The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Circadian Integration of Metabolism and Energetics
Open accessAbstract
Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms with changes in cellular environment. Genetic disruption of clock genes in mice perturbs metabolic functions of specific tissues at distinct phases of the sleep/wake cycle. Circadian desynchrony, a characteristic of shift work and sleep disruption in humans, also leads to metabolic pathologies. Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This complex interconnected regulatory framework, ensures that the same molecules that regulate metabolism and reproduction, also contribute to a bidirectional feedback system with the autonomous circadian circuits [224,231]. This results in synchronicity of internal physiology with environmental cues, to optimize both individual and species survival.”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [231]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The molecular mechanisms of circadian clocks are similar across all species and are regulated by genetic enhancer/repressor elements, epigenetic modulation by methylation and acetylation, post-translation modification of regulatory proteins, and a variety of hormonal and signaling molecules [220,229,231].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [231]
Experimental — accuracy not yet measuredIn the citing paper
“The liver is the focus of circadian regulation of metabolic pathways, especially those controlling the synthesis and metabolism of glucose, lipid, cholesterol and bile acid (Bass and Takahashi, 2010).”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Bass and Takahashi, 2010
In the citing paper
“Circadian dysfunction among night-shift workers and individuals suffering from sleep dyspnea has been identified as a common risk factor of obesity, metabolic disorders, NAFLD and cancer including HCC (Bass and Takahashi, 2010; Fu and Kettner, 2013; Hu et al., 2013; Kao et al., 2012; Kim et al., 2013; Zimberg et al., 2012).”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Bass and Takahashi, 2010
In the citing paper
“Systemic and tissue-specific disruption of the circadian machinery leads to changes in cellular functions such as cell division and metabolism, both highly relevant to cancer (Bass and Takahashi, 2010; Hanahan and Weinberg, 2011; Masri et al., 2016; Sahar and Sassone-Corsi, 2009).”
From Circadian Rhythm Disruption Promotes Lung Tumorigenesis (2016) · cites this paper as Bass and Takahashi, 2010
In the citing paper
“Sleep loss is often accompanied with circadian misalignment, also known to cause changes in the regulation of the immune system and metabolism and associate to cardiovascular diseases7273.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [72]
In the citing paper
“Evidence is rapidly accumulating to indicate that misalignment between central and peripheral clocks has a host of adverse effects, including an increased risk of obesity and type 2 diabetes (37, 39).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [39]
In the citing paper
“For the metabolic syndrome, a systematic review by Canuto et al. in 2013 of ten studies, identified eight studies that found a positive association between shift work and metabolic syndrome after adjustment for sociodemographic and behavioural factors (19) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [19]
In the citing paper
“However, only three studies also adjusted for sleep duration and these showed conflicting results.”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Self-citationAdverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Entrainment of the circadian clock in the liver by feeding
Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
Self-citationHigh-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528
Self-citation
Cited by
Sorted by citations
Items 501–600 of 1,001
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8486-x · Cited by 54
Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington’s Disease
Whittaker, D. S., Loh, D. H., Wang, H. B., Tahara, Y., Kuljis, D. A., Cutler, T., Ghiani, C. A., Shibata, S., Block, G. D., & Colwell, C. S. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418790401 · Cited by 54
