The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Synaptic Amplifier of Inflammatory Pain in the Spinal Dorsal Horn
Abstract
Inflammation and trauma lead to enhanced pain sensitivity (hyperalgesia), which is in part due to altered sensory processing in the spinal cord. The synaptic hypothesis of hyperalgesia, which postulates that hyperalgesia is induced by the activity-dependent long-term potentiation (LTP) in the spinal cord, has been challenged, because in previous studies of pain pathways, LTP was experimentally induced by nerve stimulation at high frequencies (∼100 hertz). This does not, however, resemble the real low-frequency afferent barrage that occurs during inflammation. We identified a synaptic amplifier at the origin of an ascending pain pathway that is switched-on by low-level activity in nociceptive nerve fibers. This model integrates known signal transduction pathways of hyperalgesia without contradiction.
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Cites
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Synaptic Plasticity in Spinal Lamina I Projection Neurons That Mediate Hyperalgesia
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Self-citationSelective Induction of LTP and LTD by Postsynaptic [Ca2+]i Elevation
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Cited by
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913
Neuronal circuitry for pain processing in the dorsal horn
Todd, A. J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2947 · Cited by 1,475
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain
Bliss, T. V. P., Collingridge, G. L., Kaang, B.-K., & Zhuo, M. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.68 · Cited by 782
Metadata
- Authors
- Ikeda, H., Stark, J., Fischer, H., Wagner, M., Drdla, R., Jäger, T., & Sandkühler, J.
- Venue
- Science
- Published
- 2006-06-16
- Volume
- 312
- Issue
- 5780
- Pages
- 1659-1662
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2109991720
- Cited by
- 450
- References
- 26
- FWCI
- 16.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ikeda, H., Stark, J., Fischer, H., Wagner, M., Drdla, R., Jäger, T., & Sandkühler, J. (2006). Synaptic Amplifier of Inflammatory Pain in the Spinal Dorsal Horn. Science. https://doi.org/10.1126/science.1127233
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
