Mesh electronics: a new paradigm for tissue-like brain probes
Open accessAbstract
Existing implantable neurotechnologies for understanding the brain and treating neurological diseases have intrinsic properties that have limited their capability to achieve chronically-stable brain interfaces with single-neuron spatiotemporal resolution. These limitations reflect what has been dichotomy between the structure and mechanical properties of living brain tissue and non-living neural probes. To bridge the gap between neural and electronic networks, we have introduced the new concept of mesh electronics probes designed with structural and mechanical properties such that the implant begins to 'look and behave' like neural tissue. Syringe-implanted mesh electronics have led to the realization of probes that are neuro-attractive and free of the chronic immune response, as well as capable of stable long-term mapping and modulation of brain activity at the single-neuron level. This review provides a historical overview of a 10-year development of mesh electronics by highlighting the tissue-like design, syringe-assisted delivery, seamless neural tissue integration, and single-neuron level chronic recording stability of mesh electronics. We also offer insights on unique near-term opportunities and future directions for neuroscience and neurology that now are available or expected for mesh electronics neurotechnologies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Syringe-implanted mesh electronics showed stable long-term mapping and modulation of brain activity at the single-neuron level.
“Syringe-implanted mesh electronics showed stable long-term mapping and modulation of brain activity at the single-neuron level [Fig.3(c)].95”
From From flexible electronics technology in the era of IoT and artificial intelligence toward future implanted body sensor networks (2019) · cites this paper as [95]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,148 · see citing works
Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
Cui, Y., Wei, Q., Park, H., & Lieber, C. M. (2001) · Science · doi:10.1126/science.1062711 · Cited by 5,799 · see citing works
Self-citationReach and grasp by people with tetraplegia using a neurally controlled robotic arm
Hochberg, L. R., Bacher, D., Jarosiewicz, B., Masse, N. Y., Simeral, J. D., Vogel, J., Haddadin, S., Liu, J., Cash, S. S., van der Smagt, P., et al. (2012) · Nature · doi:10.1038/nature11076 · Cited by 2,719 · see citing works
Multiplexed electrical detection of cancer markers with nanowire sensor arrays
Zheng, G., Patolsky, F., Cui, Y., Wang, W. U., & Lieber, C. M. (2005) · Nature Biotechnology · doi:10.1038/nbt1138 · Cited by 2,430 · see citing works
Self-citationZagrean, L. (2014) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2014.529 · Cited by 1,926 · see citing works
Response of brain tissue to chronically implanted neural electrodes
Polikov, V. S., Tresco, P. A., & Reichert, W. M. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.08.015 · Cited by 1,896 · see citing works
The cognitive neuroscience of ageing
Grady, C. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3256 · Cited by 1,286 · see citing works
Wang, E., Yao, H.-B., Chen, Y., Wang, G., Gao, W., Sun, Y., Guo, J., Hu, J., Jiang, C., & Hu, J. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350082 · Cited by 1,176 · see citing works
Viventi, J., Kim, D.-H., Vigeland, L., Frechette, E. S., Blanco, J. A., Kim, Y.-S., Avrin, A. E., Tiruvadi, V. R., Hwang, S.-W., Vanleer, A. C., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2973 · Cited by 1,136 · see citing works
Electronic dura mater for long-term multimodal neural interfaces
Minev, I. R., Musienko, P., Hirsch, A., Barraud, Q., Wenger, N., Moraud, E. M., Gandar, J., Capogrosso, M., Milekovic, T., Asboth, L., et al. (2015) · Science · doi:10.1126/science.1260318 · Cited by 1,082 · see citing works
NeuroGrid: recording action potentials from the surface of the brain
Khodagholy, D., Gelinas, J. N., Thesen, T., Doyle, W., Devinsky, O., Malliaras, G. G., & Buzsáki, G. (2015) · Nature Neuroscience · doi:10.1038/nn.3905 · Cited by 938 · see citing works
Biran, R., Martin, D. C., & Tresco, P. A. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.04.020 · Cited by 893 · see citing works
Translational principles of deep brain stimulation
Kringelbach, M. L., Jenkinson, N., Owen, S. L. F., & Aziz, T. Z. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2196 · Cited by 853 · see citing works
Patolsky, F., Timko, B. P., Yu, G., Fang, Y., Greytak, A. B., Zheng, G., & Lieber, C. M. (2006) · Science · doi:10.1126/science.1128640 · Cited by 832 · see citing works
Self-citationRegulation of synaptic connectivity by glia.