Microbiome dynamics in obesity
Thaiss, C. A. (2018) · Science · doi:10.1126/science.aav6870 · Cited by 54
Circadian Rhythm Is Disrupted by ZNF704 in Breast Carcinogenesis
Yang, C., Wu, J., Liu, X., Wang, Y., Liu, B., Chen, X., Wu, X., Yan, D., Han, L., Liu, S., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0493 · Cited by 54
Chronic circadian shift leads to adipose tissue inflammation and fibrosis
Xiong, X., Lin, Y., Lee, J., Paul, A., Yechoor, V. K., Figueiro, M. G., & Ma, K. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111110 · Cited by 53
Circadian rhythms and cancer: implications for timing in therapy
El‐Tanani, M., Rabbani, S. A., Ali, A. A., Alfaouri, I. G. A., Nsairat, H., Al-Ani, I. H., Aljabali, A. A. A., Rizzo, M., Patoulias, D., Khan, M. A., et al. (2024) · Discover Oncology · doi:10.1007/s12672-024-01643-4 · Cited by 53
Circadian Regulation of Macronutrient Absorption
Hussain, M. M., & Pan, X. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415599081 · Cited by 53
KPNB1 mediates PER/CRY nuclear translocation and circadian clock function
Lee, Y., Jang, A. R., Francey, L. J., Sehgal, A., & Hogenesch, J. B. (2015) · eLife · doi:10.7554/elife.08647 · Cited by 53
Weger, M., Weger, B. D., Diotel, N., Rastegar, S., Hirota, T., Kay, S. A., Strähle, U., & Dickmeis, T. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.04.035 · Cited by 53
Mice Deficient in Cryptochrome 1 (Cry1−/−) Exhibit Resistance to Obesity Induced by a High-Fat Diet
Griebel, G., Ravinet‐Trillou, C., Beeské, S., Avenet, P., & Pichat, P. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00049 · Cited by 53
Complex dynamics of transcription regulation
Stavreva, D. A., Varticovski, L., & Hager, G. L. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.03.004 · Cited by 53
Circadian clocks, diets and aging
Chaudhari, A., Gupta, R., Makwana, K., & Kondratov, R. V. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-160006 · Cited by 53
Circadian and Circannual Regulation in the Horse: Internal Timing in an Elite Athlete
Murphy, B. A. (2019) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2019.02.026 · Cited by 54
Vitale, J. A., Bonato, M., Torre, A. L., & Banfi, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174318 · Cited by 53
Circadian and Sleep Metabolomics Across Species
Malik, D. M., Paschos, G. K., Sehgal, A., & Weljie, A. M. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.04.027 · Cited by 54
Sleep-Wake Behavior in the Rat
Stephenson, R., Lim, J., Famina, S., Caron, A. M., & Dowse, H. B. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412461247 · Cited by 53
Wu, C. W., Liu, P.-Y., Tsai, P.-J., Wu, Y.-C., Hung, C.-S., Tsai, Y.-C., Cho, K.-H., Biswal, B. B., Chen, C.-J., & Lin, C.-P. (2012) · Brain Connectivity · doi:10.1089/brain.2012.0075 · Cited by 52
The role of circadian clocks in metabolic disease.
Li, M., Li, C.-M., & Wang, Z. (2012) · Europe PMC (PubMed Central) · Cited by 52
Jin, S., Zhou, X., Gu, F., Zhong, G., & Yi, X. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00672 · Cited by 52
Schmidt, M. H., Swang, T. W., Hamilton, I. M., & Best, J. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185746 · Cited by 52
Man, A. W. C., Xia, N., Daiber, A., & Li, H. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14850 · Cited by 52
Kosaisawe, N., Sparta, B., Pargett, M., Teragawa, C., & Albeck, J. G. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.01.014 · Cited by 52
Hesse, J., Martinelli, J., Aboumanify, O., Ballesta, A., & Relógio, A. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.08.051 · Cited by 52
Vargas-Martínez, F., Uvnäs-Moberg, K., Petersson, M., Olausson, H. A., & Jiménez-Estrada, I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.001 · Cited by 51
From Blue Light to Clock Genes in Zebrafish ZEM-2S Cells
Ramos, B. C. R., Moraes, M. N., Poletini, M. O., de Lima, L. H. R. G., & Castrucci, A. M. D. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106252 · Cited by 51
Circadian clock components in the rat neocortex: daily dynamics, localization and regulation
