Cited by 1,014T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

Pearce, Erika L., Mullen, Alan C., Martins, Gislâine A., Krawczyk, Connie M., Hutchins, Anne S., Zediak, Valerie P., Banica, Monica, DiCioccio, Catherine B., Gross, Darrick A., Mao, Chai-an, Shen, Hao, Cereb, Nezih, Yang, Soo Y., Lindsten, Tullia, Rossant, Janet, Hunter, Christopher A., Reiner, Steven L.·2003·Science

DOI 10.1126/science.1090148

Open this paper in CoChat — free account

Abstract

Activated CD8 + T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8 + T cells. We now show that Eomesodermin ( Eomes ), a paralogue of T-bet , is induced in effector CD8 + T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8 + T cells, including interferon-γ (IFN-γ), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8 + T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.

Integrity signals

Registry

Crossref · 10.1126/science.1090148

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory
Shedlock, D. J., & Shen, H. (2003) · Science · doi:10.1126/science.1082305 · Cited by 1,450
Self-citation
Distinct Effects of T-bet in T H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells
Szabo, S. J., Sullivan, B. M., Stemmann, C., Satoskar, A. R., Sleckman, B. P., & Glimcher, L. H. (2002) · Science · doi:10.1126/science.1065543 · Cited by 1,172
Molecular and functional profiling of memory CD8 T cell differentiation.
Kaech, S., Hemby, S., Kersh, E., & Ahmed, R. (2002) · Cell · doi:10.1016/s0092-8674(02)01139-x · Cited by 1,081
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
Pircher, H., Bürki, K., Lang, R., Hengartner, H., & Zinkernagel, R. M. (1989) · Nature · doi:10.1038/342559a0 · Cited by 1,019

