Mesh nanoelectronics: seamless integration of electronics with tissues.
Open accessAbstract
Nanobioelectronics represents a rapidly developing field with broad-ranging opportunities in fundamental biological sciences, biotechnology, and medicine. Despite this potential, seamless integration of electronics has been difficult due to fundamental mismatches, including size and mechanical properties, between the elements of the electronic and living biological systems. In this Account, we discuss the concept, development, key demonstrations, and future opportunities of mesh nanoelectronics as a general paradigm for seamless integration of electronics within synthetic tissues and live animals. We first describe the design and realization of hybrid synthetic tissues that are innervated in three dimensions (3D) with mesh nanoelectronics where the mesh serves as both as a tissue scaffold and as a platform of addressable electronic devices for monitoring and manipulating tissue behavior. Specific examples of tissue/nanoelectronic mesh hybrids highlighted include 3D neural tissue, cardiac patches, and vascular constructs, where the nanoelectronic devices have been used to carry out real-time 3D recording of electrophysiological and chemical signals in the tissues. This novel platform was also exploited for time-dependent 3D spatiotemporal mapping of cardiac tissue action potentials during cell culture and tissue maturation as well as in response to injection of pharmacological agents. The extension to simultaneous real-time monitoring and active control of tissue behavior is further discussed for multifunctional mesh nanoelectronics incorporating both recording and stimulation devices, providing the unique capability of bidirectional interfaces to cardiac tissue. In the case of live animals, new challenges must be addressed, including minimally invasive implantation, absence of deleterious chronic tissue response, and long-term capability for monitoring and modulating tissue activity. We discuss each of these topics in the context of implantation of mesh nanoelectronics into rodent brains. First, we describe the design of ultraflexible mesh nanoelectronics with size features and mechanical properties similar to brain tissue and a novel syringe-injection methodology that allows the mesh nanoelectronics to be precisely delivered to targeted brain regions in a minimally invasive manner. Next, we discuss time-dependent histology studies showing seamless and stable integration of mesh nanoelectronics within brain tissue on at least one year scales without evidence of chronic immune response or glial scarring characteristic of conventional implants. Third, armed with facile input/output interfaces, we describe multiplexed single-unit recordings that demonstrate stable tracking of the same individual neurons and local neural circuits for at least 8 months, long-term monitoring and stimulation of the same groups of neurons, and following changes in individual neuron activity during brain aging. Moving forward, we foresee substantial opportunities for (1) continued development of mesh nanoelectronics through, for example, broadening nanodevice signal detection modalities and taking advantage of tissue-like properties for selective cell targeting and (2) exploiting the unique capabilities of mesh nanoelectronics for tackling critical scientific and medical challenges such as understanding and potentially ameliorating cell and circuit level changes associated with natural and pathological aging, as well as using mesh nanoelectronics as active tissue scaffolds for regenerative medicine and as neuroprosthetics for monitoring and treating neurological diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activities of individual neurons and localized neural circuits can be monitored and stimulated over timelines of eight months or more.
“This group also showed that the activities of individual neurons and localized neural circuits could be monitored and stimulated over timelines of eight months or more, for applications such as recording of alterations in the activities of specific neurons as the brain ages (Dai et al., 2018).”
From Human Brain/Cloud Interface (2019) · cites this paper as Dai et al., 2018
In “Mesh Nanoelectronics in Live Animals” (page unavailable), the paper reports tracking the same neurons and local circuits for eight months. Although it broadly describes recording and stimulation on a year time scale, its specific evidence for stable responses to chronic stimulation spans nearly three months, not eight or more. The Conclusions and Outlook identifies studying changes during brain aging as an application. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMesh nanoelectronics can integrate stably within brain tissue for at least 1 year without evidence of chronic immune response or glial scarring characteristic of conventional implants.
“Dai et al. (2018) also demonstrated “stable integration of mesh nanoelectronics within brain tissue on at least 1 year scales without evidence of chronic immune response or the glial scarring characteristic of conventional implants.””
From Human Brain/Cloud Interface (2019) · cites this paper as Dai et al., 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
Cui, Y., Wei, Q., Park, H., & Lieber, C. M. (2001) · Science · doi:10.1126/science.1062711 · Cited by 5,799 · see citing works
Self-citationMultiplexed electrical detection of cancer markers with nanowire sensor arrays
Zheng, G., Patolsky, F., Cui, Y., Wang, W. U., & Lieber, C. M. (2005) · Nature Biotechnology · doi:10.1038/nbt1138 · Cited by 2,430 · see citing works
Self-citationResponse of brain tissue to chronically implanted neural electrodes
Polikov, V. S., Tresco, P. A., & Reichert, W. M. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.08.015 · Cited by 1,896 · see citing works
Interfering with pH regulation in tumours as a therapeutic strategy
Neri, D., & Supuran, C. T. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3554 · Cited by 1,551 · see citing works
Wang, E., Yao, H.-B., Chen, Y., Wang, G., Gao, W., Sun, Y., Guo, J., Hu, J., Jiang, C., & Hu, J. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350082 · Cited by 1,176 · see citing works
The ageing cortical synapse: hallmarks and implications for cognitive decline
Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965 · see citing works
A Leadless Intracardiac Transcatheter Pacing System
REYNOLDS, D. W., Duray, G. Z., Omar, R., Soejima, K., Neužil, P., Zhang, S., Narasimhan, C., Steinwender, C., Brugada, J., Lloyd, M. S., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1511643 · Cited by 935 · see citing works
Translational principles of deep brain stimulation
Kringelbach, M. L., Jenkinson, N., Owen, S. L. F., & Aziz, T. Z. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2196 · Cited by 853 · see citing works
Patolsky, F., Timko, B. P., Yu, G., Fang, Y., Greytak, A. B., Zheng, G., & Lieber, C. M. (2006) · Science · doi:10.1126/science.1128640 · Cited by 832 · see citing works
Self-citationThree-Dimensional, Flexible Nanoscale Field-Effect Transistors as Localized Bioprobes
Tian, B., Cohen‐Karni, T., Qing, Q., Duan, X., Xie, P., & Lieber, C. M. (2010) · Science · doi:10.1126/science.1192033 · Cited by 798 · see citing works
Self-citationMaterials and technologies for soft implantable neuroprostheses
Lacour, S. P., Courtine, G., & Guck, J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.63 · Cited by 738 · see citing works
Syringe-injectable electronics
Liu, J., Fu, T.-M., Cheng, Z., Hong, G., Zhou, T., Jin, L., Duvvuri, M., Jiang, Z., Kruskal, P., Xie, C., et al. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.115 · Cited by 687 · see citing works
Self-citationNeural recording and modulation technologies
Chen, R., Canales, A., & Anikeeva, P. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.93 · Cited by 655 · see citing works
Decoding motor imagery from the posterior parietal cortex of a tetraplegic human
Aflalo, T., Kellis, S., Klaes, C., Lee, B., Shi, Y., Pejsa, K., Shanfield, K., Hayes-Jackson, S., Aisen, M., Heck, C., et al. (2015) · Science · doi:10.1126/science.aaa5417 · Cited by 649 · see citing works
Macroporous Nanowire Nanoelectronic Scaffolds for Synthetic Tissues
Jia Liu, B., Dvir, T., Jin, L., Tsui, J. H., Qing, Q., Suo, Z., Langer, R., Kohane, D. S., Lieber, C. M., & Tian, B. (2012) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 642 · see citing works
Self-citationZhang, A., & Lieber, C. M. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00608 · Cited by 629 · see citing works
Self-citationMetabolic acidosis: pathophysiology, diagnosis and management
Kraut, J. A., & Madias, N. E. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.33 · Cited by 558 · see citing works
Feiner, R., Engel, L., Fleischer, S., Malki, M., Gal, I., Shapira, A., Shacham‐Diamand, Y., & Dvir, T. (2016) · Nature Materials · doi:10.1038/nmat4590 · Cited by 460 · see citing works
Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes
Xie, C., Liu, J., Fu, T.-M., Dai, X., Zhou, W., & Lieber, C. M. (2015) · Nature Materials · doi:10.1038/nmat4427 · Cited by 404 · see citing works
Self-citationInsights into the mechanisms of deep brain stimulation
Ashkan, K., Rogers, P., Bergman, H., & Ughratdar, I. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.105 · Cited by 365 · see citing works
Stable long-term chronic brain mapping at the single-neuron level
Tian-ming Fu, B., Hong, G., Zhou, T., Schuhmann, T. G., Viveros, R. D., & Lieber, C. M. (2016) · Nature Methods · doi:10.1038/nmeth.3969 · Cited by 326 · see citing works
Self-citationA nanoscale combing technique for the large-scale assembly of highly aligned nanowires
Yao, J., Yan, H., & Lieber, C. M. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.55 · Cited by 297 · see citing works
Self-citationQing, Q., Jiang, Z., Xu, L., Gao, R., Mai, L., & Lieber, C. M. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.273 · Cited by 257 · see citing works
Self-citationZhou, T., Hong, G., Fu, T.-M., Yang, X., Schuhmann, T. G., Viveros, R. D., & Lieber, C. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705509114 · Cited by 227 · see citing works
Self-citationDai, X., Zhou, W. M., Gao, T., Jia Liu, B., & Lieber, C. M. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.96 · Cited by 199 · see citing works
Self-citationNanowire transistor arrays for mapping neural circuits in acute brain slices
Qing, Q., Pal, S. K., Tian, B., Duan, X., Timko, B. P., Cohen‐Karni, T., Murthy, V. N., & Lieber, C. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914737107 · Cited by 197 · see citing works
Self-citationLong Term Stability of Nanowire Nanoelectronics in Physiological Environments
Zhou, W. M., Dai, X., Tian-ming Fu, B., Xie, C., Jia Liu, B., & Lieber, C. M. (2014) · Nano Letters · doi:10.1021/nl500070h · Cited by 149 · see citing works
Self-citationLocal β-Adrenergic Stimulation Overcomes Source-Sink Mismatch to Generate Focal Arrhythmia
Myles, R. C., Wang, L., Kang, C., Bers, D. M., & Ripplinger, C. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.262345 · Cited by 141 · see citing works
Hong, G., Tian-ming Fu, B., Zhou, T., Schuhmann, T. G., Huang, J., & Lieber, C. M. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b02987 · Cited by 128 · see citing works
Self-citationAdvances in nanowire bioelectronics
Zhou, W. M., Dai, X., & Lieber, C. M. (2016) · Reports on Progress in Physics · doi:10.1088/0034-4885/80/1/016701 · Cited by 117 · see citing works
Self-citationSpontaneous Internalization of Cell Penetrating Peptide-Modified Nanowires into Primary Neurons
Lee, J., Zhang, A., You, S. S., & Lieber, C. M. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b00020 · Cited by 98 · see citing works
Self-citationHou, J. H., Kralj, J. M., Douglass, A. D., Engert, F., & Cohen, A. E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00344 · Cited by 94 · see citing works
Syringe-injectable electronics with a plug-and-play input/output interface.
Schuhmann, T. G., Yao, J., Hong, G., Fu, T.-M., & Lieber, C. M. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03081 · Cited by 63 · see citing works
Self-citationShape-Controlled Deterministic Assembly of Nanowires
Zhao, Y., Yao, J., Xu, L., Mankin, M. N., Zhu, Y., Wu, H., Mai, L., Zhang, Q., & Lieber, C. M. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b00292 · Cited by 61 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Novel electrode technologies for neural recordings
Hong, G., & Lieber, C. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0140-6 · Cited by 695 · see citing works
Self-citationWang, L., Xie, S., Wang, Z., Liu, F., Yang, Y., Tang, C., Wu, X., Liu, P., Li, Y., Saiyin, H., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0462-8 · Cited by 387 · see citing works
Polymer nanocomposite meshes for flexible electronic devices
Gong, M., Zhang, L., & Wan, P. (2020) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2020.101279 · Cited by 270 · see citing works
Inorganic semiconductor biointerfaces
Jiang, Y., & Tian, B. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0062-3 · Cited by 239 · see citing works
Wearable and Implantable Soft Bioelectronics Using Two-Dimensional Materials
Choi, C., Lee, Y., Cho, K. W., Koo, J. H., & Kim, D. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00491 · Cited by 233 · see citing works
An atlas of nano-enabled neural interfaces
Ledesma, H. A., Li, X., Carvalho-de-Souza, J. L., Wei, W., Bezanilla, F., & Tian, B. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0487-x · Cited by 181 · see citing works
Cheng, C., Li, S., Xia, Y., Ma, L., Nie, C., Roth, C., Thomas, A., & Haag, R. (2018) · Advanced Materials · doi:10.1002/adma.201802669 · Cited by 162 · see citing works
Flexible Electrodes for In Vivo and In Vitro Electrophysiological Signal Recording
Zhu, M., Wang, H., Li, S., Liang, X., Zhang, M., Dai, X., & Zhang, Y. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202100646 · Cited by 158 · see citing works
Self-citationPrinting Flexible and Hybrid Electronics for Human Skin and Eye‐Interfaced Health Monitoring Systems
Kim, K., Kim, B., & Lee, C. H. (2019) · Advanced Materials · doi:10.1002/adma.201902051 · Cited by 146 · see citing works
Nanowired Bioelectric Interfaces
Tian, B., & Lieber, C. M. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00795 · Cited by 142 · see citing works
Self-citationLi, Y., Yang, C., & Guo, X. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00347 · Cited by 132 · see citing works
The future of neuroscience: flexible and wireless implantable neural electronics
McGlynn, E., Nabaei, V., Ren, E., Galeote‐Checa, G., Das, R., Curia, G., & Heidari, H. (2021) · Advanced Science · doi:10.1002/advs.202002693 · Cited by 115 · see citing works
Recent advances in bioelectronics chemistry
Fang, Y., Meng, L., Promiński, A., Schaumann, E. N., Seebald, M., & Tian, B. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00333f · Cited by 115 · see citing works
Origami Biosystems: 3D Assembly Methods for Biomedical Applications
Quiñones, V. A. B., Zhu, H. Y., Solovev, A. A., Mei, Y., & Gracias, D. H. (2018) · Advanced Biosystems · doi:10.1002/adbi.201800230 · Cited by 98 · see citing works
Martins, N. R. B., Angelica, A., Chakravarthy, K., Svidinenko, Y., Boehm, F. J., Opris, I., Lebedev, M. A., Swan, M., Garan, S. A., Rosenfeld, J. V., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00112 · Cited by 91 · see citing works
Recent development of implantable and flexible nerve electrodes
Shi, Y., Liu, R., He, L. M., Feng, H., Li, Y., & Li, Z. (2020) · Smart Materials in Medicine · doi:10.1016/j.smaim.2020.08.002 · Cited by 90 · see citing works
Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs
Jung, Y. H., Kim, J. U., Lee, J. S., Shin, J. H., Jung, W., Ok, J., & Kim, T. (2020) · Advanced Materials · doi:10.1002/adma.201907478 · Cited by 88 · see citing works
Hybrid Silicon Nanowire Devices and Their Functional Diversity
Baraban, L., Ibarlucea, B., Baek, E., & Cuniberti, G. (2019) · Advanced Science · doi:10.1002/advs.201900522 · Cited by 82 · see citing works
Hydrogel Gate Graphene Field-Effect Transistors as Multiplexed Biosensors
Bay, H. H., Vo, R., Dai, X., Hsu, L. H. H., Mo, Z., Cao, S., Li, W., Omenetto, F. G., & Jiang, X. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00431 · Cited by 77 · see citing works
Self-citationFluorescent silicon nanomaterials: from synthesis to functionalization and application
Song, B., & He, Y. (2019) · Nano Today · doi:10.1016/j.nantod.2019.03.005 · Cited by 73 · see citing works
Zhao, H., Kim, Y., Wang, H., Ning, X., Xu, C., Suh, J., Han, M., Pagan‐Diaz, G. J., Lu, W., Li, H., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100077118 · Cited by 66 · see citing works
Nanowire-enabled bioelectronics
Zhang, A., Lee, J., & Lieber, C. M. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101135 · Cited by 64 · see citing works
Self-citationZahra, T., Javeria, U., Jamal, H., Baig, M. M., Akhtar, F., & Kamran, U. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342880 · Cited by 62 · see citing works
Modularized Field-Effect Transistor Biosensors
Dai, X., Vo, R., Hsu, L. H. H., Deng, P. J., Zhang, Y., & Jiang, X. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b02939 · Cited by 54 · see citing works
Self-citationConducting Hydrogel‐Based Neural Biointerfacing Technologies
Zhang, P., Yang, Y., Li, Z., Xue, Y., Wang, F., Shan, L., Wang, Y., Shi, X., Wu, K., & Liu, J. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202422869 · Cited by 54 · see citing works
Engineering strategies towards overcoming bleeding and glial scar formation around neural probes
Otte, E., Vlachos, A., & Asplund, M. (2022) · Cell and Tissue Research · doi:10.1007/s00441-021-03567-9 · Cited by 50 · see citing works
Bukhtiar, A., & Zou, B. (2024) · Materials Advances · doi:10.1039/d4ma00523f · Cited by 49 · see citing works
Nanoenabled Direct Contact Interfacing of Syringe-Injectable Mesh Electronics
Lee, J. M., Hong, G., Lin, D., Schuhmann, T. G., Sullivan, A. T., Viveros, R. D., Park, H., & Lieber, C. M. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b03019 · Cited by 48 · see citing works
Self-citationGels, jets, mosquitoes, and magnets: a review of implantation strategies for soft neural probes
Apollo, N. V., Murphy, B. B., Prezelski, K., Driscoll, N., Richardson, A. G., Lucas, T. H., & Vitale, F. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/abacd7 · Cited by 45 · see citing works
Feng, X., Zhao, X., Liu, Y., Li, M., Qie, F., Guo, J., Zhang, Y., Li, T., Yuan, W., & Yan, Y. L. (2018) · Nature Communications · doi:10.1038/s41467-018-06150-z · Cited by 45 · see citing works
Photo–cross-linkable, insulating silk fibroin for bioelectronics with enhanced cell affinity
Ju, J., Hu, N., Cairns, D. M., Liu, H., & Timko, B. P. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003696117 · Cited by 42 · see citing works
Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology
Gibney, S., Hicks, J. M., Robinson, A. J., Jain, A., Sanjuan‐Alberte, P., & Rawson, F. J. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1693 · Cited by 41 · see citing works
Soft–Hard Composites for Bioelectric Interfaces
Lin, Y., Fang, Y., Yue, J., & Tian, B. (2020) · Trends in Chemistry · doi:10.1016/j.trechm.2020.03.005 · Cited by 33 · see citing works
Biomaterials-based bioengineering strategies for bioelectronic medicine
Panda, A. K., & Basu, B. (2021) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2021.100630 · Cited by 33 · see citing works
Advanced One- and Two-Dimensional Mesh Designs for Injectable Electronics
Viveros, R. D., Zhou, T., Hong, G., Tian-ming Fu, B., Lin, H. G., & Lieber, C. M. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b01727 · Cited by 32 · see citing works
