Cited by 1,014T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

Pearce, Erika L., Mullen, Alan C., Martins, Gislâine A., Krawczyk, Connie M., Hutchins, Anne S., Zediak, Valerie P., Banica, Monica, DiCioccio, Catherine B., Gross, Darrick A., Mao, Chai-an, Shen, Hao, Cereb, Nezih, Yang, Soo Y., Lindsten, Tullia, Rossant, Janet, Hunter, Christopher A., Reiner, Steven L.·2003·Science

DOI 10.1126/science.1090148

Open this paper in CoChat — free account

Abstract

Activated CD8 + T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8 + T cells. We now show that Eomesodermin ( Eomes ), a paralogue of T-bet , is induced in effector CD8 + T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8 + T cells, including interferon-γ (IFN-γ), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8 + T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.

Integrity signals

Registry

Crossref · 10.1126/science.1090148

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory
Shedlock, D. J., & Shen, H. (2003) · Science · doi:10.1126/science.1082305 · Cited by 1,450
Self-citation
Distinct Effects of T-bet in T H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells
Szabo, S. J., Sullivan, B. M., Stemmann, C., Satoskar, A. R., Sleckman, B. P., & Glimcher, L. H. (2002) · Science · doi:10.1126/science.1065543 · Cited by 1,172
Molecular and functional profiling of memory CD8 T cell differentiation.
Kaech, S., Hemby, S., Kersh, E., & Ahmed, R. (2002) · Cell · doi:10.1016/s0092-8674(02)01139-x · Cited by 1,081
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
Pircher, H., Bürki, K., Lang, R., Hengartner, H., & Zinkernagel, R. M. (1989) · Nature · doi:10.1038/342559a0 · Cited by 1,019

