Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target

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The Receptor RAGE as a Progression Factor Amplifying Arachidonate-Dependent Inflammatory and Proteolytic Response in Human Atherosclerotic Plaques: Role of Glycemic Control

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Coexpression of Microsomal-Type Prostaglandin E Synthase with Cyclooxygenase-2 in Brain Endothelial Cells of Rats during Endotoxin-Induced Fever

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Anovulation in Cyclooxygenase-2-Deficient Mice Is Restored by Prostaglandin E2 and Interleukin-1β*

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Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E 2 -Dependent Plaque Instability

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Pathway across the blood–brain barrier

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Cellular Prostaglandin E2 Production by Membrane-bound Prostaglandin E Synthase-2 via Both Cyclooxygenases-1 and -2

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Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function

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Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis

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Lipopolysaccharide-Dependent Prostaglandin E2 Production Is Regulated by the Glutathione-Dependent Prostaglandin E2 Synthase Gene Induced by the Toll-Like Receptor 4/MyD88/NF-IL6 Pathway

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Identification and Characterization of a Novel Type of Membrane-Associated Prostaglandin E Synthase

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Roles of Cyclooxygenase (COX)-1 and COX-2 in Prostanoid Production by Human Endothelial Cells: Selective Up-Regulation of Prostacyclin Synthesis by COX-2

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Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1

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Microsomal Prostaglandin E Synthase Is Regulated by Proinflammatory Cytokines and Glucocorticoids in Primary Rheumatoid Synovial Cells

Stichtenoth, D. O., Thorén, S., Bian, H., Peters-Golden, M., Jakobsson, P.-J., & Crofford, L. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.469 · Cited by 269

Carrageenan-induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 (PGE2) Response in the Central Nervous System Associated with the Induction of Microsomal PGE2 Synthase-1

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Hyperplastic gastric tumors induced by activated macrophages in COX‐2/mPGES‐1 transgenic mice

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Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis

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Prostaglandin Biosynthesis, Transport, and Signaling in Corpus Luteum: A Basis for Autoregulation of Luteal Function

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Glutathione transferases: new functions

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Inflammation following stroke

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Localization of Cyclooxygenase-2 in Human Sporadic Colorectal Adenomas

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Coordinate up‐ and down‐regulation of glutathione‐dependent prostaglandin E synthase and cyclooxygenase‐2 in A549 cells: Inhibition by NS‐398 and leukotriene C4

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Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer.

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Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2synthase in human lung fibroblasts: implications for lung inflammation and cancer

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Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis

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Expression of Cyclooxygenases 1 and 2 and Prostaglandin E Synthase in Bovine Endometrial Tissue During the Estrous Cycle1

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Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis

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Transforming Growth Factor-β1 Enhances Ha-ras-induced Expression of Cyclooxygenase-2 in Intestinal Epithelial Cells via Stabilization of mRNA

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Function of prostanoid receptors: studies on knockout mice

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Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer.

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Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

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Segregated Coupling of Phospholipases A2, Cyclooxygenases, and Terminal Prostanoid Synthases in Different Phases of Prostanoid Biosynthesis in Rat Peritoneal Macrophages

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Human Microsomal Prostaglandin E Synthase-1

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Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E2 Biosynthesis

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Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis

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Up-regulation of Prostaglandin E2 Synthesis by Interleukin-1β in Human Orbital Fibroblasts Involves Coordinate Induction of Prostaglandin-Endoperoxide H Synthase-2 and Glutathione-dependent Prostaglandin E2 Synthase Expression

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Structural Basis for Detoxification and Oxidative Stress Protection in Membranes

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Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cells

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Concordant Induction of Prostaglandin E2Synthase with Cyclooxygenase-2 Leads to Preferred Production of Prostaglandin E2over Thromboxane and Prostaglandin D2in Lipopolysaccharide-Stimulated Rat Peritoneal Macrophages

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Bioinformatic and enzymatic characterization of the MAPEG superfamily

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Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886

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Suppression of the Functionally Coupled Cyclooxygenase-2/Prostaglandin E Synthase as a Basis of Simvastatin-Dependent Plaque Stabilization in Humans

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Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury

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Up‐regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: Critical roles of the ERK‐1/2 and p38 signaling pathways

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Key enzymes for renal prostaglandin synthesis: site-specific expression in rodent kidney (rat, mouse)

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S-Allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties

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Expression of COX-2 and PGE synthase and synthesis of PGE2 in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors

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Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium

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Arachidonic Acid Metabolites in Cutaneous Carcinomas: Evidence Suggesting That Elevated Levels of Prostaglandins in Basal Cell Carcinomas Are Associated With an Aggressive Growth Pattern

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Activation of Peroxisome Proliferator-activated Receptor γ Inhibits Interleukin-1β-induced Membrane-associated Prostaglandin E2 Synthase-1 Expression in Human Synovial Fibroblasts by Interfering with Egr-1

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Human Vascular Smooth Muscle Cells but Not Endothelial Cells Express Prostaglandin E Synthase

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Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E synthase-1

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Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3

Ekström, L., Lyrenäs, L., Jakobsson, P., Morgenstern, R., & Kelner, M. J. (2003) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(03)00077-0 · Cited by 26

Expression of Prostaglandin I2Synthase, but Not Prostaglandin E Synthase, Changes in Myometrium of Women at Term Pregnancy

Giannoulias, D., Alfaidy, N., Holloway, A. C., Gibb, W., Sun, M., Lye, S. J., & Challis, J. R. G. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020521 · Cited by 26

Microsomal Prostaglandin E2 Synthase-1 Is Induced by Conditional Expression of RET/PTC in Thyroid PCCL3 Cells through the Activation of the MEK-ERK Pathway

Puxeddu, E., Mitsutake, N., Knauf, J. A., Moretti, S., Kim, H. W., Seta, K. A., Brockman, D. E., Myatt, L., Millhorn, D. E., & Fagin, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306003200 · Cited by 26

Species-specific expression of microsomal prostaglandin E synthase-1 and cyclooxygenases in male monkey reproductive organs

Lazarus, M., Eguchi, N., Matsumoto, S., Nagata, N., Yano, T., Killian, G. J., & Urade, Y. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.03.018 · Cited by 25

Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx

Kawata, R., Hyo, S., Maeda, T., Urade, Y., & Takenaka, H. (2005) · Acta Oto-Laryngologica · doi:10.1080/00016480500452541 · Cited by 20

15-deoxy-Δ12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells

Schroäder, O., Yudina, Y., Sabirsh, A., Zahn, N., Haeggstroäm, J. Z., & Stein, J. M. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600008-jlr200 · Cited by 20

Evaluation of coexpression of microsomal prostaglandin E synthase-1 and cyclooxygenase-2 in interleukin-1– stimulated equine articular chondrocytes

Farley, J., Sirois, J., MacFarlane, P.-H., Kombé, A., & Laverty, S. (2005) · American Journal of Veterinary Research · doi:10.2460/ajvr.2005.66.1985 · Cited by 20

Expression of Microsomal Prostaglandin E Synthase in Bovine Endometrium: Coexpression with Cyclooxygenase Type 2 and Regulation by Interferon-

Parent, J. (2002) · Endocrinology · doi:10.1210/en.143.8.2936 · Cited by 20

Induction of Microsomal Prostaglandin E Synthase-1 in Human Gingival Fibroblasts

Yucel‐Lindberg, T., Hallström, T., Kats, A., Mustafa, M., & Modéer, T. (2004) · Inflammation · doi:10.1023/b:ifla.0000033024.13748.c1 · Cited by 19

Ontogeny and Regulation of Ovine Placental Prostaglandin E2 Synthase1

Martin, R. L., Whittle, W. L., Holloway, A. C., Gyomorey, S., Gibb, W., Lye, S. J., & Challis, J. R. G. (2002) · Biology of Reproduction · doi:10.1095/biolreprod.101.002519 · Cited by 18

Differential regulation of prostaglandin E biosynthesis by interferon‐ γ in colonic epithelial cells

Wright, K. L., Weaver, S. A., Patel, K. M., Coopman, K., Feeney, M., Kolios, G. C., Robertson, D. A., & Ward, S. G. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705719 · Cited by 17

Differential expression and regulation of prostaglandin E synthases in the mouse ovary during sexual maturation and luteal development

Sun, T., Deng, W., Diao, H., Ni, H., Bai, Y., Ma, X., Xu, L., & Yang, Z. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06147 · Cited by 17

Inhibition of GSH-dependent PGH2 isomerase in mammary adenocarcinoma cells by allicin.

Shalinsky, D. R., McNamara, D. B., & AGRAWAL, K. C. (1989) · Prostaglandins · doi:10.1016/0090-6980(89)90037-3 · Cited by 15

Expression of Prostaglandin E2 Synthases in Mouse Postnatal Cortical Neurons

Echeverría, V., Greenberg, D., & Doré, S. (2005) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2005.tb00056.x · Cited by 14

On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens

Stark, K., Bylund, J., Törmä, H., Sahlén, G., & Oliw, E. H. (2004) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2004.09.014 · Cited by 13

The induction of prostaglandin E synthase and upregulation of cyclooxygenase-2 by 9-cis retinoic acid

Tsukamoto, H., Hishinuma, T., Tayama, R., Narahara, K., Suzuki, N., Tomioka, Y., & Goto, J. (2004) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2004.07.001 · Cited by 13

Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages

Schaloske, R. H., Provins, J. W., Kessen, U. A., et al. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.11.005 · Cited by 13

Despite Transcriptional and Functional Coordination, Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Largely Reside in Distinct Lipid Microdomains in WISH Epithelial Cells

Ackerman, W. E., Robinson, J. M., & Kniss, D. A. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6710.2005 · Cited by 12

Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat)

Theilig, F., Dêbiec, H., Nafz, B., Ronco, P. M., Nüsing, R. M., Seyberth, H. W., Pavenstädt, H. J., Bouby, N., & Bachmann, S. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00099.2006 · Cited by 12

Inhibitory effect of PPAR‐Gamma activator on IL‐6 and mPGES protein expression in PBMC induced by homocysteine

Peng, Y., Liu, H., Liu, F., Wang, H., Liu, Y., & Duan, S. (2005) · Hemodialysis International · doi:10.1111/j.1542-4758.2005.01165.x · Cited by 11

Evaluation of the whole prostaglandin biosynthetic pathway in lung cancer.

DuBois, R. N. (2003) · PubMed · Cited by 11

Developmental regulation of prostaglandin E2synthase in porcine ductus arteriosus

Bouayad, A., Fouron, J., Hou, X., Beauchamp, M., Quiniou, C., Abran, D., Peri, K. G., Clyman, R. I., Varma, D. R., & Chemtob, S. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00437.2003 · Cited by 9

Expression of COX-2 and PGE synthase and synthesis of PGE2in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors

Jabbour, H. N., Milne, S. A., Williams, A. R. W., Anderson, R. A., & Boddy, S. C. (2001) · British Journal of Cancer · doi:10.1038/sj.bjc.6692033 · Cited by 8

Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease

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Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

Smith, W. L., Urade, Y., & Jakobsson, P.-J. (2011) · Chemical Reviews · doi:10.1021/cr2002992 · Cited by 503

COX2/mPGES1/PGE 2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells

Prima, V., Kaliberova, L. N., Kaliberov, S., Curiel, D. T., & Kusmartsev, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612920114 · Cited by 494

Nonsteroidal Anti-Inflammatory Drugs and the Kidney

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Prostaglandins and sickness behavior: Old story, new insights

Pecchi, E., Dallaporta, M., Jean, A., Thirion, S., & Troadec, J.-D. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.040 · Cited by 135