Self-citationBioinspired flexible electronics for seamless neural interfacing and chronic recording
Li, H., Wang, J., & Fang, Y. Z. (2020) · Nanoscale Advances · doi:10.1039/d0na00323a · Cited by 31 · see citing works
Liu, Y., Yin, P., Chen, J., Cui, B., Zhang, C., & Wu, F. (2020) · International Journal of Polymer Science · doi:10.1155/2020/5659682 · Cited by 31 · see citing works
Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
Schuhmann, T. G., Zhou, T., Hong, G., Lee, J. M., Tian-ming Fu, B., Park, H., & Lieber, C. M. (2018) · Journal of Visualized Experiments · doi:10.3791/58003 · Cited by 30 · see citing works
Self-citationYalçın, Y. D., & Lüttge, R. (2021) · Organs-on-a-Chip · doi:10.1016/j.ooc.2021.100006 · Cited by 28 · see citing works
Neuron‐Inspired Ferroelectric Bioelectronics for Adaptive Biointerfacing
Wang, F., Wang, L., Zhu, X., Lu, Y., & Du, X. (2025) · Advanced Materials · doi:10.1002/adma.202416698 · Cited by 26 · see citing works
Biomimetic Flexible Sensors and Their Applications in Human Health Detection
Yu, H., Li, H., Sun, X., & Pan, L. (2023) · Biomimetics · doi:10.3390/biomimetics8030293 · Cited by 25 · see citing works
Semiconductor Nanowire‐Based Cellular and Subcellular Interfaces
Shi, J., Sun, C., Liang, E., & Tian, B. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107997 · Cited by 21 · see citing works
Nanoelectronics for Minimally Invasive Cellular Recordings
Pei, F., & Tian, B. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201906210 · Cited by 21 · see citing works
Methods for Powering Bioelectronic Microdevices
Lee, P. M., Xiong, Z., & Ho, J. S. (2018) · Bioelectronics in Medicine · doi:10.2217/bem-2018-0005 · Cited by 20 · see citing works
Nanocomposite Hydrogels as Functional Extracellular Matrices
Jooken, S., Deschaume, O., & Bartic, C. (2023) · Gels · doi:10.3390/gels9020153 · Cited by 17 · see citing works
Soft Conductive Interfacing for Bioelectrical Uses: Adhesion Mechanisms and Structural Approaches
Kim, J. H., Oh, J., Park, Y., Kim, J. J., & Jeong, U. (2023) · Macromolecules · doi:10.1021/acs.macromol.2c02236 · Cited by 16 · see citing works
Cellular-scale silicon probes for high-density, precisely localized neurophysiology
Egert, D., Pettibone, J. R., Lemke, S. M., Patel, P. R., Caldwell, C. M., Cai, D., Ganguly, K., Chestek, C. A., & Berke, J. D. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00352.2020 · Cited by 16 · see citing works
Siwakoti, U., Jones, S. A., Kumbhare, D., Cui, X. T., & Castagnola, E. (2025) · Biosensors · doi:10.3390/bios15020100 · Cited by 16 · see citing works
Advances in flexible high-density microelectrode arrays for brain-computer interfaces
Ban, S., Chong, D., Kwon, J., Lee, S., Huang, Y., Yoo, S., & Yeo, W. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.118102 · Cited by 15 · see citing works
3D conductive material strategies for modulating and monitoring cells
Li, X., Mao, M., Han, K., Yao, C., Gu, B., He, J., & Li, D. (2022) · Progress in Materials Science · doi:10.1016/j.pmatsci.2022.101041 · Cited by 14 · see citing works
Deterministic Assembly of Three-Dimensional Suspended Nanowire Structures
Gao, H., Yin, B., Wu, S., Liu, X., Fu, T., Zhang, C., Lin, J., & Yao, J. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b02198 · Cited by 14 · see citing works
Precision at Deep Brain: Noninvasive Temporal Interference Stimulation
Xu, S., Cui, H., Xiao, X., Manshaii, F., Hong, G., & Chen, J. (2025) · ACS Nano · doi:10.1021/acsnano.5c15238 · Cited by 13 · see citing works
Self-citationRobinson, K. J., Voelcker, N. H., & Thissen, H. W. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.12.037 · Cited by 12 · see citing works
Cleanroom strategies for micro- and nano-fabricating flexible implantable neural electronics
Walton, F., Cerezo‐Sánchez, M., McGlynn, E., Das, R., & Heidari, H. (2022) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2021.0009 · Cited by 12 · see citing works