Flagged first, then by citations

Show all 18 references

Sorted by citations

Items 501–600 of 1,000

Memory CD 8 T cell inflation vs tissue‐resident memory T cells: Same patrollers, same controllers?
Welten, S. P. M., Sandu, I., Baumann, N. S., & Oxenius, A. (2018) · Immunological Reviews · doi:10.1111/imr.12649 · Cited by 34
Differential gene expression of tumor-infiltrating CD8 + T cells in advanced versus early-stage colorectal cancer and identification of a gene signature of poor prognosis
Saleh, R., Nair, V. S., Toor, S. M., Taha, R. Z., Murshed, K., Al‐Dhaheri, M., Khawar, M., Petkar, M. A., Nada, M. A., Al‐Ejeh, F., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001294 · Cited by 34
IFN-γ and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4+ but not CD8+ T cells
Barbi, J. J., Oghumu, S., Lezama-Dávila, C. M., & Satoskar, A. R. (2007) · Blood · doi:10.1182/blood-2007-03-081307 · Cited by 32
Kinetics of the Immune Response Profile in Guinea Pigs after Vaccination withMycobacterium bovisBCG and Infection withMycobacterium tuberculosis
Grover, A., Taylor, J. L., Troudt, J. M., Keyser, A., Arnett, K. A., Izzo, L. S., Rholl, D. A., & Izzo, A. A. (2009) · Infection and Immunity · doi:10.1128/iai.00704-09 · Cited by 32
Transcriptional and post-transcriptional regulation of NK cell development and function
Leong, J. W., Wagner, J. A., Ireland, A. R., & Fehniger, T. A. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.03.003 · Cited by 32
Distinct Compartmentalization of CD4+ T-Cell Effector Function Versus Proliferative Capacity during Pulmonary Cryptococcosis
Lindell, D. M., Moore, T. A., McDonald, R. A., Toews, G. B., & Huffnagle, G. B. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050522 · Cited by 32
Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity
Sun, Y., Preiss, N. K., Valenteros, K. B., Kamal, Y., Usherwood, Y.-K., Frost, H. R., & Usherwood, E. J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000459 · Cited by 34
Metabolites Profiling of Melanoma Interstitial Fluids Reveals Uridine Diphosphate as Potent Immune Modulator Capable of Limiting Tumor Growth
Vecchio, E., Caiazza, C., Mimmi, S., Avagliano, A., Iaccino, E., Brusco, T., Nisticò, N., Maisano, D., Aloisio, A., Quinto, I., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.730726 · Cited by 31
Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis
Cardoso, A., Martins, A. C. M., Maceiras, A. R., Liu, W., Castro, I., Castro, A. G., Bandeira, A., Santo, J. P. D., Cumano, A., Li, Y., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109887 · Cited by 36
Age-Related Alterations in Peripheral Immune Landscape with Magnified Impact on Post-Stroke Brain
Lü, J., Li, H., Zhang, G., Yang, F., Zhang, X., Ping, A., Xu, Z., Gu, Y., Wang, R., Ying, D., et al. (2023) · Research · doi:10.34133/research.0287 · Cited by 32
Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy
Chen, Z., Zhu, Z., Hu, T., Yao, C., & Wu, T. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01378-4 · Cited by 37
A Common Promoter Variant of TBX21 is Associated with Allele Specific Binding to Yin‐Yang 1 and Reduced Gene Expression
Li, J., Li, J., Deng, G., Zhao, W., Dan, Y., Wang, Y., & Chen, S. (2011) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2011.02520.x · Cited by 30
Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells
Bae, J. E., Samur, M., Munshi, A., Hideshima, T., Keskin, D. B., Kimmelman, A. C., Lee, A., Dranoff, G., Anderson, K. C., & Munshi, N. C. (2014) · OncoImmunology · doi:10.4161/21624011.2014.970914 · Cited by 30
Conversations that count: Cellular interactions that drive T cell fate
Duckworth, B. C., & Groom, J. R. (2021) · Immunological Reviews · doi:10.1111/imr.12945 · Cited by 32
Cutting Edge: Innate Memory CD8+ T Cells Are Distinct from Homeostatic Expanded CD8+ T Cells and Rapidly Respond to Primary Antigenic Stimuli
Huang, W., Hu, J., & August, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202988 · Cited by 30
The rationale for the IL‐2‐independent generation of the self‐renewing central memory CD8+ T cells
Fearon, D. T., Carr, J. M., Telaranta, A. I., Carrasco, M. J., & Thaventhiran, J. E. D. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00390.x · Cited by 30
