Dietary composition programmes placental phenotype in mice
Open accessAbstract
Non‐technical summary Studies on mice using severe diets show alterations in placental function, and fetal and adult health. However, little is known about the effects of mild dietary variations on the placenta. We investigated placental growth and function in mice fed diets with similar energy, but small differences in protein and sugar content. We show that placental adaptations occur to help support fetal growth: reduced protein leads to increased glucose transport and transporter gene expression in late pregnancy; just prior to term, amino acid transport expression correlated with protein intake; the placental endocrine compartment was smaller with the least dietary protein and somewhat larger with slight reduction in protein. Placentas in mice fed the least protein were better adapted than those exposed to slight protein reduction. These results may provide a good index of conditions in the womb and have important implications for the pre‐birth programming of life expectancy.
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Even relatively modest changes in dietary composition within the range recommended for rodent pregnancy can alter placental weight and zonal proportions near term.
“Even relative modest changes in dietary composition within the range recommended for rodent pregnancy can alter placental weight and zonal proportions near term (119, 301).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [119]
Even relatively minor changes in dietary composition alter placental clearance of glucose and amino acids with consequences for growth of mouse pups near term.
“Even relatively minor changes in dietary composition are known to alter placental clearance of glucose and amino acids with consequences for growth of the mouse pups near term (119).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [119]
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Self-citation
- Authors
- Coan, P. M., Vaughan, O. R., McCarthy, J., Mactier, C., Burton, G. J., Constância, M., & Fowden, A. L.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Coan, P. M.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2011-07-15
- Volume
- 589
- Issue
- 14
- Pages
- 3659-3670
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC3167124
- OpenAlex
- W2147749833
- Cited by
- 67
- References
- 47
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 9 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/B50118X/1, BB/C513626/1, BB/B50118X/2)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- maternal diet, casein, glucose transport, GLUT1, insulin-like growth factor II, amino acid transport, placental development, fetal weight, intrauterine programming, placental nutrient transfer
- MeSH terms
- Aminoisobutyric Acids, Animals, Biological Transport, Diet, Eating, Female, Insulin-Like Growth Factor II, Male, Maternal-Fetal Exchange, Mice, Inbred C57BL, Organ Size, Phenotype, Placenta, Pregnancy, Proteins, Fetal Weight, Amino Acid Transport Systems, Fetal Development, Glucose Transport Proteins, Facilitative, Glucose Transporter Type 1, Mice
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