Flagged first, then by citations

Show all 18 references

Sorted by citations

Items 901–1,000 of 1,000

Characterization Of The Mamu-A*01-Restricted Cd8-Positive T Lymphocyte Immunodominance Hierarchy In Simian Immunodeficiency Virus-Infected Rhesus Monkeys
Osuna-Gutierrez, C. E. (2012) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Molecular genetics of T cell development
Rothenberg, E. V., & Taghon, T. (2005) · Ghent University Academic Bibliography (Ghent University)
Identification of a novel human CD4[superscript +] T cell population and overcoming the immunosuppressive environment in large established tumors
Triplett, T. (2012) · doi:10.6083/m4k0729m
DNA methylation profiles of cytokine and transcription factor genes in immune cells
Bonn, U. U. L. (2008)
Regulation of the cyclin-dependent kinase inhibitor p21 by TBX3
Hare, S. (2013) · Open University of Cape Town (University of Cape Town)
The Role Of miRNAs In CD8+ T Cell Differentation
Amorim, A. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/h70p-6p39
The Role of NOTCH3 Signaling in T Helper Cell Differentiation and Induction of EAE
Ayaz, F. (2021) · Scholarworks (University of Massachusetts Amherst) · doi:10.7275/7602425.0
Adaptive Immunity and Organization of Lymphoid Tissues
Dustin, M. L. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1738-9.00019-0
Genetic-epigenetic Interactions: Sequence-dependent and Independent DNA Nethylation
Ptak, C. (2013) · TSpace (University of Toronto)
The Role of T-box Transcription Factors in the Development and Plasticity of Natural Killer Cell Lineages
Pikovskaya, O. (2016) · doi:10.7916/d8tb16q6
Development Of High Throughput Epigenomic Profiling Technologies And Their Application To Twin Based DNA Methylation Studies
Kaminsky, Z. A. (2009) · TSpace (University of Toronto)
The Role Of miRNAs In CD8 + T Cell
Amorim, D. O. R. (2014)
Molecular determinants of human T cell differentiation and host-pathogen interaction.
Sundrud, M. S. (2005) · Europe PMC (PubMed Central)
Adaptive Immunity including Organization of Lymphoid Tissues
Dustin, M. L. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3285-4.10017-8
Distal regulation of the interferon gamma locus
Collins, P. L. (2011)
O FATOR DE TRANSCRIÇÃO NFAT1 DE CÉLULAS DENDRÍTICAS É NECESSÁRIO PARA A MODULAÇÃO DA DIFERENCIAÇÃO DE LINFÓCITOS T CD4
Barboza, B. A. (2010)
The Role of Peroxisome Proliferator-activated Receptor Alpha in the Regulation of Sex Differences in T Helper 1 Immunity
Zhang, M. (2015) · TSpace (University of Toronto)
The Role of TEC Family Kinases in Innate T Cell Development and Function: a Dissertation
Felices, M. (2008) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/3s3e-g486
during Infection Production by CD8 T Cells γ for In Vivo IFN- Cutting Edge: T-bet and IL-27R Are Critical
Mohrs, M., Johnson, L. L., Woodland, D. L., Kohlmeier, J. E., Pearl, J. E., Mayer, D., Mohrs, K., & Reiley, W. W. (2013)
The Effects of Imatinib Mesylate on Antigen-Specific Cd8+ T Cell Responses
Sinai, P. (2006)
Thymocytesof Memory-like CD8 -Catenin Control the β T Cell Factor-1 and
Sen, J. M., Sharma, A., Chen, Q., Nguyen, T. T. T., & Yu, Q. (2017)
Roles of transcription factor T-bet in memory CD4+ T cell generation, function, homeostasis and tissue targeting
Chen, J. K. (2017) · doi:10.7916/d84m9gxs
The State of T Cell Immunity against Influenza Virus in Humans and Exploration of Potential Strategies to Enhance Cell-Mediated Protection from Influenza Infection
Wagar, L. E. (2013) · TSpace (University of Toronto)
Late Antigen Regulates the Differentiation of Cytotoxic CD4 T Cells in Influenza Infection
Vong, A. M. (2017) · eScholarship@UMassChan · doi:10.13028/m2nt1p
Etiology and Epidemiology of Chronic Lymphocytic Leukemia
Speedy, H. E., Catovsky, D., & Houlston, R. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64263-5_6
Negative Regulators of Colonic Peripheral Regulatory T Cell Development
Ai, T. L. (2018) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7jh3kk5
Adaptive Immunity and Organization of Lymphoid Tissues
Dustin, M. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-31696-5.00018-8
Gene expression profiling in autoimmune diseases : a story of ups and downs
Houtman, M. (2018) · Figshare
Cell Specific Expression, Regulation and Consequences of GITRL Induction in a Persistent Viral Infection
Chang, Y.-H. (2016) · TSpace (University of Toronto)
Histone Methyltransferases and T Cell Heterogeneity
Purushe, J., & Zhang, Y. (2017) · CRC Press eBooks · doi:10.1201/9781315371689-11
Studies of innate and adaptive lymphocytes in human liver diseases and viral infections
Zimmer, C. L. (2019) · Figshare
Modelling melanoma control by immunotherapy and tissue-resident memory T cells using CRISPR/Cas9-based approaches
Effern, M. (2019) · Minerva Access (University of Melbourne)