High Eomesodermin Expression among CD57 + CD8 + T Cells Identifies a CD8 + T Cell Subset Associated with Viral Control during Chronic Human Immunodeficiency Virus Infection
Simonetta, F., Hua, S., Lécuroux, C., Gérard, S., Boufassa, F., Sáez‐Cirión, A., Pancino, G., Goujard, C., Lambotte, O., Venet, A., et al. (2014) · Journal of Virology · doi:10.1128/jvi.02013-14 · Cited by 28
Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology
Brucklacher-Waldert, V., Ferreira, C., Innocentin, S., Kamdar, S., Withers, D. R., Kullberg, M. C., & Veldhoen, M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600137 · Cited by 30
MicroRNA-124 involves in ankylosing spondylitis by targeting ANTXR2
Xia, Y., Chen, K., Zhang, M., Wang, L., Ma, C., Lin, Y., & Zhao, Y. (2015) · Modern Rheumatology · doi:10.3109/14397595.2015.1023887 · Cited by 29
Transgene and immune gene expression following intramuscular injection of Atlantic salmon (Salmo salar L.) with DNA-releasing PLGA nano- and microparticles
Hølvold, L. B., Fredriksen, B. N., Bøgwald, J., & Dalmo, R. A. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.06.030 · Cited by 29
NK Cell Genesis: A Trick of the Trail
Narni-Mancinelli, É., & Vivier, É. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.001 · Cited by 29
Eomesoderminlo CTLA4hi Alloreactive CD8+ Memory T Cells Are Associated With Prolonged Renal Transplant Survival Induced by Regulatory Dendritic Cell Infusion in CTLA4 Immunoglobulin–Treated Nonhuman Primates
Ezzelarab, M. B., Lu, L., Guo, H., Zahorchak, A. F., Shufesky, W. J., Cooper, D. K. C., Morelli, A. E., & Thomson, A. W. (2015) · Transplantation · doi:10.1097/tp.0000000000000871 · Cited by 29
HIV-1 Tat affects the programming and functionality of human CD8+ T cells by modulating the expression of T-box transcription factors
Sforza, F., Nicoli, F., Gallerani, E., Finessi, V., Reali, E., Cafaro, A., Caputo, A., Ensoli, B., & Gavioli, R. (2014) · AIDS · doi:10.1097/qad.0000000000000315 · Cited by 29
Curtailed T‐cell activation curbs effector differentiation and generates CD8+ T cells with a naturally‐occurring memory stem cell phenotype
Zanon, V., Pilipow, K., Scamardella, E., Paoli, F. D., Simone, G. D., Price, D. A., Martínez-Usatorre, A., Romero, P. J., Mavilio, D., Roberto, A., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646732 · Cited by 29
Domain binding and isotype dictate the activity of anti-human OX40 antibodies
Griffiths, J., Hussain, K., Smith, H. L., Sanders, T. J., Cox, K. L., Semmrich, M., Mårtensson, L., Kim, J., Inzhelevskaya, T., Penfold, C., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001557 · Cited by 31
Identification and Characterization of a Master Transcription Factor of Th1 Cells, T-bet, Within Flounder (Paralichthys olivaceus)
Tian, H., Xing, J., Tang, X., Chi, H., Sheng, X., & Zhan, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.704324 · Cited by 29
NK Cell Functional Impairment after Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Reduced Levels of T-bet and Eomesodermin
Simonetta, F., Pradier, A., Bosshard, C., Masouridi‐Levrat, S., Chalandon, Y., & Roosnek, E. E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501522 · Cited by 29
Expression of T-bet, Eomesodermin and GATA-3 in porcine αβ T cells
Rodríguez-Gómez, I. M., Talker, S. C., Käser, T., Stadler, M., Hammer, S. E., Saalmüller, A., & Gerner, W. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.02.022 · Cited by 29
Double Negative T Regulatory Cells: An Emerging Paradigm Shift in Reproductive Immune Tolerance?
Bafor, E. E., Valencia, J. C., & Young, H. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.886645 · Cited by 29
Clinically Relevant Reactivation of Polyomavirus BK (BKPyV) in HLA-A02-Positive Renal Transplant Recipients Is Associated with Impaired Effector-Memory Differentiation of BKPyV-Specific CD8+ T Cells
van Aalderen, M. C., Remmerswaal, E. B. M., Heutinck, K. M., ten Brinke, A., Feltkamp, M. C. W., van der Weerd, N. C., der Pant, K. A. M. I. V. D., Bemelman, F. J., van Lier, R. A. W., & ten Berge, I. J. M. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005903 · Cited by 28
Temporal cross‐talk between TCR and STAT signals for CD8 T cell effector differentiation