Nano-enabled cellular engineering for bioelectric studies
Shi, J., Clayton, C., & Tian, B. (2019) · Nano Research · doi:10.1007/s12274-019-2580-8 · Cited by 12 · see citing works
Meng, Z., Gu, B., Yao, C., Li, J., Yu, K., Ding, Y. C., He, P., Jiang, N., Li, D., & He, J. (2024) · International Journal of Extreme Manufacturing · doi:10.1088/2631-7990/ad9365 · Cited by 9 · see citing works
Electroceuticals for neural regenerative nanomedicine
Tomaskovic‐Crook, E., Higginbottom, S. L., James, E. C., Rathbone, S. J. C., & Crook, J. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820223-4.00007-3 · Cited by 9 · see citing works
Nano‐ and Microscale Optical and Electrical Biointerfaces and Their Relevance to Energy Research
Hou, K., Yang, C., Shi, J., Kuang, B., & Tian, B. (2021) · Small · doi:10.1002/smll.202100165 · Cited by 8 · see citing works
An Integrated Optogenetic and Bioelectronic Platform for Regulating Cardiomyocyte Function
Bolonduro, O. A., Chen, Z., Fucetola, C. P., Lai, Y., Cote, M., Kajola, R. O., Rao, A. A., Liu, H., Tzanakakis, E. S., & Timko, B. P. (2024) · Advanced Science · doi:10.1002/advs.202402236 · Cited by 7 · see citing works
Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
Schuhmann, T. G., Zhou, T., Hong, G., Lee, J. M., Tian-ming Fu, B., Park, H., & Lieber, C. M. (2018) · Journal of Visualized Experiments · doi:10.3791/58003-v · Cited by 7 · see citing works
Self-citationPan, Y., Wang, W., Shui, Y., Murphy, J. F., & Huang, Y. Y. S. (2024) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2024.101930 · Cited by 6 · see citing works
Next-Generation Neural Interfaces Enabled by Nano-Bioelectronics- Review
Kishore Kanna, R., Danquah-Amoah, A., & Amponsah, S. (2024) · NanoNEXT · doi:10.54392/nnxt2444 · Cited by 5 · see citing works
Precise Control of Diazirine Reduction to Tune the Mechanical Properties of Electrocuring Adhesives
Ambrosi, A., Singh, M., Webster, R. D., & Steele, T. W. J. (2021) · ChemElectroChem · doi:10.1002/celc.202100594 · Cited by 5 · see citing works
1D and 2D Nanomaterials-based Electronics for Neural Interfaces
Xu, K., & Wang, J. (2020) · Acta Physico-Chimica Sinica · doi:10.3866/pku.whxb202003050 · Cited by 4 · see citing works
Cognitive Augmentation Via a Brain/Cloud Interface
Angelica, A., Opriș, I. C., Lebedev, M., & Boehm, F. (2021) · Contemporary clinical neuroscience · doi:10.1007/978-3-030-54564-2_17 · Cited by 3 · see citing works
Perspectives for Seamless Integration of Bioelectronic Systems in Neuromedicine
Nair, V., & Tian, B. (2020) · Springer eBooks · doi:10.1007/978-3-030-41854-0_16 · Cited by 3 · see citing works
Transparent and conformal microcoil arrays for spatially selective neuronal activation
Raghuram, V., Datye, A. D., Fried, S. I., & Timko, B. P. (2024) · Device · doi:10.1016/j.device.2024.100290 · Cited by 2 · see citing works
Future Prospected of Engineered Nanobiomaterials in Human Health Care
Freitas, G. B. L. D., & de Almeida, D. J. (2020) · Springer eBooks · doi:10.1007/978-981-32-9840-8_14 · Cited by 2 · see citing works
Reporter Scaffolds for Clinically Relevant Cell Transplantation Studies
Bolger, M. W., Groynom, R., Bogie, K. M., & Lavik, E. (2019) · Annals of Biomedical Engineering · doi:10.1007/s10439-019-02393-z · Cited by 2 · see citing works
Photo-Crosslinkable, Insulating Silk Fibroin for Bioelectronics with Enhanced Cell AffinityPreprint
Ju, J., Hu, N., Cairns, D. M., Liu, H., & Timko, B. P. (2020) · ChemRxiv · doi:10.26434/chemrxiv.11888202 · Cited by 2 · see citing works
Valentim, W. L., Tylee, D. S., & Polimanti, R. A. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1635 · Cited by 1 · see citing works
Toward Long-Term Bioelectronic Interfaces: Mechanical Compliance Meets Immunocompatibility
Zhu, Z., Zhou, X., Yin, Y., Ji, J., Wang, Y., & Zhang, P. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c13701 · Cited by 1 · see citing works
