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Cited by 227

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Host modulation: controlling the inflammation to control the infection

Bartold, P. Mark, Van Dyke, Thomas E.·2017·Periodontology 2000
DOI 10.1111/prd.12169
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Abstract

Historically, periodontal disease (gingivitis and periodontitis) has been recognized as being primarily of bacterial origin. However, recent evidence indicates that while bacteria are necessary for disease development they are not sufficient for the clinical manifestation of the many and varied forms of periodontal disease. It is becoming increasingly apparent that it is the host inflammatory response to the subgingival bacteria that is responsible for the tissue damage and, most likely, progression of the disease. We explore the concept that it is the subgingival microenvironment modified by the inflammatory response that leads to a change from a commensal to pathogenic microbiota. In this review, we examine the evidence for the emerging paradigm supporting the central role of inflammation rather than specific microbiota in the pathogenesis of periodontitis, and that by controlling the inflammation, it is possible to control the infection. As an extension of this, we propose a working model for the ongoing monitoring of periodontal patients using the medical model of ‘treat to target’.

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Metadata

Authors
Bartold, P. M., & Van Dyke, T. E.
Venue
Periodontology 2000
Publisher
Wiley
Published
2017-07-31
Volume
75
Issue
1
Pages
317-329
ISSN
  • 0906-6713 (ISSN-L)
  • 1600-0757
DOI
10.1111/prd.12169
OpenAlex
W2741071665
Cited by
227
References
11
FWCI
25.21
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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