Verdeil, G., Chaix, J., Schmitt‐Verhulst, A., & Auphan‐Anezin, N. (2006) · European Journal of Immunology · doi:10.1002/eji.200636347 · Cited by 28
Novel TGF-β Antagonist Inhibits Tumor Growth and Angiogenesis by Inducing IL-2 Receptor-Driven STAT1 Activation
Penafuerte, C., Bautista-Lopez, N., Bouchentouf, M., Birman, E., Forner, K., & Galipeau, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003816 · Cited by 28
Phenotype and Functional Characterization of Long-term gp100-Specific Memory CD8+ T Cells in Disease-Free Melanoma Patients Before and After Boosting Immunization
Walker, E., Haley, D. P., Petrausch, U., Floyd, K., Miller, W. L., Sanjuan, N., Alvord, G., Fox, B. A., & Urba, W. J. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0022 · Cited by 28
Many Th Cell Subsets Have Fas Ligand–Dependent Cytotoxic Potential
Kotov, D. I., Kotov, J. A., Goldberg, M. F., & Jenkins, M. K. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700420 · Cited by 28
ThPOK Derepression Is Required for Robust CD8 T cell Responses to Viral Infection
Setoguchi, R., Taniuchi, I., & Bevan, M. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901428 · Cited by 28
ERK Signaling Controls Innate-like CD8+ T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors
Maurice, D., Costello, P. S., Sargent, M., & Treisman, R. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800704 · Cited by 27
Cheating the Hunger Games; Mechanisms Controlling Clonal Diversity of CD8 Effector and Memory Populations
Kavazović, I., Polić, B., & Wensveen, F. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02831 · Cited by 29
Eomes Impedes Durable Response to Tumor Immunotherapy by Inhibiting Stemness, Tissue Residency, and Promoting the Dysfunctional State of Intratumoral CD8+ T Cells
Sun, R., Wu, Y., Zhou, H., Wu, Y., Yang, Z., Gu, Y., Jiang, J., Lu, B., & Zhu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.640224 · Cited by 29
Regulatory Mechanisms and Reversal of CD8+T Cell Exhaustion: A Literature Review
Zhu, W., Li, Y., Han, M., & Jiang, J. (2023) · Biology · doi:10.3390/biology12040541 · Cited by 28
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation
Adler, A. J., & Vella, A. T. (2012) · OncoImmunology · doi:10.4161/onci.22837 · Cited by 28
From the thymus to longevity in the periphery
Wakim, L. M., & Bevan, M. J. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.03.003 · Cited by 27
The smallest unit: effector and memory CD8+ T cell differentiation on the single cell level
Buchholz, V. R., Gräf, P., & Busch, D. H. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00031 · Cited by 27
Defining the molecular blueprint that drives CD8+ T cell differentiation in response to infection
Russ, B. E., Denton, A. E., Hatton, L. A., Croom, H. A., Olson, M. R., & Turner, S. (2012) · Front. Immun. · doi:10.3389/fimmu.2012.00371 · Cited by 31
NFAT1 and NFAT2 Differentially Regulate CTL Differentiation Upon Acute Viral Infection
Xu, T., Keller, A., & Martínez, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00184 · Cited by 26
JNK2 negatively regulates CD8+ T cell effector function and anti‐tumor immune response
Tao, J., Gao, Y., Li, M. O., He, W., Chen, L., Harvev, B., Davis, R. J., Flavell, R. A., & Yin, Z. (2007) · European Journal of Immunology · doi:10.1002/eji.200636726 · Cited by 27
The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection
Peng, J. (2004) · International Immunology · doi:10.1093/intimm/dxh200 · Cited by 27
Not‐so‐great expectations: re‐assessing the essence of T‐cell memory
Intlekofer, A. M., Wherry, E. J., & Reiner, S. L. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00396.x · Cited by 27
Self-citation
Identification of a New Pathway for Th1 Cell Development Induced by Cooperative Stimulation with IL-4 and TGF-β
Tofukuji, S., Kuwahara, M., Suzuki, J., Ohara, O., Nakayama, T., & Yamashita, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103799 · Cited by 27
TNIK signaling imprints CD8+ T cell memory formation early after priming
Jaeger-Ruckstuhl, C. A., Hinterbrandner, M., Höpner, S., Correnti, C., Lüthi, U., Friedli, O., Freigang, S., Sayed, M. F. A., Bührer, E. D., Amrein, M. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15413-7 · Cited by 25