Rath, M. F., Rohde, K., Fahrenkrug, J., & Møller, M. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0415-4 · Cited by 51
Wu, E., Zhang, T., Tan, C., Peng, C., Chisti, Y., Wang, Q., & Gong, J. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02044-y · Cited by 51
Takeda, Y., Kang, H. S., Lih, F. B., Jiang, H., Blaner, W. S., & Jetten, A. M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku766 · Cited by 50
Sasaki, H., Ohtsu, T., Ikeda, Y., Tsubosaka, M., & Shibata, S. (2014) · Chronobiology International · doi:10.3109/07420528.2014.935785 · Cited by 50
Discovering and validating between-subject variations in plasma lipids in healthy subjects
Begum, H., Li, B., Shui, G., Cazenave‐Gassiot, A., Soong, R. C. T., Ong, R. T., Little, P., Teo, Y., & Wenk, M. R. (2016) · Scientific Reports · doi:10.1038/srep19139 · Cited by 50
Ray, S., & Reddy, A. B. (2016) · BioEssays · doi:10.1002/bies.201500056 · Cited by 50
Park, J., Cederroth, C. R., Basinou, V., Meltser, I., Lundkvist, G. B. S., & Canlon, B. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3616-15.2016 · Cited by 50
Fan, Z., Zhao, M. L., Joshi, P. D., Li, P., Zhang, Y., Guo, W., Xu, Y., Wang, H., Zhao, Z., & Yan, J. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx156 · Cited by 50
Circadian Metabolomics in Time and Space
Dyar, K. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00369 · Cited by 50
Shift work, chronotype and the risk of cardiometabolic risk factors
Hulsegge, G., Picavet, H. S. J., van der Beek, A. J., Verschuren, W. M. M., Twisk, J. W. R., & Proper, K. I. (2018) · European Journal of Public Health · doi:10.1093/eurpub/cky092 · Cited by 50
Hartsock, M. J., & Spencer, R. L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.023 · Cited by 52
Ershow, A. G., Peterson, C. M., Riley, W. T., Rizzo, A., & Wansink, B. C. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500202 · Cited by 50
Telomeres as Therapeutic Targets in Heart Disease
Yeh, J.-K., Lin, M.-H., & Wang, C.-Y. (2019) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2019.05.009 · Cited by 49
Predictive models of glucose control: roles for glucose‐sensing neurones
Kosse, C., González, J. A., & Burdakov, D. (2014) · Acta Physiologica · doi:10.1111/apha.12360 · Cited by 49
Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity
Cha, J. Y., Kim, H. J., Yu, J. H., Xu, J., Kim, D., Paul, B. D., Choi, H., Kim, S., Lee, Y. J., Ho, G. P. H., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320454110 · Cited by 49
Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder
Lindberg, D. M., Andres‐Beck, L. G., Jia, Y., Kang, S., & Choi, D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00009 · Cited by 49
The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer
Morgan, M. N., Dvuchbabny, S., Martinez, C.-A., Kerr, B., Cistulli, P. A., & Cook, K. M. (2019) · Clocks & Sleep · doi:10.3390/clockssleep1040034 · Cited by 50
Circadian regulation of astrocyte function: implications for Alzheimer’s disease
McKee, C. A., Lananna, B. V., & Musiek, E. S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03314-y · Cited by 49
Yan, R., Ho, C., & Zhang, X. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000187 · Cited by 49
Man, A. W. C., Xia, N., & Li, H. (2020) · Antioxidants · doi:10.3390/antiox9100968 · Cited by 49
Tognini, P., Samad, M., Kinouchi, K., Liu, Y., Helbling, J., Moisan, M., Eckel‐Mahan, K. L., Baldi, P., & Sassone‐Corsi, P. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016589117 · Cited by 49
Tang, Y., Du, X., Sun, S., Shi, W. M., Han, Y., Zhou, W., Zhang, J., Teng, S., Ren, P., & Liu, G. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.1c06735 · Cited by 49
Escobar, C., Espítia‐Bautista, E., Guzmán‐Ruiz, M. A., Guerrero‐Vargas, N. N., Hernández-Navarrete, M. Á., Castellanos, A., Morales-Pérez, B., & Buijs, R. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-63227-w · Cited by 48
Hu, L., Li, G., Shu, Y.-Y., Hou, X., Yang, L., & Jin, Y. T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.935919 · Cited by 48
Zhang, R., Cai, X., Lin, C., Yang, W., Lv, F., Wu, J., & Ji, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1008820 · Cited by 48
Does the circadian system regulate lactation?
