Cited by 265T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

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Arrested Differentiation, the Self-Renewing Memory Lymphocyte, and Vaccination

Fearon, Douglas T., Manders, Peter, Wagner, Simon D.·2001·Science

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Abstract

Vaccination for persistent viral or bacterial infections must program the immune system for a lifelong need to generate antigen-specific effector lymphocytes. How the immune system does this is not known, but recent studies have shown that a subset of B lymphocytes, the germinal center B cell, is capable of self-renewal because it expresses a transcriptional repressor, BCL6, that blocks terminal differentiation. If a similar mechanism for arresting differentiation exists for long-lived, antigen-selected lymphocytes, a stem cell–like capacity for self-renewal could be the basis for the continual generation of effector lymphocytes from the memory pool. Understanding how to regulate the terminal differentiation of lymphocytes will improve immunotherapeutic approaches for chronic infectious diseases and cancer.

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Authors: Fearon, D. T., Manders, P., & Wagner, S. D.
Affiliations: University of Cambridge (GB)
Corresponding author: Fearon, Douglas T.
ORCID: Fearon, Douglas T.
Wagner, Simon D.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2001-07-13
Volume: 293
Issue: 5528
Pages: 248-250
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1062589
OpenAlex: W2038067604
Cited by: 265
References: 32
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2023: 10 · 2022: 11 · 2021: 14 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 10 · 2016: 8 · 2015: 11 · 2014: 10 · 2013: 10 · 2012: 11
FWCI: 1.40
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: BCL6, terminal differentiation, germinal center B cells, memory B cells, viral persistence, bacterial infection, vaccination, chronic infectious diseases, cancer immunotherapy
MeSH terms: Animals, B-Lymphocytes, Cell Differentiation, DNA-Binding Proteins, Humans, Immunologic Memory, Lymphocytes, Proto-Oncogene Proteins, Receptors, Antigen, Stem Cells, T-Lymphocytes, Transcription Factors, Vaccination, Leukopoiesis, Proto-Oncogene Proteins c-bcl-6

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Arrested Differentiation, the Self-Renewing Memory Lymphocyte, and Vaccination

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