NK Cells in a Tug-of-War With Cancer: The Roles of Transcription Factors and Cytoskeleton
Lee, E. H. C., Wong, D. C. P., & Ding, J. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.734551 · Cited by 28
Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts
Barbosa, C. H., Canto, F. B., Gomes, A., Brandão, L. M., Lima, J. R., Melo, G. A., Granato, A., Neves, E. G. A., Dutra, W. O., Oliveira, A. C., et al. (2022) · eLife · doi:10.7554/elife.74636 · Cited by 26
CD4+ Cytotoxic T Lymphocytes in Cancer Immunity and Immunotherapy
Wang, B., Hu, S., Fu, X., & Li, L. (2022) · Advanced Biology · doi:10.1002/adbi.202200169 · Cited by 29
Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells
Smith, C., Elhassen, D., Gras, S., Wynn, K. K., Dasari, V., Tellam, J., Tey, S., Rehan, S., Liu, Y. C., Rossjohn, J., et al. (2012) · Blood · doi:10.1182/blood-2012-03-420182 · Cited by 26
14-3-3z sequesters cytosolic T-bet, upregulating IL-13 levels in TC2 and CD8+ lymphocytes from patients with scleroderma
Cascio, S., Medsger, T. A., Hawse, W. F., Watkins, S. C., Milcarek, C., Moreland, L. W., Lafyatis, R., & Fuschiotti, P. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.10.029 · Cited by 26
Eomesodermin is expressed in mouse oocytes and pre‐implantation embryos
McConnell, J. M. L., Petrie, L., Stennard, F. A., Ryan, K., & Nichols, J. (2005) · Molecular Reproduction and Development · doi:10.1002/mrd.20318 · Cited by 26
Longitudinal Requirement for CD4+ T Cell Help for Adenovirus Vector–Elicited CD8+ T Cell Responses
Provine, N. M., Larocca, R. A., Penaloza‐MacMaster, P., Borducchi, E. N., McNally, A. G., Parenteau, L. R., Kaufman, D. R., & Barouch, D. H. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302806 · Cited by 24
Multitarget Direct‐Acting Antiviral Therapy Is Associated With Superior Immunologic Recovery in Patients Coinfected With Human Immunodeficiency Virus and Hepatitis C Virus
Shrivastava, S., Bhatta, M., Ward, H., Romani, S., Lee, R., Rosenthal, E. S., Osinusi, A. O., Kohli, A., Masur, H., Kottilil, S., et al. (2018) · Hepatology Communications · doi:10.1002/hep4.1258 · Cited by 25
Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion
Balkhi, M. Y. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1747349 · Cited by 26
The NF‐κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties
Gugasyan, R., Horat, E., Kinkel, S., Ross, F. J., Grigoriadis, G., Gray, D. H. D., O’Keeffe, M. A., Berzins, S. P., Belz, G. T., Grumont, R. J., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.435 · Cited by 25
Differential Gene Expression Profiling of Orbital Adipose Tissue in Thyroid Orbitopathy
Khong, J. J., Wang, L. Y., Smyth, G. K., McNab, A. A., Hardy, T. G., Selva, D. N., Llamas, B., Jung, C., Sharma, S., Burdon, K. P., et al. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17185 · Cited by 25
Eomes partners with PU.1 and MITF to Regulate Transcription Factors Critical for osteoclast differentiation
Carey, H. A., Hildreth, B. E., Samuvel, D. J., Thies, K., Rosol, T. J., Toribio, R. E., Charles, J. F., Ostrowski, M. C., & Sharma, S. M. (2018) · iScience · doi:10.1016/j.isci.2018.12.018 · Cited by 25
Runx proteins and transcriptional mechanisms that govern memory CD8 T cell development
Pipkin, M. E. (2021) · Immunological Reviews · doi:10.1111/imr.12954 · Cited by 24
Gene Regulatory Circuits in Innate and Adaptive Immune Cells
Saini, A., Ghoneim, H. E., Lio, C. J., Collins, P. L., & Oltz, E. M. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-025949 · Cited by 24
Epstein-Barr Virus and multiple sclerosis in a Spanish cohort: A two-years longitudinal study
Domínguez‐Mozo, M. I., Lozano, L. L., Pérez‐Pérez, S., García-Martínez, Á., Torrejón, M. J., Arroyo, R., & Álvarez‐Lafuente, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.991662 · Cited by 24
Transcriptional Control of NK Cells
Sun, J. C.-Y. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_452 · Cited by 24
Regulation of Gene Expression in Peripheral T Cells by Runx Transcription Factors
Djuretic, I. M., Cruz‐Guilloty, F., & Rao, A. (2009) · Advances in immunology · doi:10.1016/s0065-2776(08)04001-7 · Cited by 24