Plaut, K. I., & Casey, T. (2011) · animal · doi:10.1017/s1751731111002187 · Cited by 48
Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms
Li, A., Wiater, M. F., Oostrom, M. T., Smith, B. R., Wang, Q., Dinh, T. T., Roberts, B. L., Jansen, H. T., & Ritter, S. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00086.2012 · Cited by 48
Central signalling cross‐talk between insulin and leptin in glucose and energy homeostasis
Boucsein, A., Kamstra, K., & Tups, A. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12944 · Cited by 48
Erkekoğlu, P., & Baydar, T. (2012) · Journal of Research in Pharmacy Practice · doi:10.4103/2279-042x.108369 · Cited by 47
How is the inner circadian clock controlled by interactive clock proteins?
Merbitz-Zahradnik, T., & Wolf, E. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.05.024 · Cited by 47
Persistence, Entrainment, and Function of Circadian Rhythms in Polar Vertebrates
Williams, C. T., Barnes, B. M., & Buck, C. L. (2015) · Physiology · doi:10.1152/physiol.00045.2014 · Cited by 47
Chen, X., Zhou, Y., Xu, H., Ding, M., Zhang, Y., Zhang, M., Hu, M., Huang, X. H., & Song, L. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.03.006 · Cited by 47
McKee, C. A., Lee, J., Cai, Y., Saito, T., Saido, T. C., & Musiek, E. S. (2022) · Scientific Reports · doi:10.1038/s41598-022-05862-z · Cited by 47
Guido, M. E., Monjes, N. M., Wagner, P. M., & Salvador, G. A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02595-4 · Cited by 46
Hu, S., Hu, C., Luo, L., Zhang, H., Zhao, S., Liu, Z., & Zeng, L. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.133500 · Cited by 46
Disassociation between Preprandial Gut Peptide Release and Food-Anticipatory Activity
Dailey, M. J., Stingl, K. C., & Moran, T. H. (2011) · Endocrinology · doi:10.1210/en.2011-1464 · Cited by 46
Wang, H., Gu, Y., Zheng, L., Liu, L., Meng, G., Wu, H., Xia, Y., Bao, X., Shi, H., Sun, S., et al. (2018) · Liver International · doi:10.1111/liv.13896 · Cited by 46
Shift Work and the Risk of Cardiovascular Diseases and Metabolic Syndrome Among Jordanian Employees
Farha, R. K. A., & Alefishat, E. A. (2018) · Oman Medical Journal · doi:10.5001/omj.2018.43 · Cited by 46
Peng, H., Zhang, J., Zhang, P., Chen, L., Tang, L., Yang, X., He, Q., Wen, X., Sun, Y. H., Liu, N., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0997-7 · Cited by 46
Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters
Petkau, N., Budak, H., Zhou, X., Oster, H., & Gregor Eichele, C. (2019) · eLife · doi:10.7554/elife.43235 · Cited by 46
Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues
Khalyfa, A., Gaddameedhi, S., Crooks, E., Zhang, C., Li, Y., Qiao, Z., Trzépizur, W., Kay, S. A., Andrade, J., Satterfield, B. C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176396 · Cited by 46
Kohtala, S., Alitalo, O., Rosenholm, M., Rozov, S. V., & Rantamäki, T. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107741 · Cited by 47
BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cellsPreprint
Zhu, P., Hamlish, N. X., Thakkar, A. V., Steffeck, A. W. T., Rendleman, E. J., Khan, N. H., Waldeck, N. J., DeVilbiss, A., Martin-Sandoval, M. S., Mathews, T. P., et al. (2022) · Genes & Development · doi:10.1101/gad.349066.121 · Cited by 46
The SCN Clock Governs Circadian Transcription Rhythms in Murine Epididymal White Adipose Tissue
Kolbe, I., Husse, J., Salinas, G., Lingner, T., Astiz, M., & Oster, H. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416666170 · Cited by 45
Estrogens Prevent Metabolic Dysfunctions Induced by Circadian Disruptions in Female Mice