The Role of NF?B in T-lymphocyte Development and Function
Gugasyan, R. (2012) · Journal of Clinical & Cellular Immunology
Determination and Quantitation of Cytotoxic T Cell-Mediated Cell Death
Fu, H., & Qui, H. Z. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1162-3_14
TCF-7 is dispensable for anti-tumor response but required for persistent function of mature CD8 T cellsPreprint
Harris, R., Mammadli, M., Hiner, S., Suo, L., Yang, Q., Sen, J. M., & Karimi, M. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.22.436494
Phenotypic and functional characterisation of circulating cytomegalovirus-specific T cells in healthy virus carriers and lung transplant candidatesPreprint
Altaf, M., Irfan, M. A., Naheed, N., & Aleemuddin, N. (2021) · medRxiv · doi:10.1101/2021.06.04.21256785
Immunopathogenesis of Hepatitis B Virus Infection
Chua, C., Salimzadeh, L., & Gehring, A. J. (2021) · Springer eBooks · doi:10.1007/978-981-16-3615-8_4
Chronic CD27-CD70 Costimulation Promotes Type 1-Specific Polarization of Effector TregsPreprint
Anta, N. B., Acolty, V., Azouz, A., Oldenhove, G., Yagita∥, H., Léo, O., Goriely, S., & Moser, M. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3924613
Differential Maintenance, Function, and Transcriptional Profile of CD8⁺ T cells with Age
Renkema, K. R. (2013) · UA Campus Repository (The University of Arizona)
A “Toll Bridge” for Tumor-Specific T Cells
Dávila, E. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0170-5_10
TH17 Cells, Proteins Associated with TH17 Polarization, and Their Role in Graft vs. Host Disease
Serody, J. S., Moran, T. P., & Blazar, B. R. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9371-7_18
Faculty Opinions recommendation of Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype.
Li, X. C. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717957676.793462081
Lymphocytes: Antigen‐Induced Gene Activation
Suárez‐Fueyo, A., Madrenas, J., & Criado, G. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0001191.pub3
Phenotypic profile of Mycobacterium tuberculosis -specific CD4 T cell responses in HIV-positive patients who develop Tuberculosis-associated Immune Reconstitution Inflammatory SyndromePreprint
Moseki, R. M., Barber, D. L., Bruyn, E. D., Shey, M. S., van der Plas, H., Wilkinson, R. J., Meintjes, G., & Riou, C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.20.500909
Phenotypic Profile of Mycobacterium tuberculosis-Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
Moseki, R. M., Barber, D. L., Bruyn, E. D., Shey, M. S., van der Plas, H., Wilkinson, R. J., Meintjes, G., & Riou, C. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac546 · Cited by 1
Application of weighted gene co-expression network analysis to explore potential prognostic markers of head and neck squamous cell carcinomaPreprint
He, L., Zeng, Y., Gao, Y., & Xie, X. (2022) · Research Square · doi:10.21203/rs.3.rs-2171735/v1
HIV-1 Exploitation of Dendritic Cell Functionality and Initial Responses in Mucosal Tissues : Elucidation of Influence of HIV-1 Complement Opsonization, and HIV-1-HSV-2 Co-infection
Svanberg, C. (2023) · Linköping University medical dissertations · doi:10.3384/9789180751230
Cytotoxic T lymphocytes in multiple sclerosis: New targets for treatment?
Boldrini, V. D. O. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18578-6.00007-6
Estudo da atividade de células citotóxicas em portadores de esclerose múltipla em uso de diferentes tratamentos
Boldrini, V. D. O. (2020) · doi:10.47749/t/unicamp.2020.1238365
Establishment of the Myeloid TBX-Code Reveals Aberrant Expression of T-Box Gene TBX1 in Chronic Myeloid Leukemia
Nagel, S., Haake, J., Pommerenke, C., Meyer, C., & MacLeod, R. A. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010032
Upregulated Circulating CD4 KLRD1 T Cells Exhibit Characteristics of CD4 Cytotoxic T Lymphocytes in Systemic Lupus Erythematosus PatientsPreprint
Li, Q., Yuan, Z., Bahabayi, A., Zhou, S., Wang, G., Zhang, Z., Xiong, Z., Xu, Q., Wang, P., & Liu, C. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4687146
Thymic self-recognition-mediated TCR signal strength modulates antigen- specific CD8 + T cell pathogenicity in non-obese diabetic micePreprint
Ho, C.-L., Yeh, L., Liu, Y.-W., Dong, J.-L., & Sytwu, H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.10.596762
Thymic self-recognition-mediated TCR signal strength modulates antigen- specific CD8+ T cell pathogenicity in non-obese diabetic micePreprint
Ho, C.-L., Yeh, L., Liu, Y.-W., Dong, J.-L., & Sytwu, H. (2024) · eLife · doi:10.7554/elife.99897
Thymic self-recognition-mediated TCR signal strength modulates antigen-specific CD8+ T cell pathogenicity in non-obese diabetic micePreprint
Ho, C.-L., Yeh, L., Liu, Y.-W., Dong, J.-L., & Sytwu, H. (2024) · eLife · doi:10.7554/elife.99897.1