Transcription Factor T-Bet in Atlantic Salmon: Characterization and Gene Expression in Mucosal Tissues during Aeromonas Salmonicida Infection
Kumari, J., Zhang, Z., Swain, T., Chi, H., Niu, C., Bøgwald, J., & Dalmo, R. A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00345 · Cited by 24
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors
dos Santos, P. R., Turnbull, E. L., Monteiro, M., Legrand, A., Conrod, K. E., Baalwa, J., Pellegrino, P., Shaw, G. M., Williams, I. G., Borrow, P., et al. (2012) · Blood · doi:10.1182/blood-2011-12-395186 · Cited by 24
CD103+CD8+ T lymphocytes in non-small cell lung cancer are phenotypically and functionally primed to respond to PD-1 blockade
Wang, P., Huang, B. Y., Gao, Y., Yang, J., Liang, Z., Zhang, N., Fu, X., & Li, L. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.02.002 · Cited by 24
Cryo-thermal therapy inducing MI macrophage polarization created CXCL10 and IL-6-rich pro-inflammatory environment for CD4+T cell-mediated anti-tumor immunity
Liu, P., Jia, S., Lou, Y., He, K., & Xu, L. X. (2019) · International Journal of Hyperthermia · doi:10.1080/02656736.2019.1579373 · Cited by 24
Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways
Kleinstern, G., Yan, H., Hildebrandt, M. A. T., Vijai, J., Berndt, S. I., Ghesquières, H., McKay, J., Wang, S., Nieters, A., Ye, Y., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz228 · Cited by 26
CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant
Yeh, A. C., Varelias, A., Reddy, A., Barone, S. M., Olver, S. D., Chilson, K., Onstad, L., Ensbey, K. S., Henden, A. S., Samson, L. D., et al. (2021) · Blood · doi:10.1182/blood.2020009492 · Cited by 24
CD8+ T Cell Differentiation: Choosing a Path through T-bet
Hamilton, S. E., & Jameson, S. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.003 · Cited by 24
Functional heterogeneity of human effector CD8+ T cells
Takata, H., Naruto, T., & Takiguchi, M. (2011) · Blood · doi:10.1182/blood-2011-03-343251 · Cited by 24
Eomesodermin—At Dawn of Cell Fate Decisions During Early Embryogenesis
Probst, S., & Arnold, S. J. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.09.001 · Cited by 23
Molecular insight into T cell exhaustion in hepatocellular carcinoma
Zhu, Y., Tan, H., Wang, J., Zhuang, H., Zhao, H., & Lu, X. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107161 · Cited by 28
Analysis of the heterogeneity and complexity of murine extraorbital lacrimal gland via single-cell RNA sequencing
Huang, D., Jiao, X., Huang, S., Liu, J., Si, H., Qi, D., Pei, X., Lu, D., Wang, Y., & Li, Z. (2024) · The Ocular Surface · doi:10.1016/j.jtos.2024.06.005 · Cited by 23
Nuclear HMGB1 is critical for CD8 T cell IFN-γ production and anti-tumor immunity
Xu, Z., Ma, W., Wang, J., Chen, H., Li, H., Yin, Z., Hao, J., & Chen, K. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114591 · Cited by 24
Blood and beyond: Properties of circulating and tissue‐resident human virus‐specific αβ CD8+ T cells
van Aalderen, M. C., Remmerswaal, E. B. M., ten Berge, I. J. M., & van Lier, R. A. W. (2014) · European Journal of Immunology · doi:10.1002/eji.201344269 · Cited by 24
Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy
Mittal, P., Rose, M. S., Wang, X., Ryan, J. M., Wasser, J. S., Vella, A. T., & Adler, A. J. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1502032 · Cited by 22
Down‐regulation of EOMES drives T‐cell exhaustion via abolishing EOMES‐mediated repression of inhibitory receptors of T cells in liver cancer
He, H.-W., Yi, Y., Cai, X., Wang, J., Ni, X., Fu, Y., & Qiu, S. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15898 · Cited by 23
Beyond target cell death – Granzyme serine proteases in health and disease
Nüssing, S., Sutton, V. R., Trapani, J. A., & Parish, I. A. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101152 · Cited by 23
Regulation of CD8+ T-cell cytotoxicity in HIV-1 infection
Saeidi, A., Buggert, M., Che, K. F., Kong, Y. Y., Velu, V., Larsson, M., & Shankar, E. M. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.10.009 · Cited by 23
CD134/CD137 dual costimulation‐elicited IFN‐γ maximizes effector T‐cell function but limits Treg expansion
Rose, M. S., Taylor, R. A., Bandyopadhyay, S., Qui, H. Z., Hagymasi, A. T., Vella, A. T., & Adler, A. J. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2012.74 · Cited by 23
