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The sigma‐1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus
Open accessAbstract
The sigma receptor (σR), once considered a subtype of the opioid receptor, is now described as a distinct pharmacological entity. Modulation of N‐methyl‐d‐aspartate receptor (NMDAR) functions by σR‐1 ligands is well documented; however, its mechanism is not fully understood. Using patch‐clamp whole‐cell recordings in CA1 pyramidal cells of rat hippocampus and (+)pentazocine, a high‐affinity σR‐1 agonist, we found that σR‐1 activation potentiates NMDAR responses and long‐term potentiation (LTP) by preventing a small conductance Ca 2+‐activated K+current (SK channels), known to shunt NMDAR responses, to open. Therefore, the block of SK channels and the resulting increased Ca 2+influx through the NMDAR enhances NMDAR responses and LTP. These results emphasize the importance of the σR‐1 as postsynaptic regulator of synaptic transmission.
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Receptor trafficking and synaptic plasticity
Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046
Chapter 12 Potassium currents in hippocampal pyramidal cells
Storm, J. F. (1990) · Progress in Brain Research · doi:10.1016/s0079-6123(08)61248-0 · Cited by 743
N-Methyl-d-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease
Waxman, E. A., & Lynch, D. R. (2005) · The Neuroscientist · doi:10.1177/1073858404269012 · Cited by 372
Gu, N., Vervaeke, K., Hu, H., & Storm, J. F. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.086835 · Cited by 363
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Cited by
The pharmacology of sigma-1 receptors.
Maurice, T., & Su, T.-P. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.07.001 · Cited by 654
The sigma-1 receptor chaperone as an inter-organelle signaling modulator
Su, T.-P., Hayashi, T., Maurice, T., Buch, S., & Ruoho, A. E. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.08.007 · Cited by 466
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems
Su, T.-P., Su, T.-C., Nakamura, Y., & Tsai, S.-Y. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.01.003 · Cited by 320
The sigma-1 receptor: roles in neuronal plasticity and disease
Kourrich, S., Su, T.-P., Fujimoto, M., & Bonci, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.09.007 · Cited by 245
Pedarzani, P., & Stocker, M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8216-x · Cited by 173
Metadata
- Authors
- Martina, M., Turcotte, M. B., Halman, S., & Bergeron, R.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2006-12-21
- Volume
- 578
- Issue
- 1
- Pages
- 143-157
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1561309798
- Cited by
- 187
- References
- 6
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Martina, M., Turcotte, M. B., Halman, S., & Bergeron, R. (2007). The sigma‐1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2006.116178
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
