Cited by 1,014T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

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Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

Pearce, Erika L., Mullen, Alan C., Martins, Gislâine A., Krawczyk, Connie M., Hutchins, Anne S., Zediak, Valerie P., Banica, Monica, DiCioccio, Catherine B., Gross, Darrick A., Mao, Chai-an, Shen, Hao, Cereb, Nezih, Yang, Soo Y., Lindsten, Tullia, Rossant, Janet, Hunter, Christopher A., Reiner, Steven L.·2003·Science

DOI 10.1126/science.1090148

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Abstract

Activated CD8 + T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8 + T cells. We now show that Eomesodermin ( Eomes ), a paralogue of T-bet , is induced in effector CD8 + T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8 + T cells, including interferon-γ (IFN-γ), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8 + T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.

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Authors: Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., Shen, H., Cereb, N., Yang, S. Y., Lindsten, T., Rossant, J., Hunter, C. A., & Reiner, S. L.
Affiliations: Mount Sinai Hospital (CA)
Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Corresponding author: Reiner, Steven L.
ORCID: Pearce, Erika L.
Mullen, Alan C.
Krawczyk, Connie M.
Mao, Chai-an
Shen, Hao
Cereb, Nezih
Yang, Soo Y.
Rossant, Janet
Hunter, Christopher A.
Reiner, Steven L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-11-07
Volume: 302
Issue: 5647
Pages: 1041-1043
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1090148
OpenAlex: W2119319172
Cited by: 1,014
References: 18
Citations by year: 2026: 25 · 2025: 36 · 2024: 32 · 2023: 47 · 2022: 45 · 2021: 72 · 2020: 60 · 2019: 49 · 2018: 63 · 2017: 33 · 2016: 50 · 2015: 45 · 2014: 56 · 2013: 69 · 2012: 56
FWCI: 8.86
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (T32GM007229, GM-07229)
National Institute of Allergy and Infectious Diseases (AI 042370, R01AI042370)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: Eomesodermin, CD8+ T cells, effector T cell differentiation, transcription factors, T-bet, interferon-gamma, perforin, granzyme B, cell-mediated immunity, transcriptional regulation
MeSH terms: T-bet Transcription Factor, Amino Acid Sequence, Animals, Arenaviridae Infections, Base Sequence, Cell Differentiation, Cytotoxicity, Immunologic, Gene Expression Regulation, Interferon-gamma, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, RNA, Messenger, Serine Endopeptidases, Transcription Factors, CD8-Positive T-Lymphocytes, Th2 Cells, T-Box Domain Proteins, Mice, Pore Forming Cytotoxic Proteins, Granzymes, Perforin

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Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

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