Perforinexpression bei humanen peripheren mononukleären Zellen nach anti-CD3 Stimulation –Zusammenhang mit Zellgröße und Zytotoxizität
Tanase, D. (2009)
Transcriptomic profiling identifies breed-specific immune signatures of Tuberculosis susceptibility in cattlePreprint
Kumar, R., Gandham, S., Maity, H. K., Sarkar, U., & Dey, B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.19.619179
Development of Natural Killer Cells and ILC1s
Stokic-Trtica, V., & Klose, C. S. N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00043-0
Axl inhibition on dendritic cells enhances STING anticancer therapy through type I interferon signalingPreprint
Aguilera, T. A., Gonzalez, I., Elghonaimy, E. A., Zhang, Q., Montgomery, I., Leung, P. Q., Rodriguez, A., Diegeler, S., Swancutt, K. L., & Brekken, R. A. (2025) · Research Square · doi:10.21203/rs.3.rs-5569516/v1
An efficient framework to decipher microRNA regulatory programs applied to T cells
Zhu, H., Sankaran, D. G., Smith, N. L., Daly, C. W. P., Mon, K. J. Y., Tabilas, C., Wissink, E. M., Rudd, B. D., & Grimson, A. (2025) · Genes and Immunity · doi:10.1038/s41435-025-00351-5
PD-1 blockade during T cell priming enhances long-term protection against metastatic tumors by epigenetically tuning T cell exhaustionPreprint
Dinter, T., Mackowiak, S. D., Rogers, Z. J., Bhandarkar, V., Carney, M. Y., Zhang, Y. J., Morgan, D. M., Pop, L., Chatterjee, F., Lutz, E. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.25.690601
The Role of Notch Signaling in T Cell-mediated Immune Disorders.
Sandy, A. R. (2013) · Deep Blue (University of Michigan)
Pronounced regulatory T cell activity in human schistosomiasis: differences in T cell proliferation and cytokine responses before and after treatment with Praziquantel
Schmiedel, Y. (2012)
STAT Transcription Factors: Controlling All Aspects of NK Cell Biology
Putz, E. M., Zebedin, E., & Sexl, V. (2012) · Springer eBooks · doi:10.1007/978-3-7091-0891-8_12
Th1 Cells
Annunziato, F., & Romagnani, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00533-0
Thymic self-recognition-mediated TCR signal strength modulates antigen- specific CD8+ T cell pathogenicity in non-obese diabetic micePreprint
Ho, C.-L., Yeh, L., Liu, Y.-W., Dong, J.-L., & Sytwu, H. (2025) · eLife · doi:10.7554/elife.99897.2
Multi-omics Profiling Identifies Molecular and Cellular Signatures of Regular Physical Activity in Human Peripheral BloodPreprint
Song, X., Lv, J., Ge, S., Xu, S., Wu, Y., Zheng, Y., Zhou, W., Li, L., Zhang, Y., Zhang, J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.13.699221
scTELL: a single-cell ATAC-seq tool for locus-specific transposable element identification in chromatin accessibility
Jeong, K., Ha, H. H., Xing, J., Choi, J., & Kim, K. (2026) · Mobile DNA · doi:10.1186/s13100-026-00395-y · Cited by 1
Cytomegalovirus Drives the Development of Cytotoxic CD4 + T Cells in Patients With Multiple Sclerosis
Hoeks, C., Boeckx, B., Baeten, P., Hermans, D., Randall, J., Wijmeersch, B. V., Popescu, V., Somers, V. A., Stinissen, P., Lambrechts, D., et al. (2026) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200561
Modulation des fonctions des lymphocytes T CD8 par l'Interleukine-4 et les cytokines de la famille γc
Ventre, E. (2011) · theses.fr (ABES) · doi:10.70675/5ca0f9f5z72cfz44c0z90a5z0150f799b1e3
Rôle de la profération induite par la lymphopénie dans la rupture de la tolérance périphérique des lymphocytes T CD8+
Villard, M. (2013) · theses.fr (ABES) · doi:10.70675/1bde1fdczc9c0z4057zb72azd892a904f814
Étude du rôle de l’inflammasome et de la kinase Styk1 dans la régulation des lymphocytes cytotoxiques
Fauteux‐Daniel, S. (2018) · theses.fr (ABES) · doi:10.70675/e5b20efbzd517z4af5z92a9z60598ef91d59
Rôle du facteur de transcription Foxo3 dans la différenciation des LT CD4+ et la susceptibilité à l'auto-immunité
Stienne, C. (2015) · theses.fr (ABES) · doi:10.70675/2c3f3df6z7589z4d1aza311zce4830fc17fa
Anti-CTLA-4 antibody / CTLA-4 molecule immuno-modulator mechanisms and its consequences on the reinforcement of anti-melanoma immune responses
Félix, J. (2016) · theses.fr (ABES) · doi:10.70675/7f1fe613ze350z4646zbae5zf6c28579026a
Identification and characterization of new genetic defects involved in Epstein-Barr virus immune response and T-cell proliferation
Winter, S. (2018) · theses.fr (ABES) · doi:10.70675/67cef707z5693z4647zb040z54d3d036a6de
Rôles de la stimulation chronique du TCR et de la reprogrammation cellulaire dans les lymphomes T périphériques
Carras, S. (2018) · theses.fr (ABES) · doi:10.70675/7f9619cfzc846z4beczbdd1z3dea984ba3ae
Rôle de l'E3 ubiquitine ligase ASB2α dans le contrôle de la réponse immunitaire anti-tumorale
Spinner, C. A. (2018) · theses.fr (ABES) · doi:10.70675/20536a75za7d8z4249zbc3fz16ff73ed2d76
Follicular CD4 T Cells Tutor CD8 Early Memory Precursors : an Initiatory Journey to the Frontier of B Cell Territory