Breakdown in Repression of IFN-γ mRNA Leads to Accumulation of Self-Reactive Effector CD8+ T Cells
Chang, P.-P., Lee, S. K., Hu, X., Davey, G. M., Duan, G., Cho, J.-H., Karupiah, G., Sprent, J., Heath, W. R., Bertram, E. M., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102432 · Cited by 23
Significant role for IRF3 in both T cell and APC effector functions during T cell responses
Guinn, Z., Lampe, A. T., Brown, D. M., & Petro, T. M. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.08.015 · Cited by 23
The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs
Arra, A., Lingel, H., Kuropka, B., Pick, J., Schnoeder, T. M., Fischer, T., Freund, C., Pierau, M., & Brunner-Weinzierl, M. C. (2017) · OncoImmunology · doi:10.1080/2162402x.2016.1273300 · Cited by 23
Reactive glia promote development of CD103+CD69+ CD8+ T‐cells through programmed cell death‐ligand 1 (PD‐L1)
Prasad, S., Hu, S., Sheng, W. S., Chauhan, P., & Lokensgard, J. R. (2018) · Immunity Inflammation and Disease · doi:10.1002/iid3.221 · Cited by 24
Checkpoint Blockade Rescues the Repressive Effect of Histone Deacetylases Inhibitors on γδ T Cell Function
Bhat, S. A., Vedpathak, D., & Chiplunkar, S. V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01615 · Cited by 23
Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
Sud, A., Thomsen, H., Orlando, G., Försti, A., Law, P., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., et al. (2018) · Blood · doi:10.1182/blood-2018-06-855296 · Cited by 23
Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse
Kiyama, T., Long, Y., Chen, C.-K., Whitaker, C. M., Shay, A., Wu, H., Badea, T. C., Mohsenin, A., Parker‐Thornburg, J., Klein, W. H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.077 · Cited by 21
Self-citation
HDAC1 Controls CD8+ T Cell Homeostasis and Antiviral Response
Tschismarov, R., Firner, S., Gil‐Cruz, C., Göschl, L., Boucheron, N., Steiner, G. E., Matthias, P., Seiser, C., Ludewig, B., & Ellmeier, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110576 · Cited by 23
Bcl11b prevents the intrathymic development of innate CD8 T cells in a cell intrinsic manner
Hirose, S., Touma, M., Go, R., Katsuragi, Y., Sakuraba, Y., Gondo, Y., Abe, M., Sakimura, K., Mishima, Y., & Kominami, R. (2014) · International Immunology · doi:10.1093/intimm/dxu104 · Cited by 23
Expression profile of cytokine and transcription factor genes during embryonic development of zebrafish Danio rerio
Ito, K., Takizawa, F., Yoshiura, Y., Ototake, M., & Nakanishi, T. (2008) · Fisheries Science · doi:10.1111/j.1444-2906.2008.01526.x · Cited by 22
Loss of the orphan nuclear receptor NR2F6 enhances CD8+ T-cell memory via IFN-γ
Jakic, B., Olson, W. J., Siegmund, K., Klepsch, V., Kimpel, J., Labi, V., Zehn, D., Baier, G., & Hermann‐Kleiter, N. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03470-9 · Cited by 22
Characterization of Tbr2‐expressing retinal ganglion cells
Chen, C.-K., Kiyama, T., Weber, N., Whitaker, C. M., Pan, P., Badea, T. C., Massey, S. C., & Mao, C. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25208 · Cited by 23
Self-citation
The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
Chen, H., Smith, M., Herz, J., Li, T., Hasley, R. B., Saout, C. L., Zhu, Z., Cheng, J., Gronda, A., Martina, J. A., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103387 · Cited by 22
Decreased expression of T‐cell‐associated immune markers predicts poor prognosis in patients with follicular lymphoma
Rai, S., Inoue, H., Sakai, K., Hanamoto, H., Matsuda, M., Maeda, Y., Haeno, T., Watatani, Y., Kumode, T., Serizawa, K., et al. (2021) · Cancer Science · doi:10.1111/cas.15224 · Cited by 22
Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation
Fu, Y., Wang, J., Liu, C., Liao, K., Gao, X., Tang, R., Binbin, F., Hong, Y., Xiao, N., Xiao, C., et al. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01075-0 · Cited by 21
T‐bet‐dependent regulation of CD8+ T‐cell expansion during experimental Trypanosoma cruzi infection
Cobb, D. A., Guo, S., Lara, A. M., Manque, P., Buck, G. A., & Smeltz, R. B. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03169.x · Cited by 22

