Cited by 67Birth, Development, and HealthPregnancy and preeclampsia studiesGestational Diabetes Research and Management

Dietary composition programmes placental phenotype in mice

Open access
Coan, P. M., Vaughan, O. R., McCarthy, J., Mactier, C., Burton, G. J., Constância, M., Fowden, A. L.·2011·The Journal of Physiology

Abstract

Non‐technical summary Studies on mice using severe diets show alterations in placental function, and fetal and adult health. However, little is known about the effects of mild dietary variations on the placenta. We investigated placental growth and function in mice fed diets with similar energy, but small differences in protein and sugar content. We show that placental adaptations occur to help support fetal growth: reduced protein leads to increased glucose transport and transporter gene expression in late pregnancy; just prior to term, amino acid transport expression correlated with protein intake; the placental endocrine compartment was smaller with the least dietary protein and somewhat larger with slight reduction in protein. Placentas in mice fed the least protein were better adapted than those exposed to slight protein reduction. These results may provide a good index of conditions in the womb and have important implications for the pre‐birth programming of life expectancy.

Integrity signals

Registry

Crossref · 10.1113/jphysiol.2011.208629

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Even relatively modest changes in dietary composition within the range recommended for rodent pregnancy can alter placental weight and zonal proportions near term.

    “Even relative modest changes in dietary composition within the range recommended for rodent pregnancy can alter placental weight and zonal proportions near term (119, 301).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [119]

  • Even relatively minor changes in dietary composition alter placental clearance of glucose and amino acids with consequences for growth of mouse pups near term.

    “Even relatively minor changes in dietary composition are known to alter placental clearance of glucose and amino acids with consequences for growth of the mouse pups near term (119).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [119]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Coan, P. M., Vaughan, O. R., McCarthy, J., Mactier, C., Burton, G. J., Constância, M., & Fowden, A. L.
Affiliations
University of Cambridge (GB)
Corresponding author
Coan, P. M.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2011-07-15
Volume
589
Issue
14
Pages
3659-3670
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
OpenAlex
W2147749833
Cited by
67
References
47
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 9 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 6 · 2013: 5 · 2012: 4
FWCI
4.72
Type
journal article
Language
en
Open access
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Biotechnology and Biological Sciences Research Council (BB/B50118X/1, BB/C513626/1, BB/B50118X/2)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
maternal diet, casein, glucose transport, GLUT1, insulin-like growth factor II, amino acid transport, placental development, fetal weight, intrauterine programming, placental nutrient transfer
MeSH terms
Aminoisobutyric Acids, Animals, Biological Transport, Diet, Eating, Female, Insulin-Like Growth Factor II, Male, Maternal-Fetal Exchange, Mice, Inbred C57BL, Organ Size, Phenotype, Placenta, Pregnancy, Proteins, Fetal Weight, Amino Acid Transport Systems, Fetal Development, Glucose Transport Proteins, Facilitative, Glucose Transporter Type 1, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review