Abduh, M. S. (2018) · theses.fr (ABES) · doi:10.70675/b5f08798z8366z4462zb25bz8fceb8652333
Étude d'une nouvelle population de lymphocytes T « innate-memory » : implication dans l'immunité anti-leucémique au cours de la leucémie myéloïde chronique
Jacomet, F. (2015) · doi:10.70675/451f34fdzed61z46bezae7az84003c470f76
Rôles des facteurs de transcription Foxo3 et Eomes dans la différenciation et les fonctions des lymphocytes T CD4
Michieletto, M. F. (2018) · theses.fr (ABES) · doi:10.70675/08ff4eefze6baz4742zb02ez0942397f8c5a
Rôle de la Neuropiline-1 dans les fonctions effectrices des lymphocytes T CD8 antitumoraux
Leclerc, M. (2018) · theses.fr (ABES) · doi:10.70675/13aee211zad7bz4b07z9a5fz29b15750d99c
Fonction régulatrice des lymphocytes MAIT dans un modèle expérimental de réaction du greffon contre l'hôte (GvHD)
Talvard-Balland, N. (2020) · theses.fr (ABES) · doi:10.70675/c97ca95bz9e5az4b51z9511zb52baa5010a2
Transcriptional Control of NK and iNKT Cell Development
Zhang, J. (2020) · theses.fr (ABES) · doi:10.70675/073dcbf5z7332z40c0zbba4z555a9ace31a5
L'absence de CD226 caractérise des LT CD8+ hyporépondeurs au TCR et aux fonctions antitumorales défectueuses
Weulersse, M. (2019) · theses.fr (ABES) · doi:10.70675/2a56dbcazd721z44daz9b18z27d6c10e6137
Role of co-activating receptors CD226 and CD137 in T cell exhaustion
Pichler, A. (2020) · theses.fr (ABES) · doi:10.70675/ec9fb2bazf7a9z4305z9a58zb5cbc6e74e63
A genetic dissection of human ILC development and plasticity
Croft, C. A. (2021) · theses.fr (ABES) · doi:10.70675/73858fbbz7a53z457fz91ecz36b3626efecf
Etude des syndromes lymphoprolifératifs lymphocytaires T induits par un dysfonctionnement de l'adaptateur moléculaire LAT
Joachim, A. (2021) · theses.fr (ABES) · doi:10.70675/e6219312z1b66z4f26z9cb6z7577451dfe70
Étude du rôle de l’Interleukine-33 dans l’activation des cellules NK et de leur activité anti-tumorale dans le cancer du sein
Eberhardt, A. (2020) · theses.fr (ABES) · doi:10.70675/ed817781z824dz4b2czb834z2a1966520143
Characterization of the Tumor Microenvironment in Chronic Lymphocytic Leukemia by Mass Cytometry : Implications for Immunotherapy
Wierz, M. (2020) · theses.fr (ABES) · doi:10.70675/80454a47z3b6bz4b8bza0c3z684d69f087b3
Les lymphocytes T CD8 innés, une nouvelle population T non conventionnelle (re)programmée en transplantation rénale
Daniel, L. (2021) · doi:10.70675/3ed3ac7cz4b73z4bbdzb6c9ze682c5022f59
Normal and pathological functions of the T cell signaling protein, THEMIS, in CD4+ T cells
Yang, C. (2021) · theses.fr (ABES) · doi:10.70675/59026c4ezea46z4241za55azd03232fac9cd
Rôle du facteur de transcription Eomes dans la modulation de la réponse antitumorale des lymphocytes T au cours de la thérapie ciblant 4-1BB
Agesta, A. (2023) · theses.fr (ABES) · doi:10.70675/ba376f07z6ad4z4a48zb0ddz8eedda6038ee
Modulation de l'activation des lymphocytes T et des réponses anti-tumorales par le fer
Porte, S. (2022) · theses.fr (ABES) · doi:10.70675/4251e200zd50ez4a76zb869zb97fa8d3e879
Le facteur de transcription Eomes régule les fonctions suppressives et la plasticité des cellules T régulatrices
Peroceschi, R. (2024) · theses.fr (ABES) · doi:10.70675/1253a351z345ez4a59za033z3f19256baba1
Expansions de NK et Lymphocytes T gamma delta comme outil thérapeutique post-allogreffe dans la Leucémie Aigue Myeloide
Salem, N. (2023) · theses.fr (ABES) · doi:10.70675/0394e8a0zffacz40e6zb645z3b93709d4b26
Eomes fate-labeling reveals a subset of Eomeslo NK cells that exhibits an ILC1-like phenotype
Stokic-Trtica, V., Steffen, J., Gao, X., Düsedau, H. P., Boulekou, S., Arnold, S. J., Triantafyllopoulou, A., Romagnani, C., Diefenbach, A., Tanriver, Y., et al. (2026) · Mucosal Immunology · doi:10.1016/j.mucimm.2026.04.003
The role of interferons in systemic lupus erythematosus
Nimoni, A., & Niewold, T. B. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33957-8.00023-8
OMIP ‐ 121 : Immune Phenotyping of Canine Peripheral Leukocytes by Mass Cytometry
Luong, H. T. T., Revets, D., Vercammen, S., de Marco, A., de Rooster, H., & Cosma, A. (2026) · Cytometry Part A · doi:10.1002/cyto.a.70040
Transcription factors remodel tumor immune microenvironment by impacting multiple immune cells
Xue, B., He, C., & Tian, Y. (2026) · Discover Oncology · doi:10.1007/s12672-026-05508-w
CD8 + Tissue‐Resident Memory T Cells in Health and Disease
Ai, Y.-H., Xu, T., Lin, S., Xiao, M., Lin, Y.-X., Ma, H. Y., Liu, Y., Wang, Y., Yin, L., Huang, M., et al. (2026) · MedComm · doi:10.1002/mco2.70838
Epigenetic landscape, key transcriptional regulators, and in vivo identification of human Tr1 cells
Cepika, A., Amaya, L., Waichler, C., Narula, M., Mantilla, M., Thomas, B. C., Chen, P. P., Freeborn, R. A., Pavel-Dinu, M., Nideffer, J., et al. (2026) · Science Advances · doi:10.1126/sciadv.aec6358 · Cited by 3