Zhu, L., Zou, F., Yang, Y., Xu, P., Saito, K., Hinton, A. O., Jr., Yan, X., Ding, H., Wu, Q., Fukuda, M., et al. (2015) · Endocrinology · doi:10.1210/en.2014-1922 · Cited by 45
LACTATION BIOLOGY SYMPOSIUM: Circadian clocks as mediators of the homeorhetic response to lactation1
Casey, T., & Plaut, K. I. (2012) · Journal of Animal Science · doi:10.2527/jas.2011-4590 · Cited by 45
Zhou, L., Gao, Q., Nie, M., Gu, J., Hao, W., Wang, L., & Cao, J. (2016) · Scientific Reports · doi:10.1038/srep36335 · Cited by 45
Sleep Deprivation and Gene Expression
Souza, A. D. C., & Ribeiro, S. T. G. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_360 · Cited by 45
Oishi, K., Uchida, D., & Itoh, N. (2012) · Chronobiology International · doi:10.3109/07420528.2012.699127 · Cited by 45
Knitting Up the Raveled Sleave of Care
Yang, G., Paschos, G. K., Curtis, A. M., Musiek, E. S., McLoughlin, S. C., & FitzGerald, G. A. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007225 · Cited by 45
Baeza-Raja, B., Eckel-Mahan, K., Zhang, L., Vagena, E., Tsigelny, I. F., Sassone-Corsi, P., Ptacek, L. J., & Akassoglou, K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2757-12.2013 · Cited by 44
The relationship between fasting-induced torpor, sleep, and wakefulness in laboratory mice
Huang, Y., Flaherty, S. J., Pothecary, C. A., Foster, F., Peirson, S. N., & Vyazovskiy, V. V. (2021) · SLEEP · doi:10.1093/sleep/zsab093 · Cited by 42
Food for Thought: Hormonal, Experiential, and Neural Influences on Feeding and Obesity
Karatsoreos, I. N., Thaler, J. P., Borgland, S. L., Champagne, F. A., Hurd, Y. L., & Hill, M. N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3452-13.2013 · Cited by 44
Webel, A. R., Moore, S. M., Hanson, J. E., Patel, S. R., Schmotzer, B. J., & Salata, R. A. (2013) · Applied Nursing Research · doi:10.1016/j.apnr.2012.10.002 · Cited by 44
Paredes, J. F., López‐Olmeda, J. F., Martínez, F. J. S., & Sánchez‐Vázquez, F. J. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1104327 · Cited by 44
Covassin, N., Singh, P., & Somers, V. K. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.06588 · Cited by 44
Disruptions in gut microbial-host co-metabolism and the development of metabolic disorders
Rajani, C., & Jia, W. P. (2018) · Clinical Science · doi:10.1042/cs20171328 · Cited by 44
Yang, M., Ren, B., Qiao, L., Ren, B., Hu, Y., Zhao, R., Ren, Z., & Du, J. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.07.018 · Cited by 44
Ma, D., Liu, T., Chang, L., Rui, C., Xiao, Y., Li, S., Hogenesch, J. B., Chen, Y. E., & Lin, J. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.685982 · Cited by 44
Extracellular Vesicles: Potential Participants in Circadian Rhythm Synchronization
Tao, S., & Guo, S. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.26518 · Cited by 44
The Genetics of Circadian Rhythms in Neurospora
Lakin‐Thomas, P. L., Bell‐Pedersen, D., & Brody, S. (2011) · Advances in genetics · doi:10.1016/b978-0-12-387690-4.00003-9 · Cited by 44
Fame, R. M., Kalugin, P. N., Petrova, B., Xu, H., Soden, P. A., Shipley, F. B., Dani, N., Grant, B. F., Pragana, A., Head, J. P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39326-3 · Cited by 43
Stroke in the Time of Circadian Medicine
Mergenthaler, P., Balami, J. S., Neuhaus, A. A., Mottahedin, A., Albers, G. W., Rothwell, P. M., Saver, J. L., Young, M. E., & Buchan, A. M. (2024) · Circulation Research · doi:10.1161/circresaha.124.323508 · Cited by 43
Pharmacological targeting of BMAL1 modulates circadian and immune pathways
Pu, H., Bailey, L. C., Bauer, L. G., Voronkov, M., Baxter, M. D., Huber, K., Khorasanizadeh, S., Ray, D. W., & Rastinejad, F. (2025) · Nature Chemical Biology · doi:10.1038/s41589-025-01863-x · Cited by 47
