrating Peptide-Conjugated Liposomal Drug Delivery System

Keum, T., Noh, G., Seo, J.-E., Bashyal, S., Sohn, D. H., & Lee, S. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s335774 · Cited by 19 · see citing works

Erythro-PmBs: A Selective Polymyxin B Delivery System Using Antibody-Conjugated Hybrid Erythrocyte Liposomes

Krivić, H., Himbert, S., Sun, R., Feigis, M., & Rheinstadter, M. C. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00017 · Cited by 18 · see citing works

Engineered versus hybrid cellular vesicles as efficient drug delivery systems: a comparative study with brain targeted vesicles

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Microneedle-based two-step transdermal delivery of Langerhans cell-targeting immunoliposomes induces a Th1-biased immune response

Yu, Y., Wang, H., Guo, B., Wang, B., Wan, Z., Zhang, Y., Sun, L., & Yang, F. H. (2022) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2022.06.004 · Cited by 14 · see citing works

Engineering M1-derived nanovesicles loading with docosahexaenoic acid synergizes ferroptosis and immune activation for treating hepatocellular carcinoma

Meng, M., Zhang, X., Li, Q., Han, J., Chen, Y., Qiao, H., Yang, Y., & Huang, X. (2023) · Cancer Nanotechnology · doi:10.1186/s12645-023-00166-x · Cited by 13 · see citing works

Large-Scale Preparation of Synovial Fluid Mesenchymal Stem Cell-Derived Exosomes by 3D Bioreactor Culture

Duan, L., Li, X., Xu, X. G., Xu, L., Wang, D., Ouyang, K., & Liang, Y. (2022) · Journal of Visualized Experiments · doi:10.3791/62221 · Cited by 12 · see citing works

Heterogeneous Subcellular Origin of Exosome-Mimetic Nanovesicles Engineered from Cells

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Dendritic lipopeptide liposomes decorated with dual-targeted proteins

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Engineered Hybrid Nanosystem for Homologous Targeting of EMT Induced Triple Negative Breast Cancer Cells

Saha, M., & Ghosh, S. S. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00925 · Cited by 5 · see citing works

Brucea javanica derived exosome-like nanovesicles deliver miRNAs for cancer therapy

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Exosome for mRNA delivery: Strategies and therapeutic applications

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Nanoparticle-Based Drug Delivery Systems in Inhaled Therapy: Improving Respiratory Medicine

Cojocaru, E., Petriș, O. R., & Cojocaru, C. (2024) · Pharmaceuticals · doi:10.3390/ph17081059 · Cited by 123 · see citing works

Research Advances of Engineered Exosomes as Drug Delivery Carrier

Huang, L., Wu, E., Liao, J., Wei, Z., Wang, J., & Chen, Z. (2023) · ACS Omega · doi:10.1021/acsomega.3c04479 · Cited by 107 · see citing works

Smart Nanoplatforms Responding to the Tumor Microenvironment for Precise Drug Delivery in Cancer Therapy

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Leveraging nature’s nanocarriers: Translating insights from extracellular vesicles to biomimetic synthetic vesicles for biomedical applications

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Platelet-rich plasma-derived exosomes boost mesenchymal stem cells to promote peripheral nerve regeneration

Zhang, Y., Yi, D., Hong, Q., Cao, J., Geng, X., Liu, J., Xu, C., Cao, M., Chen, C., Xu, S., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.043 · Cited by 75 · see citing works

Brain‐derived extracellular vesicles: Potential diagnostic biomarkers for central nervous system diseases

Xu, X., Iqbal, Z., Xu, L., Wen, C., Duan, L., Xia, J., Yang, N., Zhang, Y., & Liang, Y. (2024) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13610 · Cited by 68 · see citing works

Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis

Luo, D., Zhu, H., Li, S., Wang, Z., & Xiao, J. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1309946 · Cited by 64 · see citing works

Biomimetic Nanoparticles for Basic Drug Delivery

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Bone Targeting Nanoparticles for the Treatment of Osteoporosis

Wen, C., Xu, X. M., Zhang, Y., Xia, J., Liang, Y., & Xu, L. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s444347 · Cited by 58 · see citing works

Environmental pollutants and exosomes: A new paradigm in environmental health and disease

Javdani-Mallak, A., & Salahshoori, I. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.171774 · Cited by 58 · see citing works