Authors: Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., Shen, H., Cereb, N., Yang, S. Y., Lindsten, T., Rossant, J., Hunter, C. A., & Reiner, S. L.
Affiliations: Mount Sinai Hospital (CA)
Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Corresponding author: Reiner, Steven L.
ORCID: Pearce, Erika L.
Mullen, Alan C.
Krawczyk, Connie M.
Mao, Chai-an
Shen, Hao
Cereb, Nezih
Yang, Soo Y.
Rossant, Janet
Hunter, Christopher A.
Reiner, Steven L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-11-07
Volume: 302
Issue: 5647
Pages: 1041-1043
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1090148
OpenAlex: W2119319172
Cited by: 1,014
References: 18
Citations by year: 2026: 25 · 2025: 36 · 2024: 32 · 2023: 47 · 2022: 45 · 2021: 72 · 2020: 60 · 2019: 49 · 2018: 63 · 2017: 33 · 2016: 50 · 2015: 45 · 2014: 56 · 2013: 69 · 2012: 56
FWCI: 8.86
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (T32GM007229, GM-07229)
National Institute of Allergy and Infectious Diseases (AI 042370, R01AI042370)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: Eomesodermin, CD8+ T cells, effector T cell differentiation, transcription factors, T-bet, interferon-gamma, perforin, granzyme B, cell-mediated immunity, transcriptional regulation
MeSH terms: T-bet Transcription Factor, Amino Acid Sequence, Animals, Arenaviridae Infections, Base Sequence, Cell Differentiation, Cytotoxicity, Immunologic, Gene Expression Regulation, Interferon-gamma, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, RNA, Messenger, Serine Endopeptidases, Transcription Factors, CD8-Positive T-Lymphocytes, Th2 Cells, T-Box Domain Proteins, Mice, Pore Forming Cytotoxic Proteins, Granzymes, Perforin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks