Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 417

The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.

Two forms of electrical resonance at theta frequencies, generated by M‐current, h‐current and persistent Na+current in rat hippocampal pyramidal cells

Open access
Hu, Hua, Vervaeke, Koen, Storm, Johan F.·2002·The Journal of Physiology
DOI 10.1113/jphysiol.2002.029249
Open this paper in CoChat — free account

Abstract

Coherent network oscillations in the brain are correlated with different behavioural states. Intrinsic resonance properties of neurons provide a basis for such oscillations. In the hippocampus, CA1 pyramidal neurons show resonance at theta (θ) frequencies (2‐7 Hz). To study the mechanisms underlying θ‐resonance, we performed whole‐cell recordings from CA1 pyramidal cells (n= 73) in rat hippocampal slices. Oscillating current injections at different frequencies (ZAP protocol), revealed clear resonance with peak impedance at 2‐5 Hz at ≈33 °C (increasing to ≈7 Hz at ≈38 °C). The θ‐resonance showed a U‐shaped voltage dependence, being strong at subthreshold, depolarized (≈‐60 mV) and hyperpolarized (≈‐80 mV) potentials, but weaker near the resting potential (‐72 mV). Voltage clamp experiments revealed three non‐inactivating currents operating in the subthresold voltage range: (1) M‐current (IM), which activated positive to ‐65 mV and was blocked by the M/KCNQ channel blocker XE991 (10 μ m); (2) h‐current (Ih), which activated negative to ‐65 mV and was blocked by the h/HCN channel blocker ZD7288 (10 μ m); and (3) a persistent Na+current (INaP), which activated positive to ‐65 mV and was blocked by tetrodotoxin (TTX, 1 μ m). In current clamp, XE991 or TTX suppressed the resonance at depolarized, but not hyperpolarized membrane potentials, whereas ZD7288 abolished the resonance only at hyperpolarized potentials. We conclude that these cells show two forms of θ‐resonance: ‘M‐resonance’ generated by the M‐current and persistent Na+current in depolarized cells, and ‘H‐resonance’ generated by the h‐current in hyperpolarized cells. Computer simulations supported this interpretation. These results suggest a novel function for M/KCNQ channels in the brain: to facilitate neuronal resonance and network oscillations in cortical neurons, thus providing a basis for an oscillation‐based neural code.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1113/jphysiol.2002.029249

Cites

82 of 82 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Cited by

See all 417

Metadata

Authors
Hu, H., Vervaeke, K., & Storm, J. F.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2002-12
Volume
545
Issue
3
Pages
783-805
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2002.029249
OpenAlex
W2163071226
Cited by
417
References
82
FWCI
3.87
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.