Eroglu, C., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09612 · Cited by 813 · cited 1× · see citing works
“Third, brain tissue comprises organized 3D networks of neurons and non-neuronal cells, such as astrocytes and microglia, which impacts two major points for probe design: firstly, The probe structure should not disrupt the 3D connectivity where each neuron is innervated by as many as 10 000 presynaptic endings [6]; sec…”
Three-Dimensional, Flexible Nanoscale Field-Effect Transistors as Localized Bioprobes
Tian, B., Cohen‐Karni, T., Qing, Q., Duan, X., Xie, P., & Lieber, C. M. (2010) · Science · doi:10.1126/science.1192033 · Cited by 798 · see citing works
Self-citationFrom the neuron doctrine to neural networks
Yuste, R. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3962 · Cited by 748 · see citing works
Materials and technologies for soft implantable neuroprostheses
Lacour, S. P., Courtine, G., & Guck, J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.63 · Cited by 738 · see citing works
Kozai, T. D. Y., Langhals, N. B., Patel, P. R., Deng, X., Zhang, H., Smith, K. L., Lahann, J., Kotov, N. A., & Kipke, D. R. (2012) · Nature Materials · doi:10.1038/nmat3468 · Cited by 721 · see citing works
Syringe-injectable electronics
Liu, J., Fu, T.-M., Cheng, Z., Hong, G., Zhou, T., Jin, L., Duvvuri, M., Jiang, Z., Kruskal, P., Xie, C., et al. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.115 · Cited by 687 · see citing works
Self-citationNeural recording and modulation technologies
Chen, R., Canales, A., & Anikeeva, P. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.93 · Cited by 655 · see citing works
Flexible polyimide-based intracortical electrode arrays with bioactive capability
Rousche, P. J., Pellinen, D. S., Pivin, D. P., Williams, J. C., Vetter, R. J., & Kipke, D. R. (2001) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.914800 · Cited by 644 · see citing works
Macroporous Nanowire Nanoelectronic Scaffolds for Synthetic Tissues
Jia Liu, B., Dvir, T., Jin, L., Tsui, J. H., Qing, Q., Suo, Z., Langer, R., Kohane, D. S., Lieber, C. M., & Tian, B. (2012) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 642 · see citing works
Self-citationGenetically encoded indicators of neuronal activity
Lin, M. Z., & Schnitzer, M. J. (2016) · Nature Neuroscience · doi:10.1038/nn.4359 · Cited by 631 · see citing works
Zhang, A., & Lieber, C. M. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00608 · Cited by 629 · see citing works
Self-citationIntracellular recording of action potentials by nanopillar electroporation
Xie, C., Lin, Z. C., Hanson, L., Cui, Y., & Cui, B. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.8 · Cited by 592 · see citing works
Next-generation probes, particles, and proteins for neural interfacing
Rivnay, J., Wang, H., Fenno, L., Deisseroth, K., & Malliaras, G. G. (2017) · Science Advances · doi:10.1126/sciadv.1601649 · Cited by 514 · see citing works
Neuronal basis of age-related working memory decline
Wang, M., Gamo, N. J., Yang, Y., Jin, L. E., Wang, X.-J., Laubach, M., Mazer, J. A., Lee, D., & Arnsten, A. F. T. (2011) · Nature · doi:10.1038/nature10243 · Cited by 485 · see citing works
Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor
Duan, X., Gao, R., Xie, P., Cohen‐Karni, T., Qing, Q., Choe, H. S., Tian, B., Jiang, X., & Lieber, C. M. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.223 · Cited by 456 · see citing works
Self-citationThe mechanobiology of brain function
Tyler, W. J. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3383 · Cited by 422 · see citing works
Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes
Xie, C., Liu, J., Fu, T.-M., Dai, X., Zhou, W., & Lieber, C. M. (2015) · Nature Materials · doi:10.1038/nmat4427 · Cited by 404 · see citing works
Self-citationRestoring sensorimotor function through intracortical interfaces: progress and looming challenges
Bensmaia, S. J., & Miller, L. E. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3724 · Cited by 368 · see citing works
Chronic, wireless recordings of large-scale brain activity in freely moving rhesus monkeys
Schwarz, D. A., Lebedev, M., Hanson, T., Dimitrov, D. F., Lehew, G., Meloy, J., Rajangam, S., Subramanian, V., Ifft, P. J., Li, Z., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2936 · Cited by 348 · see citing works
Photovoltaic restoration of sight with high visual acuity
Lorach, H., Goetz, G., Smith, R., Lei, X., Mandel, Y., Kamins, T. I., Mathieson, K., Huie, P., Harris, J. S., Sher, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3851 · Cited by 341 · see citing works
Grid cells and cortical representation
Moser, E. I., Roudi, Y., Witter, M. P., Kentros, C., Bonhoeffer, T., & Moser, M.-B. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3766 · Cited by 335 · see citing works
Stable long-term chronic brain mapping at the single-neuron level
Tian-ming Fu, B., Hong, G., Zhou, T., Schuhmann, T. G., Viveros, R. D., & Lieber, C. M. (2016) · Nature Methods · doi:10.1038/nmeth.3969 · Cited by 326 · see citing works
Self-citationPrasad, A., Xue, Q.-S., Sankar, V., Nishida, T., Shaw, G., Streit, W. J., & Sanchez, J. C. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/5/056015 · Cited by 298 · see citing works
Advanced Neurotechnologies for Chronic Neural Interfaces: New Horizons and Clinical Opportunities
Kipke, D. R., Shain, W. G., Buzsáki, G., Fetz, E. E., Henderson, J. M., Hetke, J. F., & Schalk, G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3879-08.2008 · Cited by 283 · see citing works
Progress and challenges in probing the human brain
Poldrack, R. A., & Farah, M. J. (2015) · Nature · doi:10.1038/nature15692 · Cited by 278 · see citing works
Improving data quality in neuronal population recordings
Harris, K. D., Quiroga, R. Q., Freeman, J., & Smith, S. L. (2016) · Nature Neuroscience · doi:10.1038/nn.4365 · Cited by 261 · see citing works
Qing, Q., Jiang, Z., Xu, L., Gao, R., Mai, L., & Lieber, C. M. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.273 · Cited by 256 · see citing works
Self-citationElectromechanical cardioplasty using a wrapped elasto-conductive epicardial mesh
Park, J., Choi, S., Janardhan, A. H., Lee, S.-Y., Raut, S. S., Soares, J., Shin, K., Yang, S., Lee, C., Kang, K., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad8568 · Cited by 253 · see citing works
Perge, J. A., Homer, M. L., Malik, W. Q., Cash, S., Eskandar, E., Friehs, G., Donoghue, J. P., & Hochberg, L. R. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/3/036004 · Cited by 243 · see citing works
Zhou, T., Hong, G., Fu, T.-M., Yang, X., Schuhmann, T. G., Viveros, R. D., & Lieber, C. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705509114 · Cited by 227 · see citing works
Self-citationDai, X., Zhou, W. M., Gao, T., Jia Liu, B., & Lieber, C. M. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.96 · Cited by 199 · see citing works
Self-citationPathological circuit function underlying addiction and anxiety disorders
Lüthi, A., & Lüscher, C. (2014) · Nature Neuroscience · doi:10.1038/nn.3849 · Cited by 192 · see citing works
Neuronal migration in the adult brain: are we there yet?
Ghashghaei, H. T., Lai, C., & Anton, E. S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2074 · Cited by 192 · see citing works
Benfenati, V., Toffanin, S., Bonetti, S., Turatti, G., Pistone, A., Chiappalone, M., Sagnella, A., Stefani, A., Generali, G., Ruani, G., et al. (2013) · Nature Materials · doi:10.1038/nmat3630 · Cited by 168 · see citing works
Highly scalable multichannel mesh electronics for stable chronic brain electrophysiology
Tian-ming Fu, B., Hong, G., Viveros, R. D., Zhou, T., & Lieber, C. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717695114 · Cited by 153 · see citing works
Self-citationNondestructive nanostraw intracellular sampling for longitudinal cell monitoring
Cao, Y., Hjort, M., Chen, H., Birey, F., Leal‐Ortiz, S., Han, C. M., Santiago, J. G., Pașca, S. P., Wu, J. C., & Melosh, N. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615375114 · Cited by 151 · see citing works
Brain activity mapping at multiple scales with silicon microprobes containing 1,024 electrodes
Shobe, J. L., Claar, L. D., Parhami, S., Bakhurin, K. I., & Masmanidis, S. C. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00464.2015 · Cited by 146 · see citing works
Hong, G., Tian-ming Fu, B., Zhou, T., Schuhmann, T. G., Huang, J., & Lieber, C. M. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b02987 · Cited by 128 · see citing works
Self-citationA novel stimulus artifact removal technique for high-rate electrical stimulation
Heffer, L. F., & Fallon, J. B. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.01.023 · Cited by 121 · see citing works
A Large-Scale Interface for Optogenetic Stimulation and Recording in Nonhuman Primates
Yazdan-Shahmorad, A., Diaz-Botia, C. A., Hanson, T., Kharazia, V., Ledochowitsch, P., Maharbiz, M. M., & Sabes, P. N. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.013 · Cited by 106 · see citing works
Spontaneous Internalization of Cell Penetrating Peptide-Modified Nanowires into Primary Neurons
Lee, J., Zhang, A., You, S. S., & Lieber, C. M. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b00020 · Cited by 98 · see citing works
Self-citationMultifunctional three-dimensional macroporous nanoelectronic networks for smart materials
Jia Liu, B., Xie, C., Dai, X., Jin, L., Zhou, W. M., & Lieber, C. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305209110 · Cited by 89 · see citing works
Self-citationNanowires: Building Blocks for Nanoscience and Nanotechnology
Zhang, A., Zheng, G., & Lieber, C. M. (2016) · Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) · doi:10.1007/978-3-319-41981-7 · Cited by 64 · see citing works
Self-citationSyringe-injectable electronics with a plug-and-play input/output interface.
Schuhmann, T. G., Yao, J., Hong, G., Fu, T.-M., & Lieber, C. M. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03081 · Cited by 63 · see citing works
Self-citationBeyond the Patch Clamp: Nanotechnologies for Intracellular Recording
Kruskal, P. B., Jiang, Z., Gao, T., & Lieber, C. M. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.004 · Cited by 58 · see citing works
Self-citationMacroporous nanowire nanoelectronic scaffolds for synthetic tissues
Tian, B., Liu, J., Dvir, T., Jin, L., Tsui, J. H., Qing, Q., Suo, Z., Langer, R., Kohane, D. S., & Lieber, C. M. (2012) · Nature Materials · doi:10.1038/nmat3404 · Cited by 20 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- [13]Steif PS Mechanics of materials Upper Saddle River, NJ Pearson 2012
- [60]Dyson FJ Imagined worlds Cambridge, Mass Harvard University Press 1997
Cited by
Sorted by citations
Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation
Liu, Y., Liu, J., Chen, S., Lei, T., Kim, Y., Niu, S., Wang, H., Wang, X., Foudeh, A. M., Tok, J. B.-H., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0335-6 · Cited by 811 · see citing works
Novel electrode technologies for neural recordings
Hong, G., & Lieber, C. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0140-6 · Cited by 695 · see citing works
Self-citationAn, B. W., Heo, S., Ji, S., Bien, F., & Park, J.-U. (2018) · Nature Communications · doi:10.1038/s41467-018-04906-1 · Cited by 426 · see citing works
Self-powered cardiovascular electronic devices and systems
Zheng, Q., Tang, Q., Wang, Z. L., & Li, Z. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0426-4 · Cited by 348 · see citing works
Inorganic semiconductor biointerfaces
Jiang, Y., & Tian, B. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0062-3 · Cited by 239 · see citing works
Microbial biofilms for electricity generation from water evaporation and power to wearables
Liu, X., Ueki, T., Gao, H., Woodard, T. L., Nevin, K. P., Fu, T., Fu, S., Sun, L., Lovley, D. R., & Yao, J. (2022) · Nature Communications · doi:10.1038/s41467-022-32105-6 · Cited by 183 · see citing works
Darabi, M. A., Khosrozadeh, A., Wang, Y., Ashammakhi, N. A., Alem, H., Erdem, A., Chang, Q., Xu, K., Liu, Y., Luo, G., et al. (2020) · Advanced Science · doi:10.1002/advs.201902740 · Cited by 168 · see citing works
Lee, S., Shi, Q., & Lee, C. (2019) · APL Materials · doi:10.1063/1.5063498 · Cited by 164 · see citing works
Flexible Electrodes for In Vivo and In Vitro Electrophysiological Signal Recording
Zhu, M., Wang, H., Li, S., Liang, X., Zhang, M., Dai, X., & Zhang, Y. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100646 · Cited by 158 · see citing works
Printing Flexible and Hybrid Electronics for Human Skin and Eye‐Interfaced Health Monitoring Systems
Kim, K., Kim, B., & Lee, C. H. (2019) · Advanced Materials · doi:10.1002/adma.201902051 · Cited by 146 · see citing works
Silent Speech Interfaces for Speech Restoration: A Review
González, J. A., Gomez-Alanis, A., Martín-Doñas, J. M., Pérez-Córdoba, J. L., & Gomez, A. M. (2020) · IEEE Access · doi:10.1109/access.2020.3026579 · Cited by 141 · see citing works
Functionality of Flexible Pressure Sensors in Cardiovascular Health Monitoring: A Review
Mishra, S., Mohanty, S., & Ramadoss, A. (2022) · ACS Sensors · doi:10.1021/acssensors.2c00942 · Cited by 135 · see citing works
Ultra‐Deformable and Tissue‐Adhesive Liquid Metal Antennas with High Wireless Powering Efficiency
Yamagishi, K., Zhou, W., Ching, T., Huang, S. Y., & Hashimoto, M. (2021) · Advanced Materials · doi:10.1002/adma.202008062 · Cited by 131 · see citing works
Recent advances in bioelectronics chemistry
Fang, Y., Meng, L., Promiński, A., Schaumann, E. N., Seebald, M., & Tian, B. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00333f · Cited by 115 · see citing works
Devising Materials Manufacturing Toward Lab‐to‐Fab Translation of Flexible Electronics
Luo, Y., Wang, M., Wan, C., Cai, P., Loh, X. J., & Chen, X. (2020) · Advanced Materials · doi:10.1002/adma.202001903 · Cited by 114 · see citing works
Flexible and Implantable Microelectrodes for Chronically Stable Neural Interfaces
Shi, J., & Fang, Y. Z. (2018) · Advanced Materials · doi:10.1002/adma.201804895 · Cited by 104 · see citing works
Biointerface design for vertical nanoprobes
Elnathan, R., Barbato, M. G., Guo, X., Mariano, A., Wang, Z., Santoro, F., Shi, P., Voelcker, N. H., Xie, X., Young, J. L., et al. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00464-7 · Cited by 104 · see citing works
Wong, G. C. L., Antani, J. D., Lele, P. P., Chen, J., Nan, B., Kühn, M. J., Persat, A., Bru, J.-L., Høyland‐Kroghsbo, N. M., Siryaporn, A., et al. (2021) · Physical Biology · doi:10.1088/1478-3975/abdc0e · Cited by 90 · see citing works
Precision electronic medicine in the brain
Patel, S. R., & Lieber, C. M. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0234-8 · Cited by 95 · see citing works
Self-citationRecent development of implantable and flexible nerve electrodes
Shi, Y., Liu, R., He, L. M., Feng, H., Li, Y., & Li, Z. (2020) · Smart Materials in Medicine · doi:10.1016/j.smaim.2020.08.002 · Cited by 90 · see citing works
Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs
Jung, Y. H., Kim, J. U., Lee, J. S., Shin, J. H., Jung, W., Ok, J., & Kim, T. (2020) · Advanced Materials · doi:10.1002/adma.201907478 · Cited by 88 · see citing works
Bioinspired Materials for In Vivo Bioelectronic Neural Interfaces
Woods, G. A., Rommelfanger, N. J., & Hong, G. (2020) · Matter · doi:10.1016/j.matt.2020.08.002 · Cited by 87 · see citing works
Self-citationBrain–Computer Interfaces in Neurorecovery and Neurorehabilitation
Young, M. J., Lin, D. J., & Hochberg, L. R. (2021) · Seminars in Neurology · doi:10.1055/s-0041-1725137 · Cited by 89 · see citing works
Soucy, J. R., Aguzzi, E. A., Cho, J. Y., Gilhooley, M. J., Keuthan, C. J., Luo, Z., Monavarfeshani, A., Saleem, M. A., Wang, X., Wohlschlegel, J., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00655-y · Cited by 82 · see citing works
Soft Implantable Bioelectronics
Koo, J. H., Song, J., Kim, D., & Son, D. (2021) · ACS Materials Letters · doi:10.1021/acsmaterialslett.1c00438 · Cited by 77 · see citing works
Bioinspired Prosthetic Interfaces
Li, P., Ali, H. P. A., Cheng, W. M., Yang, J., & Tee, B. C. K. (2020) · Advanced Materials Technologies · doi:10.1002/admt.201900856 · Cited by 75 · see citing works
Stretchable mesh microelectronics for the biointegration and stimulation of human neural organoids
Li, T. L., Liu, Y., Forró, C., Yang, X., Beker, L., Bao, Z., Cui, B., & Pașca, S. P. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121825 · Cited by 73 · see citing works
Self-citationPrinted nanofilms mechanically conforming to living bodies
Yamagishi, K., Takeoka, S., & Fujie, T. (2019) · Biomaterials Science · doi:10.1039/c8bm01290c · Cited by 72 · see citing works
Xu, S., Momin, M., Ahmed, S., Hossain, A., Veeramuthu, L., Pandiyan, A., Kuo, C., & Zhou, T. (2023) · Advanced Materials · doi:10.1002/adma.202303267 · Cited by 67 · see citing works
Self-citationPark, Y., Kwon, Y. W., Koh, C. S., Kim, E., Lee, D. H., Kim, S., Mun, J., Hong, Y., Lee, S., Kim, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45768-0 · Cited by 69 · see citing works
Translational Neuroelectronics
Jastrzebska‐Perfect, P., Chowdhury, S., Spyropoulos, G. D., Zhao, Z., Cea, C., Gelinas, J. N., & Khodagholy, D. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909165 · Cited by 64 · see citing works
Nanowire-enabled bioelectronics
Zhang, A., Lee, J., & Lieber, C. M. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101135 · Cited by 64 · see citing works
Self-citationZahra, T., Javeria, U., Jamal, H., Baig, M. M., Akhtar, F., & Kamran, U. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342880 · Cited by 62 · see citing works
Long-term stability strategies of deep brain flexible neural interface
Lv, S., Xu, Z., Mo, F., Wang, Y., Duan, Y., Liu, Y., Jing, L., Shan, J., Jia, Q., Wang, M., et al. (2025) · npj Flexible Electronics · doi:10.1038/s41528-025-00410-x · Cited by 74 · see citing works
Cutrone, A., & Micera, S. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801345 · Cited by 57 · see citing works
Bio-inspired micro/nanostructures for flexible and stretchable electronics
Li, H., Lv, S., & Fang, Y. Z. (2020) · Nano Research · doi:10.1007/s12274-020-2628-9 · Cited by 53 · see citing works
Self‐Healing Materials for Bioelectronic Devices
Liu, C. Y., Kelley, S. O., & Wang, Z. (2024) · Advanced Materials · doi:10.1002/adma.202401219 · Cited by 53 · see citing works
Conducting Hydrogel‐Based Neural Biointerfacing Technologies
Zhang, P., Yang, Y., Li, Z., Xue, Y., Wang, F., Shan, L., Wang, Y., Shi, X., Wu, K., & Liu, J. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202422869 · Cited by 54 · see citing works
64-Channel Carbon Fiber Electrode Arrays for Chronic Electrophysiology
Guitchounts, G., & Cox, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-60873-y · Cited by 51 · see citing works
How is flexible electronics advancing neuroscience research?
Chen, Y., Rommelfanger, N. J., Mahdi, A. I., Wu, X., Keene, S. T., Obaid, A., Salleo, A., Wang, H., & Hong, G. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120559 · Cited by 52 · see citing works
Self-citationOscillotherapeutics – Time-targeted interventions in epilepsy and beyond
Takeuchi, Y., & Berényi, A. (2020) · Neuroscience Research · doi:10.1016/j.neures.2020.01.002 · Cited by 51 · see citing works
Conducting polymer scaffolds: a new frontier in bioelectronics and bioengineering
Nasser, R. A., Arya, S. S., Alshehhi, K. H., Teo, J. C. M., & Pitsalidis, C. (2024) · Trends in biotechnology · doi:10.1016/j.tibtech.2023.11.017 · Cited by 52 · see citing works
Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology
Forró, C., Caron, D., Angotzi, G. N., Gallo, V., Berdondini, L., Santoro, F., Palazzolo, G., & Panuccio, G. (2021) · Micromachines · doi:10.3390/mi12020124 · Cited by 50 · see citing works
Nanoenabled Direct Contact Interfacing of Syringe-Injectable Mesh Electronics
Lee, J. M., Hong, G., Lin, D., Schuhmann, T. G., Sullivan, A. T., Viveros, R. D., Park, H., & Lieber, C. M. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b03019 · Cited by 48 · see citing works
Self-citationLee, S., & Lee, C. (2018) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2018.05.004 · Cited by 48 · see citing works
Bioactive Neuroelectronic Interfaces
Adewole, D. O., Serruya, M. D., Wolf, J. A., & Cullen, D. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00269 · Cited by 48 · see citing works
Ling, W., Yu, J., Ma, N., Ya, L., Wu, Z., Liang, R., Hao, Y., Pan, H., Liu, W., Fu, B., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002644 · Cited by 46 · see citing works
Advances in visual prostheses: engineering and biological challenges
Borda, E., & Ghezzi, D. (2022) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ac812c · Cited by 44 · see citing works
Atomically thin bioelectronics
Kireev, D., Kutagulla, S., Hong, J., Wilson, M. N., Ramezani, M., Kuzum, D., Ahn, J., & Akinwande, D. (2024) · Nature Reviews Materials · doi:10.1038/s41578-024-00728-4 · Cited by 42 · see citing works
Tissue-like Neural Probes for Understanding and Modulating the Brain
Hong, G., Viveros, R. D., Zwang, T. J., Yang, X., & Lieber, C. M. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00122 · Cited by 45 · see citing works
Self-citationFunctional rewiring across spinal injuries via biomimetic nanofiber scaffolds
Usmani, S., Biagioni, A. F., Medelin, M., Scaini, D., Casani, R., Aurand, E. R., Padró, D., Egimendia, A., Ramos‐Cabrer, P., Scarselli, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005708117 · Cited by 41 · see citing works
Biohybrid neural interfaces: improving the biological integration of neural implants
Boulingre, M., Lara, R. P., & Green, R. A. (2023) · Chemical Communications · doi:10.1039/d3cc05006h · Cited by 39 · see citing works
Research Progress on the Flexibility of an Implantable Neural Microelectrode
Zhao, H., Liu, R., Zhang, H., Cao, P., Liu, Z., & Li, Y. (2022) · Micromachines · doi:10.3390/mi13030386 · Cited by 36 · see citing works
Graphene and graphene-related materials as brain electrodes
Xu, B., Pei, J., Feng, L., & Zhang, X. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01795k · Cited by 37 · see citing works
Lee, S., Chung, W. G., Jeong, H., Cui, G., Kim, E., Lim, J. A., Seo, H., Kwon, Y. W., Byeon, S. H., Lee, J., et al. (2024) · Advanced Materials · doi:10.1002/adma.202404428 · Cited by 36 · see citing works
He, G., Dong, X., & Qi, M. (2020) · Materials Research Express · doi:10.1088/2053-1591/abb857 · Cited by 37 · see citing works
3D-printed flexible neural probes for recordings at single-neuron level
Momin, M., Feng, L., Ahmed, S., Ren, J., Hossain, A., Zhang, S., & Zhou, T. (2024) · Device · doi:10.1016/j.device.2024.100519 · Cited by 33 · see citing works
Self-citationOvercoming failure: improving acceptance and success of implanted neural interfaces
Dalrymple, A. N., Jones, S. T., Fallon, J. B., Shepherd, R. K., & Weber, D. J. (2025) · Bioelectronic Medicine · doi:10.1186/s42234-025-00168-7 · Cited by 36 · see citing works
Advanced One- and Two-Dimensional Mesh Designs for Injectable Electronics
Viveros, R. D., Zhou, T., Hong, G., Tian-ming Fu, B., Lin, H. G., & Lieber, C. M. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b01727 · Cited by 32 · see citing works
Self-citationNanoscale surface coatings and topographies for neural interfaces
Cho, Y., Choi, Y., & Seong, H. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.12.025 · Cited by 32 · see citing works
Bioinspired flexible electronics for seamless neural interfacing and chronic recording
Li, H., Wang, J., & Fang, Y. Z. (2020) · Nanoscale Advances · doi:10.1039/d0na00323a · Cited by 31 · see citing works
Liu, R., Zhao, S., & Jia Liu, B. (2020) · ACS Applied Electronic Materials · doi:10.1021/acsaelm.0c00753 · Cited by 30 · see citing works
Bioelectrical interfaces with cortical spheroids in three-dimensions
Kalmykov, A., Reddy, J. W., Bedoyan, E., Wang, Y., Garg, R., Rastogi, S. K., Cohen-Karni, D., Chamanzar, M., & Cohen‐Karni, T. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abf290 · Cited by 31 · see citing works
Shan, L., Xue, Y., Chen, X., Wang, Y., Feng, Y., Li, D., Wang, C., Zhang, P., Wang, F., Guo, L., et al. (2025) · Advanced Materials · doi:10.1002/adma.202511014 · Cited by 30 · see citing works
NeuroRoots, a bio-inspired, seamless Brain Machine Interface device for long-term recordingPreprint
Ferro, M. D., Proctor, C. M., Gonzalez, A., Zhao, E. T., Slézia, A., Pas, J., Dijk, G., Donahue, M. J., Williamson, A., Malliaras, G. G., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/460949 · Cited by 30 · see citing works
Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
Schuhmann, T. G., Zhou, T., Hong, G., Lee, J. M., Tian-ming Fu, B., Park, H., & Lieber, C. M. (2018) · Journal of Visualized Experiments · doi:10.3791/58003 · Cited by 30 · see citing works
Self-citationLarge-scale, closed-loop interrogation of neural circuits underlying cognition.
Khodagholy, D., Ferrero, J. J., Park, J., Zhao, Z., & Gelinas, J. N. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.10.003 · Cited by 27 · see citing works
A Framework for Ethics in Cyber-Physical-Human Systems
Khargonekar, P. P., & Sampath, M. (2020) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2020.12.1251 · Cited by 27 · see citing works
Imai, A., Takahashi, S., Furubayashi, S., Mizuno, Y., Sonoda, M., Miyazaki, T., Miyashita, E., & Fujie, T. (2023) · Advanced Materials Technologies · doi:10.1002/admt.202300300 · Cited by 26 · see citing works
Direct ink writing of silicone elastomers to fabricate microfluidic devices and soft robots
Yamagishi, K., Karyappa, R. B., Ching, T., & Hashimoto, M. (2024) · MRS Communications · doi:10.1557/s43579-024-00631-7 · Cited by 25 · see citing works
Garwood, I. C., Major, A. J., Antonini, M., Correa, J., Lee, Y., Sahasrabudhe, A., Mahnke, M. K., Miller, E. K., Brown, E. N., & Anikeeva, P. (2023) · Science Advances · doi:10.1126/sciadv.adh0974 · Cited by 24 · see citing works
Implantable Neural Microelectrodes: How to Reduce Immune Response
Xiang, Y., Zhao, Y., Cheng, T., Sun, S., Wang, J., & Pei, R. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00238 · Cited by 24 · see citing works
Soft, Flexible, and Stretchable Platforms for Tissue‐Interfaced Bioelectronics
Yamagishi, K., Lee, S., Yokota, T., & Someya, T. (2026) · Advanced Science · doi:10.1002/advs.202521521 · Cited by 24 · see citing works
Multisite Dopamine Sensing With Femtomolar Resolution Using a CMOS Enabled Aptasensor Chip
Sessi, V., Ibarlucea, B., Florent Seichepine, A., Klinghammer, S., Ibrahim, I., Heinzig, A., Szabó, N., Mikolajick, T., Hierlemann, A. R., Frey, U., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.875656 · Cited by 23 · see citing works
Emerging Trends of Biomedical Circuits and Systems
Sawan, M., Yang, J., Tarkhan, M., Chen, J., Wang, M., Wang, C., Xia, F., & Chen, Y.-H. (2021) · Foundations and Trends® in Integrated Circuits and Systems · doi:10.1561/3500000005 · Cited by 22 · see citing works
Ferro, M. D., Proctor, C. M., Gonzalez, A., Jayabal, S., Zhao, E. T., Gagnon, M., Slézia, A., Pas, J., Dijk, G., Donahue, M. J., et al. (2024) · AIP Advances · doi:10.1063/5.0216979 · Cited by 20 · see citing works
Kim, C., Jeong, J., & Kim, S. J. (2019) · Sensors · doi:10.3390/s19051069 · Cited by 22 · see citing works
Lifetime engineering of bioelectronic implants with mechanically reliable thin film encapsulations
Niemiec, M., & Kim, K. (2023) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ad0b19 · Cited by 21 · see citing works
Semiconductor Nanowire‐Based Cellular and Subcellular Interfaces
Shi, J., Sun, C., Liang, E., & Tian, B. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107997 · Cited by 21 · see citing works
Soft, wireless and subdermally implantable recording and neuromodulation tools
Cai, L., & Gutruf, P. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abe805 · Cited by 22 · see citing works
Complex Organic Synthesis: Structure, Properties, and/or Function?
Whitesides, G. M. (2018) · Israel Journal of Chemistry · doi:10.1002/ijch.201800016 · Cited by 19 · see citing works
N3-MEA Probes: Scooping Neuronal Networks
Kireev, D., Montes, V. R., Stevanovic, J., Srikantharajah, K., & Offenhäusser, A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00320 · Cited by 18 · see citing works
3D electronic and photonic structures as active biological interfaces
Wang, H., Sun, P., Yin, L., & Sheng, X. (2019) · InfoMat · doi:10.1002/inf2.12054 · Cited by 19 · see citing works
Design and manufacturing of soft electronics for in situ biochemical sensing
Xing, Y., Wang, J., & Li, J. (2024) · International Journal of Extreme Manufacturing · doi:10.1088/2631-7990/ad65a0 · Cited by 19 · see citing works
Analysis of Light Propagation on Physiological Properties of Neurons for Nanoscale Optogenetics
Wirdatmadja, S., Johari, P., Desai, A., Bae, Y., Stachowiak, E. K., Stachowiak, M. K., Jornet, J. M., & Balasubramaniam, S. (2019) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2019.2891271 · Cited by 18 · see citing works
Towards biomimetic electronics that emulate cells
Lubrano, C., Matrone, G. M., Forró, C., Jahed, Z., Offenhäusser, A., Salleo, A., Cui, B., & Santoro, F. (2020) · MRS Communications · doi:10.1557/mrc.2020.56 · Cited by 18 · see citing works
Nanocomposite Hydrogels as Functional Extracellular Matrices
Jooken, S., Deschaume, O., & Bartic, C. (2023) · Gels · doi:10.3390/gels9020153 · Cited by 17 · see citing works
A binary stiffness compliant neural microprobe
Sharafkhani, N., Long, J. M., Adams, S. D., & Kouzani, A. Z. (2023) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2023.114759 · Cited by 17 · see citing works
Wang, T., Liu, J., Zhao, Y., & Lu, Y. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.06.015 · Cited by 16 · see citing works
Soft Conductive Interfacing for Bioelectrical Uses: Adhesion Mechanisms and Structural Approaches
Kim, J. H., Oh, J., Park, Y., Kim, J. J., & Jeong, U. (2023) · Macromolecules · doi:10.1021/acs.macromol.2c02236 · Cited by 16 · see citing works
Convergence of Implantable Bioelectronics and Brain–Computer Interfaces
Huynh, M. A., Nguyen, T.-H., Nguyen, T.-K., & Nguyen, N.-T. (2023) · ACS Applied Electronic Materials · doi:10.1021/acsaelm.3c00879 · Cited by 15 · see citing works
Stitching Flexible Electronics into the Brain
Lee, J. M., Lin, D., Pyo, Y., Kim, H., Park, H., & Lieber, C. M. (2023) · Advanced Science · doi:10.1002/advs.202300220 · Cited by 15 · see citing works
Self-citationFlexible and Soft Materials and Devices for Neural Interface
Castagnola, E., Zheng, X. S., & Cui, X. T. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_5 · Cited by 14 · see citing works
Syringe-Injectable, Self-Expandable, and Ultraconformable Magnetic Ultrathin Films
Yamagishi, K., Nojiri, A., Iwase, E., & Hashimoto, M. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b17567 · Cited by 14 · see citing works
3D Printed Biohybrid Microsystems
Prinz, V. Y., & Fritzler, K. B. (2022) · Advanced Materials Technologies · doi:10.1002/admt.202101633 · Cited by 14 · see citing works
Ownership when AI robots do more of the work and earn more of the income
Freeman, R. B. (2018) · Journal of Participation and Employee Ownership · doi:10.1108/jpeo-04-2018-0015 · Cited by 14 · see citing works
Flexible and smart electronics for single-cell resolved brain–machine interfaces
Lee, A. J., Wang, W., & Jia Liu, B. (2023) · Applied Physics Reviews · doi:10.1063/5.0115879 · Cited by 11 · see citing works
Implantable and Flexible Electronics for In vivo Brain Activity Recordings
Wang, J., Tian, H., & Fang, Y. Z. (2019) · Chinese Journal of Analytical Chemistry · doi:10.1016/s1872-2040(19)61192-8 · Cited by 12 · see citing works
Nano-enabled cellular engineering for bioelectric studies
Shi, J., Clayton, C., & Tian, B. (2019) · Nano Research · doi:10.1007/s12274-019-2580-8 · Cited by 12 · see citing works
Sharon, A., Shmoel, N., Erez, H., Jankowski, M. M., Friedmann, Y., & Spira, M. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.764448 · Cited by 10 · see citing works
- Authors
- Hong, G., Yang, X., Zhou, T., & Lieber, C. M.
- Affiliations
- Harvard University (US)
- Corresponding author
- Lieber, Charles M
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 50
- Pages
- 33-41
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC5984112
- OpenAlex
- W2771797278
- Cited by
- 159
- References
- 59
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 18 · 2023: 23 · 2022: 18 · 2021: 23 · 2020: 23 · 2019: 21 · 2018: 11
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Neurobiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Air Force Office of Scientific Research (FA9550-14-1-0136)
- American Heart Association (K99/R00, 16POST27250219)
- National Institute on Drug Abuse
- National Institute on Aging (1K99AG056636-01)
- National Institutes of Health (1R21DA043985-01, 1DP1EB025835-01)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
- Keywords
- neural probes, chronic neural recording, single-neuron resolution, immune response, brain activity modulation
- MeSH terms
- Animals, Brain, Electronics, Humans, Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