Bioinspired cellular membrane-derived vesicles for mRNA delivery

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Global Trends of Exosomes Application in Clinical Trials: A Scoping Review

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Extracellular Vesicles: A New Star for Gene Drug Delivery

Sun, M., Zhang, H., Liu, J., Chen, J., Cui, Y., Wang, S., Zhang, X., & Yang, Z. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s446224 · Cited by 38 · see citing works

Recent advances in the clinical application of exosomes for disease diagnosis and therapeutic strategies

Wen, C., Ma, H., Xu, L., Gu, Z., Li, H., Zhang, Y., Liang, Y., & Xu, X. G. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002518 · Cited by 35 · see citing works

Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis

Zhang, Z., Zhao, S., Sun, Z., Zhai, C., Xia, J., Wen, C., Zhang, Y., & Zhang, Y. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00485-2 · Cited by 33 · see citing works

Lysosomal destabilization: A missing link between pathological calcification and osteoarthritis

Ye, T., Wang, C.-Y., Yan, J.-F., Qin, Z.-X., Qin, W., Ma, Y., Wan, Q.-Q., Lu, W., Zhang, M., Tay, F. R., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.12.001 · Cited by 40 · see citing works

Targeted immunotherapy: harnessing the immune system to battle multiple myeloma

Xu, L., Wen, C., Xia, J., Zhang, H., Liang, Y., & Xu, X. G. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01818-6 · Cited by 30 · see citing works

Precision exosome engineering for enhanced wound healing and scar revision

Liu, C., Chen, C., Cheng, K., Gao, A. S., Li, Q., Atala, A., & Zhang, Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06578-0 · Cited by 27 · see citing works

Mesenchymal stem cells and extracellular vesicles for knee osteoarthritis: clinical application, mechanism exploration and prospect

Li, Y., Fu, T., Yu, W., Wen, H., Wang, Z., Lyu, Z., Wen, X., Ba, T., Chen, Z., Shan, K., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04783-8 · Cited by 27 · see citing works

The evolving landscape of gene therapy strategies for the treatment of osteoarthritis

Grol, M. W. (2024) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.12.009 · Cited by 25 · see citing works

Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment

Xiong, J., Liu, Z., Jia, L., Sun, Y., Guo, R., Xi, T., Li, Z., Wu, M., Jiang, H., & Li, Y. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.02.023 · Cited by 24 · see citing works

Engineered exosomes-based theranostic strategy for tumor metastasis and recurrence

Deng, M., Wu, S., Huang, P., Liu, Y., Li, C. V., & Zheng, J. (2023) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2023.100870 · Cited by 23 · see citing works

From Plant Based Therapy to Plant-Derived Vesicle-Like Nanoparticles for Cancer Treatment: Past, Present and Future

An, Y., Sun, J., Ma, S., Xu, M., Xu, J., Liu, C., Wang, S., & Xia, Q. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s499893 · Cited by 21 · see citing works

Optimizing Exosome Lipid Hybrid Nanoparticles for Enhanced siRNA Delivery and Improved Therapeutic Anticancer Efficacy In Vivo

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Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection

Kim, M.-J., Kim, J. Y., Rhim, W.-K., Cimaglia, G., Want, A., Morgan, J. E., Williams, P. A., Park, C. G., Han, D. K., & Rho, S. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01777-0 · Cited by 21 · see citing works

Emerging roles of extracellular vesicles in oral and maxillofacial areas

Wang, Q., Sun, J., Jiang, H., & Yu, M. (2025) · International Journal of Oral Science · doi:10.1038/s41368-024-00341-9 · Cited by 21 · see citing works

Exosomal bioactive molecules: molecular regulation, functional heterogeneity, and translational implications in disease diagnostics and therapeutics

Chigozie, V. U. (2026) · Clinical and Experimental Medicine · doi:10.1007/s10238-026-02092-9 · Cited by 20 · see citing works

Exosomes as new generation vehicles for drug delivery systems

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Swelling, Rupture and Endosomal Escape of Biological Nanoparticles Per Se and Those Fused with Liposomes in Acidic Environment

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Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

Al-Jipouri, A., Eritja, À., & Božić, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010485 · Cited by 19 · see citing works

Stem Cell-Derived Exosomes: Natural Intercellular Messengers with Versatile Mechanisms for the Treatment of Diabetic Retinopathy

Song, Y., Yin, C., & Kong, N. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s475234 · Cited by 19 · see citing works

Recent advances and future prospects of engineered exosomes as advanced drug and gene delivery systems

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A synthetic model of bioinspired liposomes to study cancer-cell derived extracellular vesicles and their uptake by recipient cells

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3D bioprinted scaffolds of polysaccharide hydrogels in osteochondral and cartilage tissue engineering

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Milk-derived exosome nanovesicles: recent progress and daunting hurdles

Wang, K., Zhao, X., Yang, S., Qi, X., Zang, G., Li, C., Li, A., & Chen, B. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2338831 · Cited by 14 · see citing works

From Polyphenols to Prodrugs: Bridging the Blood–Brain Barrier with Nanomedicine and Neurotherapeutics

Tanaka, M., Araujo, A. C., Valenti, V. E., Guiguer, E. L., Catharin, V. C. S., Gualhardi, C. M., de Souza Bastos Mazuqueli Pereira, E., de Alvares Goulart, R., de Argolo Haber, R. S., de Carvalho, A. C. A., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052370 · Cited by 13 · see citing works

Extracellular vesicles in chronic wound therapy: engineering strategies and advanced delivery systems for enhanced regeneration

Ding, L., Zhang, T., Pan, Y., Liu, J., Ma, T., Zhou, H., Zhu, Q., Tai, Z., & Chen, Z. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102298 · Cited by 13 · see citing works

Strategies, Challenges and Application Prospects for Exosome Engineering Modifications in Tumor Targeted Therapeutics

Ge, X., Shan, S., Lu, H., Wang, W., Gao, C., & Fu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s572435 · Cited by 14 · see citing works

Gastric cancer and mesenchymal stem cell-derived exosomes: from pro-tumorigenic effects to anti-cancer vehicles

Dolatshahi, M., Bahrami, A. R., Sheikh, Q. I., Ghanbari, M., & Matin, M. M. (2023) · Archives of Pharmacal Research · doi:10.1007/s12272-023-01477-8 · Cited by 13 · see citing works

Exosomes promise better bone regeneration

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Unlocking exosome therapeutics: The critical role of pharmacokinetics in clinical applications

Yadav, D. K., Sahu, K. K., Sucheta, Minz, S., & Pradhan, M. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.102749 · Cited by 12 · see citing works

Bioinspired nanocarriers for advanced drug delivery

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Biomedical Applications of Calcium Carbonate Nanoparticles: A Review of Recent Advances

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Engineered Hybrid Vesicles and Cellular Internalization in Mammary Cancer Cells

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Nanomaterials in the treatment and diagnosis of rheumatoid arthritis: Advanced approaches

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Extracellular vesicle mimetics as delivery vehicles for oligonucleotide-based therapeutics and plasmid DNA

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Exploring the ncRNA landscape in exosomes: Insights into wound healing mechanisms and therapeutic applications.

Gowtham, A., & Kaundal, R. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139206 · Cited by 11 · see citing works

Prospects of engineered exosomes in clinical applications: a review

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Plant-derived exosomes as bioactive compounds carriers for precision nutrition

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Synovia tissue-specific exosomes participate in the dual variation of the osteoarthritis microenvironment via miR-182

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Round window membrane extracellular vesicles facilitate inner ear drug delivery

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Exploring the Potential of Exosomal Biomarkers in Mild Traumatic Brain Injury and Post-Concussion Syndrome: A Systematic Review

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Engineered hybrid exosomes responsive to reactive oxygen species target the treatment of spinal cord injury by repairing mitochondrial damage and promoting neuronal function recovery

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Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges

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Analysis of genetic biomarkers, polymorphisms in ADME-related genes and their impact on pharmacotherapy for prostate cancer

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Biologics-based technologies for highly efficient and targeted RNA delivery

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Biomaterial-enhanced delivery of stem cell-derived exosomes for skin inflammatory diseases: Mechanisms and therapeutic advances

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Tunable wrinkled topographies direct dendritic cell maturation and immune phenotypes

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HDAC1-overexpressing dermal papilla cell-derived extracellular vesicles modulate p53 and Wnt/β-catenin signaling to rescue hair follicle regeneration in androgenetic alopecia

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Exosomes Next-Generation Approaches in Breast Cancer: Nano Drug Delivery to AI-Based Prediction

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