Authors: Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., Shen, H., Cereb, N., Yang, S. Y., Lindsten, T., Rossant, J., Hunter, C. A., & Reiner, S. L.
Affiliations: Mount Sinai Hospital (CA)
Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Corresponding author: Reiner, Steven L.
ORCID: Pearce, Erika L.
Mullen, Alan C.
Krawczyk, Connie M.
Mao, Chai-an
Shen, Hao
Cereb, Nezih
Yang, Soo Y.
Rossant, Janet
Hunter, Christopher A.
Reiner, Steven L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-11-07
Volume: 302
Issue: 5647
Pages: 1041-1043
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1090148
OpenAlex: W2119319172
Cited by: 1,014
References: 18
Citations by year: 2026: 25 · 2025: 36 · 2024: 32 · 2023: 47 · 2022: 45 · 2021: 72 · 2020: 60 · 2019: 49 · 2018: 63 · 2017: 33 · 2016: 50 · 2015: 45 · 2014: 56 · 2013: 69 · 2012: 56
FWCI: 8.86
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (T32GM007229, GM-07229)
National Institute of Allergy and Infectious Diseases (AI 042370, R01AI042370)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: Eomesodermin, CD8+ T cells, effector T cell differentiation, transcription factors, T-bet, interferon-gamma, perforin, granzyme B, cell-mediated immunity, transcriptional regulation
MeSH terms: T-bet Transcription Factor, Amino Acid Sequence, Animals, Arenaviridae Infections, Base Sequence, Cell Differentiation, Cytotoxicity, Immunologic, Gene Expression Regulation, Interferon-gamma, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, RNA, Messenger, Serine Endopeptidases, Transcription Factors, CD8-Positive T-Lymphocytes, Th2 Cells, T-Box Domain Proteins, Mice, Pore Forming Cytotoxic Proteins, Granzymes, Perforin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks