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Cited by 1,097Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

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Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition

Pouille, Frédéric, Scanziani, Massimo·2001·Science
DOI 10.1126/science.1060342
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Abstract

The temporal resolution of neuronal integration depends on the time window within which excitatory inputs summate to reach the threshold for spike generation. Here, we show that in rat hippocampal pyramidal cells this window is very narrow (less than 2 milliseconds). This narrowness results from the short delay with which disynaptic feed-forward inhibition follows monosynaptic excitation. Simultaneous somatic and dendritic recordings indicate that feed-forward inhibition is much stronger in the soma than in the dendrites, resulting in a broader integration window in the latter compartment. Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows.

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Metadata

Authors
Pouille, F., & Scanziani, M.
Affiliations
  • Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
  • University of Zurich (CH)
Corresponding author
Scanziani, Massimo
ORCID
Scanziani, Massimo
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2001-08-10
Volume
293
Issue
5532
Pages
1159-1163
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1060342
OpenAlex
W2067501282
Cited by
1,097
References
1
Citations by year
2026: 25 · 2025: 33 · 2024: 33 · 2023: 51 · 2022: 51 · 2021: 40 · 2020: 41 · 2019: 33 · 2018: 54 · 2017: 56 · 2016: 56 · 2015: 62 · 2014: 62 · 2013: 63 · 2012: 62
FWCI
8.84
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
temporal fidelity, feedforward inhibition, hippocampal pyramidal neurons, coincidence detection, somatic inhibition, dendritic integration, synaptic delay, disynaptic inhibition
MeSH terms
Action Potentials, Animals, Axons, Bicuculline, Dendrites, Electric Stimulation, Evoked Potentials, Hippocampus, Interneurons, Neural Inhibition, Synaptic Transmission, Pyridazines, Receptors, GABA-A, Time Factors, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, GABA Antagonists, Excitatory Postsynaptic Potentials, Rats, GABA-A Receptor Antagonists, In Vitro Techniques

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