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σ-1 Receptors (σ1 Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export
Abstract
The brain sigma-1 receptors can bind neurosteroids and psychotropic drugs, including neuroleptics and cocaine and are implicated in schizophrenia, depression, and drug dependence. In this study, we found that sigma-1 receptors specifically target lipid storage sites (lipid droplets) on the endoplasmic reticulum by forming a distinct class of lipid microdomains. Both endogenously expressing sigma-1 receptors and transfected C-terminally enhanced yellow fluorescent protein (EYFP)-tagged sigma-1 receptors (Sig-1R-EYFP) target unique "ring-like" structures associated with endoplasmic reticulum reticular networks in NG108-15 cells. The ring-like structures contain neutral lipids and are enlarged by the oleate treatment, indicating that they are endoplasmic reticulum-associated lipid droplets (ER-LDs). sigma-1 receptors colocalize with caveolin-2, a cholesterol-binding protein in lipid rafts on the ER-LDs, but not with adipocyte differentiation-related protein (ADRP), a cytosolic lipid droplet (c-LD)-specific protein. When the double-arginine ER retention signal on the N terminus of sigma-1 receptors is truncated, sigma-1 receptors no longer exist on ER-LDs, but predominantly target c-LDs, which contain ADRP. sigma-1 receptors on ER-LDs form detergent-resistant raft-like lipid microdomains, the buoyancy of which is different from that of plasma membrane lipid rafts. (+)-Pentazocine causes sigma-1 receptors to disappear from the microdomains. N-Terminally EYFP-tagged sigma-1 receptors (EYFP-Sig-1R) failed to target ER-LDs. EYFP-Sig-1R-transfected cells showed an unrestricted distribution of neutral lipids all over the endoplasmic reticulum network, decreases in c-LDs and cholesterol in plasma membranes, and the bulbous aggregation of endoplasmic reticulum. Thus, sigma-1 receptors are unique endoplasmic reticulum proteins that regulate the compartmentalization of lipids on the endoplasmic reticulum and their export from the endoplasmic reticulum to plasma membrane and c-LDs.
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“Interestingly, SIGMAR1 appears to promote the compartmentalization of cholesterol in ER membranes (158), although depletion of cholesterol promoted mitochondrial–ER association in in vitro membrane association assays and cell models (159).”
From Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies (2016) · cites this paper as [158]
Citations
Cites
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Martin, W. R., Eades, C. G., Thompson, J. A., Huppler, R. E., & Gilbert, P. E. (1976) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30536-7 · Cited by 2,992
Anderson, R. G. W. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.199 · Cited by 1,941
Purification, molecular cloning, and expression of the mammalian sigma1-binding site.
Hanner, M., Moebius, F. F., Flandorfer, A., Knaus, H. G., Striessnig, J., Kempner, E. S., & Glossmann, H. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.8072 · Cited by 914
Cholesterol metabolism in the brain
Dietschy, J. M., & Turley, S. D. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00003 · Cited by 906
The Surface of Lipid Droplets Is a Phospholipid Monolayer with a Unique Fatty Acid Composition
Tauchi-Sato, K., Ozeki, S., Houjou, T., Taguchi, R., & Fujimoto, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207712200 · Cited by 753
Brasaemle, D., Barber, T., Wolins, N. E., Serrero, G., Blanchette‐Mackie, E. J., & Londos, C. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34939-7 · Cited by 644
Mechanisms of lipid-body formation
Murphy, D. J., & Vance, J. E. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01349-8 · Cited by 577
Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems
Su, T., London, E. D., & Jaffe, J. H. (1988) · Science · doi:10.1126/science.2832949 · Cited by 548
Self-citationSu, T.-P. (1982) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33330-6 · Cited by 435
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Murphy, D. J. (2011) · PROTOPLASMA · doi:10.1007/s00709-011-0329-7 · Cited by 410
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Moretti, F., Bergman, P., Dodgson, S. E., Marcellin, D., Claerr, I., Goodwin, J. M., DeJesus, R., Kang, Z., Antczak, C., Begue, D., et al. (2018) · EMBO Reports · doi:10.15252/embr.201845889 · Cited by 166
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Lahmy, V., Meunier, J., Malmström, S., Naert, G., Givalois, L., Kim, S. H., Villard, V., Vamvakides, A., & Maurice, T. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.70 · Cited by 165
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HAYASHI, T., & Su, T. (2005) · Current Neuropharmacology · doi:10.2174/157015905774322516 · Cited by 154
Self-citationKim, F. J., Kovalyshyn, I., Burgman, M., Neilan, C., Chien, C., & Pasternak, G. W. (2010) · Molecular Pharmacology · doi:10.1124/mol.109.057083 · Cited by 151
Meunier, J., & Hayashi, T. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.160960 · Cited by 148
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Villard, V., Espallergues, J., Keller, E., Alkam, T., Nitta, A., Yamada, K., Nabeshima, T., Vamvakides, A., & Maurice, T. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.212 · Cited by 107
