Increase in Activity During Calorie Restriction Requires Sirt1

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SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan

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Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience

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The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats

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SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty

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A Molecular Perspective on Sirtuin Activity

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Bioenergetics of aging and calorie restriction

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Sirt1: Def-eating senescence?

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Metabolic Reprogramming of Human Cells in Response to Oxidative Stress: Implications in the Pathophysiology and Therapy of Mitochondrial Diseases

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The Dihydrolipoamide Acetyltransferase Is a Novel Metabolic Longevity Factor and Is Required for Calorie Restriction-mediated Life Span Extension

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SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets

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The sirtuin class of histone deacetylases: Regulation and roles in lipid metabolism

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dSir2 and longevity in Drosophila

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Longevity Genes: Insights from Calorie Restriction and Genetic Longevity Models

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SIRT1 in metabolic syndrome: Where to target matters

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Resveratrol activates SIRT1 in a Lamin A-dependent manner

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Hormetic efficacy of rutin to promote longevity in Drosophila melanogaster

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Uncoupling protein homologs may provide a link between mitochondria, metabolism and lifespan

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Roles of NAD+ in Acute and Chronic Kidney Diseases

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Sirtuin regulation in calorie restriction

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The Protective Mechanism of SIRT1 in the Regulation of Mitochondrial Biogenesis and Mitochondrial Autophagy in Alzheimer’s Disease

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Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

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Regulation of Gene Expression through Food—Curcumin as a Sirtuin Activity Modulator

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Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling

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Regulation and protection of mitochondrial physiology by sirtuins

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Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice

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Calorie restriction effects on silencing and recombination at the yeast rDNA

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SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction

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Energy restriction and potential energy restriction mimetics

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Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes

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Higher body fatness in intrauterine growth retarded juvenile pigs is associated with lower fat and higher carbohydrate oxidation during ad libitum and restricted feeding

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Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion

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SIRT1 variants are associated with aging in a healthy Han Chinese population

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SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

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Sirtuins are not conserved longevity genes

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Cardiac Sirt1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion

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A systems-approach to NAD+ restoration

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Epsilon PKC Increases Brain Mitochondrial SIRT1 Protein Levels via Heat Shock Protein 90 following Ischemic Preconditioning in Rats

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The expression of Sirtuins 1 and 4 in peripheral blood leukocytes from patients with type 2 diabetes

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Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression

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Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses

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Metabolic regulation of Sirtuins upon fasting and the implication for cancer

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SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside

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Effects of age and gender on Sirt 1 mRNA expressions in the hypothalamus of the mouse

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dSir2 mediates the increased spontaneous physical activity in flies on calorie restriction

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Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction

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Sirt1’s Complex Roles in Neuroprotection

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Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels

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Sirtuins and Pyridine Nucleotides

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The role of transcriptional regulators in central control of appetite and body weight

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Calorie restriction increases primordial follicle reserve in mature female chemotherapy-treated rats

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SIRT1: A novel target to prevent atherosclerosis

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The developmental origins of sarcopenia: from epidemiological evidence to underlying mechanisms

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Patterns and processes of human life history evolution

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Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol

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The Interplay between Autophagy and Aging

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CYP epoxygenase metabolites of docosahexaenoic acid protect HL-1 cardiac cells against LPS-induced cytotoxicity through SIRT1

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Neural and Molecular Mechanisms Involved in Controlling the Quality of Feeding Behavior: Diet Selection and Feeding Patterns

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A rapidly occurring compensatory decrease in physical activity counteracts diet-induced weight loss in female monkeys

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Mangiferin Protects Retinal Ganglion Cells in Ischemic Mouse Retina via SIRT1

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Cardiovascular protection afforded by caloric restriction: Essential role of nitric oxide synthase

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Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects

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Adipose tissue inflammation in diabetes and heart failure

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Behavioral and Neural Correlates of Acute and Scheduled Hunger in C57BL/6 Mice

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Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-β Induced Sirt1

Xing, Z., Pan, W., Zhang, J., Xianlin, X., Zhang, X., He, X., & Fan, M. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00832 · Cited by 29

Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst, and stromal cell decidualization, in mice

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Distribution of the longevity gene product, SIRT1, in developing mouse organs

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Sirtuin biology and relevance to diabetes treatment

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Intrathecal SRT1720, a SIRT1 agonist, exerts anti-hyperalgesic and anti-inflammatory effects on chronic constriction injury-induced neuropathic pain in rats.

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Epigenetic modifications in mouse cerebellar Purkinje cells: effects of aging, caloric restriction, and overexpression of superoxide dismutase 1 on 5-methylcytosine and 5-hydroxymethylcytosine

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On the complex relationship between energy expenditure and longevity: Reconciling the contradictory empirical results with a simple theoretical model

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The African killifish: A short‐lived vertebrate model to study the biology of sarcopenia and longevity

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Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling

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Drosophila serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice

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Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans

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SIRT1 Activation Promotes β-Cell Regeneration by Activating Endocrine Progenitor Cells via AMPK Signaling-Mediated Fatty Acid Oxidation

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SIRT1 accelerates the progression of activity-based anorexia

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Dietary restriction and aging in rodents: a current view on its molecular mechanisms.

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Anti-aging effects of oligomeric proanthocyanidins isolated from persimmon fruits

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The role of sirtuins in the regulation of metabolic homeostasis in skeletal muscle

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The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease

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The sirtuins in the pathogenesis of cancer

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Adenylyl Cyclase Type 5 Disruption Prolongs Longevity and Protects the Heart Against Stress

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Different gene expression of skin tissues between mice with weight controlled by either calorie restriction or physical exercise.

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Metabolic regulation of immunological aging

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Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPARδ-dependent manner

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Histone Acetylation and Deacetylation

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Circadian Clocks in Fuel Harvesting and Energy HomeostasisPreprint

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Aging and Cancer: Are Sirtuins the Link?

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