Multifunctional Freestanding Microprobes for Potential Biological Applications
Yang, N., Wang, Z., Xu, J., Gui, L., Tang, Z., Zhang, Y., Yi, M., Yue, S., & Xu, S. (2019) · Sensors · doi:10.3390/s19102328 · Cited by 1 · see citing works
A flexible implant for acute intrapancreatic electrophysiology
Pascual, D., Brauns, L., Domes, R., Tisler, M., Kögel, M., Stumpf, A., Kirschniak, A., Rolinger, J., Kraushaar, U., & Jones, P. D. (2023) · Biomedical Microdevices · doi:10.1007/s10544-023-00662-2 · Cited by 1 · see citing works
Extreme Mechanics of Hydrogels TowardIn SituHydrogel Bioelectronics
Wong, T. H., Zhao, X., & Lin, S. (2024) · doi:10.1002/9783527842308.ch1 · Cited by 1 · see citing works
Biomimicry for Injectable Mesh Nanoelectronics
Clayton, C., & Tian, B. (2019) · Bioelectronics in Medicine · doi:10.2217/bem-2019-0017 · Cited by 1 · see citing works
Augmentation of Brain Functions by Nanotechnology
Opriș, I. C., Preza, N., Lebedev, M., Noga, B. R., Chang, S. J., Casanova, M. F., Lupușoru, M. O. D., Pulgar, V. M., Khizroev, S., Bohorquez, J. E., et al. (2021) · Contemporary clinical neuroscience · doi:10.1007/978-3-030-54564-2_11
Integrating Molecular Functionalities into Electrical Circuits
Guo, X., Xiang, D., & Li, Y. (2020) · doi:10.1002/9783527818914.ch9
Neuroflex: Intraneural and Extraneural Flexible Sensor Architectures for Neural Probing
Patil, A. C., & Thakor, N. V. (2022) · Handbook of Neuroengineering · doi:10.1007/978-981-15-2848-4_16-2
Photo-Crosslinkable, Insulating Silk Fibroin for Bioelectronics with Enhanced Cell AffinityPreprint
Ju, J., Hu, N., Cairns, D. M., Liu, H., & Timko, B. P. (2020) · ChemRxiv · doi:10.26434/chemrxiv.11888202.v1
Neuroflex: Intraneural and Extraneural Flexible Sensor Architectures for Neural Probing
Patil, A. C., & Thakor, N. V. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_16
Chronic recording of brain activity in awake toads
Shaykevich, D. A., Woods, G. A., O’Connell, L. A., & Hong, G. (2024) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2025.110449
Self-citationLiu, T., Park, J., Okafor, S. S., Montgomery, S. K., Goestenkors, A. P., Semar, B. A., Alvarez, R. M., O'Hare, C. P., Wu, Y., Yu, J. S., et al. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c09421
Gu, W., Ju, J., & Wang, L. (2026) · Small · doi:10.1002/smll.74206
Garg, A., Zong, Z., Nie, M., Deaver, S. E., Order, E. M. V., Mejia, E., Vikesland, P. J., Gloag, E. S., & Zhou, W. M. (2026) · Advanced Science · doi:10.1002/advs.76330
He, Z., Ma, J., Liu, Y., & Du, Z. J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156752
- Authors
- Dai, X., Hong, G., Gao, T., & Lieber, C. M.
- Affiliations
- Harvard University (US)
- Corresponding author
- Lieber, Charles M.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-01-30
- Volume
- 51
- Issue
- 2
- Pages
- 309-318
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- PMC
- PMC5820158
- OpenAlex
- W2787592787
- Cited by
- 86
- References
- 34
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 10 · 2023: 6 · 2022: 4 · 2021: 12 · 2020: 17 · 2019: 19 · 2018: 8
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Accounts of Chemical Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH Office of the Director (1DP1EB025835-01)
- Harvard University
- American Heart Association (16POST27250219)
- Air Force Office of Scientific Research (FA9550-14-1-0136)
- U.S. Naval Research Laboratory (N00173-16-2-C007)
- National Institute on Aging (1K99AG056636-01)
- National Institute on Drug Abuse (1R21DA043985-01)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Keywords
- nanobioelectronics, cardiac patch, neural implants, glial scar, single-unit recording, neural circuits, brain aging
- MeSH terms
- Animals, Brain, Electronics, Medical, Humans, Neurons, Primates, Tissue Engineering, Mice, Rats, Electrical Equipment and Supplies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