Regulation of myocardial metabolism by the cardiomyocyte circadian clock
Chatham, J. C., & Young, M. E. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.06.016 · Cited by 43
Circadian rhythms in leukocyte trafficking
Druzd, D., de Juan, A., & Scheiermann, C. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-013-0414-4 · Cited by 43
Manipulating the Circadian and Sleep Cycles to Protect Against Metabolic Disease
Nohara, K., Yoo, S. H., & Chen, Z. (. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00035 · Cited by 43
Circadian rhythm abnormalities – Association with the course of inflammatory bowel disease
Sobolewska-Włodarczyk, A., Włodarczyk, M., Szemraj, J., Stec‐Michalska, K., Fichna, J., & Wiśniewska‐Jarosińska, M. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.04.007 · Cited by 43
Onaolapo, A. Y., & Onaolapo, O. J. (2018) · World Journal of Diabetes · doi:10.4239/wjd.v9.i7.99 · Cited by 43
Rivera-Reyes, A., Ye, S., Marino, G. E., Egolf, S., Ciotti, G. E., Chor, S., Liu, Y., Posimo, J. M., Park, P. M. C., Pak, K., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1142-4 · Cited by 43
Appropriate Thiamin Pyrophosphate Levels Are Required for Acclimation to Changes in Photoperiod
Rosado-Souza, L., Proost, S., Moulin, M., Bergmann, S., Bocobza, S. E., Aharoni, A., Fitzpatrick, T. B., Mutwil, M., Fernie, A. R., & Obata, T. (2019) · PLANT PHYSIOLOGY · doi:10.1104/pp.18.01346 · Cited by 43
Shen, X., Chen, Y., Zhang, J., Xu, Y., Liu, W., Guo, Y., Shan, Q., & Liu, S. (2019) · Environment International · doi:10.1016/j.envint.2019.04.058 · Cited by 43
Liu, Z., Qian, M., Tang, X., Hu, W., Sun, S., Guo, L., Zhang, S., Meng, F., Cao, X., Sun, J. L., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0136-6 · Cited by 43
The Molecular Clock and Neurodegenerative Disease: A Stressful Time
Carter, B., Justin, H. S., Gulick, D., & Gamsby, J. J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.644747 · Cited by 42
Circadian Oscillations of Molecular Clock Components in the Cerebellar Cortex of the Rat
Rath, M. F., Rohde, K., & Møller, M. (2012) · Chronobiology International · doi:10.3109/07420528.2012.728660 · Cited by 42
Metadata
- Authors
- Bass, J., & Takahashi, J. S.
- Affiliations
- Northwestern University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bass, Joseph
- Venue
- Science
- Published
- 2010-12-03
- Volume
- 330
- Issue
- 6009
- Pages
- 1349-1354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3756146
- OpenAlex
- W2157481078
- Cited by
- 1,910
- References
- 69
- Citations by year
- 2026: 112 · 2025: 123 · 2024: 106 · 2023: 112 · 2022: 146 · 2021: 124 · 2020: 125 · 2019: 137 · 2018: 112 · 2017: 124 · 2016: 117 · 2015: 130 · 2014: 129 · 2013: 123 · 2012: 117
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5p50mh074924-05)
- National Institute on Aging (P01AG011412)
- National Heart, Lung, and Blood Institute (R01HL097817)
- National Institute of Mental Health (P50 MH-074924, R01MH078024)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- circadian clock, clock genes, circadian rhythm, metabolism, cellular energetics, sleep deprivation, shift work, circadian desynchrony, obesity, diabetes mellitus, sleep-wake cycle
- MeSH terms
- Animals, Diabetes Mellitus, Energy Metabolism, Gene Expression Regulation, Homeostasis, Humans, Metabolism, Obesity, Sleep Deprivation, Transcription, Genetic, Protein Biosynthesis, Signal Transduction, Sleep Disorders, Circadian Rhythm, Feedback, Physiological, Gene Regulatory Networks, Metabolic Networks and Pathways, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