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Schon, E. A., & Área-Gómez, E. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100495 · Cited by 98
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Self-citationWilliamson, C. D., Wong, D. S., Bozidis, P., Zhang, A., & Colberg‐Poley, A. M. (2015) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0327s68 · Cited by 84
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Self-citationSigma Receptor 1 Modulates Endoplasmic Reticulum Stress in Retinal Neurons
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Self-citationHayashi, T., Justinová, Z., Hayashi, E., Cormaci, G., Mori, T., Tsai, S., Barnes, C., Goldberg, S. R., & Su, T. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.159244 · Cited by 84
Self-citationShioda, N., Ishikawa, K., Tagashira, H., Ishizuka, T., Yawo, H., & Fukunaga, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.349142 · Cited by 79
Sambo, D. O., Lebowitz, J. J., & Khoshbouei, H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.009 · Cited by 75
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Li, X., Ye, J., Zhou, L., Gu, W., Fisher, E. A. A., & Li, P. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m026591 · Cited by 74
Wang, J., SAUL, A. B., Roon, P., & Smith, S. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521749113 · Cited by 70
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Malar, D. S., Thitilertdecha, P., Ruckvongacheep, K. S., Brimson, S., Tencomnao, T., & Brimson, J. M. (2023) · CNS Drugs · doi:10.1007/s40263-023-01007-6 · Cited by 77
Maurice, T. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1838483 · Cited by 71
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A Role for Sigma Receptors in Stimulant Self Administration and Addiction
Katz, J. L., Su, T., Hiranita, T., Hayashi, T., Tanda, G., Kopajtic, T. A., & Tsai, S. (2011) · Pharmaceuticals · doi:10.3390/ph4060880 · Cited by 74
Self-citationMartin‐Fardon, R., Maurice, T., Aujla, H., Bowen, W. D., & Weiss, F. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301323 · Cited by 70
Fallica, A. N., Pittalà, V., Modica, M. N., Salerno, L., Romeo, G., Marrazzo, A., Helal, M. A., & Intagliata, S. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02265 · Cited by 69
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Scharwey, M., Tatsuta, T., & Langer, T. (2013) · Journal of Cell Science · doi:10.1242/jcs.134130 · Cited by 74
Francardo, V., Geva, M., Bez, F., Denis, Q., Steiner, L., Hayden, M. R., & Cenci, M. A. (2019) · Neurotherapeutics · doi:10.1007/s13311-018-00699-9 · Cited by 68
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Zhemkov, V., Ditlev, J. A., Lee, W.-R., Wilson, M., Liou, J., Rosen, M. K., & Борисович, Б. И. (2021) · eLife · doi:10.7554/elife.65192 · Cited by 66
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Carnally, S. M., Johannessen, M., Henderson, R. M., Jackson, M. B., & Edwardson, J. M. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.12.4293 · Cited by 67
Accelerated retinal ganglion cell death in mice deficient in the Sigma-1 receptor.
Mavlyutov, T. A., Nickells, R. W., & Guo, L. (2011) · PubMed Central · Cited by 66
Elements in support of the ‘non-identity’ of the PGRMC1 protein with the σ2 receptor
Abate, C., Niso, M., Infantino, V., Menga, A., & Berardi, F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.067 · Cited by 63
Hayashi, T., & Su, T. (2010) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-8622-8_13 · Cited by 66
Self-citationSigma 1 receptor: A novel therapeutic target in retinal disease
Smith, S. B., Wang, J., Cui, X., Mysona, B. A., Zhao, J., & Bollinger, K. E. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.07.003 · Cited by 67
Fujimoto, T., & Ohsaki, Y. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1377.010 · Cited by 67
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The role of sigma-1 receptors in the pathophysiology of neuropsychiatric diseases
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Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases
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Garofalo, T., Manganelli, V., Grasso, M., Mattei, V., Ferri, A., Misasi, R., & Sorice, M. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1100-x · Cited by 63
Metadata
- Authors
- Hayashi, T., & Su, T.-P.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Su, Tsung-Ping
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 306
- Issue
- 2
- Pages
- 718-725
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2156975935
- Cited by
- 262
- References
- 41
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 6 · 2023: 14 · 2022: 5 · 2021: 25 · 2020: 13 · 2019: 9 · 2018: 6 · 2017: 13 · 2016: 12 · 2015: 12 · 2014: 18 · 2013: 11 · 2012: 12
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- sigma-1 receptor, lipid rafts, lipid droplets, endoplasmic reticulum, caveolin-2, ADRP, pentazocine, neutral lipids, cholesterol, neurosteroids, NG108-15 cells
- MeSH terms
- Sigma-1 Receptor, Animals, Bacterial Proteins, Binding Sites, Endoplasmic Reticulum, Guinea Pigs, Hybridomas, Intracellular Membranes, Luminescent Proteins, Tumor Cells, Cultured, Protein Structure, Tertiary, Receptors, sigma, Mice, Rats
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