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Cited by 254

The DOI matches its Crossref record.

Xanthine oxidase in human skeletal muscle following eccentric exercise: a role in inflammation.

Open access
Hellsten, Y, Frandsen, U, Orthenblad, N, Sjødin, B, Richter, E A·1997·The Journal of Physiology
DOI 10.1113/jphysiol.1997.sp021855
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Abstract

1. The present study tested the hypothesis that the level of xanthine oxidase is elevated in injured human skeletal muscle in association with inflammatory events. Seven male subjects performed five bouts of strenuous one‐legged eccentric exercise. Muscle biopsies from both the exercised and the control leg, together with venous blood samples, were obtained prior to exercise and at 45 min, 24, 48 and 96 h after exercise. The time courses of xanthine oxidase immunoreactivity and indicators of muscle damage and inflammation were examined. 2. The number of xanthine oxidase structures observed by immunohistological methods in the exercised muscle was up to eightfold higher than control from day 1 to day 4 after exercise (P < 0.05). The increase was attributed to an enhanced expression of xanthine oxidase in microvascular endothelial cells and an invasion of leucocytes containing xanthine oxidase. 3. The concentration of plasma interleukin‐6 was significantly higher 90 min after exercise than before exercise (P < 0.05) and remained higher than pre‐exercise levels throughout the 4 days. On day 4 the plasma creatine kinase activity was approximately 150‐fold higher (P < 0.05) than resting levels. 4. Despite the increase in xanthine oxidase in the muscle there were no detectable changes in the levels of muscle malondialdehyde or in plasma antioxidant capacity up to 4 days post‐exercise. 5. It is concluded that eccentric exercise leads to an increased level of xanthine oxidase in human muscle and that the increase is associated with secondary inflammatory processes. The increase in xanthine oxidase in the muscle occurs mainly in microvascular endothelial cells, but occurs also via infiltrating leucocytes containing xanthine oxidase. A role for leucocytes in xanthine oxidase induction in endothelium is proposed.

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Metadata

Authors
Hellsten, Y., Frandsen, U., Orthenblad, N., Sjødin, B., & Richter, E. A.
Venue
The Journal of Physiology
Publisher
Wiley
Published
1997-01
Volume
498
Issue
1
Pages
239-248
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.1997.sp021855
OpenAlex
W1976663715
Cited by
254
References
0
FWCI
12.26
Type
journal article
Language
en
Open access
green

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